Download Stanca Mihaela Ciupe - VT Math Department

Stanca Mihaela Ciupe
University Address
Virginia Tech
Department of Mathematics
416 McBryde Hall
Blacksburg, VA, 24060
Telephone: (540) 231-3190
Email: [email protected]
Education
2005
Ph.D
1998
1997
M.S
B.A
University of Michigan, Ann Arbor, Applied and Interdisciplinary Mathematics
Advisor: Dr. Patrick W. Nelson.
Dissertation title: Development and applications of mathematical tools in models of
infectious diseases and biological phenomenon
Babes-Bolyai University, Cluj-Napoca, Romania, Mathematics.
Babes-Bolyai University, Cluj-Napoca, Romania.
Employment
August 2011- present
August 2009-2011
August 2006-2009
July 2005-July 2006
2000 - 2005
1999 - 2000
Tenure-track assistant professor,
Mathematics Department, Virginia Tech.
Tenure-track assistant professor,
Mathematics Department, University of Louisiana at Lafayette.
Postdoctoral research associate, Duke University Medical Center
Laboratory of Computational Immunology
Sponsor: Dr. Thomas B. Kepler.
Postdoctoral researcher , Santa Fe Institute
Los Alamos National Laboratory
Sponsor: Dr. Alan S. Perelson.
Graduate Student Instructor, University of Michigan.
Thesis advisor: Dr. Patrick W. Nelson.
Teaching Assistant, Ohio State University.
Grants and Awards
Awarded:
PI: NSF DMS-1214582 Research Grant Understanding the antibody responses following Human Immunodeficiency Virus infection
Sept 2010-August 2013, $143,975.
VT Mentoring Grant, 2012, $1,500.
UL Lafayette Summer Research Award, 2010, $4,800.
Fields Institute Travel Award to attend Thematic Program on the Mathematics of Drug Resistance in Infectious Diseases, 2010.
NSF Post-doc/ Early Career Travel Award to attend SIAM Annual Meeting, 2008, 2010.
Landahl travel grant to attend SMB Annual Meeting, 2003, 2007, 2008, 2010.
Allen L. Shields Memorial Fellowship, University of Michigan, 2005.
Graduate student Research Assistant, University of Michigan, 2004-2005.
Department Fellow, University of Michigan, 2001-2002.
Research Interests
Mathematical modeling; Mathematical Biology; Theoretical immunology; Delay differential equations; Model selection theory;
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Publications
Peer reviewed:
11. SM Ciupe and S Hews. Mathematical models of e-antigen mediated immune tolerance and activation following
prenatal HBV infection. PLoS One, 7:e39591, 2012.
10. J Forde, J Volpe, and SM Ciupe. Latently infected cell activation: A way to reduce the size of the hiv reservoir?
Bulletin of Mathematical Biology, 74:1651–1672, 2012.
9. Stanca M. Ciupe, Patrick De Leenheer, and Thomas B. Kepler. Paradoxical suppression of broadly neutralizing
antibodies in the presence of strain specific antibodies during HIV infection. Journal of Theoretical Biology,
277:55–66, 2011.
8. Stanca M. Ciupe, Anne Catlla, Jonathan Forde, and David G Schaeffer. Dynamics of hepatitis b virus infection:
what causes viral clearance? Mathematical Population Studies, 18:87–105, 2011.
7. Stanca M. Ciupe, Blythe H. Devlin, M. Louise Markert, and Thomas B. Kepler. The dynamics of T-cell receptor
repertoire diversity following thymus transplantation for DiGeorge Anomaly. PLoS Computational Biology,
5:1–13, 2009.
6. PW Nelson, N Smith, SM Ciupe, W Zou, G S Omenn, and M Pietropaolo. Modeling dynamic fluctuations in type
1 diabetes progression. Mathematical Biosciences and Engineering, 6:753 – 778, 2009.
5. Timothy A. Kohler, Sarah Cole, and Stanca M.Ciupe. Population and Warfare: A Test of the Turchin Model in
Puebloan Societies. University of California Press, Berkeley and Los Angeles, 2008.
4. Stanca M. Ciupe, Ruy M. Ribeiro, Patrick W. Nelson, Geoffrey Dusheiko, and Alan S. Perelson. The role of cells
refractory to productive infection in acute hepatitis B viral dynamics. Proceedings of the Natlional Acadademy
of Sciences USA, 104:5050–5055, 2007.
3. Stanca M Ciupe, Ruy M Ribeiro, Patrick W Nelson, and Alan S Perelson. Modeling the mechanisms of acute
hepatitis B virus infection. Journal of Theoretical Biology, 247:23–35, 2007.
2. Stanca M. Ciupe, Benjamin de Bivort, David M. Bortz, and Patrick W. Nelson. Estimates of kinetic parameters from
HIV patient data during primary infection through the eyes of three different models. Mathematical Biosciences,
200:1–27, 2006.
1. Stanca M. Ciupe. Development and applications of mathematical tools in models of infectious diseases and biological phenomenon. PhD thesis, University of Michigan, June 2005.
Unpublished results
2. Stanca M. Ciupe, Blythe H. Devlin, M. Louise Markert, and Thomas B. Kepler. Using Kullback-Leibler divergence
to quantify total T cell receptors diversity by flow cytometry. 2009.
1. Stanca M. Ciupe and Patrick W. Nelson. An asymptotic analysis of the van der Pol delay differential equation.
2006.
Work in progress
4. Stanca M. Ciupe, Ruy M. Ribeiro, and Alan S. Perelson. Antibody responses during Hepatitis B viral infection.
2012.
3. SM Ciupe, R Leblanc, and A Perelson. Estimating the average number of viral surface antigens bound by neutralizing antibodies during chronic infections: a hepatitis B application. 2012.
2. SM Ciupe, T Robin, and E Schwartz. Viral evolution under the pressure of antibodies in EIAV infection. 2012.
1. SM Ciupe and C Chan. B cells dynamics during early HIV infection in Rhesus macaques. 2012.
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Presentations
2012 Oct. SEARCDE 2012, Wake Forest, NC.
Sep. Virginia Tech Undergraduate Research Seminar.
Jul. SMB Annual Meeting, Knoxville, Tn.
Jun. AIMS 2012, Orlando, FL.
Mar. AMS regional meeting, Washington, DC.
Feb.
Models and methods for analysis of lymphocyte repertoire generation, development, selection and
evolution, Jerusalem, Israel.
Jan. System Approaches in Immunology, Santa Fe, NM.
2011 Nov. Virginia Tech, Virginia Bioinformatics Institute Research seminar.
Oct. Virginia Tech, Research Days.
Oct. Virginia Tech, SGTA faculty Research seminar.
Jul. SMB Annual Meeting, Krakow, Poland.
Apr. Department of Mathematics, Duke University, Mathematical biology seminar.
Feb. Claremont McKenna Colleges, Department of Mathematics, colloquium.
Jan. Virginia Tech, Department of Mathematics, colloquium.
Jan. AMS and AMAA joint meetings, New Orleans, LA.
2010 Jul. SMB Annual Meeting, Rio de Janeiro, Brazil.
Jul. Fields institute Theme Weeks on Mathematical Immunology, Toronto, CA.
Jul. SIAM Annual Meeting, Pittsburgh, PA.
Jan. Systems Approaches in Immunology, Santa Fe, NM.
2009 Oct. UL Lafayette, Mathematics Colloquium, Lafayette LA.
Oct. Baylor University, Mathematics Colloquium, Waco, TX.
May. Banff International Research Station for Mathematical Innovation and Discovery, Banff, CA.
Apr. North Carolina State Univ., Biomathematics Seminar, Raleigh, NC.
Apr. AMS Special Sesion, Raleigh, NC.
Mar. University of Louisiana, Lafayette, Mathematics Department Colloquium, Lafayette, LA.
Mar. University of Michigan, Dearborn, Mathematics Department Colloquium, Dearborn, MI.
2008 Aug. SIAM for Life Sciences Minisymposium, Montreal, CA.
Jul. Annual Meeting for the Society of Mathematical Biology, Toronto, CA.
Apr. Duke University, Center for Computational Immunology Group meeting.
Feb. Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School.
Feb. University of Maryland Baltimore County, Department of Mathematics Colloquium.
2007 Oct. Duke University, Department of Immunology Work in Progress Seminar.
Sep. CHAVI Annual Meeting, Duke University.
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Aug. Annual Meeting for the Society of Mathematical Biology, San Jose, California.
May Applications of Analysis to Mathematical Biology (in honor of Mike Reed), Duke University.
Apr. Duke University, Department of Mathematics, Applied Applied Mathematics and Analysis Seminar.
Feb. Duke University, Center for Computational Immunology Group meeting.
2006 Feb. University of Utah, Mathematical Biology Seminar.
Feb. Duke University, Center for Computational Biology Seminar.
2005 Sep. Working group-Human Frontiers in Science, Santa Fe Institute.
Jul. Annual Meeting for the Society of Mathematical Biology, University of Dresden, Germany.
2004 Aug. Annual Meeting for the Society of Mathematical Biology, University of Michigan
Jul. Michigan math and science Scholars MMSS Program.
Jun. Summer School in Cell Biology and Mathematical Modeling, Hvar, Croatia.
2003 Aug. Annual Meeting for the Society of Mathematical Biology, University of Dundee, Scotland.
Jan. University of Michigan, Applied and Interdisciplinary Mathematics Student Seminar.
Teaching Interests
Introductory classes, Mathematical Modeling; Mathematical Biology; Delay Differential Equations; Asymptotic
Analysis.
Teaching experience
2012
Fall
Model and Simulations of Biological Systems I, Virginia Tech.
Fall
Integrated Science Course I- COS 2984, Virginia Tech.
Spring
Model and Simulations of Biological Systems II, Virginia Tech.
2011 Fall
Model and Simulations of Biological Systems I, Virginia Tech.
Spring
Mathematical Biology, University of Louisiana, Lafayette.
Spring
Mathematical models with applications in medicine, University of Louisiana, Lafayette.
2010 Fall
Applied Calculus, University of Louisiana, Lafayette.
Spring
Applied Calculus, University of Louisiana, Lafayette.
2009 Fall
Applied Calculus, University of Louisiana, Lafayette.
2006 - 2009
Tutorials in Mathematical Biology, Duke University - Laboratory of Computational Immunology.
2004 Winter
Calculus II, University of Michigan.
Summer Graduate Student Assistant, Michigan Math and Science Scholars Program.
Summer Graduate Student Assistant, Michigan Math and Science Scholars Program.
03-04 Summer Mathematical Modeling in Biology, University of Michigan.
01-03
Calculus I, University of Michigan (4 semesters).
2002 Spring
Course Coordinator, Calculus I, University of Michigan.
2002 Winter
Helped develop the course pack for Introduction to Math Biology, Math 563, University of Michigan.
00-01
Pre-calculus, University of Michigan (2 semesters).
2000
Calculus I, Ohio State University (2 semesters).
97-99
Algebra and geometry teacher, Cluj-Napoca, Romania.
Professional activities
Member
American Mathematical Society
Society of Mathematical Biology
Association for Women in Mathematics
Society for Industrial and Applied Mathematics
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NSF grant panelist.
Reviewer
The Wellcome Trust Project Grants
Bulletin of Mathematical Biology
Journal of Theoretical Biology
PLoS Computational Biology
Journal of Mathematical Analysis and Applications
Mathematical Biosciences
Mathematical Biosciences and Engineering
Journal of Biological Systems
Optimization and Engineering
Journal of Differential Equations and Dynamical Systems
Participant and organizer
Society of Mathematical Biology Annual Meeting, Krakow, Poland, June-July 2011.
Society of Mathematical Biology Annual Meeting, Rio de Janeiro, Brazil, July 2010.
Fields institute Theme Weeks on Mathematical Immunology, Toronto, CA, July 2010.
SIAM Life Sciences Meeting, Pittsburgh, PA, July 2010.
Systems Approaches in Immunology, Santa Fe, NM, January 2010.
FACM09, New Jersey Institute of Technology, Newark, NJ, June 2009.
Banff International Research Station for Mathematical Innovation and Discovery, May, 2009.
AMS Special Session, Raleigh, April 2009.
Society of Mathematical Biology Annual Meeting, Toronto, CA, July-Aug 2008.
SIAM Life Sciences Meeting, Montreal, CA, Aug 2008.
Computational and Systems Immunology, Durham, June 2008.
Summer School Biodefense Immune Modeling Summer School Pittsburgh, 2007
Applications of Analysis to Mathematical Biology Conference Duke 2007
Summer School Cell Biology and Mathematical Modelling, Hvar, Croatia, 2004.
VIGRE Working Group Mathematical Biology, 2003-present
Applied and Interdisciplinary Mathematics AIM seminar, 2001-present.
VIGRE Working Group Complex Adaptive Systems, 2004-present.
September, 2012