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Depolarization Muscle and nerve cells have a strong electric character. Under normal circumstances, the cell is negative inside, positive outside; the potential difference across the cell membrane is about -70 mV. When a nerve cell “fires” or a muscle cell contracts, this potential changes. Channels open to allow sodium ions to come into the cell, changing the potential to +40 mV inside the cell. - + + - + + - Dipole potential The potential difference between two points in the field of a dipole is proportional to the component of the dipole moment along the line connecting the points. The electric field of the heart As the heart beats, a wave of depolarization sweeps across the tissue. Cells that have not yet depolarized are +; cells that have depolarized are -. Net result: a dipole moment. The dipole moment of the heart at its largest. A basic electrocardiogram As the heart beats, the dipole moment changes. The largest magnitude dipole moment occurs when all of the heart muscle save the left ventricle has depolarized. At any instant, the potential difference recorded between two electrodes is the component of the dipole moment vector of the heart. The electric field of the heart As the heart beats, the dipole moment changes. A measurement of the potential difference between two points sweeps out a curve showing the varying component of the dipole moment vector. The orientation of the heart Focus on the largest peak of the electrocardiogram; this comes during the ventricular depolarization. Depending on how the electrodes are placed, the component of the dipole moment at this instant will be large or small. You can tell the orientation by trying different electrode arrangements. !V = V2 " V1 !V = V2 " V1 !V = V2 " V1 time time time