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Supplementary Information 1. Search strings used to collect data of new antimalarial drug targets (Data collected from Derwent
Innovation Index)
Drug Targets
CDK
DNA Replication
Transcription
Fatty Acid Synthesis
Search String
Topic=(“cdk inhibitor”) Refined by: Topic=(malaria OR protoz*)
Topic=(“ Cyclin dependent kinase’’) Refined by: Topic=(malaria or protoz*)
Topic=(“Pfmrk”) or (“PK5) or (“PK6)
Topic= (“DNA Replication”) Refined by: Topic=(malaria OR protoz*)
Topic=(ciprofloxacin) AND Topic=(malaria or protoz*)
Topic=("RNA polymerase") AND Topic=(malaria OR protoz*)
Topic=("RNA polymerase inAhibi*") AND Topic=(malaria OR protoz*)
Topic=(rifampin) OR Topic=(rifampicin) Refined by: Topic=(malaria OR protoz*)
Topic=(streptolydigin OR microcin OR myxopyronin) AND Topic=(malaria OR
protoz*)
Topic=(Fatty acid synthesis) AND Topic=(malaria)
Topic=(FabI OR enoyl-ACP reductase) AND Topic=(malaria)
Topic=(FabI OR enoyl-ACP reductase) AND Topic=(plasmodium OR malaria OR
protozoa)
Isoprenoid biosynthesis
Folate pathway
Glycolysis
Salvage pathway
Shikimate pathway
Mitochondrial targets
Food Vacuoles
Topic=(FabI OR enoyl-ACP reductase) AND Title=(plasmodium OR malaria OR
protozoa)
Topic=(DOXP) AND Topic=(malaria)
Topic=(dihydrofolate reductase)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=(dihydropteroate synthase)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=(methotrexate)
Refined by: Topic=(dihydrofolate reductase) AND Topic=(malaria OR
Plasmodium OR protozoa)
Topic=(aminopterin)
Refined by: Topic=(dihydrofolate reductase) AND Topic=(malaria OR
Plasmodium OR protozoa)
Topic=('lactate dehydrogenase inhibitor)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=('Purine nucleoside phosphorylase') OR Topic=(pnp)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=(Hypoxanthine guanine) OR Topic=(HGXPT)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=(Shikimate pathway)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=(ubiquinol cytochrome oxidoreductase)
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
Topic=('plasmepsin protease')
Refined by: Topic=(malaria OR Plasmodium OR protozoa)
2. Search strings used to collect data of existing anti malaria drugs (Data collected from Derwent
Innovation Index)
Drugs
Search Strings
Artemisinins
Topic=(Artemisinins) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=(Artemisinins) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=(New AND Artemisinins) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Lumefantrine
Topic=( Lumefantrine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Title=( Lumefantrine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Amodiaquine
Topic=( Amodiaquine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Title=( Amodiaquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Piperaquine
Topic=( Piperaquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=( Piperaquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Pyronaridine
Topic=( Pyronaridine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=( Pyronaridine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Mefloquine
Topic=( Mefloquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=( Mefloquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Quinine/Quinidine
Topic=( Quinine OR Quinidine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Title=( Quinine OR Quinidine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Atovaquone
Topic=( Atovaquone) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=( Atovaquone) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Chloroquine
Topic=( Chloroquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=( Chloroquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Pyrimethamine
Topic=( Pyrimethamine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Title=( Pyrimethamine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Primaquine
Topic=( Primaquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
Title=( Primaquine) Refined by: Topic=(malaria
OR Plasmodium OR protozoa)
3. Search strings used to collect data of antimalarial vaccines (Data collected from Derwent
Innovation Index)
Vaccines
Search Strings
Pre-erythrocytic vaccines
Topic=(‘pre-erthrocytic vaccines’) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Topic=(‘pre-erthrocytic’ AND vaccines) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Topic=(Sporozoite AND Liver Stage) Refined by:
Topic=(malaria OR Plasmodium OR protozoa) Refined
by: Topic=( pre-erthrocytic AND vaccine)
Anti cytoadhesion and Placental malaria vaccine
Blood stage vaccine
Sexual stage vaccine
Topic=(EMP AND vaccine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Topic=(VAR2CSA AND vaccine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Topic=(PAM AND vaccine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Topic=(Pregnancy associated malaria AND vaccine)
Refined by: Topic=(malaria OR Plasmodium OR
protozoa)
Topic=(merozoite surface protein AND vaccine)
Refined by: Topic=(malaria OR Plasmodium OR
protozoa)
Topic=( apical membrane protein AND vaccine)
Refined by: Topic=(malaria OR Plasmodium OR
protozoa)
Topic=(‘Blood stage’ AND vaccine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
Topic=(‘Sexual stage’ AND vaccine) Refined by:
Topic=(malaria OR Plasmodium OR protozoa)
4. Search string used to collect data for quantitative analysis (Data collected from Derwent Innovation
Index)
Title=( malaria* OR plasmod* OR anopheles) Title/Abstract/Claims=( treat* OR drug* OR vaccin* OR adjuvant*
OR excipient OR diagnos* OR antimalarial* OR chemotherapeutic*)