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Siomycin A from Streptomyces sioyaensis Catalog Number S6076 Storage Temperature –20 °C CAS RN 12656-09-6 Synonyms: Mutabilycin, Sporangiomycin, Mutabillicin, Antibiotic 6741-21 Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices. Preparation Instructions The product is soluble in DMSO. Storage/Stability Store the product sealed at –20 °C. Under these conditions the product is stable for at least 2 years. Product Description Molecular formula: C71H81N19O18S5 Molecular Weight: 1648.84 Siomycin A is a macrocyclic antibiotic with potent and selective antibacterial activity against Gram-negative and Gram-positive bacteria, including Mycobacterium tuberculosis and other clinical resistant strains.1-3 Siomycin A has been reported to inhibit antibody production.4 It also inhibits the oncogenic transcription factor, forkhead box M1, (FoxM1, previously known as HFH-11B, Trident, WIN, or MPP2). FoxM1 is overexpressed in a number of different carcinomas; whereas, its expression is turned off in terminally differentiated cells.5 The reduced transcription activity was reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B phosphatase, Survivin, cyclin B, Aurora B kinase, and CENPB. Siomycin A was shown to reduce anchorage-independent growth of cells in soft agar. Moreover, in vitro assays found Siomycin A was able to selectively induce apoptosis of transformed but not normal cells.5-7 References 1. Tokura, K., et al., Water-soluble Siomycin derivatives. Preparation, chemical structures and biological properties of half- esters of the peptide antibiotic. J. Antibiotics, 34, 800-810 (1981). 2. Wakisaka, Y., et al., Fermentative preparation of S35-Siomycin, A sulfur-containing peptide antibiotic. J. Antibiotics, 26, 104-106 (1973). 3. Yagi, S., et al., Stimulative effect of elemental sulfur of Siomycin production by Streptomyces sioyaensis. Appl. Microbiol., 22, 153-156 (1971). 4. Ueno, M., et al., Suppressive effect of antibiotic Siomycin on antibody production. J. Antibiotics, 57, 590-596 (2004). 5. Radhakrishnan, S.K., et al., Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead box M1. Cancer Res., 66, 97319734 (2006). 6. Bhat, U.G., et al., Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle, 7, 1851-1855 (2008). 7. Gartel, A.L., FoxM1 inhibitors as potential anticancer drugs. Informa Pharmac. Sci., Expert Opin. Ther. Targets, 12, 663-665 (2008). DWF,KAA,MAM 09/10-1 Purity: ≥98% (HPLC) Sigma brand products are sold through Sigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side of the invoice or packing slip.