Download DGL, active molecules carrier

DGL, active molecules carrier
Characteristics of a DGL
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DGL : Dendri-Graft Poly-Lysine
Spherical-shaped nanoparticle
Wide range of sizes (1 to 8 nm radius from G1 to G5)
100% composed of essential amino acids (L-Lysine)
Many amine functions on surface
80 % of free volume (flexible tree-like generated
structure)
Added value of Colcom’s DGL
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Natural biocompatibility
Non-immunogenic
Water soluble (cationic DGL)
Easily customizable
High strucural flexibility
Reproducibility of production
High production capacity
Controlled narrow poly-dispersity
Capture of metals (Ag+, Co2+, Cu2+,
Zn2+, Ni2+)
DGL : a tool for various transports
Depending on the applications you are looking for, we construct a DGL
(size, charge, hydrophobicity) that will lead to specific behaviors and
respond precisely to your needs.
NH2
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DGL bearing a reactive function: maleimide, thiol, acetylenic or azido
in order to graft the bioactive molecule.
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Tagged DGL: by a fluorophore (fluorescein) or a chromophore
(erythrosine) for the localization or the detection.
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Chemical modification of DGL’s surface: conversion of a cationic
surface into an anionic, neutral, hydrophilic or hydrophobic surface.
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Modification of surface amino acids: replacement of lysine by
another amino acid.
NHS
SH
HOOC
O NH OH
N3
NH2
N
2
N3
3) Cibles (compilation)
T
T
T
T
1 Tag inside
Tags outside
Combination of different modifications: grafting on the same DGL of
bioeactive molecules, specific ligands, fluorophores and PEG chains
for a DDS (Drug Delivery System).
Applications
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Drug delivery: solubilization, transport and targeting of bioactive molecules (drugs,
proteins, peptides, ADN, siRNA…). Crossing through the blood-brain barrier.
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In vivo or in vitro diagnostic :
 Fluorophores markers: detection and localization of in vivo DGL
 Capture of MRI contrast agents (increases the contrast and reduces the toxicity)
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Metal catalysis : solubilization and stabilization of catalysts.
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Biomolecules encapsulation : the DGL is used as structural architecture for encapsulation of
biomolecules under a silica layer in order to stabilize and protect them.
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Immunization booster: the DGL is used as a hapten carrier in second immunization and allows
the production of antibodies specifically directed against a target by significantly reducing the
production of antibodies against the carrier protein used in primo immunization.
Tech2Market - www.tech2market.fr
[email protected]
+33 (0)1.46.71.93.34
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