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4/18/2017 Cell Reproduction Mitosis and Meiosis Cell Division or Cell Reproduction Two types of cell division: – Mitosis - most common type of cell division – Meiosis – process that produces sex cells for reproduction of organisms. – Mitotic Index –the ratio between the number of cells in a population undergoing mitosis to the number of cells in a population not undergoing mitosis. (the ratio of cells dividing to cells resting) – Chromosome - the part of a cell that contains the genes which control how an animal or plant grows and what it becomes – Diploid - containing two complete sets of chromosomes, one from each parent – Haploid - having a single set of unpaired chromosomes 1 4/18/2017 Mitosis Remember by: Mitosis has a T like ‘two’ or ‘twins’ because it results in two twin cells replacing the original cell – Cell division process that occurs in most cells in the body – Results in two diploid daughter cells that are identical to and replace the original cell – Each daughter cell has the same number of chromosomes as the original cell – Chromosomes in the daughter cells are exact replicas of the chromosomes in the original (parent) cell. – Functions: ₋ ₋ ₋ Growth of organism from single celled fertilized egg to adult* Replacement/regeneration of damaged or ‘old’ cells* Asexual reproduction * These are the main functions of mitosis, occurring in all organisms. Meiosis – Occurs only in reproductive organs – Cell division process that results in sex cells, ovum (egg) and sperm – Results in four haploid cells with half the number of chromosomes as the original cell ₋ ₋ In males, these become 4 sperm cells In females, only one of these becomes a viable ovum (egg cell) and three polar bodies that disintegrate. – Chromosomes in the haploid cells are unique compared to each other and the original cell due to crossing over – Crossing over - process in genetics by which the two chromosomes of a homologous pair exchange equal segments with each other. 2 4/18/2017 Latin and Greek prefixes Prefixes: – A – not, without – Ana – up, back, again – Inter – within, inside – Intra – between, – Meta – between, along, after – Mito -- thread – Pro – forward, favoring, before – Sis – condition, state Phase – a characteristic form, appearance, or stage of development that occurs in a cycle – Telo – end Stages of Cell Division: Interphase Mitosis Meiosis – Near the end of this phase, the cell copies its DNA in preparation for cell division – Near the end of this phase, the cell copies its DNA in preparation for cell division – Resting phase – time between phases of cell division – Resting phase – time between phases of cell division 3 4/18/2017 Stages of Cell Division: Interphase Stages of Cell Division: Prophase/Prophase 1 - First phase of cell division Mitosis – Chromosomes become visible as paired chromatids – Spindle fibers begin to form – Nuclear membrane disintegrates Meiosis – Chromosomes become visible as paired chromatids and attach to nuclear membrane – Paired chromosomes exchange gene sequences – Spindle fibers begin to form – Nuclear membrane disintegrates 4 4/18/2017 Stages of Cell Division: Prophase/Prophase 1 Mitosis - Prophase Meiosis – Prophase 1 Stages of Cell Division: Prometaphase/Prometaphase 1 Mitosis Meiosis – Spindle fibers attach to each of the chromosomes – Spindle fibers from opposite sides attach to one of each pair of chromosomes – Centrioles at opposite ends of the cell – Centrioles at opposite ends of the cell 5 4/18/2017 Stages of Cell Division: Metaphase/Metaphase 1 Mitosis Meiosis – Spindle fibers begin to tug each chromosome toward opposite ends of the cell – Spindle fibers begin to tug chromosomes toward opposite ends of the cell – Chromosomes line up along the metaphase plate, an imaginary line in the middle of the cell – Chromosomes line up along the metaphase plate, with pairs on opposite sides of the line Stages of Cell Division: Metaphase/Metaphase 1 Mitosis - Metaphase Meiosis – Metaphase 1 6 4/18/2017 Stages of Cell Division: Anaphase/Anaphase 1 Mitosis Meiosis – The fibers pull the sister chromatids to opposite ends of the cell – Sister chromatids do not separate – Chromosomes break at centromeres and – Chromosomes pairs separate, one moving to each end of the cell Stages of Cell Division: Anaphase/Anaphase 1 Mitosis - Anaphase Meiosis – Anaphase 1 7 4/18/2017 Stages of Cell Division: Telophase/Telophase 1 and Cytokinesis Mitosis Meiosis – Mitosis is now considered complete – For sperm cells, cell division is approximately equal, for egg cells, forms one large and one small cell. – Cytokinesis – division of the cytoplasm and formation of cell wall/membrane occurs. – Chromatids – now considered chromosomes – arrive at opposite ends of the cell, – new nuclear membrane forms – Cytokinesis – division of the cytoplasm and formation of cell wall/membrane occurs. – Chromosomes pairs arrive at opposite ends of the cell – New nuclear membrane may form Stages of Cell Division: Telophase/Telophase 1 Mitosis - Telophase Meiosis – Telophase 1 8 4/18/2017 Stages of Cell Division: Cytokinesis Mitosis - Cytokinesis Meiosis – Cytokinesis Stages of Cell Division: Interphase II (Meiosis) Mitosis – Mitosis and cytokinesis are complete Meiosis – Chromosomes do not replicate 9 4/18/2017 Stages of Cell Division: Prophase II Meiosis – Spindle fibers begin to form – Nuclear membrane disintegrates – Chromosomes do not attach to the nuclear membrane or exchange gene sequences. Stages of Cell Division: Metaphase II Meiosis – Chromosomes line up along the metaphase plate – Spindle fibers begin to tug each chromosome toward opposite ends of the cell (as in mitosis metaphase) 10 4/18/2017 Stages of Cell Division: Anaphase II Meiosis – (as in mitosis) The fibers pull the chromatids apart – Chromatids move to opposite ends of the cells Meiosis Stages of Cell Division: Telophase II – Chromatids arrive at either end of the dividing cell and a new nuclear membrane forms – For males, there are two dividing cells – For females, there is one dividing cell; as in Telophase 1, most of the cytoplasm will be concentrated in one of the two forming cells 11 4/18/2017 Stages of Cell Division: Cytokinesis Meiosis – The cell(s) complete division – For males, there are now four haploid cells – For females, there is one haploid cell and two polar bodies (failed cells – one from each of Meiosis 1 and Meiosis 2) CELL DIVISION IS NOW COMPLETE. 12