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Role of Research in the Field of UTI -Past, Present and Future(from my Personal History) Joichi Kumazawa My history 1: Postgraduate School (1960-1964) 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) 3: Harvard Medical School (1969-1970) 4: Dept. of Urology, Kyushu University (The second term) (19701979) 5: Dept. of Urology, Saga Medical College (1979-1984) 6: Dept. of Urology, Kyushu University (The third term) (1984-1998) 7: After the retirement from Kyushu University (1998-present) 1: Postgraduate school (1960-1964) (Dept. of Bacteriology and Dept. of Urology) # Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates # Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients) # Annual meeting of JUA: First symposium on UTIs (Tokyo, 1962) # UTIs in children 非特異性尿路感染症に関する研究 第1報 尿路分離菌の年次的変遷について 大学院生 熊澤淨一 九州大学医学部泌尿器科教室(主任 富川梁次教授) Studies of non-Specific Urinary Tract Infection. I. Chronological changes of Bacteria Isolated in Urinary Tract Infection. Zyoichi KUMAZAWA M.D Department of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine, Kyushu University, Fukuoka, Japan 福岡医学雑誌第54巻第10号(昭和38年11月25日) FUKUOKA ACTA MEDICA, 54(10):1072-1083,1962 Number of bacteria in first-catch urine (VB1), mid-stream urine (VB2) and urine by catheter-collection Number of bacteria in urine in patients with or without UTI 1: Postgraduate school (1960-1964) Dept. of Bacteriology and Dept. of Urology # Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates # Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients) # Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962] # UTIs in children 非特異性尿路感染症に関する研究 第2報 尿路分離菌の病原性に関する免疫学的研究 大学院生 熊澤淨一 九州大学医学部泌尿器科教室(主任 富川梁次教授) Studies of non-Specific Urinary Tract Infection. I. Immunological Determination on Pathogenicity of Bacteria Isolated in Urinary Tract Infection. Zyoichi KUMAZAWA M.D Department of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine, Kyushu University, Fukuoka, Japan 福岡医学雑誌第54巻第10号(昭和38年11月25日) FUKUOKA ACTA MEDICA, 54(10):1084-1103,1963 Antibody titers in 22 patients with >105/ml of bacteriuria during >7 days Bacterial species Antibody titer >160 <160 Escherichia coli 5 1 Pseudomonas aeruginosa 4 Proteus spp 2 1 Staphylococcus spp 1 2 Klebsiella spp 2 1 Enterobacter aerogenes 3 Total 17 (77.3%) 5 (22.7%) 1: Postgraduate school (1960-1964) Dept. of Bacteriology and Dept. of Urology # Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates # Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients) # Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962] # UTIs in children 小児泌尿器疾患の統計的観察 S. Sakamoto, J. Kumazawa and M. Ishizu Statistical Observation of Urogenital Diseases in Children 九州大学医学部泌尿器科教室(主任 富川梁次教授) 坂本公孝 熊澤淨一 石津又三 皮膚と泌尿 (昭和39年2月発行) HIFU to HINYO 26(1):43-48,1964 UTIs in pediatric outpatients Incidence Basic diseases Number Infection (%) Uncomplicated UTIs 143 67 46.9 (Hemorrhagic cystitis) (53) (52) (98.1) Inflammation of genital region 29 5 17.2 Urinary Stone 21 14 66.6 Congenital urinary obstruction 24 13 54.2 Neurogenic bladder 17 9 53.0 Urinary tumor 9 6 66.6 Nephritis or nephrosis 25 2 8.0 Others 538 6 1.1 Total 806 122 15.1 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) # Experimental pyelonephritis # VUR in children # Publish: 「尿路感染症の臨床:Clinical aspect of UTIs」(1965) # Chronological changes in urinary isolates # Detection of fallen bacteria in the hospital: Pseudomonas aeruginosa 実験的腎盂腎炎に対するEnduracidinの効果 Effect of Enduracidin on Experimental Pyelonephritis S. Momose, J. Kumazawa, S. Narahashi, S. Hidaka CHEMOTHERAPY 16(4):466-469,1968 百瀬俊郎 熊澤淨一 楢橋勝利 日高正昭 九州大学医学部泌尿器科 Experimental method 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) # Experimental pyelonephritis # VUR in children # 「尿路感染症の臨床:Clinical aspect of UTIs」published (1965) # Chronological changes in urinary isolates # Detection of fallen bacteria in the hospital: Pseudomonas aeruginosa いわゆる萎縮腎型腎盂腎炎に関する2,3の考察 Some Aspects on So-called Atrophic Pyelonephritis K. Sakamoto, J. Kumazawa, K. Narahashi From Department of Urology, Faculty of Medicine, Kyushu University (Director: Prof. Dr. S. Momose) 泌尿器科紀要 第12巻第1号 Acta Urologica Japonica 12(1):71-77,1966 VUR in patients with chronic UTIs Generation Number VUR Incidence (%) Children Adults 8 22 5 5 62.5 22.7 Total 30 10 33.3 Clinical aspect of UTIs published in 1965 3: Harvard Medical School (1969-1970) # Experimental pyelonephritis # Quantitative culture of bacteria in urine (Dip Slide Method) 基疾患を伴う実験的腎盂腎炎に対する化学療法の効果 The effect of Chemotherapy for the Experimental Pyelonephritis with Some Underlying Course J. Kumazawa Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan Channing Laboratory (Director: Prof. Edward H. Kass), Department of Medicine, Harvard Medical School, Boston. Mass., USA 熊澤淨一 九州大学医学部泌尿器科(主任:百瀬俊郎) 西日本泌尿器科 第33巻第2号 Nishinihon J. Urol. 33(2):183-189,1971 簡易尿中細菌定量培養法 Evaluation of Simplified Quantitative Culture Methods of Urinary Bacteria J. Kumazawa, S. Nakamuta, H. Ito, S. Hieda Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan 熊澤淨一、中牟田誠一、伊藤秀明、稗田定 九州大学医学部泌尿器科(主任:百瀬俊郎) 西日本泌尿器科 第38巻第4号 Nishinihon J. Urol. 38(4):477-487,1976 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates Significance of Anaerobic Bacteria Isolated from the Urinary Tract I. Clinical studies J. Kumazawa, H. Kiyohara, K. Narahashi, M. Hidaka, S. Momose From the Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan J. Urol 112:257-260,1974 Significance of Anaerobic Bacteria Isolated from the Urinary Tract II. Experimental studies J. Kumazawa, H. Kiyohara, S. Momose From the Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan Invest. Urol. 13:309-312,1975 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates Clinical Effectiveness of Piromidic Acid (PA) on Acute Nonspecific Cystitis. Evaluation with Double Blind Method J. Kumazawa, S. Momose et al Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan Chemotherapy 19(5):657-664,1971 A Double Blind Controlled Study to Compare CS-1170 (Cefmetazole) and Cefazolin in the Treatment of Chronic Complicated Urinary Tract Infections S. Momose, J. Kumazawa, et al Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan Nishinihon J. Urol. 41(1):173-200,1979 UTI薬効評価基準 Criteria for Evaluation of Clinical Efficacy of Antimicrobial Agents on Urinary Tract Infection (第4版暫定案) 1996年12月5日 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates 小児尿路感染症-現況と治療の問題点Urinary Tract Infection in Childhood J. Kumazawa Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan 熊澤淨一 九州大学医学部泌尿器科(主任:百瀬俊郎) 西日本泌尿器科 第35巻第2号 Nishinihon J. Urol. 35(2):144-152,1973 VUR and Pyelonephritis J. Kumazawa Associate Professor, Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan Proceedings of The First Asian Pacific Congress of Nephrology p 94-97, 1979 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates 泌尿器科的手技と病院感染 ー緑膿菌感染を中心にー Pseudomonas aeruginosa: Hospital Infection in Urological Field J. Kumazawa, S. Nakamuta, H. Ito, S. Momose Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan 熊澤淨一,中牟田誠一、伊藤秀明、百瀬俊郎 九州大学医学部泌尿器科 最新医学 第30巻第3号 Saishin Igaku 30(3):402-407,1975 Closed drainage system(閉鎖式持続導尿装置)の使用経験 A Clinical Application of Closed Urinary Drainage System J. Kumazawa, S Nakamuta, S. Momose Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan 熊澤淨一,中牟田誠一、百瀬俊郎 九州大学医学部泌尿器科(主任:百瀬俊郎) 西日本泌尿器科 第38巻第5号 Nishinihon J. Urol. 38(5):660-668,1976 5: Dept. of Urology, Saga Medical College (1979-1984) # Development of New Antimicrobial agents: A Person in Charge of Clinical trials Fluoroquinolones, Cephems, Aminoglycosides etc # Enterococcus spp # Establishment of STD Research Group in Fukuoka and Saga (1984) 6: Dept. of Urology, Kyushu University (The third term) (19841998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Dr Tetsuro Matsumoto Sub-leader; Dr Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control Increases renal scarring by bacteria with mannose-sensitive pili T. Matsumoto, Y. Mizunoe, N. Sakamoto, M. Tanaka, J. Kumazawa Department of Urology, Faculty of Medeicine, Kyushu University Urol. Res. 18:299-303,1990 Role of superoxide in renal scarring following infection by mannose-sensitve piliated bacteria T. Matsumoto, Y. Mizunoe, N. Ogata, M. Tanaka, J. Kumazawa Department of Urology, Faculty of Medicine, Kyushu University Urol. Res. 19:229-233,1991 分子生物学的アプローチによる尿路感染症の解析 Molecular Biological Approach in the Research of UTIs 九州大学医学部泌尿器科 熊澤淨一 Joichi Kumazawa Department of Urology, Faculty of Medicine, Kyushu University 日本泌尿器科学会雑誌第85巻第1号 Jap. J. Urol. 85(1):14-18,1994 6: Dept. of Urology, Kyushu University (The third term) (19841998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Tetsuro Matsumoto Sub-leader; Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control Urinary Tract Infection in Geriatric Patients T. Matsumoto, J. Kumazawa Department of Urology, School of Medicine, University of Occupational and Environmental Health Department of Urology, Faculty of Medicine, Kyushu University Int. J. Antimicrob. Agents 11:269-273,1999 6: Dept. of Urology, Kyushu University (The third term) (19841998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Tetsuro Matsumoto Sub-leader; Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control Emergence of In Vitro Resistance to Fluoroquinolones in Neisseria gonorrhoeae Isolated in Japan M. Tanaka, T. Matsumoto, I. Kobayashi, U.Uchino, J. Kumazawa Department of Urology, Faculty of Medicine, Kyushu University Antimicrob. Agents Chemother. 39:2367-2370,1995 Development of Fluoroquinolone Resistance and Mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolated in Japan M. Tanaka, K. Takahashi, T. Saika, I. Kobayashi, T.Ueno, J. Kumazawa Department of Urology, Faculty of Medicine, Kyushu University J. Urol. 159:2215-2219,1998 6: Dept. of Urology, Kyushu University (The third term) (19841998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Tetsuro Matsumoto Sub-leader; Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control 院内感染防止対策指針 Guidelines for the Prevention of Nosocomial Infections 九州大学医学部附属病院院内感染予防対策委員会 Infection Control Committee, Kyushu University Hospital 6: Dept. of Urology, Kyushu University (The third term)(1984-1998) # Establish: Japanese Society for STDs (1988) # Establish: International UTI symposium (1989) # Establish: Japanese Research Group for UTIs (1990) # Congress and Meeting(UTI) 1st Asian Urological Congress (1990) 7th Korea-Japan Urological Congress (1990) 7th Annual meeting of Japanese Society of Environmental Infection 5th Annual meeting of Japanese Society for STDs 82nd Annual meeting of Japanese Urological Association 42nd Annual meeting of Japanese Society of Chemotherapy # Officer of Society; President of Japanese Society of Chemotherapy (1997-2002) # Books (UTIs) New Urology (Nanzando) (1986) Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992) Urogenital Tract Infections Q & A (Iyaku Journal) (1995) 6: Dept. of Urology, Kyushu University (The third term)(1984-1998) # Establish: Japanese Society for STDs (1988) # Establish: International UTI symposium (1989) # Establish: Japanese Research Group for UTIs (1990) # Congress and Meeting(UTI) 1st Asian Urological Congress (1990) 7th Korea-Japan Urological Congress (1990) 7th Annual meeting of Japanese Society of Environmental Infection 5th Annual meeting of Japanese Society for STDs 82nd Annual meeting of Japanese Urological Association 42nd Annual meeting of Japanese Society of Chemotherapy # Officer of Society; President of Japanese Society of Chemotherapy (1997-2002) # Books (UTIs) New Urology (Nanzando) (1986) Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992) Urogenital Tract Infections Q & A (Iyaku Journal) (1995) Japanese Research Association on UTIs 6: Dept. of Urology, Kyushu University (The third term)(1984-1998) # Establish: Japanese Society for STDs (1988) # Establish: International UTI symposium (1989) # Establish: Japanese Research Group for UTIs (1990) # Congress and Meeting(UTI) 1st Asian Urological Congress (1990) 7th Korea-Japan Urological Congress (1990) 7th Annual meeting of Japanese Society of Environmental Infection 5th Annual meeting of Japanese Society for STDs 82nd Annual meeting of Japanese Urological Association 42nd Annual meeting of Japanese Society of Chemotherapy # Officer of Society; President of Japanese Society of Chemotherapy (1997-2002) # Books (UTIs) New Urology (Nanzando) (1986) Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992) Urogenital Tract Infections Q & A (Iyaku Journal) (1995) 7: After the retirement from Kyushu University (1998-present) # Congress 10th Western Pacific Congress of Chemotherapy and Infectious Diseases (2006) # Officers of Society President; Western Pacific Society of Chemotherapy (2000-2004) Vice President; International Society of Chemotherapy (2001-2005) # Books (UTIs) Nosocomial and Health Care-Associated Infections in Urology (WHO) (2000) STD (Nanzando) (2004) 7: After the retirement from Kyushu University (1998-present) # Congress 10th Western Pacific Congress of Chemotherapy and Infectious Diseases (2006) # Officers of Society President; Western Pacific Society of Chemotherapy (2000-2004) Vice President; International Society of Chemotherapy (2001-2005) # Books (UTIs) Nosocomial and Health Care-Associated Infections in Urology (WHO) (2000) STD (Nanzando) (2004) Future perspective and Dream # International epidemiological research Diseases Pathogens and antimicrobial susceptibility # International network for the prevention of infectious diseases # Development and popularization of rapid and accurate method for the diagnosis # Development of novel antimicrobial agents which has newer antimicrobial mechanisms Acknowledgement Dr Edward H. Kass Dr Maxwell Finland Dr Kenji Takeya Dr Tetsuro Matsumoto Dr Yong-Hyun Cho EXTRA # Fukuoka Medical NGO # Fukuoka Research Group for Forensic Medicine # Kitakyushu research group for excretion care system