Download Curriculum Vitae - Johns Hopkins Medicine

CURRICULUM VITAE
The Johns Hopkins University School of Medicine
Charles G. Eberhart MD PhD
Oct 19, 2016
DEMOGRAPHIC AND PERSONAL INFORMATION
Current Appointments
2006-present Chief of Ophthalmic Pathology
2009-present Director of Neuropathology
2011-present Professor, Departments of Pathology, Ophthalmology and Oncology
Personal Data
Charles G. Eberhart M.D., Ph.D.
Department of Pathology-Ross Building 558
720 Rutland Ave
Baltimore, MD, 21205
Phone: 410-502-5185
FAX: 410-955-9777/410-614-3457
Email: [email protected]
Education and Training
1983-1988
BA
University of Texas at Austin, Major: Biochemistry
1988-1989
Research Fellow
1989-1997
MD-PhD
1997-1999
1999-2001
Resident
Fellow
Max Planck Institute for Biochemistry, Munich, Germany.
Laboratory of Dr. Dieter Oesterheldt
University of Texas Southwestern Medical School, Dallas, Texas.
Dissertation research in laboratory of Dr. Steven Wasserman
Anatomic Pathology, Johns Hopkins Hospital, Baltimore, MD
Neuropathology, Johns Hopkins Hospital, Baltimore, MD.
Professional Experience
2001-2002
2003-2006
2004-2006
2006-2011
2011-present
2006-present
2009-present
2014-present
2015-present
Instructor, Department of Pathology, Johns Hopkins University School of Medicine
Assistant Professor, Department of Pathology, Johns Hopkins University School of Medicine
Assistant Professor, Department of Oncology, Johns Hopkins University School of Medicine
Associate Professor, Departments of Pathology, Ophthalmology and Oncology, Johns Hopkins
University School of Medicine
Professor, Departments of Pathology, Ophthalmology and Oncology, Johns Hopkins
University School of Medicine
Chief of Ophthalmic Pathology Division, Johns Hopkins University School of Medicine
Director of Neuropathology Division, Johns Hopkins University School of Medicine
Volunteer Clinical Professor, Department of Ophthalmology, University of Maryland
Member, Wilmer Center for Nanomedicine, Johns Hopkins University School of Medicine
PUBLICATIONS
Original Research (Mentee names underlined)
1. Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, DiNardo S, Wasserman SA.
Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile
mutants generated by single P element mutagenesis. Genetics 1993;135(2):489-505.
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2. Eberhart CG, Wasserman SA. The pelota locus encodes a protein required for meiotic cell division: an analysis
of G2/M arrest in Drosophila spermatogenesis. Development 1995;121(10):3477-3486.
3. Eberhart CG, Maines JZ, Wasserman SA. Meiotic cell cycle requirement for a fly homologue of human Deleted
in Azoospermia. Nature 1996;381:783-785.
4. Eberhart CG, Tihan T, Burger PC. Nuclear localization and mutation of beta-catenin in medulloblastomas. J
Neuropathol Exp Neurol 2000;59(4):333-337.
5. Eberhart CG, Brat DJ, Cohen KJ, Burger PC. Pediatric neuroblastic brain tumors containing abundant neuropil
and true rosettes. Pediatr Dev Pathol 2000;3(4):346-352.
6. Eberhart CG, Kaufman WE, Tihan T, Burger PC. Apoptosis, neuronal maturation and neurotrophin signaling
within medulloblastoma nodules. J Neuropath Exp Neurol 2001; 60(5):462-469.
7. Clatterbuck RE, Eberhart CG, Crain BJ, Rigamonti D. Ultrastructural and immunocytochemical evidence that an
incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations. J Neurol Neurosurg
Psychiatry 2001; 71(2):188-192.
8. Eberhart CG and Argani P. Wnt signaling in human development: beta-catenin nuclear translocation in fetal lung,
kidney, placenta, capillaries, adrenal and cartilage. Pediatr Dev Pathol 2001;4(4):351-357.
9. Eberhart CG, Morrison A, Gyure KA, Frazier J, Smialek JE, Troncoso JC. Decreasing incidence of sudden
death due to undiagnosed primary central nervous system tumors. Arch Pathol Lab Med 2001;125(8):1024-1030.
10. Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ. Pten regulates
neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 2001;29(4):404-411.
11. Brat DJ, Scheithauer BW, Eberhart CG, Burger PC. Extraventricular neurocytomas: pathologic features and
clinical outcome. Am J Surg Pathol 2001;25(10):1252-1260.
12. Eberhart CG, Kratz JE, Schuster A, Goldthwaite P, Cohen KJ, Perlman EJ, Burger PC. Comparative genomic
hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain
Pathol 2002;12(1):36-44.
13. Eberhart CG, Kepner JL, Goldthwaite PT, Kun LE, Duffner PK, Friedman HS, Strother DR, Burger PC.
Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002;94(2):552-560.
14. Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK,
Taipale J, Olson JM, Beachy PA. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science
2002;297(5586):1559-1561.
15. Caparrelli DJ, Cattaneo SM 2nd, Bethea BT, Shake JG, Eberhart C, Blue ME, Marbán E, Johnston MV,
Baumgartner WA, Gott VL. Pharmacological preconditioning ameliorates neurological injury in a model of spinal
cord ischemia. Ann Thorac Surg 2002;74(3):838-844.
16. Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired
phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell
2002;110(6):751-762.
17. Kratz JE, Stearns D, Huso DL, Slunt HH, Price DL, Borchelt DR, Eberhart CG. Expression of stabilized betacatenin in differentiated neurons of transgenic mice does not result in tumor formation. BMC Cancer 2002;2(2):33.
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18. Gabikian P, Clatterbuck RE, Eberhart CG, Tyler BM, Tierney TS, Tamargo RJ. Prevention of experimental
cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and
efficacy studies in rabbits and rats. Stroke 2002;33(11):2681-2686.
19. Eberhart CG, Cohen KJ, Tihan T, Goldthwaite PT, Burger PC. Medulloblastomas with systemic metastases:
evaluation of tumor histopathology and clinical behavior in 23 patients. J Pediatr Hematol Oncol 2003;25(3):198203.
20. Fan X, Wang Y, Kratz J, Brat DJ, Robitaille Y, Moghrabi A, Perlman EJ, Dang CV, Burger PC, Eberhart CG.
hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. Am J
Pathol 2003;162(6):1763-1769.
21. Boon K, Edwards JB, Siu I-M, Olschner D, Eberhart CG, Marra MA, Strausberg RL, Riggins GJ. Comparison
of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene
2003;22(48):7687-7694.
22. Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne R, Rehg JE, Eberhart CG, Sherr CJ, Roussel MF.
Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res 2003;63(17):54205427.
23. Eberhart CG, Kratz J, Wang Y, Summers K, Stearns D, Cohen K, Dang CV, Burger PC. Histopathological and
molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC and anaplasia. J Neuropathol Exp Neurol
2004;63(5):441-449.
24. Boon K, Edwards JB, Eberhart CG, Riggins GJ. Identification of astrocytoma associated genes including cell
surface markers. BMC Cancer 2004;4:39.
25. Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D, Brat DJ, Perry A, Eberhart CG. Notch1 and notch2
have opposite effects on embryonal brain tumor growth. Cancer Res 2004;64(21):7787-7793.
26. Boon K, Eberhart CG, Riggins GJ. Genomic amplification of orthodenticle homolog 2 in medulloblastomas.
Cancer Res 2005;65(3):703-707.
27. Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis AT, Bouffard JP, Mena H, Burger PC, Eberhart
CG. Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR
pathway. J Neuropathol Exp Neurol 2005;64(4):341-349.
28. Eberhart CG, Chaudhry A, Daniel RW, Khaki L, Shah KV, Gravitt PE. Increased p53 immunopositivity in
anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. BMC Cancer 2005;5:19.
29. Purow BW, Haque RM, Noel MW, Su Q, Burdick MJ, Lee J, Sundaresan T, Pastorino S, Park JK, Mikolaenko I,
Maric D, Eberhart CG, Fine HA. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for
glioma cell survival and proliferation. Cancer Res 2005;65(6):2353-2363.
30. Pan E, Pellarin M, Holmes E, Smirnov I, Misra A, Eberhart CG, Burger PC, Biegel JA, Feuerstein BG.
Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer
Res 2005;11:4733-4740.
31. Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr
SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF. The tumor
suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes
Dev 2005;19(22):2656-2667.
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32. Inda MM, Perot C, Guillaud-Bataille M, Danglot G, Rey JA, Bello MJ, Fan X, Eberhart C, Zazpe I, Portillo E,
Tuñón T, Martínez-Peñuela JM, Bernheim A, Castresana JS. Genetic heterogeneity in supratentorial and
infratentorial primitive neuroectodermal tumours of the central nervous system. Histopathology 2005;47(6):631-637.
33. Rand V, Huang J, Stockwell T, Ferriera S, Buzko O, Levy S, Busam D, Li K, Edwards JB, Eberhart C, Murphy
KM, Tsiamouri A, Beeson K, Simpson AJ, Venter JC, Riggins GJ, Strausberg RL. Sequence survey of receptor
tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci 2005;102(40):14344-14349.
34. Raza SM, Anderson WS, Eberhart CG, Wolinsky JP, Gokaslan ZL. The application of surgical cordectomy in
the management of an intramedullary-extramedullary atypical meningioma: case report and literature review. J
Spinal Disord Tech 2005;18(5):449-454.
35. Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner EB, Eberhart CG, Laterra J, Abounader R. The
scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor
malignancy. Cancer Res 2005;65(20):9355-9362.
36. Connors SL, Crowell DE, Eberhart CG, Copeland J, Newschaffer CJ, Spence SJ, Zimmerman AW. Beta2adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins. J Child Neurol
2005;20(11):876-884.
37. Dang L, Fan X, Chaudhry A, Wang M, Gaiano N, Eberhart CG. Notch3 signaling initiates choroid plexus
tumor formation. Oncogene 2006;25(3):487-491.
38. Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S.
Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking
neuronal differentiation. Mol Cell Biol 2006;26(5):1666-1678.
39. Stearns D, Chaudhry A, Abel TW, Burger PC, Dang CV, Eberhart CG. c-myc overexpression causes anaplasia
in medulloblastoma. Cancer Res 2006;66(2):673-681.
40. Eberhart CG, Copeland J, Abel TW. Brief report: S6 ribosomal protein phosphorylation in autistic frontal
cortex and cerebellum: a tissue array analysis. J Autism Dev Disord 2006;36(8)1131-1135.
41. Dixit VD, Weeraratna AT, Yang H, Bertak D, Cooper-Jenkins A, Riggins GJ, Eberhart CG, Taub DD. Ghrelin
and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma cell motility. J
Biol Chem 2006;281(24):16681-16690.
42. Park JT, Li M, Nakayama K, Mao TL, Davidson B, Zhang Z, Kurman RJ, Eberhart CG, Shih IM, Wang TL.
Notch3 gene amplification in ovarian cancer. Cancer Res 2006;66(12):6312-6318.
43. Chu LC, Eberhart CG, Grossman SA, Herman JG. Epigenetic silencing of multiple genes in primary CNS
lymphoma. Int J Cancer 2006;119(10):2487-2491.
44. Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, Eberhart CG. Notch pathway inhibition depletes stemlike cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006;66(15):7445-7452.
45. Gallia GL, Rand V, Siu IM, Eberhart CG, James CD, Marie SK, Oba-Shinjo SM, Carlotti CG, Caballero OL,
Simpson AJ, Brock MV, Massion PP, Carson BS Sr, Riggins GJ. PIK3CA gene mutations in pediatric and adult
glioblastoma multiforme. Mol Cancer Res 2006;4(10):709-714.
46. Bar EE, Chaudhry A, Eberhart CG. Hedgehog signaling promotes medulloblastoma survival via Bcl2. Am J
Pathol 2007;170(1):347-355.
47. von Bueren AO, Shalaby T, Rajtarova J, Stearns D, Eberhart CG, Helson L, Arcaro A, Grotzer MA. Antiproliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. BMC Cancer 2007;7:19.
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48. Cheslack-Postava K, Fallin MD, Avramopoulos D, Connors SL, Zimmerman AW, Eberhart CG, Newschaffer
CJ. beta2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort. Mol Psychiatry
2007;12(3):283-291.
49. Lo KC, Rossi MR, Eberhart CG, Cowell JK. Genome wide copy number abnormalities in pediatric
medulloblastomas as assessed by array comparative genome hybridization. Brain Pathol 2007;17(3):282-296.
50. Rodriguez FJ, Eberhart C, O'neill BP, Slezak J, Burger PC, Goldthwaite P, Wu W, Giannini C. Histopathologic
grading of adult medulloblastomas. Cancer 2007;109(12):2557-2565.
51. Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Piccirillo S, Vescovi AL,
DiMeco F, Olivi A, Eberhart CG. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer
cells in glioblastoma. Stem Cells 2007;25(10):2524-2533.
52. Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG,
Wong PC. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of
gamma-secretase. J Biol Chem 2007;282(44):32264-32273.
53. Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG,
Wong PC. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based
liabilities. J Neurosci 2007;27(40):10849-10859.
54. Lo KC, Ma C, Bundy BN, Pomeroy SL, Eberhart CG, Cowell JK. Gain of 1q is a potential univariate negative
prognostic marker for survival in medulloblastoma. Clin Cancer Res 2007;13(23):7022-7028.
55. Li Y, Guessous F, Johnson EB, Eberhart CG, Li XN, Shu Q, Fan S, Lal B, Laterra J, Schiff D, Abounader R.
Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma.
Lab Invest 2008;(2):98-111.
56. Walker BM, Hindman HB, Ebrahimi KB, Green WR, Eberhart CG, Garcia I, Jun AS. Epithelial downgrowth
following Descemet's-stripping automated endothelial keratoplasty. Arch Ophthalmol 2008;126(2):278-280.
57. Briggs KJ, Corcoran-Schwartz IM, Zhang W, Harcke T, Devereux WL, Baylin SB, Eberhart CG, Watkins DN.
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev 2008;22(6):770-785.
58. Hatton BA, Villavicencio EH, Tsuchiya KD, Pritchard JI, Ditzler S, Pullar B, Hansen S, Knoblaugh SE, Lee D,
Eberhart CG, Hallahan AR, Olson JM. The Smo/Smo model: hedgehog-induced medulloblastoma with 90%
incidence and leptomeningeal spread. Cancer Res 2008;68(6):1768-1776.
59. Siu IM, Bai R, Gallia GL, Edwards JB, Tyler BM, Eberhart CG, Riggins GJ. Coexpression of neuronatin splice
forms promotes medulloblastoma growth. Neuro Oncol 2008;10(5):716-724.
60. Bar EE, Lin A, Tihan T, Burger PC, Eberhart CG. Frequent gains at chromosome 7q34 involving BRAF in
pilocytic astrocytoma. J Neuropathol Exp Neurol 2008;67(9):878-887.
61. Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG,
Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. Abnormal DNA methylation of CD133 in
colorectal and glioblastoma tumors. Cancer Res 2008;68(19):8094-8103.
62. Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ, Laterra J, Fults DW. Hepatocyte growth factor
and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and
growth. Cancer Res 2008;68(19):7838-7845.
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63. Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW,
Anant S, Jenkins S, Eberhart CG, Sarkaria JN, Gutmann DH. Gene expression profiling of NF-1-associated and
sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an
underexpressed candidate biomarker in aggressive subtypes. J Neuropathol Exp Neurol 2008;67(12):1194-1204.
64. Macgregor AM, Eberhart CG, Fraig M, Lu J, Halushka MK. Tissue inhibitor of matrix metalloproteinase-3
levels in the extracellular matrix of lung, kidney, and eye increase with age. J Histochem Cytochem 2009;57(3):207213.
65. Oster SF, Ebrahimi KB, Eberhart CG, Schein OD, Stark WJ, Jun AS. A clinicopathologic series of primary
graft failure after Descemet's stripping and automated endothelial keratoplasty. Ophthalmology 2009;116(4):609614.
66. Gessi M, Giangaspero F, Lauriola L, Gardiman M, Scheithauer BW, Halliday W, Hawkins C, Rosenblum MK,
Burger PC, Eberhart CG. Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive
neuroectodermal tumor. Am J Surg Pathol 2009;33(2):211-217.
67. Barnes M, Eberhart CG, Collins R, Tihan T. Expression of p75NTR in fetal brain and medulloblastomas:
evidence of a precursor cell marker and its persistence in neoplasia. J Neurooncol 2009;92(2):193-201.
68. von Bueren AO, Shalaby T, Oehler-Jänne C, Arnold L, Stearns D, Eberhart CG, Arcaro A, Pruschy M, Grotzer
MA. RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and
chemotherapy in childhood medulloblastoma cells. BMC Cancer 2009;9:10.
69. Mullendore ME, Koorstra JB, Li YM, Offerhaus GJ, Fan X, Henderson CM, Matsui W, Eberhart CG, Maitra A,
Feldmann G. Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic
cancer. Clin Cancer Res 2009;15(7):2291-2301.
70. Northcott PA, Nakahara Y, Wu X, Feuk L, Ellison DW, Croul S, Mack S, Kongkham PN, Peacock J, Dubuc A,
Ra YS, Zilberberg K, McLeod J, Scherer SW, Sunil Rao J, Eberhart CG, Grajkowska W, Gillespie Y, Lach B,
Grundy R, Pollack IF, Hamilton RL, Van Meter T, Carlotti CG, Boop F, Bigner D, Gilbertson RJ, Rutka JT, Taylor
MD. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat
Genet 2009;41(4):465-472.
71. Quigley HA, Silver DM, Friedman DS, He M, Plyler RJ, Eberhart CG, Jampel HD, Ramulu P. Iris crosssectional area decreases with pupil dilation and its dynamic behavior is a risk factor in angle closure. J Glaucoma
2009;18(3):173-179.
72. Sun P, Xia S, Lal B, Eberhart CG, Quinones-Hinojosa A, Maciaczyk J, Matsui W, Dimeco F, Piccirillo SM,
Vescovi AL, Laterra J. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell
differentiation and tumor propagation. Stem Cells 2009;27(7):1473-1486.
73. Nasonkin I, Mahairaki V, Xu L, Hatfield G, Cummings BJ, Eberhart C, Ryugo DK, Maric D, Bar E, Koliatsos
VE. Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult
mammalian neostriatum. Stem Cells 2009;27(10):2414-2426.
74. Li M, Lee KF, Lu Y, Clarke I, Shih D, Eberhart C, Collins VP, Van Meter T, Picard D, Zhou L, Boutros PC,
Modena P, Liang ML, Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Lau CC, Taylor MD, Gajjar A, Dirks PB,
Hawkins CE, Huang A. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive
neuroectodermal brain tumors. Cancer Cell 2009; 16(6):533-546.
75. Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciazczyk J, Nikkhah G,
Dimeco F, Piccirillo S, Vescovi AL, Eberhart CG. Notch pathway blockade depletes CD133-positive glioblastoma
cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010; 28:5-16. PMCID: PMC2878196
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76. Nakahara Y, Northcott PA, Li M, Kongkham PN, Smith C, Yan H, Croul S, Ra Y-S, Eberhart C, Huang A,
Bigner D, Grajkowska W, Van Meter T, Rutka JT, Taylor MD. Genetic and epigenetic inactivation of Kruppel-like
Factor 4 in medulloblastoma. Neoplasia 2010; 12(1):20-27. PMCID: PMC2805880
77. Engler C, Kelliher C, Spitze AR, Speck CL, Eberhart CG, Jun A. Unfolded protein response in Fuchs
endothelial corneal dystrophy: A unifying pathogenic pathway? Am J Ophthalmol 2010; 149(2):194-202. PMCID:
PMC2813215
78. Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chang WJ, Eberhart CG, Bergsagel PL, Dang CV.
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.
Proc Natl Acad Sci 2010; 107(8):3534-9. PMCID: PMC2840500
79. Jain D, Ebrahimi KB, Miller NR, Eberhart CG. Intraorbital meningiomas. A pathologic review using current
World Health Organization criteria. Arch Pathol Lab Med 2010; (134):766-770.
80. Gurel B, Ali TZ, Montgomery EA, Begum S, Hicks J, Goggins M, Eberhart CG, Clark DP, Bieberich CJ,
Epstein JI, De Marzo AM. NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Path 2010;
34(8):1097-105. PMCID: PMC3072223
81. Jain D, Singh K, Chirumamilla S, Bibat GM, Blue ME, Naidu SR, Eberhart CG. Ocular MECP2 protein
expression in patients with and without Rett syndrome. Pediatr Neurol 2010; 43(1):35-40. PMCID: PMC2916867
82. Bar EE, Lin A, Mahairaki V, Matsui W, and Eberhart CG. Hypoxia Increases the Expression of Stem-Cell
Markers and Promotes Clonogenicity in Glioblastoma Neurospheres. Am J Pathol 2010; 177(3):1491-502. PMCID:
PMC2928980
83. Singh K, Rajan KDA, Eberhart CG. Orbital necrobiotic xanthogranuloma associated with systemic IgG4
disease. Ocular Immunology and Inflammation 2010; 18(5):373-8.
84. Siu IM, Tyler BM, Chen JX, Eberhart CG, Thomale UW, Olivi A, Jallo GI, Riggins
GJ, Gallia GL. Establishment of a human glioblastoma stemlike brainstem rodent tumor model. J Neurosurg Pediatr
2010;6(1):92-7.
85. Shahi MH, Afzal M, Sinha S, Eberhart CG, Rey JA, Fan X, Castresana JS. Human hedgehog interacting protein
expression and promoter methylation in medulloblastoma cell lines and primary tumor samples. J Neurooncol.
2010;103(2):287-296.
86. Shahi MH, Afzal M, Sinha S, Eberhart CG, Rey JA, Fan X, Castresana JS. Regulation of sonic hedgehogGLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in
medulloblastoma and astrocytoma. BMC Cancer 2010:10:614. PMCID: PMC2989332
87. Schreck KC, Taylor P, Marchionni L, Gopalakrishnan V, Bar EE, Gaiano N, Eberhart CG. The Notch target
Hes1 directly modulates Gli1 expression and hedgehog signaling: a potential mechanism of therapeutic resistance.
Clin Cancer Res 2010;16:6060-70. PMCID: PMC3059501
88. Johnson MW, Eberhart CG, Perry A, Tihan T, Cohen KJ, Rosenblum MK, Rais-Bahrami S, Goldthwaite P,
Burger PC. Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol
2010;34(12):1783-91.
89. Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford S, Hawkins CE,
French P, Rutka J, Pfister S, Taylor M. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol
2011; 29:1408-1414.
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90. Ying M, Sang Y, Li Y, Guerrero-Cazares H, Quinones-Hinojosa A, Vescovi AL, Eberhart CG, Xia S, Laterra
J. KLF9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastomainitiating stem cells. Stem Cells 2011; 29:20-31
91. Cho Y-J, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L,
Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP
and Pomeroy SL. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor
clinical outcome. J Clin Oncol 2011;29:1424-30. PMCID: PMC3082983
92. Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG. A polymeric nanoparticle formulation of curcumin inhibits
growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther 2011;11:464-73.
93. Zhang C, Asnaghi L, Gongora C, Patek B, Hose S, Ma B, Fard MA, Brako L, Singh K, Goldberg MF, Handa JT,
Lo W-K, Eberhart CG, Zigler Jr. JS, Sinha D. A developmental defect in astrocytes inhibits programmed
regression of the hyaloid vasculature in the mammalian eye. Eur J Cell Biol 2011;90L440-8. NIHMS279995
94. Pierfelice TJ, Schreck KC, Dang L, Asnaghi L, Galano N, Eberhart CG. Notch3 activation promotes invasive
glioma formation in a tissue site-specific manner. Cancer Res 2011; 71;1115-25.
95. Engler C, Chakravarti S, Doyle J, Eberhart CG, Meng H, Stark WJ, Kelliher C, Jun AS. Transforming growth
factor-β Signaling pathway activation in keratoconus. Am J Ophthalmol 2011;151:752-9.
96. von Bueren AO, Oehler C, Shalaby T, von Hoff K, Pruschy M, Seifert B, Gerber NU, Warmuth-Metz M, Stearns
D, Eberhart CG, Kortmann RD, Rutkowski S, Grotzer MA. c-MYC expression sensitizes medulloblastoma cells to
radio- and chemotherapy and has no impact on response in medulloblastoma patients. BMC Cancer 2011;11:74.
97. Koliatsos VE, Cernak I, Xu L, Song Y, Savonenko A, Crain BJ, Eberhart CG, Frangakis CE, Melnikova T, Kim
H, Lee D. A Mouse Model of Blast Injury to Brain: Initial Pathological, Neuropathological, and Behavioral
Characterization. J Neuropathol Exp Neurol 2011;70:399-416.
98. Wei Y, Gong J, Yoshida T, Eberhart CG, Xu Z, Kombairaju P, Sporn MB, Handa JT, Duh EJ. Nrf2 has a
protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury. Free Radic Biol
Med 2011;51:216-24. NIHMS298041
99. Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, Xia S, Trageser D, Guerrero-Cázares H, Eberhart CG, QuiñonesHinojosa A, Scheffler B, Laterra J. c-Met signaling induces a reprogramming network and supports the glioblastoma
stem-like phenotype. Proc Natl Acad Sci USA 2011;108:9951-6. PMCID 3116406
100. Raabe EH, Lim KS, Kim JM, Meeker A, Mao XG, Nikkhah G, Maciaczyk J, Kahlert U, Jain D, Bar E, Cohen
KJ, Eberhart CG. BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A
Pilocytic Astrocytoma Model. Clin Cancer Res 2011;17:3590-9.
101. Orr BA, Bai H, Odia Y, Jain D, Anders RA, Eberhart CG. Yes-Associated Protein 1 Is Widely Expressed in
Human Brain Tumors and Promotes Glioblastoma Growth. J Neuropathol Exp Neurol 2011;70:568-77. PMCID
3130608
102. Northcott PA, Hielscher T, Dubuc A, Mack S, Shih D, Remke M, Al-Halabi H, Albrecht S, Jabado N, Eberhart
CG, Grajkowska W, Weiss WA, Clifford SC, Bouffet E, Rutka JT, Korshunov A, Pfister S, Taylor MD. Pediatric
and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol 2011;122:23140.
103. Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG,
Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins
GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Altered telomeres in tumors
with ATRX and DAXX mutations. Science 2011;333:425. PMCID 3174141
8
104. Gerber DE, Gallia GL, Tyler BM, Eberhart CG, Royer G, Grossman SA. A novel polymer gel for the delivery
of local therapies to intracranial tumors: In vivo safety evaluation. J Biomed Mater Res Part A 2011;99A:479-84.
105. Hindman HB, McCally RL, Kim A, D'Anna SE, Eberhart CG, Jun AS. Evaluation of the effects of circular
Descemet's membrane incision on the biomechanical, topographic and optical properties of rabbit corneas. Clin
Experiment Ophthalmol 2011;39:691-9.
106. Ma B, Sen T, Asnaghi L, Valapala M, Yang F, Hose S, McLeod DS, Lu Y, Eberhart C, Zigler JS Jr, Sinha D.
βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK
survival pathways through the PKD/Bit1-signaling axis. Cell Death Dis 2011;2(10):e217. PMCID 3219085
107. Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG,
Bar EE. BRAF Alterations in Primary Glial and Glioneuronal Neoplasms of the Central Nervous System With
Identification of 2 Novel KIAA1549: BRAF Fusion Variants. J Neuropathol Exp Neurol 2012;71:66-72.
108. Rodriguez FJ, Orr BA, Ligon KL, Eberhart CG. Neoplastic cells are a rare component in human glioblastoma
microvasculature. Oncotarget 2012;3:98-106.
109. Asnaghi L, Ebrahimi KB, Schreck KC, Bar EE, Coonfield ML, Bell WR, Handa J, Merbs SL, Harbour JW,
Eberhart CG. Notch signaling promotes growth and invasion in uveal melanoma. Clin Cancer Res
2012;18(3):654-65.
110. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW,
Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM. Molecular
subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2012;123(4):465-72.
111. Northcott PA, Shih DJ, Remke M, Cho YJ, Kool M, Hawkins C, Eberhart CG, Dubuc A, Guettouche T,
Cardentey Y, Bouffet E, Pomeroy SL, Marra M, Malkin D, Rutka JT, Korshunov A, Pfister S, Taylor MD. Rapid,
reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Acta Neuropathol
2012;123:615-26.
112. Dubuc AM, Morrissy AS, Kloosterhof NK, Northcott PA, Yu EPY, Shih D, Peacock J, Wieslawa G, van Meter
T, Eberhart CG, Pfister S, Marra MA, Weiss WA, Scherer SW, Rutka JT, French PJ, Taylor MD. Subgroupspecific alternative splicing in medulloblastoma. Acta Neuropathol 2012; 123:485-99.
113. Craig JM, Vena N, Ramkissoon S, Idbaih A, Fouse SD, Ozek M, Sav A, Hill DA, Margraf LR, Eberhart CG,
Kieran MW, Norden AD, Wen PY, Loda M, Santagata S, Ligon KL, Ligon AH. DNA Fragmentation Simulation
Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues. PLoS One.
2012;7(6):e38881.
114. Dokey A, Ramulu PY, Utine CA, Tzu JH, Eberhart CG, Shan S, Gelhbach PL, Akpek EK. Chronic hypotony
associated with the Boston Type 1 keratoprosthesis. Am J Ophthalmol 2012;154(2):266-271.
115. Kahlert U, Maciaczyk D, Doostkam S, Orr BA, Simons B, Bogiel T, Reithmeier T, Prinz M, Schubert J,
Niedermann G, Brabletz T, Eberhart CG, Nikkhah G, Maciaczyk J. Activation of canonical WNT/Beta-catenin
signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-tomesenchymal transition. Cancer Lett 2012;325(1):42-53.
116. Picard D, Miller S, Hawkins CE, Bouffet E, Rogers HA, Chan TS, Kim SK, Ra YS, Fangusaro J, Korshunov A,
Toledano H, Nakamura H, Hayden JT, Chan J, Lafay-Cousin L, Hu P, Fan X, Muraszko KM, Pomeroy SL, Lau CC,
Ng HK, Jones C, Van Meter T, Clifford SC, Eberhart C, Gajjar A, Pfister SM, Grundy RG, Huang A. Markers of
survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative
genomic analysis. Lancet Oncol. 2012;13(8):838-48.
9
117. Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG,
Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov
A, Scherer SW, Cho Y-J, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA,
Largaespada DA, Collier LS, Taylor MD. Clonal selection drives genetic divergence of metastatic medulloblastoma.
Nature 2012;482(7386):529-33.
118. Lim KJ, Rajan K, Eberhart CG. Effects of Zeng Sheng Ping/ACAPHA on Malignant Brain Tumor Growth and
Notch Signaling. 1. Anticancer Res. 2012 Jul;32(7):2689-96.
119. Li M, Lockwood W, Zielenska M, Northcott P, Ra YS, Bouffet E, Yoshimoto M, Rutka JT, Yan H, Taylor MD,
Eberhart C, Hawkins CE, Lam W, Squire JA, Huang A. Multiple CDK/CYCLIND genes are amplified in
medulloblastoma and supratentorial primitive neuroectodermal brain tumor. Cancer Genet. 2012;205(5):220-31.
120. Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D, Mosier S, Lin MT, Eberhart CG, Burger
PC. Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity.
Acta Neuropathol 2012;124(5):627-41.
121. Das CM, Taylor P, Gireud M, Singh A, Lee D, Fuller G, Ji L, Fangusaro J, Rajaram V, Goldman S, Eberhart
C, Gopalakrishnan V. The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation.
Oncogene. 2013;32:1691-1701.
122. Rodriguez FJ, Ligon AH, Horkayne-Szakaly I, Rushing EJ, Ligon KL, Vena N, Garcia DI, Cameron JD,
Eberhart CG. BRAF Duplications and MAPK Pathway Activation Are Frequent in Gliomas of the Optic Nerve
Proper. J Neuropathol Exp Neurol 2012;71(9):789-94.
123. Nance EA, Woodworth GF, Sailor KA, Shih TY, Xu Q, Swaminathan G, Xiang D, Eberhart C, Hanes J. A
dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci
Transl Med 2012;4(149):149ra119.
124. Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J,
Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V,
Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR,
Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore
RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM,
Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz
FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A,
Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ,
Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE,
Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A,
Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M,
Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS,
Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD,
Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM,
Marra MA, Taylor MD. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature
2012;488:49-56.
125. Orr BA, Haffner MC, Nelson WG, Yegnasubramanian S, Eberhart CG. Decreased 5-hydroxymethylcystosine
is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. PLoS One
2012;7(7):e41036.
126. Matthaei M, Meng H, Meeker AK, Eberhart CG, Jun AS. Endothelial Cdkn1a (p21) Overexpression and
Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci
2012;53:6718-27.
10
127. Aref D, Moffatt CJ, Agnihotri S, Ramaswamy V, Dubuc AM, Northcott PA, Taylor MD, Perry A, Olson JM,
Eberhart CG, Croul SE. Canonical TGF-β Pathway Activity is a Predictor of SHH-Driven Medulloblastoma
Survival and Delineates Putative Precursors in Cerebellar Development. Brain Pathol 2012;23(2):178-91.
128. Bai RY, Staedtke V, Lidov HG, Eberhart CG, Riggins GJ. OTX2 Represses Myogenic and Neuronal
Differentiation in Medulloblastoma Cells. Cancer Res 2012;15(22):5988-6001.
129. Grossman R, Tyler B, Brem H, Eberhart CG, Wang S, Fu DX, Wen Z, Zhou J. Growth properties of
SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging. J Neurooncol 2012;11(3):315-23.
130. Kahlert UD, Bender NO, Maciaczyk D, Bogiel T, Bar EE, Eberhart CG, Nikkhah G, Maciaczyk J.
CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related
gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like
component. Folia Neuropathol 2012; 50(4):357-68.
131. Nguyen DN, Heaphy CM, de Wilde RF, Orr BA, Odia Y, Eberhart CG, Meeker AK, Rodriguez FJ.
Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High-Grade
Astrocytomas. Brain Pathol 2013;23(3):237-43.
132. Heaphy CM, Subhawong AP, Hong SM, Goggins MG, Montgomery EA, Gabrielson E, Netto GJ, Epstein JI,
Lotan TL, Westra WH, Shih IeM, Iacobuzio-Donahue CA, Maitra A, Li QK, Eberhart CG, Taube JM, Rakheja D,
Kurman RJ, Wu TC, Roden RB, Argani P, DeMarzo AM, Terracciano L, Torbenson M, Meeker AK. Prevalence of
the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Brain Pathol
2013;23:237-43. PMCID 3181356
133. Zhukova N, Ramaswamy V, Remke M, Pfaff E, Shih DJ, Martin DC, Castelo-Branco P, Baskin B, Ray PN,
Bouffet E, von Bueren AO, Jones DT, Northcott PA, Kool M, Sturm D, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T,
Gessi M, Rutkowski S, Bognar L, Klekner A, Cho BK, Kim SK, Wang KC, Eberhart CG, Fevre-Montange M,
Fouladi M, French PJ, Kros M, Grajkowska WA, Gupta N, Weiss WA, Hauser P, Jabado N, Jouvet A, Jung S,
Kumabe T, Lach B, Leonard JR, Rubin JB, Liau LM, Massimi L, Pollack IF, Shin Ra Y, Van Meir EG, Zitterbart K,
Schüller U, Hill RM, Lindsey JC, Schwalbe EC, Bailey S, Ellison DW, Hawkins C, Malkin D, Clifford SC,
Korshunov A, Pfister S, Taylor MD, Tabori U. Subgroup-Specific Prognostic Implications of TP53 Mutation in
Medulloblastoma. J Clin Oncol 2013;31(23):2927-35.
134. Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang
DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin
H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J,
Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD,
Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B,
Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von
Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL,
Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P;
the International Cancer Genome Consortium PedBrain Tumor Project, Pfister SM. Recurrent somatic alterations of
FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 2013;45(8):927-32.
135. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence
MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho
YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL,
Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran
MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent
oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013;
110(20):8188-93.
136. Chu Q, Orr BA, Semenkow S, Bar EE, Eberhart CG. Prolonged Inhibition of Glioblastoma Xenograft
Initiation and Clonogenic Growth following In Vivo Notch Blockade. Clin Cancer Res 2013;19(12):3224-33.
11
137. Matthaei M, Hu J, Meng H, Lackner EM, Eberhart CG, Qian J, Hao H, Jun AS. Endothelial cell whole
genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy. Invest
Ophthalmol Vis Sci 2013;54(3):1931-40.
138. Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J,
Barker PB, van Zijl PC, Blakeley JO. Three-dimensional amide proton transfer MR imaging of gliomas: Initial
experience and comparison with gadolinium enhancement. J Magn Reson Imaging. 2013;38(5):1119-28.
139. Meng H, Matthaei M, Ramanan N, Grebe R, Chakravarti S, Speck CL, Kimos M, Vij N, Eberhart CG, Jun
AS. L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct
phenotypes and evidence for altered autophagy. Invest Ophthalmol Vis Sci 2013;54(3):1887-97.
140. Zheng G, Martignoni G, Antonescu C, Montgomery E, Eberhart C, Netto G, Taube J, Westra W, Epstein JI,
Lotan T, Maitra A, Gabrielson E, Torbenson M, Iacobuzio-Donahue C, Demarzo A, Shih IeM, Illei P, Wu TC,
Argani P. A broad survey of cathepsin K immunoreactivity in human neoplasms. Am J Clin Pathol
2013;139(2):151-9.
141. Vellimana AK, Recinos VR, Hwang L, Fowers KD, Li KW, Zhang Y, Okonma S, Eberhart CG, Brem H,
Tyler BM. Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs
survival in an experimental rodent glioma model. J Neurooncol 2013;111(3):229-36.
142. Asnaghi L, Handa JT, Merbs SL, Harbour JW, Eberhart CG. A role for Jag2 in promoting uveal melanoma
dissemination and growth. Invest Ophthalmol Vis Sci 2013;54(1):295-306.
143. Dubuc AM, Remke M, Korshunov A, Northcott PA, Zhan SH, Mendez-Lago M, Kool M, Jones DT,
Unterberger A, Morrissy AS, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, Witt H, Hielscher T, Hawkins
C, Vibhakar R, Croul S, Rutka JT, Weiss WA, Jones SJ, Eberhart CG, Marra MA, Pfister SM, Taylor MD.
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta
Neuropathol 2013;125(3):373-84.
144. Ho CY, Bar E, Giannini C, Marchionni L, Karajannis MA, Zagzag D, Gutmann DH, Eberhart CG, Rodriguez
FJ. MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3,
NFIB, and METAP2. Neuro Oncol 2013;15(1):69-82.
145. Matthaei M, Lackner EM, Meng H, Hicks JL, Meeker AK, Eberhart CG, Jun AS. Tissue microarray analysis
of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. Cornea 2013;32(4):473-8.
146. Lim KS, Lim KR, Price AC, Orr BA, Eberhart CG, Bar EE. Inhibition of monocarboxylate transporter-4
depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner.
Oncogene 2013 [Epub ahead of print]. PMID: 24077291
147. Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker
AK, Eberhart CG. A glioblastoma neurosphere line with alternative lengthening of telomeres. Acta Neuropathol
2013;126(4):607-8. PMCID: PMC3874856
148. Odia Y, Orr BA, Bell WR, Eberhart CG, Rodriguez FJ. cMYC expression in infiltrating gliomas: associations
with IDH1 mutations, clinicopathologic features and outcome. J Neurooncol 2013;115(2):249-59. PMCID:
PMC3881260
149. Mao XG, Hutt-Cabezas M, Orr BA, Weingart M, Taylor I, Rajan AK, Odia Y, Kahlert U, Maciaczyk J,
Nikkhah G, Eberhart CG, Raabe EH. LIN28A facilitates the transformation of human neural stem cells and
promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Oncotarget 2013;4(7):1050-64.
PMCID: PMC3759665
12
150. Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I,
Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S. Hypoxic retinal Müller cells
promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci USA.
2013;110(36):E3425-34.
151. Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J,
Baker Dphil PB, van Zijl PCM, Blakeley JO. Three-dimensional amide proton transfer MR imaging of gliomas:
Initial experience and comparison with gadolinium enhancement. Journal of Magnetic Resonance Imaging
2013;38:1119-28.
152. Baja GS, Caballero OL, Ho JSY, Zhao Q, Cohen T, Binder ZA, Salmasi V, Gallia GL, Quinones-Hinojosa A,
Olivi A, Brem H, Burger P, Strausberg RL, Simpson AJG, Eberhart CG, Riggins GJ. NY-ESO-1 expression in
meningioma suggests a rationale for new immunotherapeutic approaches. Cancer Immunol Res 2013;1(5):296-302.
153. Hütt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D,
Eberhart CG, Raabe EH, Rodriguez FJ. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma
and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro Oncol 2013;15(12):1604-14. PMID:
24203892
154. Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang
X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N,
Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B,
Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF,
Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR,
Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ,
Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S,
Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grafjkowska WA, Kim SK, Rutka JT,
Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD. Neuro-Oncology 2013;15(12): 160414. PMID: 24174164
155. Binder ZA, Siu IM, Eberhart CG, Ap Rhys C, Bai RY, Staedtke V, Zhang H, Smoll NR, Piantadosi S,
Piccirillo SG, Dimeco F, Weingart JD, Vescovi A, Olivi A, Riggins GJ, Gallia GL. Podocalyxin-like protein is
expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome. PLoS One
2013;8(10):e75945. PMID: 24146797
156. Wong RK, Greene DP, Shield DR, Eberhart CG, Huang JJ, Shayegani A. 5-Fluorourcil for epithelial
downgrowth after Descemet stripping automated endothelial keratoplasty. Cornea. 2013;32(12):1610-2. PMID:
24113368
157. Borodovsky A, Salmasi V, Turcan S, Fabius AW, Baia GS, Eberhart CG, Weingart JD, Gallia GL, Baylin SB,
Chan TA, Riggins GJ. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a
patient-derived IDH1 mutant glioma xenograft. Oncotarget. 2013;4(10):1737-47. PMID: 24077805
158. Ballester LY, Wang Z, Shandilya S, Miettinen M, Burger PC, Eberhart CG, Rodriguez FJ, Raabe E, Nazarian
J, Warren K, Quezado MM. Morphologic charateristics and immunohistochemical profile of diffuse intrinsic pontine
gliomas. Am J Surg Pathol 2013;37(9):1357-64. PMID: 24076776
159. Spina R, Filocamo G, Iaccino E, Scicchitano S, Lupia M, Chiarella E, Mega T, Bernaudo F, Pelaggi D,
Mesuraca M, Pazzaglia S, Semenkow S, Barr EE, Kool M, Pfister S, Bond HM, Eberhart CG, Steinkühler C,
Morrone G. Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential
of medulloblastoma cells. Oncotarget. 2013;4(8):12-80-92. PMID: 23907569
160. Al Wadani S, Robinson S, Myers R, Akpek EK, Eberhart CG. No increase in IgG-4 positive plasma cells in
limbal Rosai-Dorfman disease. Cornea 2014;0:1-4. PMID: 24831194
13
161. Ho CY, Troncoso JC, Knox D, Stark W, Eberhart CG. Beta-Amyloid, Phospho-Tau and Alpha-Synuclein
Deposits Similar to Those in the Brain Are Not Identified in the Eyes of Alzheimer's and Parkinson's Disease
Patients. Brain Pathol 2014;24(1):25-32.
162. Ho CY, Mosier S, Safneck J, Salomao DR, Miller NR, Eberhart CG, Gocke CD, Batista DA, Rodriguez FJ.
Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital
meningioma. Brain Pathol 2014 [Epub ahead of print]. PMID: 24773246
163. Ding D, Lim KS, Eberhart CG. Arsenic trioxide inhibits hedgehog, notch and stem cell properties in
glioblastoma neurospheres. Acta Neuropathol Commun 2014;31;2(1):31. PMCID: PMC3977902
164. Rodic N, Sharma R, Sharma R, Zampella J, Dai L, Taylor MS, Hruban RH, Iacobuzio-Donahue CA, Maitra A,
Torbenson MS, Goggins M, Shih I-M, Duffield AS, Montgomery EA, Gabrielson E, Netto GJ, Lotan TL, De Marzo
AM, Westra W, Binder ZA, Orr BA, Gallia GL, Eberhart CG, Boeke JD, Harris CR, Burns KH. Long interspersed
element-1 protein expression is a hallmark of many human cancers. Am J Pathol 2014;184:1280-1286.
165. Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung E-R, Huang H, Wu L, Eberhart C, Handa JT, Du Y, Kern TS,
Thimmulappa R, Barber AJ, Biswal S, Duh EJ. NRF2 plays a protective role in diabetic retinopathy in mice.
Diabetologia 2014;57:204-213.
166. Karajannis MA, Legault G, Fisher MJ, Milla SS, Cohen KJ, Wisoff JH, Harter DH, Goldberg JD, Hochman T,
Merkelson A, Bloom MC, Sievert AJ, Resnick AC, Dhall G, Jones DTW, Korshunov A, Pfister SM, Eberhart CG,
Zagzag D, Allen JC. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.
Neuro-Oncology 2014;0:1-9.
167. Spence T, Sin-Chan P, Picard D, Barszczyk M, Hoss K, Lu M, Kim S-K, Ra Y-S, Nakamura H, Fangusaro J,
Hwang E, Kiehna E, Toledano H, Wan Y, Shi Q, Johnston D, Michaud J, La Spina M, Buccoliero AM, Adamek D,
Camelo-Piragua S, Collins VP, Jones C, Kabbara N, Jurdi N, Varlet P, Perry A, Scharnhorst D, Fan X, Muraszko
KM, Eberhart CG, Ng H-K, Gururangan S, Van Meter T, Remke M, Lafay-Cousin L, Chan JA, Sirachainan N,
Pomeroy SL, Clifford SC, Gajjar A, Sharo M, Halliday W, Taylor MD, Grundy R, Lau CC, Lau CC, Phillips J,
Bouffet E, Dirks PB, Hawkins CE, Huang A. CNS-PNETs with C19MC amplification and/or LIN28 expression
comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol 2014 128(2):291-303. PMID:
24839957
168. Rajan A, Burris C, Iliff N, Grant M, Eshleman JR, Eberhart CG. DNA mismatch repair defects and
microsatellite instability status in periocular sebaceous carcinoma. Am J Ophthalmol 2014;157:640-7.
169. Yuan M, Eberhart CG, Kai M. RNA binding protein RBM14 promotes radio-resistance in glioblastoma by
regulating DNA repair and cell differentiation. Oncotarget. 2014;5(9):2820-6. PMID 24831194
170. Ardeljan D, Wang Y, Park S, Shen D, Chu XK, Yu C-R, Abu-Asab M, Tuo J, Eberhart CG, Olsen TW,
Mullins RF, White G, Wadsworth S, Scaria A, Chan C-C. Interleukin-17 retinotoxicity is prevented by gene transfer
of a soluble interleukin-17 receptor acting as a cytokine blocker: Implications for age-related macular degeneration.
PLoS One 2014;9(4):e95900. PMID: 24780906
171. Tilghman J, Wu H, Sang Y, Shi X, Guerrero-Cazares H, Quinones-Hinojosa A, Eberhart CG, Laterra J, Ying
M. HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Cancer Res. 2014;
74(11):3168-79. PMCID:PMC4059010
172. Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc
AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC,
Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L,
Klekner A, Saad AG, Liau LM, Albrecht S, Fontesbasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK,
Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan
X, Muraszko DM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M,
14
Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres
C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Malkin D, Grafkowska WA, Perek-Polnik
M, Bouffet E, Rutka JT, Pfister SM, Taylor MD. Cytogenetic prognostication within medulloblastoma subgroups. J
Clin Oncol. 2014;32(9):886-96. PMID: 24493713
173. Mattaei M, Hu J, Kallay L, Eberhart CG, Cursiefen C, Qian J, Lackner E-M, Jun AS. Endothelial cell
microRNA expression in human late-onset Fuchs’ dystrophy. Invest Ophthalmol Vis Sci. 2014;55(1):216-25.
PMID: 24334445
174. Lackner EM, Matthaei M, Meng H, Ardjomand N, Eberhart CG, Jun AS. Design and analysis of keratoconus
tissue microarrays. Cornea 2014;33(1):45-55.
175. Ahsan S, Raabe EH, Haffner MC, Vaghasia A, Warren KE, Quezado M, Ballester LY, Nazarian J, Eberhart
CG, Rodriguez FJ. Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global
epigenetic dysregulation in diffuse intrinsic pontine glioma. Acta Neuropathol. Commun. 2014:2;59. PMCID:
PMC4229804
176. Son HS, Villarreal G Jr, Meng H, Eberhart CG, Jun AS. On the origin of 'guttae'. Br J Ophthalmol
2014;98(9):1308-10.
177. Rajaii F, Asnaghi L, Enke R, Merbs SL, Handa JT, Eberhart CG. The demethylating agent 5-Aza reduces the
growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma. Invest Ophthalmol Vis Sci 2014;
55:6178-86.
178. Asnaghi L, Lin MH, Lim KS, Lim KJ, Tripathy A, Wendeborn M, Merbs SL, Handa JT, Sodhi A, Bar EE,
Eberhart CG. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS
One. 2014;9(8):e105372. PMCID: PMC4148307
179. Martin AM, Raabe E, Eberhart C, Cohen KJ. Management of pediatric and adult patients with
medulloblastoma. Curr Treat Options Oncol 2014;15(4):581-94. PMCID: PMC4216607
180. Matthaei M, Zhu AY, Kallay L, Eberhart CG, Cursiefen C, Jun AS. Transcript profile of cellular senescencerelated genes in Fuchs endothelial corneal dystrophy. Exp Eye Res 2014;129:13-7. PMCID: PMC4259834
181. Cameron JD, Rodriguez FJ, Rushing E, Horkayne-Szakaly I, Eberhart C. An 80-year experience with optic
nerve glioma cases at the Armed Forces Institute of Pathology: evolution from museum to molecular evaluation
suggests possible interventions in the cellular senescence and microglial pathways (an American Ophthalmological
Society thesis). Trans Am Ophthalmol Soc 2014;112:11-25. PMID: 25411512
182. Ryu J, Horkayne-Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, Troncoso JC, Koliatsos VE. The
problem of axonal injury in the brains of veterans with histories of blast exposure. Acta Neuropathol. Commun 2014
Nov 25;2(1):153. PMID: 25422066
183. Asnaghi L, Alkatan H, Mahale A, Othman M, Alwadani S, Al-Hussain H, Jastaneiah S, Yu W, Maktabi A,
Edward DP, Eberhart CG. Identification of multiple DNA copy number alterations including frequent 8p11.22
amplification in conjunctival squamous cell carcinoma. Invest Ophthalmol Vis Sci 2014 Dec 9;55(12):8604-13.
PMID: 25491297
184. Zhukova N, Ramaswamy V, Remke M, Martin DC, Castelo-Branco P, Zhang CH, Fraser M, Tse K, Poon R,
Shih DJ, Baskin B, Ray PN, Bouffet E, Dirks P, von Bueren AO, Pfaff E, Korshunov A, Jones DT, Northcott PA,
Kool M, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognar L, Cho BK, Eberhart CG,
Conter CF, Fouladi M, French PJ, Grafkowska WA, Gupta N, Hauser P, Jabado N, Vasilijevic A, Jung S, Kim SK,
Klekner A, Kumabe T, Lach B, Leonard JR, Liau LM, Massimi L, Pollack IF, Ra YS, Rubin JB, Van Meir EG,
Wang KC, Weiss WA, Zitterbart K, Bristow RG, Alman B, Hawkins CE, Malkin D, Clifford SC, Pfister SM, Taylor
15
MD, Tabori U. WNT activation y lithium abrogates TP53 mutation associated radiation resistance in
medulloblastoma. Acta Neuropathol Commun 2014 Dec 24;2:174. PMID: 25539912
185. Ryu J, Horkayne-Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, Troncoso JC, Koliatsos VE. The
problem of axonal injury in the brains of veterans with histories of blast exposure. Acta Neuropathol Commun
2014;25;2(1):153.
186. Borodovsky A, Meeker AK, Kirkness EF, Zhao Q, Eberhart CG, Gallia GL, Riggins GJ. A model of a patientderived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres. J Neurooncol 2015
Feb;121(3):479-87. PMID: 25471051
187. Kahlert UD, Suwala AK, Raabe EH, Siebzehnrubi FA, Suarez MJ, Orr BA, Bar EE, Maciaczyk J, Eberhart
CG. ZEB1 promotes invasion in human fetal neural stem cells and hypoxic glioma neurospheres. Brain Pathol
2015;25(6):724-32. PMID: 25521330
188. Lopez-Bertoni H, Lal B, Li A, Caplan M, Guerrero-Cazares H, Eberhart CG, Quinones-Hinojosa A, Glas M,
Scheffler B, Laterra J, Li Y. DNMT-dependent suppression of microRNA regulates the induction of GBM tumorpropagating phenotype by Oct4 and Sox2. Oncogene 2015 Jul 23;34(30):3994-4004. PMID: 25328136
189. Brandt WD, Schreck KC, Bar EE, Taylor I, Marchionni L, Raabe E, Eberhart CG, Rodriguez FJ. Notch
signaling activation in pediatric low-grade astrocytoma. J Neuropathol Exp Neurol 2015 Feb;74(2):121-31. PMID:
25575134
190. Kaur H, Hutt-Cabezas M, Weingart MF, Xu J, Kuwahara Y, Erdreich-Epstein A, Weissman BE, Eberhart CG,
Raabe EH. The Chromatin-Modifying Protein HMGA2 Promotes Atypical Teratoid/Rhabdoid Cell Tumorigenicity. J
Neuropathol Exp Neurol 2015 Feb;74(2):177-85. PMID: 25575139
191. Pan Q, Xu Q, Boylan NJ, Lamb NW, Emmert G, Yang JC, Tang L, Heflin T, Alwadani S, Eberhart CG, Stark
WJ, Hanes J. Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats.
J Control Release 2015;201:32-40.
192. Wang X, Dubuc AM, Ramaswamy V, Mack S, Gendoo DM, Remke M, Wu X, Garzia L, Luu B, Cavalli F,
Peacock J, Lopez B, Skowron P, Zagzag D, Lyden D, Hoffman C, Cho YJ, Eberhart C, MacDonald T, Li XN, Van
Meter T, Northcott PA, Haibe-Kains B, Hawkins C, Rutka JT, Bouffet E, Pfister SM, Korshunov A, Taylor MD.
Medulloblastoma subgroups remain stable across primary and metastatic compartments. Acta Neuropathol 2015
Mar;129(3):449-57.
193. Chang JR, Baharestani S, Salek SS, Piluek WJ, Eberhart CG, McCulley TJ. Delayed superficial migration of
retained hyaluronic acid years following periocular injection. Ophthal Plast Reconstr Surg 2015 Apr 20. [Epub
ahead of print]. PMID: 25902386
194. Weingart MF, Roth JJ, Hutt-Cabezas M, Busse TM, Kaur H, Price A, Maynard R, Rubens J, Taylor I, Mao XG,
Xu J, Kuwahara Y, Allen SJ, Erdreich-Epstein A, Weissman BE, Orr BA, Eberhart CG, Biegel JA, Raabe EH.
Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase
pathway as a therapeutic target. Onctarget 2015 Feb 20;6(5):3165-77. PMID: 25638158
195. Salvucci O, Ohnuki H, Maric D, Hou X, LiX, Yoon SO, Segarra M, Eberhart CG, Acker-Palmer A, Tosato G.
EphrinB2 controls vessel pruning through STAT1-JNK3 signaling. Nat Commun 2015 Mar 26;26(6):6576. PMID:
25807892
196. Lim KJ, Brandt WD, Heth JA, Muraszko KM, Fan X, Bar EE, Eberhart CG. Lateral inhibition of Notch
signaling in neoplastic cells. Oncotarget 2015 Jan 30;6(3):1666-77. PMID: 25557173
16
197. Mastorakos P, Zhang C, Berry S, Oh Y, Lee S, Eberhart CG, Woodworth GF, Suk JS, Hanes J. Highly
PEGylated DNA nanoparticles provide uniform and widespread gene transfer in the brain. Adv Healthc Mater 2015
May;4(7):1023-33. PMID: 25761435
198. Pan Q, Xu Q, Boylan NJ, Lamb NW, Emmert DG, Yang JC, Tang L, Heflin T, Alwadani S, Eberhart CG,
Stark WJ, Hanes J. Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in
rats. J Control Release 2015 Mar 10;201:32-40. PMID: 25576786
199. Edward DP, Alkatan H, Rafiq Q, Eberhart C, Al Mesfer S, Ghazi N, Al Safieh L, Kondkar AA, Abu Amero
KK. MicroRNA profiling in intraocular medulloepitheliomas. PLoS One 2015 Mar 5;10(3):e0121706. PMID:
25807141
200. Gilden D, White T, Khmeleva N, Heintzman A, Choe A, Boyer PJ, Grose C, Carpenter JE, Rempel A, Bos N,
Kandasamy B, Lear-Kaul K, Holmes DB, Bennett JL, Cohrs RJ, Mahalingam R, Mandava N, Eberhart CG,
Bockelman B, Poppiti RJ, Tamhankar MA, Fogt F, Amato M, Wood E, Durairaj V, Rasmussen S, Petursdottir V,
Pollak L, Mendlovic S, Chatelain D, Keyvani K, Brueck W, Nagel MA. Prevalence and distribution of VZV in
temporal arteries of patients with giant cell arteritis. Neurology 2015 May 12;84(19):1948-55. PMID: 25695965
201. Taylor IC, Hütt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J, Chang HT, Warren KE, Eberhart CG,
Raabe EH. Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and
Shows Combinatorial Efficacy With Bromodomain Inhibition. J Neuropathol Exp Neurol. 2015 Aug;74(8):778-90.
PMID: 26115193
202. Oliver V, Jaffe AE, Song J, Wang G, Zhang P, Branham KE, Swaroop A, Eberhart CG, Zack DJ, Qian J,
Merbs SL. Differential DNA Methylation Identified in the Blood and Retina of AMD Patients. Epigenetics.
2015;10(8):698-707. PMID: 26067391
203. Asnaghi L, Gezgin G, Tripathy A, Handa JT, Merbs SL, van der Velden PA, Jager MJ, Harbour JW, Eberhart
CG. EMT-associated factors promote invasive properties of uveal melanoma cells. Mol Vis. 2015; 21:919-29.
204. Kahlert UD, Suwala AK, Koch K, Natsumeda M, Orr BA, Hayashi M, Maciaczyk J, Eberhart CG.
Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells. J
Neuropathol Exp Neurol. 2015; 74(9):889-900.
205. Natsumeda M, Maitani K, Liu Y, Miyahara H, Kaur H, Chu Q, Zhang H(1), Kahlert U, Eberhart CG.
Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres. Brain Pathol. 2015
Nov 27. [Epub ahead of print]
206. Bell WR, Singh K, Rajan KDA, Eberhart CG. Expression of p16 and p53 in intraepithelial periocular
sebaceous carcinoma. Ocul Oncol Pathol 2015;2(2):71-5. PMID: 27171611
207. Vizcaino MA, Shah S, Eberhart CG, Rodriguez FJ. Clinciopathologic implications of NF1 gene alterations in
diffuse gliomas. Hum Pathol 2015 Sep;46(9):1323-30. PMID: 26190195
208. Eghrari AO, Gibas C, Watkins T, Vahedi S, Lee R, Houle E, Suarez MJ, Eberhart C, Sutton DA, Wiederhold
NP, Sikder S, Zhang SX. First human case of fungal keratitis caused by a putatively novel species of lophotrichus.
J Clin Microbiol 2015 Sep;53(9):3063-7. PMID: 26109445
209. Kahlert UD, Koch K, Suwala AK, Hartmann R, Cheng M, Maciaczyk D, Willbold D, Eberhart CG, Glunde
K, Maciaczyk J. The effect of neurosphere culture conditions on the cellular metabolism of glioma cells. Folia
Neuropathol 2015;53(3):219-25. PMID: 26443312
210. Nagel MA, White T, Khmeleva N, Rempel A, Boyer PJ, Bennett JL, Haller A, Lear-Kaul K, Kandasmy B,
Amato M, Wood E, Durairaj V, Fogt F, Tamhankar MA, Grossniklaus HE, Poppiti RJ, Bockelman B, Keyvani K,
Pollak L, Mendlovic S, Fowkes M, Eberhart CG, Buttmann M, Toyka KV, Meyer-ter-Vehn T, Petursdottir V,
17
Gilden D. Analysis of Varicella-Zoster virus in temporal arteries biopsy positive and negative for giant cell arteritis.
JAMA Neurol 2015 Nov;72(11):1281-7. PMID: 26349037
211. Korshunov A, Jakobiec FA, Eberhart CG, Hovestadt V, Capper D, Jones DT, Sturm D, Stagner AM, Edward
DP, Eagle RC, Proia AD, Koch A, Ryzhova M, Ektova A, Schüller U, Xheludkova O, Lichter P, von Deimling A,
Pfister SM, Kool M. Comparative integrated molecular analysis of intraocular medulloepitheliomas and central
nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities.
Neuropathology 2015 Dec;35(6)538-44. PMID: 26183384
212. Jenkins NC, Rao G, Eberhart CG, Pedone CA, Dubuc AM, Fults DW. Somatic cell transfer of c-Myc and
Bcl-2 induces large-cell anaplastic medulloblastomas in mice. J Neurooncol 2016;126(3)415-24. PMID:
26518543
213. Sahm F, Jakobiec FA, Meyer J, Schrimpf D, Eberhart CG, Hovestadt V, Capper D, Lambo S, Ryzhova M,
Schller U, Zheludkova O, Kumirova E, Lichter P, von Deimling A, Jones DT, Pfister SM, Kool M, Korshunov A.
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas. Genes Chromosomes
Cancer 2016;55(5):418-27. PMID: 26841698
214. Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons
PA, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, Schreiber SL, Fraenkel E,
Pomeroy SL, Mesirov JP, Tamayo P, Eberhart CG*, Raabe EH. DiSCoVERing innovative therapies for rare
tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets.
Clin Cancer Res 2016 March 24 [Epub ahead of print]. PMID: 27012813 (*corresponding author)
215. Kaur H, Ali SZ, Huey L, Hutt-Cabezas M, Taylor I, Mao XG, Weingart M, Chu Q, Rodriguez FJ, Eberhart
CG, Raabe EH. The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.
Cancer Lett 2016;18:377(1):55-64. PMID: 27102002
216. Binder ZA, Wilson KM, Salmasi V, Orr BA, Eberhart CG, Siu IM, Lim M, Weingart JD, Quinones-Hinojosa
A, Bettegowda C, Kassam AB, Olivi A, Brem H, Riggins GJ, Gallia GL. Establishment and Biological
characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines. PLoS
One. 2016 30;11(3):e0150271. PMID: 27028405
217. Mahale A, Alkatan H, Alwadani S, Othman M, Suarez MJ, Price A, Al-Hussain H, Jastaneiah S, Yu W,
Maktabi A, Deepak EP, Eberhart CG, Asnaghi L. Altered gene expression in conjunctival squamous cell
carcinoma. Mod Pathol 2016;29(5):452-60. PMID: 26916071 (*corresponding author)
218. Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi
L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Hypoxia-inducible factor 1 upregulation
of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget
2016;16;7(7):7816-28. PMID: 26761211
219. Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L,
O’Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE,
Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H,
Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C,
Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S,
Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH,
Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC. MYB-QKI
rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet 2016
Mar;48(3):273-82. PMID: 26829751
220. Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V,
Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL,
Ma Y, Tse K, Zeng T, Shumansky K, Roth AJ, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJ, Matan-Lithwick S,
18
Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X,
Pugh T, Ally A, Bilenky M, Butterfield YS, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li
HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J,
Nunes S. Shalaby T, Grotzer M, Pollack IF, Hamilton RL, LiXN, Bendel AE, Fults DW, Walter AW, Kumabe T,
Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH Jr, Stearns DS, Massimi L, Schüller
U, Sterba J, Xitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DP, Carlotti CG, Wheeler H, Hallahan AR, Ingram
W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino
M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA,
Collier LS, Dupuy AJ, Korshunov A, Jones DT, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ,
Moore RA Jabado N, Bader GD, Jones SJ, Malkin D, Marra MA, Taylor MD. Divergent clonal selection dominates
medulloblastoma at recurrence. Nature 2016 Jan 21;529(7586):351-7. PMID 26760213
221. Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K, Eberhart CG.
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells. Int J Cancer
2016 Mar 1;138(5):1246-55. PMID: 26422827
222. Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape
K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD,
Fulton D, van Landeghem FK, Santi M, van Veelen ML, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli
DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Rao AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton
RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T,
Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG,
Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R,
Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D,Wheeler H, v on Hoff K, Alonso MM, Tuñon T,
Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M,
Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro
AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE,
Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, Taylor MD.
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era:
A Retrospective Multicohort Analysis. J Clin Oncol. 2016 Jul 20;34(21):2468-77.
223. AlWadani S, Suarez MJ, Kass JJ, MacQuaid E, Edward DP, Alkatan H, Eberhart C. Subepidermal Calcified
Nodules of the Eyelid Differ in Children and Adults. Ophthal Plast Reconstr Surg. 2016 Jul 29. [Epub ahead of
print].
224. Das CM, Taylor P, Gireud M, Singh A, Lee D, Fuller G, Ji L, Fangusaro J, Rajaram V, Goldman S, Eberhart
C, Gopalakrishnan V. The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation.
Oncogene. 2016 Jul 18. [Epub ahead of print]
225. Asnaghi L, Tripathy A, Yang Q, Kaur H, Hanaford A, Yu W, Eberhart CG. Targeting Notch signaling as a
novel therapy for retinoblastoma. Oncotarget. 2016 Sep 20. [Epub ahead of print]
Review Articles (Mentee names underlined)
1. Eberhart CG. Medulloblastoma in mice lacking p53 and PARP: all roads lead to Gli. Am J Pathol.
2003;162(1):7-10.
2. Eberhart CG, Burger PC. Anaplasia and grading in medulloblastomas. Brain Pathol. 2003;13(3):376-385.
3. Fisher PG, Burger PC, Eberhart CG. Biologic risk stratification of medulloblastoma: the real time is now. J Clin
Oncol. 2004;22(6):971-974.
4. Eberhart CG. In search of the medulloblast: neural stem cells and medulloblastoma. Neurosurg Clin N Am.
2007;18(1):59-69, viii-ix.
19
5. Pardo CA, Eberhart CG. The neurobiology of autism. Brain Pathol. 2007;17(4):434-447.
6. Fan X, Eberhart CG. Medulloblastoma stem cells. J Clin Oncol. 2008;26(17):2821-2827.
7. Eberhart CG. Even cancers want commitment: lineage identity and medulloblastoma formation. Cancer Cell.
2008;14(2):105-107.
8. Briggs KJ, Eberhart CG, Watkins DN. Just say no to ATOH: how HIC1 methylation might predispose
medulloblastoma to lineage addiction. Cancer Res. 2008;68(21):8654-8656.
9. Pierfelice TJ, Schreck KC, Eberhart CG, Gaiano N. Notch, neural stem cells, and brain tumors. Cold Spring
Harb Symp Quant Biol. 2008;73:367-375.
10. Raabe EH, Eberhart CG. High-risk medulloblastoma: Does c-myc amplification overrule histopathology?
Pediatr Blood Cancer. 2010;54(3):344-345.
11. Pfister SM, Korshunov A, Kool M, Hasselblatt M, Eberhart C, Taylor MD. Molecular diagnostics of CNS
embryonal tumors. Acta Neuropathol. 2010;120(5):553-66.
12. Eberhart CG. Nervous System (Cambridge Illustrated Surgical Pathology). J Neuropath & Exp Neurol.
2010;69(1):109.
13. Eberhart CG. Molecular diagnostics in embryonal brain tumors. Brain Pathol. 2011:21:96-104.
14. Eberhart CG. Three down and one to go: modeling medulloblastoma subgroups. Cancer Cell. 2012;
21(2):137-8.
15. Orr BA, Eberhart CG. Nature versus nuture in glioblastoma. Am J Pathol. 2012;180(5):1768-71.
16. Raabe EH, Eberhart CG. Methylome alterations "mark" new therapeutic opportunities in glioblastoma. Cancer
Cell. 2012;22(4):417-8.
17. Rodriguez FJ, Lim KS, Bowers D, Eberhart CG. Pathological and molecular advances in pediatric low-grade
astrocytoma. Annu Rev Pathol. 2013;8:361-79.
18. Carvalho FLF, Simons BW, Eberhart CG, Berman DM. Notch signaling in prostate cancer: A moving target.
Prostate. 2014;74(9):933-45.
19. Zhu AY, Eberhart CG, Jun AS. Fuchs endothelial corneal dystrophy: a neurodegenerative disorder? JAMA
Ophthalmol. 2014;132(4):377-8.
20. Louis DN, Perry A, Burger P, Ellison DW, Reifenberger G, von DA, Aldape K, Brat D, Collins VP, Eberhart
C, Figarella-Branger D, Fuller GN, Giangaspero F, Giannini C, Hawkins C, Kleihues P, Korshunov A, Kros JM,
Beatriz LM, Ng HK, Ohgaki H, Paulus W, Pietsch T, Rosenblum M, Rushing E, Soylemezoglu F, Wiestler O,
Wesseling P. International Society Of Neuropathology--Haarlem consensus guidelines for nervous system tumor
classification and grading. Brain Pathol. 2014; 24(5):429-35.
21. Rusert J.M., Wu X., Eberhart C.G., Taylor M.D., and Wechsler-Reya R.J. SnapShot: Medulloblastoma.
Cancer Cell. 2014; 26(6): 940. PMID: 25490452
22. Eberhart C. Multiple cilia suppress tumour formation. Nat Cell Biol 2016 Mar 30;18(4):368-9. PMID:
27027488
20
Case Reports (Mentee names underlined)
1. Czader M, Eberhart CG, Cummings C, Westra WH. Metastasizing Mixed Tumor of the Parotid: Initial
Presentation as a Solitary Kidney Tumor and Ultimate Carcinomatous Transformation at the Primary Site. Am J
Surgical Pathology 2000;24:1159-1164.
2. Brotman DJ, Eberhart CG, Burger PC, McArthur JC, Hellmann DB. Primary angiitis of the central nervous
system and Alzheimer’s disease: clinically and pathologically evident in a single patient. J Rheumatol
2000;27(12):2935-2937.
3. Tihan T, Burger PC, Pomper M, Sanchez O, Ramzan M, Eberhart CG, Hansen C, Smith TW. Subacute
diencephalic angioencephalopathy: biopsy diagnosis and radiological features of a rare entity. Clin Neurol Neurosurg
2001;103(3):160-167.
4. Liu JM, Garonzik IM, Wang PP, Eberhart CG, Sampath P, Brem H. Ectopic recurrence of craniopharyngioma
after an interhemispheric, transcallosal approach. Neurosurgery 2002;50:639-645.
5. Seidel G, Pardo CA, Newman-Toker D, Olivi A, Eberhart CG. Neurobrucellosis Presenting as
Leukoencephalopathy: The Role of Cytotoxic T Lymphocytes. Arch Pathol Lab Med 2003;127(9):e374-377.
6. Parwani AV, Mikolaenko I, Eberhart CG, Burger PC, Rosenthal DL, Ali SZ. Rhabdoid meningioma:
Cytopathologic findings in cerebrospinal fluid. Diagnostic Cytopathology 2003;29:297-299.
7. Samdani AF, Garonzik IM, Jallo G, Eberhart CG, Zahos P. Spinal angiolipoma: case report and review of the
literature. Acta Neurochir 2004;146:299-302.
8. Walker BM, Hindman HB, Ebrahimi KB, Green WR, Eberhart CG, Garcia I, Jun AS. Epithelial downgrowth
following Descemet's-stripping automated endothelial keratoplasty. Arch Ophthalmol 2008;126:278-280.
9. Chen CS, Miller NR, Lane A, Eberhart C. Third cranial nerve palsy caused by intracranial extension of a sinoorbital natural killer T-cell lymphoma. J Neuroophthalmol 2008;28:31-35.
10. Roda RH, Gallia GL, Eberhart CG, Weingart JD, Laterra J. Epilepsy and temporal lobe injury after skull base
proton beam therapy. J Clin Neurosci 2009;16:1220-1221.
11. Ayres B, Miller NR, Eberhart CG, Dibernardo CW. Ultrasound features of orbital granular cell tumor.
Ophthalmol Plast Reconstr Surg 2009;25:320-322.
12. Sabet-Peyman EJ, Eberhart CG, Janjua K, Shah SM, Do DV, Nguyen QD. Persistent intermediate uveitis
associated with latent manifestation of facial large B-cell non-Hodgkin lymphoma. Ocul Immunol Inflamm
2009;17(5):322-324.
13. Wu-Chen WY, Weng CY, Rajan KDA, Eberhart CG, Miller NR. Unusual presentation of primary orbital
microcystic adnexal carcinoma. J Neuro-Ophthalmol 2011; 31:147-50.
14. Lee BS, Frankfort BJ, Eberhart CG, Weinberg RS. Diagnosis of intravascular lymphoma by a novel biopsy
site. Ophthalmology 2011; 18:586-90.
15. Karafin M, Jallo GI, Ayars M, Eberhart CG, Rodriguez FJ. Rosette forming glioneuronal tumor in association
with Noonan syndrome: pathobiological implications. Clin Neuropathol 2011;30:297-300.
16. Chen LY, Kesen MR, Ghafourian A, Nguyen QD, Eberhart CG, Do DV. Isolated endogenous Nocardia
endophthalmitis after immunosuppression. J Ophthalmic Inflamm Infect 2012;2(3):141-3.
21
17. Rajaii F, Ghafourian A, Eberhart CG. Intratarsal keratinous cyst – An emerging entity. Case Rep Ophthalmol
2013;4(3):160-164. PMID: 24403898
18. Rodriguez FJ, Lim KS, Bowers D, Eberhart CG. Pathological and molecular advances in pediatric low grade
astrocytoma. Annu Rev Pathol 2013;8:361-79.
19. Hsu AW, Sodhi A, Eberhart C, Montaner S, Goldberg MF. Regression of choroidal neovascularization in
response to systemic chemotherapy for cancer. Can J Ophthalmol 2013;48(4):e78-80.
20. Rodriguez M, Iliff NT, Eberhart CG, Montaner S, Sodhi A. Scleral penetration of an unusually aggressive case
of a retinal hemangioblastoma. Can J Ophthalmol 2013;48(4):e67-71.
21. Ostheimer TA, Dunn JP, Eberhart CG, Burkholder BM. Intraocular tuberculosis presenting as a large anterior
chamber mass. Ocul Immunol Inflamm 2015; 23(1):100-01.
22. Margolin E.A., Gopwani J., Eberhart C.G., and Blitz A.M. Mass confusion in a 30-year-old man. J.
Neuroophthalmol. 2014; 34(4):408-11.
23. Hessen M, Eberhart C, Butler N, Akpek EK. Sarcoidosis presenting as scleral nodule. Ocul Immunol Inflamm.
2014; 22(4):311-13.
24. Eghrari AO, Gibas C, Watkins T, Vahedi S, Lee R, Houle E, Suarez MJ, Eberhart C, Sutton DA, Wiederhold
NP, Sikder S, Zhang SX. First Human Case of Fungal Keratitis Caused by a Putatively Novel Species of
Lophotrichus. J Clin Microbiol. 2015 Jun 24. pii: JCM.00471-15. [Epub ahead of print]
Book Chapters (Mentee names underlined)
1. Giangaspero F, Eberhart CG, Haapasalo H, Pietsch T, Wiestler OD, Ellison DW. Medulloblastoma. In:
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. eds. WHO Classification of Tumours of the Central
Nervous System. 4th ed. Lyon, France: WHO Press; 2007:132-140.
2. McLendon RE, Judkins AR, Eberhart CG, Fuller GN, Sarkar C, Ng H-K. Central nervous system
primitive neuroectodermal tumours. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. eds. WHO
Classification of Tumours of the Central Nervous System. 4th ed. Lyon, France: WHO Press; 2007:141146.
3. Judkins AR, Eberhart CG, Wesseling P. Atypical teratoid/rhabdoid tumour. In: Louis DN, Ohgaki H,
Wiestler OD, Cavenee WK. eds. WHO Classification of Tumours of the Central Nervous System. 4th ed.
Lyon, France: WHO Press; 2007:147-149.
4. Eberhart CG, Wiestler OD, Eng C. Cowden disease and dysplastic gangliocytoma of the
cerebellum/Lhermitte-Duclos disease. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. eds. WHO
Classification of Tumours of the Central Nervous System. 4th ed. Lyon, France: WHO Press; 2007:226228.
5. Eberhart CG, Cavenee WK, Pietsch T. Naevoid basal cell carcinoma syndrome.
In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. eds. WHO Classification of Tumours of the Central
Nervous System. 4th ed. Lyon, France: WHO Press; 2007:232-233.
6. Wesseling P, Biegel JA, Eberhart CG, Judkins AR. Rhabdoid tumor predisposition syndrome. In:
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. eds. WHO Classification of Tumours of the Central
Nervous System. 4th ed. Lyon, France: WHO Press; 2007:234-235.
22
7. Troncoso JC, Eberhart CG. Forensic aspects of brain tumors. In: Troncoso JC, Rubio A, Flower DF,
eds. Essential Forensic Neuropathology. Philadelphia, PA: Lippincott Williams & Wilkins, a Wolters
Kluwer business; 2010:147-155.
8. Eberhart CG. Embryonal brain tumors. In: Perry, A ed. Greenfield’s Neuropathology. London:
Arnold 2014
9. Eberhart CG, Wiestler OD, Eng C. Cowden disease and dysplastic gangliocytoma of the
cerebellum/Lhermitte-Duclos disease. In: WHO Classification of Tumours of the Central Nervous System.
Revised 4th ed. Lyon, France: WHO Press; 2016:142-143.
10. Ellison DW, Eberhart CG, Pietsch T, Pfister S. Medulloblastoma. In: WHO Classification of Tumours
of the Central Nervous System. Revised 4th ed. Lyon, France: WHO Press; 2016: 185-200.
11. Korshunov A, McLendon RE, Judkins AR, Pfister S, Eberhart CG, Fuller GN, Sarkar C, Ng H-K.,
Huang A, Kool M, Wesseling P. Embryonal tumour with multilayered rosettes, C19MC-altered. In: WHO
Classification of Tumours of the Central Nervous System. Revised 4th ed. Lyon, France: WHO Press;
2016:201-205.
12. McLendon R, Judkins AR, Eberhart CG, Fuller GN, Sarkar C, NG HK, Huang A, Kool M, Pfister S.
Other CNS Embryonal Tumours. In: WHO Classification of Tumours of the Central Nervous System.
Revised 4th ed. Lyon, France: WHO Press; 2016:206-208.
13. Judkins AR, Eberhart CG, Wesseling P. Hasselblatt M. Atypical teratoid/rhabdoid tumour. In: WHO
Classification of Tumours of the Central Nervous System. Revised 4th ed. Lyon, France: WHO Press;
2016:209-212.
14. Eberhart CG, Wiestler OD, Eng C. Cowden syndrome. In: WHO Classification of Tumours of the
Central Nervous System. Revised 4th ed. Lyon, France: WHO Press; 2016:314-316..
15. Eberhart CG, Cavenee WK, Pietsch T. Naevoid basal cell carcinoma syndrome.
In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. eds. In: WHO Classification of Tumours of the
Central Nervous System. Revised 4th ed. Lyon, France: WHO Press; 2016:319-321.
16. Wesseling P, Biegel JA, Eberhart CG, Judkins AR. Rhabdoid tumor predisposition syndrome. In:
WHO Classification of Tumours of the Central Nervous System. Revised 4th ed. Lyon, France: WHO Press;
2016:321-22.
Online Material:
1. Eberhart CG, Giangaspero F. Desmoplastic/Nodular Medulloblastoma. In: Pubcan - A Public Database
of Human Cancers.
2. Eberhart CG, Giangaspero F. Medulloblastoma with Extensive Nodularity. In: Pubcan - A Public
Database of Human Cancers.
3. Eberhart CG. Anaplastic Medulloblastoma. In: Pubcan - A Public Database of Human Cancers.
23
4. Eberhart CG, Giangaspero F. Large Cell Medulloblastoma. In: Pubcan - A Public Database of Human
Cancers.
5. Eberhart CG, Giannini C, Collins VP, Kleihuis P, Rodriguez F, Koeller KK. Pilocytic Astrocytoma. In:
Pubcan - A Public Database of Human Cancers.
6. Eberhart CG, Pfister S. CNS Primitive neuroectodermal tumour, NOS. In: Pubcan - A Public Database
of Human Cancers.
Patents:
2/27/06 Novel Treatments for Cancer Stem Cells via Gamma-secretase Inhibitor-mediated Notch Pathway
Blockade. Patent Pending, JHU Reference No. 4896 (filed 2/27/2006).
FUNDING
Extramural Sponsorship:
Current Grants
T32CA193145
Burns/Eberhart (mPI)
Training Grant
Opportunities for Pathology Trainees in Cancer Support
09/21/15-08/31/20
$128,208
0.12 calendar
RO1NS055089
Eberhart (PI)
09/30/12 – 08/30/17
NIH/NINDS
$218,513
Effectively Targeting Notch in Hypoxic Brain Tumor Cells
Develop Notch inhibitors as effective new therapies for glioblastoma and other malignant brain tumors.
3 calendar
R25NS079185
Troncoso (PI)
07/01/12 – 06/30/17
NINDS
$1
Research Education Program in Experimental Neuropathology Training Grant
0.12 calendar
no salary
07/01/11 – 06/30/16
$110,000
0.12 calendar
R01CA166171
Zhou (PI)
02/05/13 – 01/31/18
NIH/NCI
$230,717
Academic-Industrial Partnership to Develop Clinical Brain Cancer Imaging
0.29 calendar
Raabe (PI)
St. Baldrick’s Foundation
Modeling high-risk Medulloblastoma using human neural stem cells
Ying (PI)
07/01/14 – 06/30/16
1.2 calendar
KKI_CDMRP
$19,578
Modeling the Most Aggressive Subgroup of Human Medulloblastoma Using Human Induced Pluripotent Stem Cells
Eberhart (PI)
06/19/14–06/18/16
0.84 calendar
King Khaled Eye Specialist Hospital (KKESH)
$86,165
Developing ADAM3A as a diagnostic marker and therapeutic target in Ocular Surface Squamous Neoplasia (OSSN)
Welsbie (PI)
09/01/14 – 08/31/16
0.12 calendar
CDMRP
$202,528
Targeting Dual Leucine Zipper Kinase as a Therapeutic Strategy for Traumatic Optic Neuropathy and Brain Injury
Eberhart (PI)
03/01/15 – 02/28/17
KKESH
$52,240
Identifying and Targeting Invasion-Promoting Molecular Pathways in Retinoblatoma
24
0.60 calendar
Pending
Walczak (PI)
11/29/15 – 11/28/16
Falk Medical Trust Foundation
$497,986
Restorative Neuro-Oncology: A Strategy for More Effective and Safer Treatment of Brain Tumors
0.6 calendar
R01CA201527
Hanes/Suk (MPI)
NIH/NHLBI
Nucleic Acid Delivery to Brain Tumors
09/01/15 – 08/31/20
$250,000
0.24 calendar
RO1CA193895
Hanes/Soo (MPI)
NIH/NCI
Nucleic Acid Delivery to Brain Tumors
09/1/15 – 08/31/20
0.24 calendar
MacPherson (PI)
07/01/16 – 06/30/21
NIH/Fred Hutch Cancer Research Center
Investigating BCOr tumor suppressor function in retinoblastoma and other cancers
0.24 calendar
Previous Grants
11/1/12-10/31/15
07/01/09-06/30/14
07/01/00-12/31/01
09/01/00-08/31/02
09/30/00-08/31/01
10/01/00-9/30/02
09/01/01-12/31/06
11/01/01-12/31/04
05/01/02-04/30/07
11/01/02-10/31/04
11/01/04-10/31/07
04/01/06-03/31/09
7/1/06-12/31/08
The Children’s Cancer Foundation, Inc.
The role of chromatin remodeling proteins in Pediatric High Grade Glioma
PI: Eberhart
NIH/NIBIB R01 EB009731
Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7T
PI: Zhou
Wingless signaling in medulloblastomas: A murine transgenic model
Childhood Brain Tumor Foundation,
PI: Eberhart
A Murine Medulloblastoma Model
Howard Hughes Medical Institute
PI: Eberhart
Wnt Signaling in Alzheimer’s Disease
2P50AG05146-18 ADRC Pilot (Price)
PI: Eberhart
Wingless Signaling in Medulloblastomas: A Murine Tumor Model
The Brain Tumor Society
PI: Eberhart
An Analysis of Medulloblastoma Pathobiology and Response to Novel Therapies using
Murine Transgenic Models
Burroughs Wellcome Fund
PI: Eberhart
Myc Signaling in Medulloblastomas
Children’s Cancer Foundation
PI: Burger , Eberhart co-investigator
Myc Signalling in Medulloblastomas
1K08NS/CA43279-01
NIH/NINDS
PI: Eberhart
Analysis of Notch Signaling in Medulloblastomas
Children’s Brain Tumor Foundation
PI: Eberhart
Notch Based Therapies for Pediatric Brain Tumors
Children’s Cancer Foundation
PI: Eberhart
Tumor Stem Cell Based Drug Discovery for Pediatric and Adult Glioma
Brain Tumor Funder’s Collaborative
PI: Laterra (Project Subcontract to CGE)
Roles for HIC-1 in Neural Development and Tumor Suppression
25
11/01/07-10/31/09
12/17/08 – 12/16/09
7/01/07-6/30/12
05/01/08 – 04/30/11
04/02/09 – 04/01/11
08/01/09 – 07/31/11
07/01/10-06/30/11
11/01/11-10/31/12
11/1/11 – 10/31/12
08/01/12 – 05/30/15
R01 NS054085-01A1
PI: Watkins, Eberhart Co-Investigator; 10% Effort
Microscopic and Molecular Analysis of Pilocytic and Pilomyxoid Astrocytoma
Children’s Cancer Foundation
PI: Eberhart
Molecular Analysis of BRAF in WHO Grade II Fibrillary Pediatric Astrocytomas
Pediatric Low Grade Astrocytoma Foundation, Inc.
PI: Eberhart
Notch Signaling in Brain Tumors
R01 NS055089
NIH/NINDS
PI: Eberhart, 21% effort
Inhibiting Notch activity and brain tumor progression using Zen Sheng Ping (ZSP)
R21 AT003893-A1
NIH/NCCAM
PI: Eberhart, 1% effort
Pediatric Low Grade Astrocytoma: Dedicated Tumor Banking and Establishment of Cell
Lines and Xenografts
Pediatric Low Grade Astrocytoma Foundation, Inc.
PI: Eberhart, 1% effort
Notch and Hedgehog Signaling in Glioblastoma
James S. McDonnell Foundation
PI: Laterra My role: Project Leader
Targeting BRAF in Pediatric Low Grade Gliomas
The Children’s Cancer Foundation, Inc
PI: Eberhart, 1% effort
Targeting BRAF and Escape from Senescence in Pediatric Low Grade Gliomas
Children’s Cancer Foundation, Inc.
PI: Eberhart, 2% effort
Preclinical Analysis of Notch Signaling in Malignant Brain and Eye Tumors
MERCK AND CO.
PI: Eberhart, no salary
Comprehensive Molecular Profiling of Oscular Surface Squamous Neoplasia
KKESH (Saudia Arabia)
PI: Eberhart, 10% effort
CLINICAL ACTIVITIES
Certification:
2001-present
Maryland Medical License D0057110
Boards:
2003 Anatomical Pathology
2003 Neuropathology
Service Responsibilities:
2001-present Autopsy Attending
2001-present Surgical Neuropathology Attending
2006-present Ophthalmic Pathology Attending
Clinical Productivity: I sign out approximately 1,500-2,000 neuropathology and ophthalmic pathology cases each
year.
Clinical Trials Activity:
2003-2006
Pathology Reviewer, ECOG Study E1F02: (Systemic High-Dose Methotrexate Followed by
Radiation for the Treatment of GBM)
26
2010-present
2014-present
Pathology Reviewer, COG ACNS1022 “A Phase II Trial of Lenalidomide in Pediatric Patients with
Recurrent, Refractory or Progressive Low-Grade CNS Gliomas”
Pathology Reviewer, COG ACNS1221 Phase II “Treatment Of Non-Metastatic Desmoplastic
Medulloblastoma In Children Less Than 4 Years Of Age”
EDUCATIONAL ACTIVITIES
Teaching:
Classroom Instruction:
2002-2006
Human Genetics Graduate Program: Faculty Mentor/Liason for 2nd year Pathology Course, (Involved
10 -15 meetings with students per year)
2003-2009
Medical School: Co-Director of 2nd year Neuro Course with Dr. Newman-Toker
2003-2010
Medical School: Lecturer in 2nd year Pathology Course, (2 lectures/yr and 21 hours of small group
instruction)
2011-2016
Medical School: Lecturer in 1st year Pathology Course, (1 lecture/yr and 8 hours of small group
instruction)
2003-present Graduate School: Lecturer Pathobiology and Disease Mechanisms (300.710)
2005-2008
Graduate School: Lecturer Pathology for Graduate Students: Basic Mechanisms (300.713)
2005-present Graduate School: Lecturer Pathology for Graduate Students: Neuropathology (300.715)
2009, 2016
Graduate School: Lecturer Biology of Cancer (ME.510.700)
2009
Graduate School: Lecturer Pathology for Graduate Students: Cancer (300.714)
2009, 2011
Graduate School: Lecturer Stem Cells (ME 440.815)
Clinical Instruction:
2001-present Sign-out with Pathology and Ophthalmology Residents and Fellows (approximately 200 days/year)
2001-present Didactic Seminars for Pathology Residents on Neuro- and Eye Pathology (approximately 2/year)
2006-present Didactic Seminars for Neurology Residents (approximately 2/year)
2007-present Didactic Seminars for JHU Ophthalmology Residents (approximately 3/year)
2011
Osler Review Course Ophthalmic Pathology Lectures (3 hours)
2011-present Didactic Seminars for Medstar/Georgetown Ophthalmology Residents (9 hours/year)
2012- present Didactic Seminars for University of Maryland Ophthalmology Residents (12 hours/year)
CME instruction:
2001-present Over 55 invited talks given for CME credit (see below for locations and dates)
2005-present 17 additional clinical presentation given for CME credit at Verhoeff Zimmerman Society and Eastern
Ophthalmic Pathology Society Meetings
Mentoring:
Clinical Residents/Fellows/Junior Faculty:
2001-2003
Min Wang, Neuropathology Fellow, Currently: Assistant Professor of Pathology, University of
Texas at Houston
2002-2004
Irina Mikolaenko, Neuropathology Fellow, Currently: Assistant Professor of Pathology, NYU
2003-2005
Jeff Sosnowsky, Neuropathology Fellow; Currently: Associate Professor of Pathology, University of
S. Alabama, Mobile, AL
2003-2005
Duncan Stearns, Neuro-Oncology Fellow; Currently: Assistant Professor of Pediatrics, Case
Western University, Cleveland, OH
2003-2005
Ty Abel, Neuropathology Fellow; Currently: Associate Professor of Pathology, Vanderbilt
University, Nashville, TN, Director, Division of Neuropathology
2007-2009
Michael Johnson, Neuropathology Fellow; Currently: Medical Examiner, KY
2009-2010
Yazmin Odia, Neurology Research Fellow; Currently: Assistant Professor of Neurology, Columbia
2009-2011
Brent Orr, Neuropathology Fellow; Currently: Asst Professor and SP Director, St. Jude, Memphis
2010
Jason Karamchandani Visiting Fellow (Eye Pathology), Stanford
27
2010, 2011
2010
2011- 2013
2011-2015
2010-2014
2012-present
2012-2013
2012-2013
2012-2013
2012-present
2012-present
2013-present
2013-2014
2013-2014
2013-present
2014
2014-2016
2014-present
2014-present
2016-present
2016-present
2016-present
Maria Sibug Saber Visiting Faculty (Eye Pathology), USC
David Bourne Visiting Faculty (Eye Pathology), UVA
Cherry Ho, Neuropathology Fellow, Currently: Attending Pathologist
Children's National Medical Center, Washington DC
Akrit Sohdi, Assistant Professor in Ophthalmology (K08 mentor)
David Nauen Neuropathology Fellow, Currently: Assistant Professor of Pathology, Johns Hopkins
Eric Raabe, Assistant Professor in Oncology (mentoring committee member)
Craig Peacock, (mentoring committee member), Currently: Assistant Professor Case Western
Valli Muthappan, Ophthalmology Resident
Pouneh Rajaii, Ophthalmology Resident, Currently: Assistant Professor of OPhthalmology, Johns Hopkins
Sama Ahsan, Clinical Fellow in Neuro-Oncology
Robert Bell, Neuropathology Fellow, Currently: Research Associate, Johns Hopkins
Mas Hayashi, Clinical Fellow in Oncology (mentoring committee member)
Michael Koldobky, Resident in Pediatrics
Craig Horbinski, Assistant Professor, U Kentucky (mentoring committee member)
Heather Ames, AP/NP resident/fellow, Johns Hopkins
Lei Zhang, Visiting Assistant Professor of Ophthalmology, Binzhou Medical College, Shandong, China
Rupal Mehta, Assistant Professor of Pathology, U of Maryland (K08 Mentor).
Jeffrey Rubens, Clinical Fellow in Oncology, Johns Hopkins
Mary Aronow, Assistant Professor in Ophthalmology, Johns Hopkins
Uri Soiberman, Assistant Professor in Ophthalmology, Johns Hopkins
Robert Moore, Pathology Resident, Johns Hopkins
Micah Maxwell, Clinical Fellow in Oncology, Johns Hopkins
Research Fellows/Faculty:
2003-2008
Xing Fan, Post-Doctoral Fellow 2003-2006; Research Associate 2007-8); Currently: Assistant
Professor of Neurosurgery, University of Michigan with independent R01 funding
Honors: American Brain Tumor Association Fellowship (2004-2006), Pathology Department Young
Investigator Award for Excellence in Research (2003, 2004, 2006), Oncology Department Young
Investigator Award for Excellence in Research (2006), American Brain Tumor Association grant
2007 ($60,000), Accelerate Brain Cancer Cure grant 2007 ($120,000), Genentech Award SNO 2007
2004
Alehandro Urberuaga, Visiting Fellow
2004-2007
Eli Bar (Post-Doctoral Fellow 2004-2007, Research Associate 2008); Currently: Assistant Professor
in Neurosurgery, Case Western University with independent R01 funding
Honors: Pathology Department Young Investigator Award for Excellence in Research (2004, 2006,
2007 [first prize])
2006-2007
Katayoon Ebrahimi, Eye Pathology Fellow; Currently: Research Associate, Department of
Ophthalmology, Johns Hopkins University
2006-2007
Robert Bell, Eye Pathology Fellow, Currently: Research Fellow, Johns Hopkins
2007-2008
Kamaljeet Singh, Eye Pathology Fellow; Currently: Assitant Professor, Brown University Hospital
2008-present Laura Asnaghi, Post-Doctoral Fellow, Research Associate since January 2012
2008-2011
Eric Raabe, Pediatric Oncology Fellow, Currently: Assistant Professor of Pediatrics, Johns Hopkins
2008-2009
Arille Spitze, Eye Pathology Fellow, Currently: Ophthalmologist, Norfolk VA
2008-2009
Deepali Jain, Eye Pathology Fellow, Currently: Assistant Professor (AIMS), New Dehli
2008; 2010
Jaroslav Majacek, Visiting Fellow, Currently: Assistant Professor, University of Dusseldorf
2009-2010
Christopher Burris, Eye Pathology Fellow, Currently: Ophthalmology Fellow, U Wisconsin
2009-2011
Anand Rajan, Eye Pathology Fellow, Currently: AP/CP resident, Washington University, St. Louis
2010-2012
Hosein Ghafourian Eye Pathology Fellow, Currently: Pathologist, Iran
2010-2011
Susannah Batko-Yovino Neuro-Oncology Fellow,
2011-2013
Qian Chu Brain Tumor Research Fellow, Currently: Associate Professor Tongii Medical University
2011
Palak Sitwalla, Eye Pathology Fellow
2012-2013
Michael Mines, Eye Pathology Fellow, Currently: Assistant Professor (USUHS), Washington DC
2012-2014
Saeed Alwadani, Eye Pathology Fellow, Currently: Assistant Professor of Ophthalmology, King Saud
University, Riyadh
2012-2014
Will Brandt, Post-Doctoral Research Fellow
28
2013-2014
2015-2016
2015-2016
2016-present
Ping An, Post-Doctoral Research Fellow, Currently: Instructor, Department of Neurobiology,
China Medical University
Ulf Kahlert, Post-Doctoral Research Fellow, Currently: Instructor, Universitat Dusseldorf, Germany
Maria Suarez, Eye Pathology Fellow, Currently: Intern, Department of Medicine, SUNY downstate
Manabu Natsumeda, Post-Doctoral Research Fellow, Currently: Assitant Professor of Neurosurgery,
Niigata University, Japan
Harpreet Kaur, Post-Doctoral Research Fellow
Hongyan Zhang, Post-Doctoral Research Fellow
Ming Yuan, Post-Doctoral Research Fellow
Amir Banihashemi, Eye Pathology Fellow, Currently: Pathology Resident SUNY Downstate
Hongwu Li, Visiting Professor (from Dalian Medical University, China)
Hiroaki Mirahara, Post-Doctoral Research Fellow, Currently: Asst. Prof. of Pediatrics, Japan
Qian Yang, Visiting Professor (from Dalian Medical University, China)
Huamin Qin, Post-Doctoral Research Fellow, Currently: Asst. Prof of Pathology, Dalian Medical
University, China
Zhigang Li, Post-Doctoral Research Fellow
Guosheng Li, Visiting Professor (from Dalian Medical University, China)
Antje Arnold, Post-Doctoral Research Fellow
Students:
2003
2003-2004
2003-2004
2005
2005-2006
2005-2006
2006
2006
2006
2006-2010
2006
2007
2007
2007-2008
2008-2012
2009
2009, 2010
2009
2009-2014
2009, 2010
2010-2014
2010-2011
2010-2011
2011- 2014
2011- present
2011- 2012
2011- 2013
2012-2013
2012-present
2012-2015
2013
2013-2016
2014
2014
2014
Eric Kuchner, Rotating Pathobiology Graduate Student
Dong Choe, Johns Hopkins Undergraduate
Joshua Copeland, U of Maryland Undergraduate, Autism Research
Sarah Brennan, Rotating Pathobiology Graduate Student
Aamir Abbas, Johns Hopkins Undergraduate, Brain Tumor Research
Jonathan Godin, Johns Hopkins Undergraduate, Brain Tumor Research
Cheryl Koh, Rotating Pathobiology Graduate Student
Brian Simons, Rotating Pathobiology Graduate Student
Po-Min Chiang, Rotating Pathobiology Graduate Student
Karisa Scheck, Neuroscience Graduate Student; Co-Mentor with Dr. Nick Gaiano
Marcela Rivas, Medical Student Elective Rotation, Eye Pathology
Elena Della Bella, Visiting Graduate Student, Italy
Jason Paluzzi, Johns Hopkins Undergraduate, Eye Pathology
Tu Nguyen, University of Maryland Undergraduate
Kah-Jing Lim, Pathobiology Graduate Student
Xing-Gang Mao, Visiting Graduate Student, China
Uhf Kahlert, Visiting Graduate Student, Germany
Sung Pil Han, Visiting Graduate Student, South Korea
Kah Suan Lin, Pathobiology Graduate Student
Jason Wolf , Summer Undergraduate Student, Brain Tumor Research
Melanie Weingart Summer Undergraduate Student, Brain Tumor Research
Xing-Gang Mao Visiting Graduate Student, China
Michael Ayers Rotating Pathobiology Graduate Student, Eye Tumor Research
Isabella Taylor Johns Hopkins Undergraduate Student/technician, Brain Tumor Research
Samantha Semenkow, Pathobiology Graduate Student
Rafaella Spina, Visiting Graduate Student, Italy
Michael Lin, Johns Hopkins Undergraduate Student, Eye Tumor Research
Dacheng Ding, Visiting Graduate Student, China
Allison Hanaford, Pathobiology Graduate Student
Clark Zhang, Biomedical Engineering Graduate Student
Jonathan Montesinos, Summer High School Student, SMU Program
Arushi Tripathy, Johns Hopkins Undergraduate Student, Eye Tumor Research
Erica Owusu, McDaniel College Undergraduate Student, Brain Tumor Research
Kalliopi Somis, Harford High School Student, Eye Tumor Research
Abigail Suwala, Visiting PhD Student (Germany), Brain tumor research
2013-2015
2013-2016
2013-2016
2013-present
2014
2014-present
2014-2015
2015
2015-2016
2015
2015-2016
29
2014
2014
2015, 2016
2016-present
Other
2000-2003
2001-2003
2002-2004
2003-2004
2004-2006
2006-2009
Katharina Koch, Visiting PhD Student (Germany), Brain tumor research
Catherine Guerra, Rotating Pathobiology Graduate Student, Brain tumor research
Nolan Key, Dulaney High School, Eye tumor research
Holly Guo, Johns Hopkins Undergraduate Student, Eye Tumor Research
Jon Kratz, Technician; Currently: Graduate Student, Colombia University, NY
Krista Summers, Technician; Currently: Medical Student, University of Maryland
George Ni, Technician; Currently: Assistant (vice) Professor, Department of Surgery, Shanghai
Second Medical University, China
Ihab Elhassan, Technician; Currently: MD/PhD Student, Howard University
Aneeka Chaudhry, Technician; Currently: Graduate Student (MPH), George Washington University
Alex Lin, Technician; Currently: Graduate Student (PhD), U Pennsylvania, Hershey
Thesis Committees
2004-2008
Kimberly Briggs, CMM
2005-2007
Louis Dang, Neuroscience-MD/PhD
2006-2010
Sarah Brennan, Pathobiology
2006-2008
Rory Goodman, Neuroscience-MD/PhD
2008-2010
Tarran Pierfelice, CMM
2008-2011
Genevieve Weber, Pathobiology
2009-2011
Jason Howard, Pharmacology
2010-2012
Brain Simons, Pathobiology
2010
Po-Min Chiang, Pathobiology
2010-2014
Arvin Gouw, Pathobiology
2011-2012
Chris Smith, Biomedical Engineering
2011-2012
Raffaela Spina, University of Catanzaro, Italy
2012-2013
Elizabeth Nance, Chemical and Biomolecular Engineering
2012-2014
Kelli M. Wilson, CMM
2012-2013
Sean Byrne, Physiology
2012-2014
Kelli Wilson, CMM
2012-2014
Alexandra Borodovsky, CMM
2013-2015
Jessica Tilghman, Neuroscience
2014-2015
Clark Zhang, Biomedical Engineering
2014-present Ross McMillan, CMM
2015-present Carolyn Tallon, Pathobiology
2016-present Minling (Mary) Gao, Pathobiology
Training Grant Activities:
2004-2013
Trainer, Neuro-Oncology Training Grant
2005-2013
Member, Neuro-Oncology Training Grant Advisory Committee
2005-2013
Trainer, T32 Training Program in the Pathobiology of Cancer
2009-present Trainer, R25 Neurology Resident and Fellow Research Training Grant
2012-present Trainer and Advisory Committee Member, R25 Experimental Neuropathology Training Grant
2015-present Principal Investigator (Dual PI with Kathy Burns), T32 NCI Opportunities for Pathology Trainees In
Cancer research (OPTIC)
SYSTEM INNOVATION and QUALITY IMPROVEMENT ACTIVITIES
System Innovation and Quality Improvement efforts within JHM:
2006-present Member, JHH Surgical and Invasive Procedure Review Committee. This committee reviews surgical
and invasive procedures at Johns Hopkins, including both individual problem cases and broader areas
of practice, in order to improve quality and identify recurring problems.
2006-present Oversee all system innovation and QC/QI activities in ophthalmic pathology
30
ORGANIZATIONAL ACTIVITIES
Institutional Administrative Appointments:
2002-2008
Pathology Residency Selection Committee
2003-2008
Pathology Medical Student Educational Advisory Committee
2005-07; 2015 Pathobiology Graduate Program Admissions Committee
2006-present Pathobiology Graduate Program Executive Committee
2006-present Wilmer Long Range Planning Committee
2006-present JHH Surgical and Invasive Procedure Review Committee
2007-2009
Pathobiology Retreat Planning Committee (Chair)
2007-2014
Wilmer Research Day Planning Committee
2007-present Wilmer Microscopy and Imaging Core (MICF) Oversight Committee
2009-2010
Chair, Search Committee, Pathology (Surgical Neuropathology – hired Fausto Rodriguez)
2009-2011
Chair, Search Committee, Pathology (Neurodegeneration – hired Liam Chen)
2010-present Molecular Pathology Seminar Committee
2012-present Wilmer Resident Didactic Committee
2012-present Wilmer Resident Pathology Division Education Champion
2014
Search Committee, Pathology Department Autopsy Faculty
2015-present Bloomberg Scholar Committee, Pathology Department
2015-2016
Search Committee, JHU Director of Pediatrics
2015
Bayer–JHU Ophthalmology Research Collaboration Joint Research Committee
Editorial Activities:
Editorial Boards
2005-present Journal of Neuropathology and Experimental Neurology
2006-present Neuro-Oncology
2008-present Brain Pathology
Ad Hoc Manuscript Reviewer:
Nature, Nature Medicine, Nature Genetics, Nature Communications, Nature Cell Biology, Cancer Cell,
Proceedings of the National Academy of Sciences (PNAS), Journal of the NCI, Cancer Research, Clinical
Cancer Research, Cancer Discovery, Journal of Biological Chemistry, Journal of Clinical Investigation,
Molecular and Cellular Biology, Oncogene, Oncotarget, Journal of Clinical Oncology, Journal of
Experimental Medicine, PLoS Genetics, PLoS One, American Journal of Pathology, Brain Pathology, Stem
Cells, Lancet Oncology, Oncotarget, Annals of Neurology, Journal of Molecular Histology, Journal of
Histochemistry and Cytochemistry, Pediatric Blood and Cancer, Neuropathology and Applied
Neurobiology, Laboratory Investigation, Cellular Oncology, Acta Neuropathologica, British Journal of
Cancer, Neoplasia, International Journal of Cancer, Neurosurgery, Glia, Neural Development, Journal of
Neuro-Oncology, Molecular Cancer Research, Clinical Neuropathology, Journal of Pathology, Archives of
Pathology and Laboratory Medicine, Cancer Letters, Journal of Molecular Medicine, Investigative
Ophthalmology and Visual Science (IOVS), Retina, Ocular Immunology and Inflammation, American
Journal of Ophthalmology, BMC Ophthalmology, JAMA Ophthalmology, Asian Pacific Journal of
Ophthalmology, Expert Review of Ophthalmology, Melanoma and Pigment Cell Research, British J
Ophthalmology, Ocular Oncology and Pathology
Professional Associations:
1999-present American Association of Neuropathology
2001-present American Association for Cancer Research
2002-2010
New Approaches to Brain Tumor Therapy (NABTT) Consortium
2003-present Society for Neurooncology
2003-present Eastern Cooperative Oncology Group
31
2004-2014
2006-present
2006-2007
2006-present
2007-present
2008-present
2009-present
2010-present
2010-present
2011-present
2015-present
American Society for Investigational Pathology
Children’s Oncology Group
New York Academy of Sciences
Association for Research in Vision and Ophthalmology
Verhoeff Zimmerman Society
American Association of Ophthalmic Oncology and Pathology
Eastern Ophthalmic Pathology Society
United States and Canadian Academy of Pathology
American Society for Clinical Investigation
International Society for Ocular Oncology
American Association of University Pathologists (Pluto Society)
Grant Reviewer
2002, 2004
Canadian Institutes of Health Research
2004 -2005
Dutch Cancer Society
2006
UK Medical Research Council
2005 -2011
Children’s Brain Tumor Foundation
2005
Singapore Biomedical Research Council
2005, 2007
Hong Kong Research Grants Committee
2006-2016
Cancer Research UK
2007-2009
The Brain Tumor Society
2007
Volkswagen Stiftung
2007, 2012
Raine Medical Research Foundation, Australia
2008
NIH/NCF Study Section (Ad Hoc reviewer)
2008-2009
Autism Speaks
2008
NIH/NCCAM (Ad Hoc reviewer)
2009
NIH/TME Study Section (Ad Hoc reviewer)
2009-present Associazone Italiana per la Ricerca sul Cancro (AIRC)
2009
NIH/BDCN-N Study Section (Ad Hoc reviewer)
2009
March of Dimes
2010
NIH/NCI-I Study Section (Ad Hoc reviewer)
2010
Department of Defense Pediatric Brain Tumor Program
2011
NIH/ZRG1 BDCN-L (Ad Hoc reviewer)
2011
NIH/ZRG1 OTCL SBIR (Ad Hoc reviewer)
2012
Michael Smith Foundation for Health Research, Canada
2012
NIH/ZRG1 CB-L SEP (Ad Hoc reviewer)
2012
NIH/ZRG OBT-S (Ad Hoc reviewer)
2012, 2013
NIH/NCI ZCA1 SRLB-C (Ad Hoc reviewer)
2012
Children with Cancer UK
2012
JHU Rangos Award
2013
Health Research Board, Ireland
2013-present Alex Lemonade Stand Foundation
2014
US Food and Drug Administration
2014
Pennsylvania Department of Health CURE grants
2014
Imperial College London
2014
Yorkshire Cancer Research
2014
NIH/ SEP NCI Program Project Meeting III
2014
NIH/SEP K99
2015
NIH CAMP study section (Ad hoc reviewer)
2015
Swiss Cancer League
2016
NIH/NCI R21 review (Ad Hoc)
2016
Einstein Foundation, Germany
2016-present NIH CAMP study section (Member)
Conference Organizer:
32
2003
2006
2009
2009
2009
2010
2010
2010
2012
2012
2013
2013
2013
2014
2014
2015
2016
Session Chair: Childhood Tumors, American Association of Neuropathology Annual Meeting, Orlando, FL.
Minisymposium Organizer: Medulloblastoma, XVI International Congress of Neuropathology, San
Francisco, CA.
Session Chair: Pediatric Tumors, American Association of Neuropathology Annual Meeting, San Antonio,
TX.
Session Chair: Astrocytoma Biology, Low Grade Astrocytoma In Early Life Conference, Nottingham,
England.
Session Chair: Medulloblastoma - Current State of Biology and Therapy, Society for Neuro-Oncology Annual
Meeting, New Orleans.
Organizer and Session Chair: Advances in Corneal and Conjunctival Pathology, American Association of
Ophthalmic Pathologists Companion Meeting at USCAP, Washington, DC
Session Chair: Neuropathology (Section G), United States and Canadian Academy of Pathology Annual
Meeting, Washington, DC
Co-organizer, Mini-Symposium on “Developmental Neurobiology and Pediatric Brain Tumors”, 2010 Canadian
Neuro-Oncology meeting, Ontario
Organizer and Session Chair: Pediatric Low Grade Gliomas, ISPNO Toronto, Canada
Session Chair, Society for Neuro-Oncology Annual Meeting, Washington, DC.
Organizer and Session Chair: Advances in Intraocular Pathology, American Association of Ophthalmic
Oncologists and Pathologists Companion Meeting at USCAP, Baltimore, MD
Planning Committee Member: SNO Pediatric Neuro-Oncology Basic and Translational Research Conference,
Fort Lauderdale, FL
Session Chair, Neuropathology, United States and Canadian Academy of Pathology (USCAP), Baltimore, MD
Session Chair, American Association of Neuropathology Annual Meeting, Portland, OR
Organizer, Eastern Ophthalmic Pathology Society Annual Meeting, Baltimore MD
Session Chair, Retinoblastoma, ARVO Annual Meeting, Denver, CO
Session Chair, Cornea-Conjunctiva, Joint VZS-EOPS Meeting, Charlston, SC
Consultantships:
2003-2005
Consultant for Genentech Corp
2005-2010
Consultant for Stemline Therapeutics
2012
Consultant for PanOptica
2012-2013
Consultant for GrayBug
Committees/Review Groups Outside JHU:
2002
Invited Pathology Reviewer, NCI Neurooncology Mouse Models Forum
2003-2006
Co-Chair, Pathology and Tissue Committee, New Approaches to Brain Tumor Therapy (NABTT)
Consortium
2004-2006
Scientific Review Council Member. Cure Autism Now (CAN) Foundation
2004
Brain Tumor Funders’ Collaborative Panel on New Glioma Therapies
2005-2006
American Association of Neuropathology Awards Committee Member
2006-present Society for Neuro-Oncology Annual Meeting Scientific and Program Planning Committees
2008-2014
Children’s Brain Tumor Foundation Annual Benefit Committee Member
2010-present Children’s Oncology Group, CNS Disease Committee Member
2010-present Children’s Oncology Group, Co-director, Low Grade Astrocytoma Subcommittee,
2011
International Society for Ocular Oncology Annual Meeting, Scientific Planning Committee Member
2012-present Children’s Oncology Group ACNS1221 Study Committee
2014-present International Society of Pediatric Neurooncology, Scientific Review Committee Member
2014
External reviewer, Molecular Pathology/Blue book program, IARC, LYON
2014
Invited Participant, WHOs NEXT conference on molecular neuropathology, Haarlem, Netherlands
2015
Consensus committee, WHO CNS Tumor Classification 4th edition update, Heidelberg, Germany
2015-present Children’s Oncology Group ACNS1422 Study Committee
RECOGNITION
33
Awards and Honors:
1987
National Merit Scholar 1987
1987
University of Texas at Austin: Phi Beta Kappa, Summa Cum Laude
1987
UT Southwestern Medical School; Honors in Pathology, Urology, Medicine
1987-1988
University of Texas Junior Fellow
1988-1989
Deutches Akademisches Austauschdienst Graduate Fellow
1992-1997
March of Dimes Graduate Fellow 19
1996-1997
Merck MSTP Fellow 19
2000-2003
Howard Hughes Postdoctoral Research Fellowship for Physicians
2001-2005
Burroughs Wellcome Fund Career Award
2004
Jean D Wilson Distinguished Alumni Lecturer, UT Southwestern MSTP,
2005
Lucien J. Rubenstain Award for Best Paper in Neuro-oncology, AANP Meeting
2007
Genentech Translational Research Award (with Xing Fan), SNO Annual Meeting
2010
Elected American Society for Clinical Investigation Member
2012
Distinguished Visiting Professor, Wills Eye Institute
2013-2015
Distinguished Visiting Professor, Dalian Medical University, China
2014-2015
Secretary, Eastern Ophthalmic Pathology Society
2015
Elected to American Association of University Pathologists (Pluto Society)
Invited Talks/Panels: (*CME credit given)
*January 2001. Pathology Grand Rounds, Johns Hopkins University “Medulloblastoma: of Mice and Men”
*September 2002. Neurosurgery Grand Rounds, Johns Hopkins University
“Medulloblastoma Pathology and Genetics”
January 2003. Carnegie Institution of Washington, Baltimore, MD
“Genetics of Medulloblastoma: Cerebellar Development Gone Awry"
February 2003. Glioma Epidemiology Workshop, National Cancer Institute, MD
“Issues and Challenges in the Histopathological Classification of Gliomas”
*July 2003. Medulloblastoma Workshop, XVth International Congress of Neuropathology, Turin, Italy “Murine
Medulloblastoma Models”
*October 2003. Brain Club Lecture Series, St. Jude Hospital, Memphis, TN
“Medulloblastoma Genetics: Development Gone Awry”
*March 2004. Department of Pathology, University of Washington, Seattle, WA
“Development Gone Awry: Pathology and Genetics of Medulloblastoma”
*June 2004. Special Course on Brain Tumors, American Assoc. of Neuropathology Annual Meeting, Cleveland, OH.
“Medulloblastoma and AT/RT”
*July 2004 Neurosurgery Grand Rounds, Johns Hopkins University
“Notch Signaling in Medulloblastoma/PNET”
September 2004. MSTP Program Jean D Wilson Distinguished Alumni Lecturer. UT Southwestern Medical School,
Dallas, TX. “Pathology and Genetic of Medulloblastoma: From Microscope to Bench to Bedside”
October 2004. Brain Tumor Seminar Series, Duke University, Durham, NC
“Pathology and Genetics of Medulloblastoma”
*November 2004. Education Day Symposium, IXth Annual Meeting, Society for Neuro-Oncology, Toronto
“Medulloblastoma Pathology”
34
December 2004. University of Texas Merck Scholars Symposium, Boston, MA
“Notch1 and Notch2 have opposite effects on embryonal brain tumor growth”
*October 2005. Molecular Pharmacology Seminar Series, Memorial Sloan Kettering Cancer Center, New York, NY
“Can We Target Cancer Stem Cells? Using Notch Inhibitors to Treat Brain Tumors”
*November 2005. Pathology Grand Rounds, Johns Hopkins University
“Notch, Hedgehog, and Brain Tumor Stem Cells”
*November 2005. Pathology Grand Rounds, U Pennsylvania, Philadelphia, PA
“The Role of Notch Signaling in Brain Tumors Progression and Tumor Stem Cells”
*January 2006. Pathology Grand Rounds, Massachusetts General Hospital, Boston, MA
“Medulloblastoma Progression, Notch Signaling and Tumor Stem Cells”
March 2006. Biology Education Session, Children’s Oncology Group Semi-annual Meeting, Chicago, IL. “Targeting
the Notch Pathway in Medulloblastoma”
April 2006. Notch, Hedgehog and Wnt Symposium, AACR Annual Meeting, Washington, DC. “Targeting the Notch
Pathway in Brain Tumors” (Replacing Dr. Clevers)
April 2006. Notch Signaling Symposium, New York Academy of Sciences, NY
“Notch Signaling and the Initiation and Growth of Brain Tumors”
*May 2006. Pathology Grand Rounds, Ohio State University, Columbus, OH
“Targeting Developmental Signaling Pathways in Medulloblastoma”
July 2006. Neural Differentiation and Brain Tumors Course, Cold Spring Harbor Laboratory,
“Neuronal/Embryonal Brain Tumors”
*September 2006. XVIth International Congress of Neuropathology, San Francisco, CA
“Targeting the Notch Signalling Pathway in Medulloblastoma”
September 2006. German Neuropathology Society Annual Meeting, Mannheim
“Targeting Developmental Signaling Pathways in Brain Tumors”
*October 2006. Texas Children’s Cancer Center Research Seminar Series, Houston, TX
“Medulloblastoma: From Microscopic Subtype to Molecular Activity”
*October 2006. Biosymposia: Diagnosis/Therapeutic Discovery in Neuro-Oncology, TX
“Targeting the Notch Pathway in Stem-Like Embryonal Brain Tumor Cells”
December 2006. Labatt BTRC/Hospital for Sick Children, Toronto, Canada
“Targeting Developmental Signaling Pathways in Brain Tumors”
*April 2007. American Association of Neuropathology Annual Meeting, Washington DC
“Controversies in Brain Tumor Stem Cells”
June 2007. Hermalin Brain Tumor Center, Detroit, MI
“Targeting Stem-like Cells in Brain Tumors Using Hedgehog and Notch Inhibitors”
*September 2007. Columbus Children’s Hospital Brain Tumor Symposium, OH
“Pathobiology of Medulloblastoma”
35
October 2007. Johns Hopkins University Brain Tumor Research Series, Baltimore, MD
“Targeting Stem-Like Cells in Brain Tumors”
*February 2008. MD Anderson Pediatric Oncology Seminar Series, Houston, TX
“Targeting Stem-like Cells in Malignant Brain Tumors Using Hedgehog and Notch Blockade”
February 2008. University of Lund Molecular Pathology Research Series, Sweden
“Notch Signaling in Malignant Brain Tumors”
May 2008. Johns Hopkins Molecular and Comparative Pathobiology Research Series
“Notch Signaling in Murine and Human Brain Tumors”
August 2008. Neural Differentiation and Brain Tumors Course, Cold Spring Harbor Laboratory,
“Developmental Signaling Pathways, Stem Cells, and Brain Tumors”
*September 2008. 7th International Updates in Neuro-Oncology, Baltimore, MD.
“Notch Signaling and Brain Tumor Stem Cells”
*September 2008. CTEP Early Drug Development Meeting, Bethesda, MD.
“Identification of Brain Tumor Cancer Stem Cells”
October 2008. Notch and Cancer Meeting, Athens, Greece.
“Induction of Brain and Eye Tumors by Notch3”
October 2008. UT Southwestern Pathology Seminar Series, Dallas, TX
“Notch and Hedgehog Are Required in Stem-Like Brain Tumor Cells”
*November 2008. Memorial Sloan Kettering Cancer Center Pathology Grand Rounds, New York, NY
“Pediatric Brain Tumors: Advances in Pathology and Genetics”
January 2009. Visiting Scientist, AVEO Pharmaceuticals, Boston, MA
“Notch Signaling and Tumors of the Brain and Eye”
*February 2009. Neurooncology Seminar Series Distinguished Speaker, Washington University, St. Louis “Stem
Cells, Developmental Signaling Cascades, and Brain Tumors”
*March 2009. AAOP Companion Society Meeting (USCAP), Boston, MA
“Advances in Orbital Neuropathology”
*April 2009. JHU Oncology Center Biology of Cancer Series, Baltimore, MD
“Notch Signaling and Tumors of the Brain and Eye”
*May 2009. ARVO Ocular Oncology Course, Ft. Lauderdale, FL
“Notch Signaling in Ocular Development and Tumorigenesis”
May 2009. JHU Department of Cell Biology Seminar Series, Baltimore, MD
“Notch and Hedgehog in Brain Tumors”
June 2009. Low Grade Astrocytoma In Early Life Conference 2009, Nottingham, England.
“BRAF in pediatric low grade gliomas: diagnostic marker, therapeutic target, or both?”
Sept 2009. NYU Neuro-Oncology Research Seminar, New York, NY
“BRAF Activation in Pediatric Low-Grade Gliomas”
Sept 2009. Carnegie Institution Department of Embryology Seminar Series, Baltimore, MD
36
“Notch Signaling and Tumors of Brain and Eye”
Oct 2009. Society for Neuro-Oncology Annual Meeting, New Orleans, LA
* “Crosstalk between Notch and Hedgehog in medulloblastoma and other brain tumors - the potential for therapeutic
resistance”
Dec 2009. AACR Biology and Genetics of Brian Tumors, San Diego, CA
* “Cellular and Molecular Origin of Embryonal Brain Tumors”
*March 2010. American Association of Ophthalmic Pathologists Companion Meeting at USCAP, Washington, DC.
“Squamous and Sebaceous Lesions of Conjunctiva - Advances in Immunohistochemical and Molecular Markers”
May 2010. The 18th International Conference on Brain Tumor Research and Therapy, Travemunde, Germany.
“Differing oncogenic potentials of Notch 1, Notch 2 and Notch 3 in optic gliomas”
July 2010. Neural Differentiation and Brain Tumors Course, Cold Spring Harbor, NY
“Developmental Signaling Pathways in Brain Tumors”
July 2010. 9th International Updates in Neuro-Oncology, Cortona, Italy
“Hypoxia, Notch and Stem-Like Glioma Cells”
August 2010. Neurosurgery Grand Rounds, Johns Hopkins University
* “Notch and Brain Tumors”
Sept 2010. AFIP Ophthalmic Pathology Course, Washington, DC.
* “Pathology of Optic Nerve”
Sept 2010. SKCCC Translational Research Conference, Baltimore, MD
* “The Role of Notch and Brain and Eye Tumors”
Sept 2010. Cleveland Clinic Foundation, Dept. of Stem Cell Biology, Cleveland, OH
“The Role of Notch and Brain and Eye Tumors”
Nov 2010. SNO Education Day/Mouse Models of Cancer Consortium, Montreal, Canada
“Notch3 Activation Promotes Site-Specific Invasive Glioma Formation”
Dec 2010. Grand Rounds, St. Jude Children’s Research Hospital, Memphis, TN
* “Modeling Pediatric Gliomas”
Dec 2010. Taipei Brain Tumor Symposium, Taipei, Taiwan
“BRAF alterations and senescence in pediatric low grade gliomas”
“Mechanisms of therapeutic resistance in glioblastoma: Notch-Hedgehog Crosstalk”
“Site specific glioma induction by Notch3”
“Using human neural stem cells to model brain tumors”
April 2011. American Society of Pediatric Hematology/Oncology Annual Meeting, Baltimore, MD
* “BRAF in Pediatric Low Grade Glioma – Pathogenesis and Treatment”
May 2011. Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Ft. Lauderdale, FL
* “Notch3 Promotes Invasive Glioma Formation in the Optic Nerve and Retina but not the Brain”
June 2011. Annual NF Conference, Jackson, WY. (Keynote Speaker)
“Molecular biology of sporadic astrocytoma - emerging links to Neurofibromatosis"
September 2011. Neural Tumors Research Forum, Cincinnati Children's Hospital Medical Center
37
“The Role of Notch signaling in the initiation and growth of brain tumors”
September 2011. Children’s Oncology Group (COG) Annual Meeting, Atlanta, GA
“Biology of pediatric low grade gliomas”
February 2012. Visiting Professor, Uniformed Services University of Health Sciences, Department of Ophthalmology
* “Pathology and genetics of optic nerve lesions”
February 2012. 15th Biennial Canadian Neuro-Oncology Meeting, Vancouver, Canada
* “Current Trends and Future Directions in Cancer Stem Cells Science”
February 2012. NBCNS/BioCARE symposium on pediatric neuroblastoma and CNS tumors, Lund, Sweden
"Recent advances in genetics and treatment of pediatric low grade gliomas"
*March 2012. Washington National Eye Center Anterior Segment Symposium. Wahsington, DC
“Rosai Dorfman Disease of the Ocular Surface”
*May 2012. ARVO Ocular Oncology Course, Ft. Lauderdale, FL.
“Targeting Notch in Uveal Melanoma”
June 2012. The 19th International Conference on Brain Tumor Research and Therapy, Niagara, Canada.
“Neoplastic cells are a rare component in human glioblastoma microvasculature.”
July 2012. Neural Differentiation and Brain Tumors Course, Cold Spring Harbor, NY.
“Notch Signaling in Brain Tumors”
October 2012. University of Catanzaro, Italy “Notch Signaling in Brain Tumors”
*December 2012. Distinguished Visiting Professor, Wills Eye Hospital, Philadelphia PA
“Advances in Ocular Tumor Genetics”
*February 2013. Ophthalmology Grand Rounds, Uniformed Services University of Health Sciences, Washington DC
“Advances in Genetics and Pathology of Uveal Melanoma”
*February 2013. Pathology Grand Rounds, Johns Hopkins University, Baltimore, MD.
“Notch Signaling in Brain Tumors”
*March 2013. American Association of Ophthalmic Pathologists and Oncologist Companion Meeting at USCAP, Baltimore,
MD. “Classification of Melanocytic Conjunctival Lesions and Emerging Eyelid Entities”
*March 2013. USCAP Ophthalmic Pathology Specialty Conference, Baltimore, MD. “An unusual intraocular tumor”
*March 2013. USCAP Neuropathology Specialty Conference, Baltimore, MD. “Nodular Medulloblastoma”
*March 2013. Moffitt Cancer Center State of the Art Neurooncology Conference, Clearwater Beach, FL
“Molecular and Pathological Advances in Gliomas”
June 2013. MISAM Conference, Montreal, Canada
“Glioblastoma Vessels – Where Do They Come From?”
*June 2013. AANP Annual Meeting Plenary Session, Charleston, SC
“Molecular Medulloblastoma Classification”
July 2013. Dalian Medical University, China
“Pathology At Johns Hopkins”
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“Overview of CNS Tumor Classification”
“Advances in NeuroOncology – Focus on Genetics and Cancer Stem Cells”
September 2013. King Khaled Eye Specialist Hospital, Saudi Arabia
“Molecular advances in Ocular Surface Squamous Neoplasia”
“Notch signaling in uveal melanoma”
“Pathology and Genetics of Optic Nerve Tumors”
January 2014, MIM, St. Moritz
“Targeting Glutamine Metabolism In Medulloblastoma”
March 2014, North American Neuro-Ophthalmology Society (NANOS) Meeting, Puerto Rico
Invited pathology reviewer
March 2014, Wuhan Forum of Translational Medicine, China
“Targeting Notch In Brain Tumors”
*April 2014, Moffit State of the Art Neuro-oncology Conference, St. Petersburg, FL
“Advances in molecular neuropathology”
*June 2014, ASCO Annual Meeting, Chicago IL
“Molecular Classification of Medulloblastoma-Driving Therapeutic Development”
*June 2014 AANP Annual Meeting, Portland OR
“Molecular Classification of Medulloblastoma”
July 2014 20th International Conference on Brain Tumor Research, Lake Tahoe, CA
“Targeting Glutamine Metabolism In A Novel Group 3 Medulloblastoma model”
August 2014. Neural Differentiation and Brain Tumors Course, Cold Spring Harbor, NY.
“Notch Signaling in Brain Tumors”
August 2014. Dalian Medical University, China
“Interesting Ophthalmic Infections”
“Advances in CNS Tumor Classification”
“Advances in Ocular Oncology”
Sept 2014. 18th International Congress of Neuropathology, Rio de Janeiro, Brazil
“What neuropathologists should know about ophthalmic pathology”
Oct 2014. Second Annual Pathology Educational Symposium, Baltimore, MD
“Common Brain and Eye Specimens”
Oct 2014. Laboratory of Pathology Research Forum, NIH, Washington, DC
“The role of Notch and other developmental signaling pathways in brain and eye tumors”
March 2015. Saudi Ophthalmology Society Annual Meeting, Riyadh
“Pathology of selected eyelid lesions”
“Orbital and eye involvement in systemic vasculitis”
“What is IgG4 disease?”
“Pathology and molecular pathology of retinoblastoma”
“Pathology of degenerative diseases of the retina”
“Optic nerve disease”
*May 2015. ARVO Annual Meeting, Denver CO
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“Lessons from glial tumors of the eye”
*June 2015. AANP Annual Meeting, Denver CO
“Ophthalmic pathology for the neuropathologist”
August 2015 International Forum on Central Nervous System Tumors, Chongqing, China
“Advances in the classification and treatment of medulloblastoma”
October 2015 Childrens Oncology Group Fall Meeting, Dallas TX
“Making sense of molecular data in neuro-oncology”
October 2015. Dalian Medical University, China
“Pathology of Degenerative Retinal Disease”
“Advances in CNS Tumor Classification”
December 2015. Stem Cells and Cancer Symposium, MedImmune, Gaithersburg, MD
“Targeting Notch in Malignant Brain Tumor Stem Cells”
December 2015. Northwestern Brain Tumor Institute, Chicago, IL
“Targeting Notch and Hedgehog in Malignant Brain Tumor Stem Cells”
*February 2016. World Ophthalmology Congress, Guadalajara, Mexico
“Cryptosporidia Keratitis”
“Ocular Erdheim Chester Disease”
“Intraocular NK/T Cell Lymphoma”
February 2016, American Association of University Pathologists (PLUTO society) Annual Meeting, Puerto Rico
“Notch in Brain and Eye Tumors”
April 2016, 21st International Conference on Brain Tumor Research (Asilomar meeting), Okinawa, Japan
“ATRX Reduction Promotes Chemoresistance and Xenograft Growth in Glioblastoma”
June 2016, First Annual Childrens Cancer Foundation Research Symposium, Landover MD
“Advances in pediatric brain tumor research”
July 2016, Niigata Brain Research Institute Summer Research Seminar, Niigata, Japan
“Targeting stem cell pathways such as Notch in malignant brain tumors”
August 2016, Niigata Neuroscience Conference, Niigata, Japan
“CNS tumor classification- Overview and updates”
August 2016, Neurosurgery Research Meeting, Niigata, Japan
“Using human neural stem cells to build brain tumor models”
August 2016, Keio University, Tokyo, Japan
“Using human neural stem cells to build brain tumor models”
September 2016, Frontiers In Academic Pathology, Icahn School of Medicine at Mount Sinai, New York
“Glial Tumors of the Optic Nerve and Retina”
September 2016, Bayer AG, Wuppertal Germany, “Using Autopsy Eyes to Study Retinal Disease”
September 2016, Universitat Dusseldorf, Germany “Modeling Brain Tumors Using Human Neural Stem Cells”
September 2016, XXXI International Congress of the IAP, Cologne, Germany “Update on Retinoblastomas”
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September 2016, XXXI International Congress of the IAP, Cologne, Germany “Two Interesting Ocular Lymphomas”
41