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Role of Research in the Field of UTI
-Past, Present and Future(from my Personal History)
Joichi Kumazawa
My history
1: Postgraduate School (1960-1964)
2: Dept. of Urology, Kyushu University (The first term) (1964-1969)
3: Harvard Medical School (1969-1970)
4: Dept. of Urology, Kyushu University (The second term) (19701979)
5: Dept. of Urology, Saga Medical College (1979-1984)
6: Dept. of Urology, Kyushu University (The third term) (1984-1998)
7: After the retirement from Kyushu University (1998-present)
1: Postgraduate school (1960-1964)
(Dept. of Bacteriology and Dept. of Urology)
# Chronological change of urinary isolates
Method of urine collection
Quantitative culture of urine: Surface spreading method
Antimicrobial susceptibility test of urinary isolates
# Pathogenesis of urinary isolates: Immunological research
(Serum antibody detection by hemagglutination in UTI patients)
# Annual meeting of JUA: First symposium on UTIs (Tokyo, 1962)
# UTIs in children
非特異性尿路感染症に関する研究
第1報 尿路分離菌の年次的変遷について
大学院生 熊澤淨一
九州大学医学部泌尿器科教室（主任 富川梁次教授）
Studies of non-Specific Urinary Tract Infection.
I. Chronological changes of Bacteria Isolated in Urinary
Tract Infection.
Zyoichi KUMAZAWA M.D
Department of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
福岡医学雑誌第54巻第10号（昭和38年11月25日）
FUKUOKA ACTA MEDICA, 54(10):1072-1083,1962
Number of bacteria
in first-catch urine (VB1), mid-stream urine (VB2)
and urine by catheter-collection
Number of bacteria in urine in patients with or without UTI
1: Postgraduate school (1960-1964)
Dept. of Bacteriology and Dept. of Urology
# Chronological change of urinary isolates
Method of urine collection
Quantitative culture of urine: Surface spreading method
Antimicrobial susceptibility test of urinary isolates
# Pathogenesis of urinary isolates: Immunological research
(Serum antibody detection by hemagglutination in UTI patients)
# Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962]
# UTIs in children
非特異性尿路感染症に関する研究
第2報 尿路分離菌の病原性に関する免疫学的研究
大学院生 熊澤淨一
九州大学医学部泌尿器科教室（主任 富川梁次教授）
Studies of non-Specific Urinary Tract Infection.
I. Immunological Determination on Pathogenicity of
Bacteria Isolated in Urinary Tract Infection.
Zyoichi KUMAZAWA M.D
Department of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
福岡医学雑誌第54巻第10号（昭和38年11月25日）
FUKUOKA ACTA MEDICA, 54(10):1084-1103,1963
Antibody titers in 22 patients
with >105/ml of bacteriuria during >7 days
Bacterial species
Antibody titer
>160
<160
Escherichia coli
5
1
Pseudomonas aeruginosa 4
Proteus spp
2
1
Staphylococcus spp
1
2
Klebsiella spp
2
1
Enterobacter aerogenes
3
Total
17 (77.3%) 5 (22.7%)
1: Postgraduate school (1960-1964)
Dept. of Bacteriology and Dept. of Urology
# Chronological change of urinary isolates
Method of urine collection
Quantitative culture of urine: Surface spreading method
Antimicrobial susceptibility test of urinary isolates
# Pathogenesis of urinary isolates: Immunological research
(Serum antibody detection by hemagglutination in UTI patients)
# Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962]
# UTIs in children
小児泌尿器疾患の統計的観察
S. Sakamoto, J. Kumazawa and M. Ishizu
Statistical Observation of Urogenital Diseases in Children
九州大学医学部泌尿器科教室（主任 富川梁次教授）
坂本公孝
熊澤淨一
石津又三
皮膚と泌尿
（昭和39年2月発行）
HIFU to HINYO 26(1):43-48,1964
UTIs in pediatric outpatients
Incidence
Basic diseases
Number Infection (%)
Uncomplicated UTIs
143
67
46.9
(Hemorrhagic cystitis)
(53)
(52)
(98.1)
Inflammation of genital region 29
5
17.2
Urinary Stone
21
14
66.6
Congenital urinary obstruction 24
13
54.2
Neurogenic bladder
17
9
53.0
Urinary tumor
9
6
66.6
Nephritis or nephrosis
25
2
8.0
Others
538
6
1.1
Total
806
122
15.1
2: Dept. of Urology, Kyushu University (The first term) (1964-1969)
# Experimental pyelonephritis
# VUR in children
# Publish: 「尿路感染症の臨床：Clinical aspect of UTIs」(1965)
# Chronological changes in urinary isolates
# Detection of fallen bacteria in the hospital:
Pseudomonas aeruginosa
実験的腎盂腎炎に対するEnduracidinの効果
Effect of Enduracidin on Experimental Pyelonephritis
S. Momose, J. Kumazawa, S. Narahashi, S. Hidaka
CHEMOTHERAPY 16(4):466-469,1968
百瀬俊郎
熊澤淨一
楢橋勝利
日高正昭
九州大学医学部泌尿器科
Experimental method
2: Dept. of Urology, Kyushu University (The first term) (1964-1969)
# Experimental pyelonephritis
# VUR in children
# 「尿路感染症の臨床：Clinical aspect of UTIs」published (1965)
# Chronological changes in urinary isolates
# Detection of fallen bacteria in the hospital:
Pseudomonas aeruginosa
いわゆる萎縮腎型腎盂腎炎に関する２，３の考察
Some Aspects on So-called Atrophic Pyelonephritis
K. Sakamoto, J. Kumazawa, K. Narahashi
From Department of Urology, Faculty of Medicine, Kyushu University
(Director: Prof. Dr. S. Momose)
泌尿器科紀要 第12巻第1号
Acta Urologica Japonica 12(1):71-77,1966
VUR in patients with chronic UTIs
Generation Number
VUR Incidence (%)
Children
Adults
8
22
5
5
62.5
22.7
Total
30
10
33.3
Clinical aspect of UTIs
published in 1965
3: Harvard Medical School (1969-1970)
# Experimental pyelonephritis
# Quantitative culture of bacteria in urine (Dip Slide Method)
基疾患を伴う実験的腎盂腎炎に対する化学療法の効果
The effect of Chemotherapy for the Experimental
Pyelonephritis with Some Underlying Course
J. Kumazawa
Department of Urology(Director: Prof. S. Momose), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
Channing Laboratory (Director: Prof. Edward H. Kass), Department of
Medicine, Harvard Medical School, Boston. Mass., USA
熊澤淨一
九州大学医学部泌尿器科（主任：百瀬俊郎）
西日本泌尿器科 第33巻第2号
Nishinihon J. Urol. 33(2):183-189,1971
簡易尿中細菌定量培養法
Evaluation of Simplified Quantitative Culture Methods of
Urinary Bacteria
J. Kumazawa, S. Nakamuta, H. Ito, S. Hieda
Department of Urology(Director: Prof. S. Momose), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
熊澤淨一、中牟田誠一、伊藤秀明、稗田定
九州大学医学部泌尿器科（主任：百瀬俊郎）
西日本泌尿器科 第38巻第4号
Nishinihon J. Urol. 38(4):477-487,1976
4: Dept. of Urology, Kyushu University (The second term) (1970
-1979)
# Anaerobic bacteria
# Clinical evaluation of drug efficacy in UTIs
Kyushu University Criteria (1970)
Japanese Criteria (1976)
(Establishment of Japanese Research Association on UTIs)
# UTIs in children: VUR
# Nosocomial infection
Pseudomonas aeruginosa
Closed drainage system
# Chronological change of urinary isolates
Significance of Anaerobic Bacteria Isolated from the
Urinary Tract
I. Clinical studies
J. Kumazawa, H. Kiyohara, K. Narahashi, M. Hidaka, S. Momose
From the Department of Urology(Director: Prof. S. Momose), Faculty of
Medicine, Kyushu University, Fukuoka, Japan
J. Urol 112:257-260,1974
Significance of Anaerobic Bacteria Isolated from the
Urinary Tract
II. Experimental studies
J. Kumazawa, H. Kiyohara, S. Momose
From the Department of Urology(Director: Prof. S. Momose), Faculty of
Medicine, Kyushu University, Fukuoka, Japan
Invest. Urol. 13:309-312,1975
4: Dept. of Urology, Kyushu University (The second term) (1970
-1979)
# Anaerobic bacteria
# Clinical evaluation of drug efficacy in UTIs
Kyushu University Criteria (1970)
Japanese Criteria (1976)
(Establishment of Japanese Research Association on UTIs)
# UTIs in children: VUR
# Nosocomial infection
Pseudomonas aeruginosa
Closed drainage system
# Chronological change of urinary isolates
Clinical Effectiveness of Piromidic Acid (PA) on Acute
Nonspecific Cystitis.
Evaluation with Double Blind Method
J. Kumazawa, S. Momose et al
Department of Urology(Director: Prof. S. Momose), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
Chemotherapy 19(5):657-664,1971
A Double Blind Controlled Study to Compare CS-1170
(Cefmetazole) and Cefazolin in the Treatment of
Chronic Complicated Urinary Tract Infections
S. Momose, J. Kumazawa, et al
Department of Urology(Director: Prof. S. Momose), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
Nishinihon J. Urol. 41(1):173-200,1979
UTI薬効評価基準
Criteria for Evaluation of Clinical Efficacy of
Antimicrobial Agents on Urinary Tract Infection
（第4版暫定案）
1996年12月5日
4: Dept. of Urology, Kyushu University (The second term) (1970
-1979)
# Anaerobic bacteria
# Clinical evaluation of drug efficacy in UTIs
Kyushu University Criteria (1970)
Japanese Criteria (1976)
(Establishment of Japanese Research Association on UTIs)
# UTIs in children: VUR
# Nosocomial infection
Pseudomonas aeruginosa
Closed drainage system
# Chronological change of urinary isolates
小児尿路感染症-現況と治療の問題点Urinary Tract Infection in Childhood
J. Kumazawa
Department of Urology(Director: Prof. S. Momose), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
熊澤淨一
九州大学医学部泌尿器科（主任：百瀬俊郎）
西日本泌尿器科 第35巻第2号
Nishinihon J. Urol. 35(2):144-152,1973
VUR and Pyelonephritis
J. Kumazawa
Associate Professor, Department of Urology, Faculty of Medicine, Kyushu
University, Fukuoka, Japan
Proceedings of The First Asian Pacific Congress of Nephrology
p 94-97, 1979
4: Dept. of Urology, Kyushu University (The second term) (1970
-1979)
# Anaerobic bacteria
# Clinical evaluation of drug efficacy in UTIs
Kyushu University Criteria (1970)
Japanese Criteria (1976)
(Establishment of Japanese Research Association on UTIs)
# UTIs in children: VUR
# Nosocomial infection
Pseudomonas aeruginosa
Closed drainage system
# Chronological change of urinary isolates
泌尿器科的手技と病院感染
ー緑膿菌感染を中心にー
Pseudomonas aeruginosa: Hospital Infection in Urological
Field
J. Kumazawa, S. Nakamuta, H. Ito, S. Momose
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka,
Japan
熊澤淨一,中牟田誠一、伊藤秀明、百瀬俊郎
九州大学医学部泌尿器科
最新医学 第30巻第3号
Saishin Igaku 30(3):402-407,1975
Closed drainage system（閉鎖式持続導尿装置）の使用経験
A Clinical Application of Closed Urinary Drainage System
J. Kumazawa, S Nakamuta, S. Momose
Department of Urology(Director: Prof. S. Momose), Faculty of Medicine,
Kyushu University, Fukuoka, Japan
熊澤淨一,中牟田誠一、百瀬俊郎
九州大学医学部泌尿器科（主任：百瀬俊郎）
西日本泌尿器科 第38巻第5号
Nishinihon J. Urol. 38(5):660-668,1976
5: Dept. of Urology, Saga Medical College (1979-1984)
# Development of New Antimicrobial agents: A Person in Charge of
Clinical trials
Fluoroquinolones, Cephems, Aminoglycosides etc
# Enterococcus spp
# Establishment of STD Research Group in Fukuoka and Saga
(1984)
6: Dept. of Urology, Kyushu University (The third term) (19841998)
# UTI Research Group in the Dept. of Urology, Kyushu University
Leader; Dr Tetsuro Matsumoto
Sub-leader; Dr Masatoshi Tanaka
Molecular biological approach in the basic and clinical research
on UTIs
Bacterial pili, Adherence, Superoxide, Renal scarring (VUR)
# UTIs in the elderly
# STDs
# Infection control
Increases renal scarring by bacteria with mannose-sensitive pili
T. Matsumoto, Y. Mizunoe, N. Sakamoto, M. Tanaka, J. Kumazawa
Department of Urology, Faculty of Medeicine, Kyushu University
Urol. Res. 18:299-303,1990
Role of superoxide in renal scarring following infection
by mannose-sensitve piliated bacteria
T. Matsumoto, Y. Mizunoe, N. Ogata, M. Tanaka, J. Kumazawa
Department of Urology, Faculty of Medicine, Kyushu University
Urol. Res. 19:229-233,1991
分子生物学的アプローチによる尿路感染症の解析
Molecular Biological Approach in the Research of UTIs
九州大学医学部泌尿器科
熊澤淨一
Joichi Kumazawa
Department of Urology, Faculty of Medicine, Kyushu University
日本泌尿器科学会雑誌第85巻第1号
Jap. J. Urol. 85(1):14-18,1994
6: Dept. of Urology, Kyushu University (The third term) (19841998)
# UTI Research Group in the Dept. of Urology, Kyushu University
Leader; Tetsuro Matsumoto
Sub-leader; Masatoshi Tanaka
Molecular biological approach in the basic and clinical research
on UTIs
Bacterial pili, Adherence, Superoxide, Renal scarring (VUR)
# UTIs in the elderly
# STDs
# Infection control
Urinary Tract Infection in Geriatric Patients
T. Matsumoto, J. Kumazawa
Department of Urology, School of Medicine, University of Occupational and
Environmental Health
Department of Urology, Faculty of Medicine, Kyushu University
Int. J. Antimicrob. Agents 11:269-273,1999
6: Dept. of Urology, Kyushu University (The third term) (19841998)
# UTI Research Group in the Dept. of Urology, Kyushu University
Leader; Tetsuro Matsumoto
Sub-leader; Masatoshi Tanaka
Molecular biological approach in the basic and clinical research
on UTIs
Bacterial pili, Adherence, Superoxide, Renal scarring (VUR)
# UTIs in the elderly
# STDs
# Infection control
Emergence of In Vitro Resistance to Fluoroquinolones
in Neisseria gonorrhoeae Isolated in Japan
M. Tanaka, T. Matsumoto, I. Kobayashi, U.Uchino, J. Kumazawa
Department of Urology, Faculty of Medicine, Kyushu University
Antimicrob. Agents Chemother. 39:2367-2370,1995
Development of Fluoroquinolone Resistance and Mutations
involving GyrA and ParC proteins among Neisseria gonorrhoeae
isolated in Japan
M. Tanaka, K. Takahashi, T. Saika, I. Kobayashi, T.Ueno, J. Kumazawa
Department of Urology, Faculty of Medicine, Kyushu University
J. Urol. 159:2215-2219,1998
6: Dept. of Urology, Kyushu University (The third term) (19841998)
# UTI Research Group in the Dept. of Urology, Kyushu University
Leader; Tetsuro Matsumoto
Sub-leader; Masatoshi Tanaka
Molecular biological approach in the basic and clinical research
on UTIs
Bacterial pili, Adherence, Superoxide, Renal scarring (VUR)
# UTIs in the elderly
# STDs
# Infection control
院内感染防止対策指針
Guidelines for the Prevention of Nosocomial Infections
九州大学医学部附属病院院内感染予防対策委員会
Infection Control Committee, Kyushu University Hospital
6: Dept. of Urology, Kyushu University (The third term)(1984-1998)
# Establish: Japanese Society for STDs (1988)
# Establish: International UTI symposium (1989)
# Establish: Japanese Research Group for UTIs (1990)
# Congress and Meeting(UTI)
1st Asian Urological Congress (1990)
7th Korea-Japan Urological Congress (1990)
7th Annual meeting of Japanese Society of Environmental Infection
5th Annual meeting of Japanese Society for STDs
82nd Annual meeting of Japanese Urological Association
42nd Annual meeting of Japanese Society of Chemotherapy
# Officer of Society; President of Japanese Society of Chemotherapy (1997-2002)
# Books (UTIs)
New Urology (Nanzando) (1986)
Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992)
Urogenital Tract Infections Q & A (Iyaku Journal) (1995)
6: Dept. of Urology, Kyushu University (The third term)(1984-1998)
# Establish: Japanese Society for STDs (1988)
# Establish: International UTI symposium (1989)
# Establish: Japanese Research Group for UTIs (1990)
# Congress and Meeting(UTI)
1st Asian Urological Congress (1990)
7th Korea-Japan Urological Congress (1990)
7th Annual meeting of Japanese Society of Environmental Infection
5th Annual meeting of Japanese Society for STDs
82nd Annual meeting of Japanese Urological Association
42nd Annual meeting of Japanese Society of Chemotherapy
# Officer of Society; President of Japanese Society of Chemotherapy (1997-2002)
# Books (UTIs)
New Urology (Nanzando) (1986)
Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992)
Urogenital Tract Infections Q & A (Iyaku Journal) (1995)
Japanese Research Association on UTIs
6: Dept. of Urology, Kyushu University (The third term)(1984-1998)
# Establish: Japanese Society for STDs (1988)
# Establish: International UTI symposium (1989)
# Establish: Japanese Research Group for UTIs (1990)
# Congress and Meeting(UTI)
1st Asian Urological Congress (1990)
7th Korea-Japan Urological Congress (1990)
7th Annual meeting of Japanese Society of Environmental Infection
5th Annual meeting of Japanese Society for STDs
82nd Annual meeting of Japanese Urological Association
42nd Annual meeting of Japanese Society of Chemotherapy
# Officer of Society; President of Japanese Society of Chemotherapy (1997-2002)
# Books (UTIs)
New Urology (Nanzando) (1986)
Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992)
Urogenital Tract Infections Q & A (Iyaku Journal) (1995)
7: After the retirement from Kyushu University
(1998-present)
# Congress
10th Western Pacific Congress of Chemotherapy and Infectious Diseases
(2006)
# Officers of Society
President; Western Pacific Society of Chemotherapy (2000-2004)
Vice President; International Society of Chemotherapy (2001-2005)
# Books (UTIs)
Nosocomial and Health Care-Associated Infections in Urology (WHO)
(2000)
STD (Nanzando) (2004)
7: After the retirement from Kyushu University
(1998-present)
# Congress
10th Western Pacific Congress of Chemotherapy and Infectious Diseases
(2006)
# Officers of Society
President; Western Pacific Society of Chemotherapy (2000-2004)
Vice President; International Society of Chemotherapy (2001-2005)
# Books (UTIs)
Nosocomial and Health Care-Associated Infections in Urology (WHO)
(2000)
STD (Nanzando) (2004)
Future perspective and Dream
# International epidemiological research
Diseases
Pathogens and antimicrobial susceptibility
# International network for the prevention of infectious diseases
# Development and popularization of rapid and accurate method
for the diagnosis
# Development of novel antimicrobial agents which has newer
antimicrobial mechanisms
Acknowledgement
Dr Edward H. Kass
Dr Maxwell Finland
Dr Kenji Takeya
Dr Tetsuro Matsumoto
Dr Yong-Hyun Cho
EXTRA
# Fukuoka Medical NGO
# Fukuoka Research Group for Forensic Medicine
# Kitakyushu research group for excretion care system