Download Exclusion zone for harmful bacteria!

Exclusion zone for
harmful bacteria!
®
Aviguard
FOR BROILERS, LAYERS, TURKEYS AND GAMEBIRDS
®
Where to use Aviguard
Aviguard should be used whenever
there is a need for establishment
or re-establishment of the normal
intestinal bacteria.
1.In day old chicks and poults – Aviguard is
sprayed on the birds to establish optimal intestinal
colonisation by beneficial bacteria, helping prevent colonisation by
pathogenic bacteria such as Salmonella, E.coli and Clostridium
perfringens. The natural beneficial bacteria in Aviguard attach to specific
sites in the gut and colonise it, preventing pathogenic strains taking hold.
2. In older birds – Aviguard may be given in the drinking water to
restore or re-establish the beneficial intestinal flora in the following
situations:
– After antibiotic treatment. One dose is given 48 hours after
completion of treatment to re-colonise the gut with beneficial bacteria
– To protect against infection by Salmonella, pathogenic strains of
E.coli and Clostridium perfringens
– For the prevention of necrotic enteritis
– To manage antibiotic resistance
– At any time of stress in the bird’s life including relocation, peak of
lay, forced moulting, bitting etc, when resistance to disease may
be reduced
– To improve litter quality
– Aviguard should be used for at least three consecutive crop cycles or
every six weeks initially to allow build up of beneficial bacteria within
the environment
Natural
immunity
• The gut and its resident bacterial flora play an important role in the
development of the immune system and resistance to disease1
• Under natural breeding conditions chicks and poults obtain their
gut flora from their parents and the environment
The modern reality
• Modern breeding conditions involve a sanitised environment
where eggs are hatched separately from the mother
• This causes a delay in the establishment of intestinal flora and
significantly increases susceptibility to pathogenic bacteria and
subsequent disease
The solution:
Aviguard
®
• A unique composition of over 200 species
of natural beneficial gut bacteria from healthy,
pathogen free adult birds
• These quickly colonise the whole intestine
• Used to establish ‘normal’ gut bacteria in chickens, turkeys and
gamebirds naturally boosting the immune system and providing
increased resistance to disease
Why is Aviguard different?
®
• Aviguard works through competitive exclusion,
a process by which normal intestinal bacteria
establish themselves, colonising the gut wall and
creating exclusion zones. This prevents transient
disease causing bacteria from becoming established
Competitive Exclusion in the gut
With Aviguard
Without Aviguard
• Aviguard is not a probiotic. Probiotics contain only
a small number of bacteria which are transient and
quickly pass through the gut. Aviguard contains over
200 species of bacteria which actively colonise the
gut resulting in a stable flora
• Optimal colonization is achieved within 48 hours
• Protects the bird by excluding pathogenic bacteria such
as Salmonella, E.coli and Clostridium perfringens
• Can help reduce the requirement for antibiotic treatment
Key:
•
Aviguard friendly bacteria
•
Potentially harmful bacteria
®
How does Aviguard work?
Intestinal Lumen
Dense bacterial barrier
Aviguard has 5 proposed modes of action:
1. Physical – attaches to the gut wall preventing the establishment of
potentially disease-causing bacteria
2. Biological – produces a low oxygen environment which harmful
bacteria do not like
3. Chemical – reduces the pH, making the environment more acidic
which inhibits intestinal pathogens
4. Biochemical – many natural gut bacteria produce antibiotic-like
substances, while others produce chemicals that inhibit bacterial
reproduction
5. Nutritional – normal bacteria compete against harmful bacteria
for nutrients
Intestinal wall
Schering Plough provide
innovative solutions for poultry
Schering-Plough is committed to the poultry industry and to maximising intestinal health
Reference
1. Haghigi HR et al. Clin Diagn Lab Immunol
2005; 12(12): 1387-1392.
Aviguard contains live commensal bacteria.
Aviguard is a trademark of Schering-Plough.
Further information is available from:
Schering-Plough Animal Health
Division of Schering-Plough Ltd
Breakspear Road South, Harefield,
Uxbridge, Middlesex UB9 6LS.