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INFANTS SOMEWHERE BETWEEN SIX A DAY AND ONE EVERY SIX DAYS IF NO BM IN THE FIRST 24 HOURS THE INFANT NEEDS A DIGITAL RECTAL EXAM LOOKING FOR IMPERFORATE ANUS A MECONIUM PLUG MICROCOLON MAY BE ASSOCIATED WITH CYSTIC FIBROSIS At least 2 of 6, for over a month if under age 4 and for two months if developmentally over 4 2 or fewer BM’s a week Incontinence once a week after initial continence Excessive stool retention Painful or Hard Bowel Movements Large fecal mass in the rectum Large stools that may obstruct the toilet IN INFANCY MOST CONSTIPATION IS DIETARY CHANGING FORMULAS MAY HELP ADDING SORBITOL CONTAINING JUICES AFTER FOUR MONTHS OFTEN HELPS START FEEDINGS WITH OAT OR BARLEY CEREALS INSTEAD OF RICE CEREAL PAINFUL STOOLS MAY LEAD TO WITHOLDING STOOLING GLYCERIN SUPPOSITORY IF NO BM AFTER 2 DAYS IF THE INFANT HAS INFREQUENT SOFT STOOLS THAT DON’T HURT AND IS GROWING – DON’T LOOK HARD FOR A PROBLEM UNINTENDED SLEEP” CONSEQUENCE OF “BACK TO IF THE PATIENT STOOLED IN THE FIRST 24 HRS OF LIFE UNLESS THERE IS ASSOCIATED VOMITING OR THE EXAM IS C/W ACUTE ABDOMEN OR THERE IS A HISTORY OF TRAUMA OBSTRUCTION – Atresia, Webs, Volvulus HIRSCHPRUNGS DISEASE- Empty rectal vault FUNCTIONAL ILEUS- Preemie, Sepsis, Lytes SMALL LEFT COLON-Maternal Diabetes, CF MATERNAL DRUGS- Magnesium, Opiates HYPOTHYROIDISM- Prolonged Jaundice, Lethargy, or Low Body Temp CBC THYROID STUDIES TTG (need total serum IGA as well) Barium Enema Anorectal Manometry Rectal Biopsy Motility Studies –Sitzmark Study OFTEN DIETARY AND TREATED WITH DIETARY CHANGES AVOID MILK, CHEESE, FF CHIPS & BRAT DIET OFFER JUICES, “P” FRUITS, AND FIBER IN DIET PROBIOTICS POTTY TRAINING IS LEARNING TO HOLD YOUR STOOL THEN STOOLING WHEN IT IS APPROPRIATE IF YOU HOLD IT TOO LONG – IT HURTS PAY ATTENTION TO WHERE THEY GO – PUT THE POTTY CHAIR THERE PAY ATTENTION TO WHEN THEY GO BE ON THE LOOKOUT THEIR FEET NEED TO TOUCH THE FLOOR NO CONSTIPATING FOODS DURING TRAINING LOTS OF “P” FRUITS AND JUICES SLIP A TABLESPOON OF MINERAL OIL IN THEIR JUICE DAILY NO ONE POOPS AT SCHOOL WHAT TIME DO THEY DEFECATE AT HOME PARENTS MAY NEED TO ADJUST THAT WHEN THEIR CHILD GOES TO SCHOOL OSMOTIC LAXATIVES: MIRALAX - 0.8 gm/kg - 1 capful/8 ounces SORBITOL 70% - 0.5-2 ml/kg up to QID LACTULOSE – 15-30 ml (10-20 g/kg MINERAL OIL Not very Palatable – mix with syrup or juice Often associated with leakage of stool Usual dose is 1 ml / kg Concern for aspiration with infants COLACE (Docusate) Capsules, Syrup and Oral Solution <2 – use 25 mg/day 2 -12 - use 50 – 150 mg daily > 12 50 -500 mg daily May use 50 – 100 mg as retention or flushing enema CONCERNS FOR HABITUATION Bisacodyl (Dulcolax) 0.3 mg/kg – 5-10 mg/day SENNA Comes as a tablet, liquid and a concentrate >2 – use 2-4 mg /day 2-5 – use 4-6 mg/day 6-11 – 5-8 mg/day Over 12 use adult dose 12- 25 mg / day The Newer Laxatives: Lubiprostone (Amitiza); Linaclotide, and Prucalopride have not been studied in children USED TO REMOVE FECAL IMPACTIONS SODIUM PHOSPHATE MINERAL OIL ENEMA USUALLY MAY USE 5-10 ML/KG NEED REPEATED DOSES INITIALLY Is by definition CHRONIC Will not be cured overnight and will need a Plan that includes diet, meds and lifestyle changes The Colon has been dilated by the retained stool and the muscles have been stretched and won’t be able to push as well Expect to treat for a week for every month At a minimum using Miralax and Fiber May need Mineral Oil or Colace Possibly Bisacodyl Need to attain good bowel habits Use the Gastro-Colic Reflex – have the pt sit on the commode after a meal for 15-30 min Expect to have to stay on top of this lifelong Reinforce the dietary habits Exercise also helps bowel function Will need follow-up in a week or two Again at 1-2 months Very often they slip UpToDate : Gregory D. Ferry, William J. Klish, Alison G Hopper MEDSCAPE: Drug Doses