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HUMAN PROTEINS C-REACTIVE PROTEIN Abbreviations CRP Accession Number P02741 Source Plasma Applications Control Manufacture, Biosensors, Clinical Chemistry, ELISA Assay, Lateral Flow, Life Science. Protein Function C-Reactive protein is an acute phase protein produced in the blood in response to any inflammatory stimulus such as infection. The increase in circulatory CRP is mediated by interleukin-6, which is produced by macrophages and adipocytes. It is a member of the pentraxin group of proteins and exists as a discoid arrangement of 5 noncovalently bound subunits. CRP binds and is activated by calcium. Tissue Occurrence & Abundance CRP is synthesised in the liver and carried in the blood. The reference range in blood is 1.5-5 mg/L. In an acute phase response levels of CRP can rise to >100mg/L. Lower level changes in levels of C-Reactive protein have been shown to be helpful in assessment of the risk of cardiac events. Function in Disease Acute inflammation can cause an increase in the concentration of circulating CRP of up to 5,000-fold that peaks 48 hours after the initial inflammatory stimulus. The blood concentration is indicative of the severity of the stimulus. CRP binds to phosphorylcholine on the surface of bacteria and is thought to assist in complement binding to foreign cells and is an early defence response against infections. Medical conditions causing elevated CRP levels in order of severity are: late pregnancy, mild inflammation, viral infection, severe bacterial infection and burns. There is evidence that patients with elevated basal levels of CRP are at increased risk of cardiovascular disease, hypertension and diabetes (1, 2, 3). Levels are elevated following acute myocardial infarction. Structure Molecular weight Amino acids Disulphide bonds pI value(s) Prosthetic group Glycosylation Oligomerisation Isoforms Order your evaluation sample today www.bbisolutions.com JULY 15/ V1 23,000 (monomer), 115,000 (pentamer) 206 1 5.3 None None Pentamer Isoform 2 lacks sequence aa 67-199 HUMAN PROTEINS C-REACTIVE PROTEIN References 1. Lloyd-Jones, D.M., Liu, K., Tian, L., Greenland, P. (2006). Narrative review: assessment of C-reactive protein in risk prediction for cardiovascular disease. Ann. Intern. Med. 145: 35–42. 2. Pradhan, A.D., Manson, J.E., Rifai, N., Buring, J.E., Ridker, P.M. (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: 327–334. 3. Dehghan, A., Kardys, I., De Maat, M.P., Uitterlinden, A.G., Sijbrands, E.J. Bootsma, A.H.’ Stijnen, T., Hofman, A., Schram, M.T., Witteman, J.C. (2007). Genetic variation, C-reactive protein levels and incidence of diabetes. Diabetes 56: 872. WHY BBI? + Our production facilities allow us to offer large batch sizes ranging from 100ug to g quantities. + With a network of global labs and hospitals, we can access many diverse testing platforms, providing you with the exact analysis results you need. + With over 25 years’ experience sourcing human biologicals at our HTA approved site; you can be confident in a secure supply. Purity >99%, >96%, >70% Stability & Formulation TRIS Buffer / NaCl containing CaCl2 and 0.09% NaN3 - 2-8°C do not freeze HPLC and 4–20% Native PAGE P100-0 – 1mg/10mg P100-7 – 1mg/10mg/100mg P100-8 – 1mg/10mg/100mg Dispensations ORDERING DETAILS – USE THE FOLLOWING CODES WHEN ORDERING Product Code Description C-Reactive Protein P100-0 > 99% pure | supplied in a TRIS buffer | sourced from normal human plasma C-Reactive Protein P100-7 >96% pure | supplied in a TRIS buffer | sourced from normal human plasma C-Reactive Protein P100-8 >70% pure | supplied in a TRIS buffer | sourced from normal human plasma Related Products BR228-D4A3 Order a sample today [email protected] Int: +44 (0) 2920 767 499 USA: 1-800-423-8199 China: +852 2159 9666 JULY 15/ V1 CRP Recombinant Fab Monoclonal Antibody