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Digest Plus
ENZYME FORMULA
Unique Digestive Enzyme Formula
•Digestive aid to help decrease bloating after high caloric,
high fat meals1
•Pancreatin enzymes help to support digestion of fat,
carbohydrates and protein
•Pepsin A and papain proteolytic enzymes provide
additional protein digestion support 2,3
Digest Plus provides a complete, well-balanced digestive formula with natural enzymes
and betaine hydrochloride to enhance the digestion of proteins, fats and carbohydrates.
Digest Plus helps to help decrease bloating after high caloric, high fat meals.1
Scientific Rationale:
EACH TABLET CONTAINS:
The exocrine pancreas assists in the normal digestion of nutrients by secreting a combination of protease,
lipase and amylase enzymes,4 which aid in the digestion of proteins, lipids, and carbohydrates5, respectively.
Decreased production of pancreatic enzymes can occur due to a variety of conditions, including aging, genetic
predisposition, illness, excessive exercise, or injury.5 Reduced exocrine pancreas function is associated with
malabsorption (especially of lipid soluble vitamins A, D, E, and K), maldigestion, steatorrhea, weight loss, and
malnutrition.6
Digestive enzyme supplementation is an established method for improving nutrient digestion and absorption
in individuals with decreased pancreatic enzyme production. Porcine-derived pancreatin is one of the most
commonly-used pancreatic digestive enzyme supplements, and contains a mixture of protease, lipase and
amylase enzymes.5 Papain digestive enzymes, derived from papaya fruit, are primarily taken to aid in protein
digestion, although they also have amylitic and weak lipolytic activities.5,7
The proteolytic enzyme pepsin A is the active version of the zymogen pepsinogen A (PGA). PGA is
synthesized by chief cells in the gastric mucosa, and released into the stomach lumen following the ingestion
of food. PGA is then converted into pepsin A by stomach acid (HCl).8
HCl facilitates protein digestion and the absorption of vitamin B12 , iron and calcium.9 Betaine is a naturally
occurring plant substance found in beets, spinach, and wheat10 that may help to support heart, kidney and liver
health.11 Betaine hydrochloride (betaine HCl) is commonly used to supplement gastric acid levels, especially
in individuals with hypochloridia. In a recent clinical study, a single 1500 mg dose of betaine HCl was effective in
reducing stomach pH in healthy participants that had hypochloridia pharmacologically induced by the proton
pump inhibitor rabeprazole. Within 30 minutes of ingestion of the betaine HCl, participant mean stomach pH was
significantly reduced from approximately 5.2 to approximately 0.6.10
The amino acid L-glutamate may help to attenuate maldigestion, as it stimulates both gastric acid secretion
and pancreatic juice secretion.12-14 In a placebo-controlled crossover clinical trial of 9 healthy men fed a protein
and carbohydrate enriched liquid meal, the addition of L-glutamate significantly increased gastric emptying
rates. Participants received one of two 400 mL liquid meals, each providing a total of 400 calories; the control
meal (12.5% casein and 12.5% dextrin), or the L-glutamate fortified meal (12.5% casein-calcium, 12.5% dextrin,
and 0.5% monosodium L-glutamate). Each of the liquid meals was labeled with 100 mg of [13C] sodium acetate.
Gastric emptying rates were measured for 3 hours after the ingestion of test meals using a 13C breath test, to
determine peak and total 13C clearance rates. Compared with the control meal, peak 13C clearance rates at 1 hour
and total 13C clearance rates during the 3 hour measurement period were both significantly increased following
ingestion of the L-glutamate meal, indicating that gastric emptying was significantly improved. The authors
concluded that the study results would be potentially useful in designing treatments for the elderly, patients with
dyspepsia, and other individuals that experience stomach discomfort caused by delayed gastric emptying.13
Betaine Hydrochloride . . . . . . . . . . . . . . . . . . . . . . 162.5 mg
L-Glutamic Acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 162.5 mg
Pancreatin 4X (from porcine pancreas)♦ . . . . . . . 65 mg
Papain (from Carica papaya fruit)♦ . . . . . . . . . . . . . 65 mg
Pepsin (from porcine stomach)♦ . . . . . . . . . . . . . . . 25mg
♦Y
ielding: 390 000 USP protease units/ 6500 USP
amylase units/ 1300 USP lipase units
Non-Medicinal Ingredients: Cellulose, hyprolose, silica,
magnesium stearate, croscarmellose sodium, natural
vanilla flavor, hypromellose, glycerin
Adults: Take one tablet three times daily with
each meal, or as recommended by your healthcare
practitioner. Use the smallest effective dose which
controls symptoms. For use beyond four weeks, consult
your healthcare practitioner.
Product Size: 90 Tablets
180 Tablets
Product Code: 10509
10509180
REFERENCES
1. NHPD Monograph on Pancreatic Enzymes. October 2014
2. NHPD Monograph on Digestive Enzymes. October 2014
3. NHPD Monograph on Papain. July 2012
4. Pezzilli R, Andriulli A, Bassi C, Balzano G, Cantore M et al. Exocrine pancreatic insufficiency in adults:
A shared position statement of the Italian association for the study of the pancreas. World Journal of
Gastroenterology. 2013 November 28; 19(44): 7930-7946
5. Roxas M. The Roles of Enzyme Supplementation in Digestive Disorders. Alternative Medicine Review.
2008; 13(4): 307-314
6. Ferrone M, Raimondo M, Scolapio JS. Pancreatic Enzyme Pharmacotherapy. Pharmacotherapy. 2007;
27(6): 910-920
7. Tyler VE, Brady LR and Robbers JE. Enzymes and other proteins. Pharmacognosy. 8th ed. Philadelphia, PA:
Lea and Febriger; 1981: 290-291
8. Richter C, Tanaka T, and Yada R. Mechanism of activation of the gastric aspartic proteinases : pepsinogen,
progastricsin and prochymosin. Biochemical Journal. 1998; 335: 481-490
9. Schubert ML. Gastric exocrine and endocrine secretion. Current Opinion in Gastroenterology. 2009;
25(6): 529-36
10. Yago MAR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR et al. Gastric Re-acidification with Betaine
HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria. Mol Pharm. 2013; 10(11):
4032–4037
11. Craig SAS. (2004) Betaine in human nutrition. American Journal of Clinical Nutrition. 80:539-49
12. Uneyama H, Gabriel AS, Kawai M, Tomoe M and Torii K. Physiological role of dietary free glutamate in the
food digestion. Asia Pacific Journal Clinical Nutrition. 2008; 17 (S1): 372-375
13. Kochetkov AM, Shlygin GK, Loranskaia TI, Vasilevskaia LS and Kondrashev Siu. The use of monosodium
glutamate in the combined therapy of patients with atrophic gastritis. Vorp Pitan. 1992; 5-6:19-22
14. Zai H, Kusano M, Hosaka H, Shimoyama Y, Nagoshi A et al. Monosodium L-glutamate added to a
high-energy, high-protein liquid diet promotes gastric emptying. American Journal of Clinical Nutrition.
2009; 89: 431–435
This information is for practitioner use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by Health Canada.
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