Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
ROASS.SyllabusTemplateSample-1.0-20160713.doc University of Manitoba Faculty of Agricultural and Food Sciences Department of Animal Science ANSC 3500 PRINCIPLES OF ANIMAL BREEDING ANSC 3500: Principles of Animal Genetics Page 2 TABLE OF CONTENTS COURSE DETAILS .................................................................................................................................................... 3 INSTRUCTOR CONTACT INFORMATION .................................................................................................................. 3 GENERAL COURSE INFORMATION .......................................................................................................................... 4 COURSE GOALS ...................................................................................................................................................... 4 INTENDED LEARNING OUTCOMES ......................................................................................................................... 5 USING COPYRIGHTED MATERIAL ........................................................................................................................... 5 RECORDING CLASS LECTURES ................................................................................................................................ 5 TEXTBOOK, READINGS, MATERIALS ....................................................................................................................... 5 COURSE TECHNOLOGY ........................................................................................................................................... 6 CLASS COMMUNICATION....................................................................................................................................... 7 EXPECTATIONS: I EXPECT YOU TO .......................................................................................................................... 7 STUDENTS ACCESSIBILITY SERVICES ....................................................................................................................... 8 EXPECTATIONS: YOU CAN EXPECT ME TO .............................................................................................................. 8 CLASS SCHEDULE.................................................................................................................................................... 9 COURSE EVALUATION METHODS ......................................................................................................................... 11 GRADING ............................................................................................................................................................. 11 REFERENCING STYLE ............................................................................................................................................ 11 ASSIGNMENT DESCRIPTIONS ............................................................................................................................... 13 ASSIGNMENT GRADING TIMES ............................................................................................................................ 13 ASSIGNMENT EXTENSION AND LATE SUBMISSION POLICY .................................................................................. 13 ANSC 3500: Principles of Animal Genetics Page 3 COURSE DETAILS Course Title & Number: ANSC 3500 Principles of Animal Genetics Number of Credit Hours: 3.0 Class Times & Days of Week: 9:30 – 10:20 on Monday, Wednesday and Friday Location for classes 220 Animal Science Building Pre-Requisites: PLNT 2520 (or 039.252) Instructor Contact Information Instructor(s) Name: Dr. George N. Gozho Preferred Form of Address: Office Location: Dr. Gozho 228 Animal Science Building Office Hours or Availability: Open door policy – no appointment necessary but please call or e-mail to confirm availability between 8:30 am and 4:30 pm. Office Phone No. 204-474-9443 Email: [email protected] All email communication must conform to the Communicating with Students university policy. (Please familiarize yourself with the policy). Use the subject line to state the reason for your e-mail and add the course number. This will help me to quickly determine which e-mails need urgent attention. Please avoid salutations such as ‘Hey You’ or ‘Hi there’. Dear Dr. Gozho will just be fine. I will screen e-mails based on the subject line and salutation and respond within 36 hours during the week only. I do not check my work e-mail over the weekend. Contact: My preference for communication is in person. Use e-mail communication only when absolutely necessary. However, you are welcome to phone my office if that is more convenient than coming in person. ANSC 3500: Principles of Animal Genetics Page 4 Course Description Formerly 035.350) Topics discussed will include population genetics, quantitative variation, selection and mating systems with particular reference to domestic species. This course describes the principles of population and quantitative genetics and it fits between the first genetics course, and advanced applied genetics course or other species-oriented production courses. This course is aimed at attracting students who are interested in agricultural animals, but students interested in natural populations and genetics in general can benefit from taking the course too. The Prerequisite for this course is PLNT 2520, a basic genetics course offered through the Department of Plant Science. Familiarity with the basic principles of genetics is an important foundation since these are built upon in the present course. Though not stated in the paper calendar, another equivalent prerequisite is the course, BOTN 2460, and this course is often taken by students from the Faculty of Science. General Course Information Modern farm animals are managed as populations. Therefore knowledge of the behaviour of genes in populations is important. The forces that affect gene frequencies and their relative importance in creating changes in gene frequencies are discussed. In farm animals, economically important traits are determined by genes located at one or a few loci (qualitative traits); or genes located on several loci (quantitative traits). Examples of both these types of traits will be discussed. This course also explores recent advances in genomic mapping in mammals and the biochemical mechanisms of specific genes that leads to manifestations of specific phenotypes for some qualitative traits. Additionally, the interaction between genes and the environment on some traits is also explored. The management of animal populations, and the forces that affect gene frequencies will be discussed. Tools for selecting superior animals for economically important traits are discussed. Course Goals The goals of the courses are: a) To convey principles of population and quantitative genetics, incorporating recent knowledge in the area of DNA markers and maps. b) To give students a basic understanding of modern techniques of genetic evaluation of farm animals, and how genetic differences between individual animals as well as breed differences are utilized to improve animal characteristics in modern production systems. ANSC 3500: Principles of Animal Genetics Page 5 Intended Learning Outcomes At the end of the course, students will be able to: a) Gain a clear understanding of principles of animal genetics and modern techniques of genetic evaluation. b) Apply genetic principles and techniques to improve the economic value and performance of farm animals c) Critically analyze and apply some of the animal improvement tools that are used notwithstanding their limitations. d) Evaluate commonly used animal breeding programs and practices and clearly enunciate their relevance, using the correct animal breeding terminology. Using Copyrighted Material Please respect copyright. The content used in this course is appropriately acknowledged and is copied in accordance with copyright laws and university guidelines. Copyrighted works, including those created by me, are made available for private study and research and must not be distributed in any format without permission. Recording Class Lectures No audio or video recording of lectures or presentations is allowed in any format, openly or surreptitiously, in whole or in part without explicit permission from me. Course materials (both paper and digital) are for your private study and research. Textbook, Readings, Materials Required textbook There is no required text for this course. You can use the following books as background reading. All the books are available in the Science Library (see the library numbers below). Supplementary readings 1. Bourdon, Richard, M. 2000. Understanding Animal Breeding, 2nd ed. Prentice Hall. {SF 105 B67 2000} 2. Nicholas, F.W. 2000. Introduction to Veterinary Genetics, Oxford Univ Press. {SF 756.5 N52 2000} 3. Van Vleck, L.D., E.J.Pollak and E.A.B. Oltenacu. 1987. Genetics for the animal sciences. W.H. Freeman and Company. {QH 432 V36 1987} The following Internet web sites contain information relevant to this course. They can be accessed from many microcomputer labs on campus, including the Agriculture microcomputer lab, using a web browser: Online resources that will be used in the course 1. Online Mendelian Inheritance in Animals. This Australian site contains description of an ever-growing database of referenced inherited characteristics of animals, which can be browsed by species, inherited disorder, or by other keywords. ANSC 3500: Principles of Animal Genetics Page 6 2. Genome maps of domestic animals. (https://www.ncbi.nlm.nih.gov/genome/). This site contains maps of the genomes of domestic animals, including information on genes and DNA markers. 3. Breeds of livestock. (http://www.ansi.okstate.edu/breeds/). This is a very useful and referenced site out of Oklahoma State University. It has information on the origins and characteristics of many livestock breeds. It also serves as a good source for contact information of breed associations for some countries for some breeds. We will not directly use this site but it can serve as a good quick resource on breed origins and characteristics. 4. Genes for Cowboys. This site from the University of Saskatchewan has information on basic genetics of simply inherited traits in cattle. This site also has information that has been drawn upon for lecture resources. Online resources that may be of interest: 5. Food and Agriculture Organization (FAO) Domestic Animal Diversity (DAD) Information System. (http://dad.fao.org/). My predecessor used this site. I have not used it but it gives information on farm livestock genetic diversity in many countries of the world. It has a database of breeds and an online library of genetic resources material. 6. Rare Breed Survival Trust. (http://www.rbst.org.uk/). This is a site from the United Kingdom that is concerned with the preservation of breeds of livestock in the UK. 7. Society for the Preservation of Poultry Antiquities. (http://www.yellowhousefarmnh.com/the-society-for-the-preservation-of). This is an interesting site concerned with genetic resources in poultry. Course Technology Lecture notes will be posted on UMlearn and students are encouraged to review and or print their own copy of the notes that they bring class. Hard copies of notes will not be provided to students. Laptops and tablets can be used to take notes during lectures. However personal direct electronic messaging / posting activities (e-mail, texting, video or voice chat, wikis, blogs, social networking (e.g. Facebook) online and offline “gaming” during scheduled class time is not permitted. Anyone expecting to receive important telephone calls during the lecture should switch their cell phones to vibrate mode and leave the classroom upon reception of such calls to minimize disrupting class activities. ANSC 3500: Principles of Animal Genetics Page 7 Class Communication The University requires all students to activate an official University email account. For full details of the Electronic Communication with Students please visit: http://umanitoba.ca/admin/governance/media/Electronic_Communication_with_Students_Pol icy_-_2014_06_05.pdf Please note that all communication between you as a student and myself must comply with the electronic communication with student policy: (http://umanitoba.ca/admin/governance/governing_documents/community/electronic_communic ation_with_students_policy.html). You are required to obtain and use your U of M email account for all communication between yourself and the university. Expectations: I Expect You To a) Attend class on time. b) Ask for help. c) Work together on assignment problems other than exams (but prepare your individual answers independently) d) To have the prerequisite background i.e., basic genetics as well as basic knowledge of Excel spreadsheet functions and also basic knowledge of statistics. e) To act in a civil, respectful, and responsible manner toward all members of the U of M community Academic Integrity: Plagiarism or any other form of cheating in the final examination, term tests or academic work is subject to serious academic penalty. Cheating in examinations or tests may take the form of copying from another student or bringing unauthorized materials into the exam room. Exam cheating can also include exam impersonation. A student found guilty of contributing to cheating in examinations or term assignments is also subject to serious academic penalty. Students should acquaint themselves with the University’s policy on plagiarism, cheating, exam impersonation and duplicate submission (See Section 7 in the online calendar: http://webapps.cc.umanitoba.ca/calendar11/Academic Regulations.pdf) For assignment work, students are encourage to work together on problems – the purpose of assignments is to understand the material. The completed assignment work that students pass for grading must be in their own words. If the Internet or published material is used in preparing such work, they must be properly referenced. ANSC 3500: Principles of Animal Genetics Page 8 Students Accessibility Services Student Accessibility Services If you are a student with a disability, please contact SAS for academic accommodation supports and services such as note-taking, interpreting, assistive technology and exam accommodations. Students who have, or think they may have, a disability (e.g. mental illness, learning, medical, hearing, injury-related, visual) are invited to contact SAS to arrange a confidential consultation. Student Accessibility Services http://umanitoba.ca/student/saa/accessibility/ 520 University Centre 204 474 7423 [email protected] Expectations: You Can Expect Me To a) Attend and deliver lectures on time. A large part of my teaching practice includes the use of PowerPoint presentations in class. b) Help you to understand the content and subject matter related to this course. I expect students to either interrupt me or come and see me immediately after the lecture if there is anything that is not clear. I will help you as much as I can to succeed in this course. ANSC 3500: Principles of Animal Genetics Page 9 Class Schedule This schedule is subject to change at the discretion of the instructor and/or based on the learning needs of the students but such changes are subject to Section 2.8 of the – ROASSProcedure. LECTURE DATE UNIT/ TOPIC 0. Introduction Jan 18, 2017 Course overview 1. Domestication Jan 20, 2017 The process of domestication. Historical and modern effects of domestication on human population 2. Breeds of Farm Animals Jan 23, 2017 Common farm animal breeds And Breed Conservation Jan 25, 2017 Conservation of animal genetic resources Jan 27, 2017 3. Genetic Improvement Jan 30, 2017 Systems approach to genetic improvement Registration Deadline 4. Mendelian Inheritance Jan 31, 2017 Feb 1, 2017 Revised deadline Mendel’s laws and gene action Feb 3, 2017 Type of gene action at a single locus and at multiple loci Feb 6, 2017 Sex related inheritance and other forms of inheritance Feb 8, 2017 (epigenetic, meiosis sex chromosome inactivation, parental imprinting, genomic imprinting, mitochondrial inheritance) Mendelian genetics detrimental and lethal conditions of animals 5. Study of Genetic Feb 10, 2017 Differences Differences in chromosomal morphology (seen through spectra karyotyping and light microscope karyotyping; e.g., 1, 29 Robertsonian translocation in cattle). Nucleotide bases as the genetic code found on the chromosomes. Feb 13, 2017 Classification of DNA sequences of chromosomes in the mammalian genome. Functional and pseudo gene sequences Term Test 1 Winter Term Fee Payment 6. Genetic Architect of a Feb 15, 2017 Feb 15, 2015 Feb 17, 2017 Trait No classes No classes No classes Unit 1 to 5 [Marked tests will be returned within 1 week] Due date Gene interactions to produce specific phenotypes - coat color in mammals will be used to illustrate these interactions. Feb 20, 2017 Feb 22, 2017 Feb 24, 2017 Louis Riel Day Mid term break Mid term break ANSC 3500: Principles of Animal Genetics Lecture Page 10 Date 6. Genome Mapping Feb 27, 2017 Unit/ Topic Assignment that uses the Online Mendelian Inheritance database to illustrate the biochemical basis for some genetic disorders. Additionally, the second section of the assignment uses the Genome database to show relative chromosome size, the sequence of common genetic markers on chromosomes of various animal species 7. Population Genetics Mar 1, 2017 Gene and genotype frequencies. The Hardy-Weinberg law and Mar 3, 2017 how gene and genotypic frequencies change at a single or at Mar 6, 2017 multiple loci to re-establish equilibrium. The Hardy-Weinberg Mar 8, 2017 law and sex-linked loci. The effect of distance between linked Mar 10, 2017 loci on the disequilibrium value and recombination frequency. Mar 13, 2017 Forces that change gene frequency i.e., non-random mating, migration, mutation, and selection Term test 2 8. Quantitative genetics Mar 15, 2017 Mar 17, 2017 Unit 1 6 to 7 [Marked tests will be returned within 1 week] Phenotypic variance components are described. Mar 20, 2017 Tools for the study of phenotypic variance components in Mar 22, 2017 quantitative traits are discussed. Mar 24, 2017 Phenotypic and genetic correlations, heritability and Mar 27, 2017 Mar 29, 2017 1 VW deadline 8. Quantitative genetics 9. Selection repeatability are discussed. Predicting breeding values for economically important traits Mar 31, 2017 Apr 3, 2017 of farm animals using both pedigree information and Apr 5, 2017 production records Apr 7, 2017 Factors that affect response to selection are studied. Apr 10, 2017 Apr 12, 2017 No classes 10. Crossbreeding Course Review Apr 14, 2017 Apr 17, 2017 Good Friday Creating a crossbred. Genetic effects in crossbreeding. Hybrid Apr 19, 2017 vigour. Rotational crossbreeding system Apr 21, 2017 Review of material covered and course evaluation VW1 = Voluntary withdrawal ANSC 3500: Principles of Animal Genetics Page 11 Course Evaluation Methods Students will be assessed by means of term tests, assignments and final examination. Each test will comprise of; a) a short multiple choice section, b) fill in the blanks or short answers, and c) a third section with questions that require longer and more thoughtful answers Missed Exams A missed exam will receive a score of zero unless the student provides a medical certificate giving the reason for missing the exam. Due Date: Assessment Tool February 15, 2017. March 15, 2017 Written on each assignment University Final Exam schedule Midterm test 1 Midterm test 2 Assignments Final Examination Value of Final Grade 25% 25% 10% 40% Grading Indicate your grading scale. A sample is given below that you can adjust to your course expectations. Letter Grade A+ A B+ B C+ C D F Percentage out of 100 Grade Point Range 92-100 4.25-4.5 84-91 3.75-4.24 77-83 3.25-3.74 70-76 2.75-3.24 65-69 2.25-2.74 60-64 2.0-2.24 50-59 Less than 2.0 Less than 50 Final Grade Point 4.5 4.0 3.5 3.0 2.5 2.0 1.0 0 Referencing Style Assignments should use the citation format adopted by the Canadian Journal of Animal Science: http://www.aic.ca/journals/cjas_instructions.cfm Make sure you cite only literature that is highly relevant and avoid multiple citations on the same point. Check each reference with the original article and refer to it in the text by the author and date. ANSC 3500: Principles of Animal Genetics Page 12 Examples of correct citations:2 Maes et al. (2004) reported a negative association between backfat levels at the end of gestation and percentage of stillborn piglets, and McKay (1993) showed that sows selected for reduced backfat thickness wean fewer piglets per litter. …the amount of adipose tissue at first service is crucial as it determines reproductive success (total born per litter and number of piglets born alive) for the first three parities (Tummaruk et al., 2007). Similarly, Zak et al. (1997) reported longer WEIs for sows that had increased catabolism prior to weaning. List multiple references in the text in chronological order. Use “et al.” when there are more than two authors but give all authors in the reference list at the end of your assignment. Example of how references should be compiled at the end of your assignment (note bolding, spacing of initials, capitalization, and punctuation): 2Examples of citations are taken from: Houde, A. A., Méthot, S., Murphy, B. D., Bordignon, V. and Palin, M. F. 2010. Relationships between backfat thickness and reproductive efficiency of sows: A two-year trial involving two commercial herds fixing backfat thickness at breeding. Can. J. Anim. Sci. 90: 429-436. Journal article: Wade, C.M. J.W. Wilton, and Miller, S.P. 2001. Determination of breeding strategies for beef cattle bull breeders selling bulls into two competing markets on a non-linear price grid. Can. J. Anin. Sci. 81: 169-177. Book chapter: Bourdon, R.M. 2000. Understanding animal breeding Pages 21–55 Upper Saddle River, NJ : Prentice Hall, Web site: Saskatchewan Pork International. 2003. Mitchell’s Gourmet Foods, Inc., Hog Settlement Grid. [Online] Available: http://www.spimg.ca/grid-mgf.htm. [2006 Mar. 21]. ANSC 3500: Principles of Animal Genetics Page 13 Assignment Descriptions In some of the assignments, students will read a scientific manuscript or a scientific source and answer questions about its content to summarize or interpret the material. Reading material is chosen to reflect the course content and amplify chosen topics. One assignment will be based upon information from online genetics databases, including the sites, Online Mendelian Inheritance in Animals (OMIA), and the National Centre for Biotechnology Information (NCBI). Other assignments offer an opportunity to review materials covered in class through exercises involving simple calculations. There will also be statistical calculations involving means and variances for quantitative traits. Assignment Due Dates Assignments are passed out at the beginning of each section and due dates are assigned and stated on each assignment. Assignment Grading Times Assignments are submitted to 201 Animal Science Building by 4:30 pm on the deadline date. The instructor will not accept assignments before or after lectures. You must sign in your work with the secretary in 201 Animal Science as proof that it was received. Graded assignments are available 1 week from the due date and the marks are made available through UMlearn. Assignment Extension and Late Submission Policy Late Assignments Students should hand in assignments on time. Otherwise late assignments will not be accepted without an acceptable explanation. ‘Acceptable’ explanation is anything unforeseen that would prevent you to complete the assignment on time. Proof of the said ‘unforeseen circumstance’ will be required. Missed Assignments Assignments which are not submitted will be given a score of zero, and that zero score will be used to calculate the overall average for assignments.