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Integumentary System Interactions Reproductive System Urinary System • Skin protects urinary organs; excretes salts and some nitrogenous wastes in sweat • Urinary system activates vitamin D made by keratinocytes; disposes of nitrogenous wastes of skin metabolism Nervous System • Skin protects nervous system organs; cutaneous sensory receptors located in skin • Nervous system regulates diameter of blood vessels in skin; activates sweat glands, contributing to thermoregulation; interprets cutaneous sensation; activates arrector pili muscles • Skin protects reproductive organs; highly modified sweat glands (mammary glands) produce milk. During pregnancy, skin stretches to accommodate growing fetus; changes in skin pigmentation may occur Endocrine System • Skin protects endocrine organs • Androgens produced by the endocrine system activate sebaceous glands and help regulate hair growth; estrogen helps maintain skin hydration Skeletal System • Skin protects bones; skin synthesizes vitamin D bones need for normal calcium absorption and deposit of bone (calcium) salts which make bones hard • Skeletal system provides support for the skin Respiratory System • Skin protects respiratory organs • Respiratory system furnishes oxygen to skin cells and removes carbon dioxide via gas exchange with blood Muscular System • Skin protects muscles • Active muscles generate large amounts of heat which increase blood flovv to the skin and may promote activation of sweat glands of skin Cardiovascular System • Skin protects cardiovascular organs; prevents fluid loss from body surface; serves as blood reservoir • Cardiovascular system transports oxygen and nutrients to skin and removes wastes from skin; provides substances needed by skin glands to make their secretions Digestive System • Skin protects digestive organs; provides vitamin D needed for calcium absorption • Digestive system provides needed nutrients for the skin Immune System • Skin protects lymphatic organs; prevents pathogen invasion • Lymphatic system prevents edema by picking up excessive leaked fluid; immune system · protects skin cells