Download C19459 C-Reactive Protein V3.indd

HUMAN PROTEINS
C-REACTIVE PROTEIN
Abbreviations
CRP
Accession Number
P02741
Source
Plasma
Applications
Control Manufacture, Biosensors, Clinical Chemistry, ELISA Assay, Lateral Flow, Life Science.
Protein Function
C-Reactive protein is an acute phase protein produced in the blood in response to any
inflammatory stimulus such as infection. The increase in circulatory CRP is mediated
by interleukin-6, which is produced by macrophages and adipocytes. It is a member
of the pentraxin group of proteins and exists as a discoid arrangement of 5 noncovalently bound subunits. CRP binds and is activated by calcium.
Tissue Occurrence
& Abundance
CRP is synthesised in the liver and carried in the blood. The reference range in
blood is 1.5-5 mg/L. In an acute phase response levels of CRP can rise to >100mg/L.
Lower level changes in levels of C-Reactive protein have been shown to be helpful in
assessment of the risk of cardiac events.
Function in
Disease
Acute inflammation can cause an increase in the concentration of circulating CRP
of up to 5,000-fold that peaks 48 hours after the initial inflammatory stimulus.
The blood concentration is indicative of the severity of the stimulus. CRP binds to
phosphorylcholine on the surface of bacteria and is thought to assist in complement
binding to foreign cells and is an early defence response against infections. Medical
conditions causing elevated CRP levels in order of severity are: late pregnancy, mild
inflammation, viral infection, severe bacterial infection and burns. There is evidence
that patients with elevated basal levels of CRP are at increased risk of cardiovascular
disease, hypertension and diabetes (1, 2, 3). Levels are elevated following acute
myocardial infarction.
Structure
Molecular weight
Amino acids
Disulphide bonds
pI value(s)
Prosthetic group
Glycosylation
Oligomerisation
Isoforms
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JULY 15/ V1
23,000 (monomer), 115,000 (pentamer)
206
1
5.3
None
None
Pentamer
Isoform 2 lacks sequence aa 67-199
HUMAN PROTEINS
C-REACTIVE PROTEIN
References
1. Lloyd-Jones, D.M., Liu, K., Tian, L., Greenland, P. (2006). Narrative review:
assessment of C-reactive protein in risk prediction for cardiovascular disease.
Ann. Intern. Med. 145: 35–42.
2. Pradhan, A.D., Manson, J.E., Rifai, N., Buring, J.E., Ridker, P.M. (2001). C-reactive
protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:
327–334.
3. Dehghan, A., Kardys, I., De Maat, M.P., Uitterlinden, A.G., Sijbrands, E.J. Bootsma,
A.H.’ Stijnen, T., Hofman, A., Schram, M.T., Witteman, J.C. (2007). Genetic variation,
C-reactive protein levels and incidence of diabetes. Diabetes 56: 872.
WHY BBI?
+ Our production facilities allow us to offer large batch sizes ranging from 100ug to g quantities.
+ With a network of global labs and hospitals, we can access many diverse testing platforms, providing you
with the exact analysis results you need.
+ With over 25 years’ experience sourcing human biologicals at our HTA approved site; you can be confident in a
secure supply.
Purity
>99%, >96%, >70%
Stability & Formulation
TRIS Buffer / NaCl containing CaCl2 and 0.09% NaN3 - 2-8°C do not freeze
HPLC and 4–20%
Native PAGE
P100-0 – 1mg/10mg
P100-7 – 1mg/10mg/100mg
P100-8 – 1mg/10mg/100mg
Dispensations
ORDERING DETAILS – USE THE FOLLOWING CODES WHEN ORDERING
Product
Code
Description
C-Reactive Protein
P100-0
> 99% pure | supplied in a TRIS buffer | sourced from normal human plasma
C-Reactive Protein
P100-7
>96% pure | supplied in a TRIS buffer | sourced from normal human plasma
C-Reactive Protein
P100-8
>70% pure | supplied in a TRIS buffer | sourced from normal human plasma
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JULY 15/ V1
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