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John A. Moran Eye Center
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2015 FOCUS
The John A. Moran Eye Center is an integral part of University of Utah
Health Care, which for five years running has won the University Health
System Consortium’s Quality Leadership Award and continues to rank
among the nation’s top academic medical centers. This winning streak
is matched by only one other health system in the US.
John A. Moran Eye Center | University of Utah Health Care
John A. Moran Eye Center
65 Mario Capecchi Drive
Salt Lake City, UT 84132
801-581-2352
University of Utah Health Care
Moran Advisory Council
ROBERT F BENNET T
Falls Church, Virginia
JOHN BLOOMBERG
La Jolla, California
REED BRINTON
Salt Lake City, Utah
AL AN S CR ANDALL, MD
John A. Moran Eye Center
IAN CUMMING
Jackson Hole, Wyoming
SPENCER F ECCLES
Salt Lake City, Utah
WAYNE IMBRESCIA
John A. Moran Eye Center
CL AUDIA S LUT TRELL
Salt Lake City, Utah
JOHN A MOR AN
Palm Beach, Florida
R ANDALL J OL SON, MD
John A. Moran Eye Center
LYNN WARD
John A. Moran Eye Center
NORM A Z ABRISKIE, MD
John A. Moran Eye Center
2015
JOHN A. MORAN EYE CENTER
FOCUS
Official Publication of the John A. Moran Eye Center
University of Utah Health Care, Salt Lake City, Utah 84132
John A. Moran Eye Center
65 Mario Capecchi Drive
Salt Lake City, UT 84132
801-581-2352
EDITOR
Linda Bult, Communications Specialist
EXTERNAL REL ATIONS TEAM/CONTRIBUTORS
Tawnja Carballo, Development Specialist
Deedra Lambert, Development Specialist
Kirsten Mallik, Director of Development
Shawn Nelson, Marketing Manager
Esther Pomeroy, Communications Manager
Heidi Reid, Major Gifts Officer
Lynn Ward, Executive Director, External Relations
OUTREACH DIVISION
Joshua Cooper, Office Assistant
Julie Crandall, Past Project Coordinator
Tara Kisow, Program Coordinator
Lori McCoy, Project Coordinator
Michael Yei, Manager
CONSULTANTS
Virginia Rainey, Editor, Writer
Gordon Vetas, Intern
GRAPHIC DESIGN
Spatafore Design
PHOTOGRAPHY
Michael Schoenfeld, major portrait photography
Jeff Allred
Amy Baxter
Lori Garfield
Matthew Hepworth
Brian McCoy
Patrick Reddish
Liz Straits
PRINTING
Printers Inc. Salt Lake City, Utah
A special thanks to the many hard working Moran Eye Center
employees, management, health care workers, physicians,
patients, and researchers who generously contributed their
time and talent to make this publication possible. Special
thanks also to Kay Spatafore and Lori Garfield, designers.
For more information about the Moran Eye Center, visit us
online at moraneyecenter.org. Follow us on Facebook at Moran
Eye Center and on Twitter @MoranEyeCenter. Requests
for additional copies of this publication may be sent to the
following: Communications Manager, Moran Eye Center,
65 Mario Capecchi Drive, Salt Lake City, Utah 84132.
©2015 John A. Moran Eye Center. All rights reserved. The
Moran Eye Center does not assume responsibility for any
representation therein, nor the quality or deliverability of the
product themselves. Reproductions of articles or photographs,
in whole or in part, contained herein are prohibited without
express written consent of the publisher, unless otherwise stated.
2015
2
Message from the Chair
The Ripple Effect
4
Go-to Experts in IOL Research
for the World
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14
16
Hope in Sight Campaign 2012-2015
18
20
22
Game-changer for Gracie
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25
26
28
30
32
34
36
Micronesia
Awards 2014
David Krizaj, PhD, Discovers Glaucoma
Treatments May Also Help Soldiers with
Blast Trauma
Specializing in Pint-size Patients
Changing Lives,
Transforming Communities
What it Takes
Work & Family with a Global Perspective
Local Outreach in a Forgotten Land
Charity Surgery Day
The Untold Story
Residents and Fellows 2014-2015
Meet Eileen Hwang, MD, PhD:
Scientific, Curious, Independent
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40
42
47
48
51
53
59
63
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Research Prodigy to World Expert
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77
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Grand Rounds 2014
National and International
Presentations 2014
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“From Darkness to Light”
The Art of Contact Lens Fitting
Utah Lions Eye Bank
Community Clinics 2015
Ophthalmologists 2015
Optometrists 2015
Research Team 2015
Adjunct Volunteer Faculty 2015
Donors 2014
Industry Leadership and Service 2014
Awards, Honors, and Appointments 2014
Clinical Trials 2014
Technology Commercialization and
Intellectual Property/Patents 2014
Published Research 2014
Research Grants and Contracts 2014
Contents
Message from the Chair
THE RIPPLE EFFECT
The John A. Moran Eye Center was designed to encourage collaboration. Our research
and clinical care pavilions are connected by bridges that promote the exchange of ideas
and information, making it easy for researchers and physicians to work together to better
understand blinding diseases and improve patient outcomes.
But our focus on collaboration doesn’t end within Moran. Over the years, our doctors
and scientists have worked with an array of partners and institutions, both in the US and
around the world, to improve products, processes, and patient outcomes. Our ideas
and innovations have rippled from home to remote areas of the globe and touched the
lives of millions of people, restoring sight and transforming communities.
Experts at Moran are widely considered thought leaders who have cultivated a broad
circle of influence, advancing research and patient care industry-wide. In FOCUS 2015,
you will read about some of their work, including the following:
The Intermountain Ocular Research Center, one of the most influential
intra-ocular lens research labs in the world.
Moran’s Outreach Initiative, a model for sustainable eye care in underserved
communities domestically and abroad.
Our Resident and Fellow Training and Education Program. Internationally
respected and innovative, we are graduating some of the most knowledgeable
and best-prepared ophthalmologists.
Trailblazing research initiatives that are hastening the pace at which discoveries
become medicine.
Caring experts who specialize in the toughest cases, affecting individuals and
families on a daily basis.
I never get tired of saying thank you to the patients, study participants, co-investigators,
alumni, and generous donors who believe in the Moran Eye Center and help advance
our research and humanitarian efforts. They spread the word about our programs and
provide the support that makes our work possible. With their assistance, we are tossing
our ideas into the sea of ophthalmology and changing the landscape as we impact the
future of vision care.
2
Sincerely,
Randall J Olson, MD
Professor and Chair, Department of Ophthalmology and Visual Sciences;
CEO, John A. Moran Eye Center, University of Utah
“When you drop any new idea in the pond of the
world, you get a ripple effect.” —Joel A. Barker
3
Go-to Experts in IOL Research for the World
THE RIPPLE EFFECT
4
Perched on the foothills overlooking the Salt Lake Valley, Moran’s Intermountain
Ocular Research Center sits at the crossroads of global research, education, and
patient care. At its helm, Nick Mamalis, MD, and Liliana Werner, MD, PhD, have
revolutionized intraocular lens (IOL) implants, design, and surgical techniques.
They advise and educate a worldwide network of ophthalmic surgeons, clinical
researchers, and intraocular lens designers. And every day, everything they do
ripples out into the community by helping to restore vision to millions of patients.
To fully understand the impact that Mamalis and Werner have on cataract surgery
outcomes, consider this: last year, over 6 million people throughout the world
received intraocular lens implants during cataract surgery—the most commonly
performed surgery today—and practically every one of those lenses or prototypes
was tested by the Mamalis Werner lab.
Pioneers
For the past 30 years, Moran’s Intermountain
Ocular Research Center has emerged as the go-to
center for new IOL technologies and design, for
IOL-related complications, for surgically removed
IOLs, and for ocular tissue with lens-induced disease. “There are very few labs in the entire world
doing the kind of work we do,” says Mamalis.
“When we began in the early 1980s, there were no
centers doing any IOL analysis or research—we
were the pioneers, and today we are doing the ultimate in translational research. As a surgeon, what
excites me the most is actually being able to take
an implant in the very early design phases, work to
make it a better implant, get it approved, and put it
in my patient’s eyes.”
Dr. Nick Mamalis, MD, director of the Ophthalmic Pathology
Laboratory and co-director of the Intermountain Ocular
Research Center, specializes in comprehensive ophthalmology,
including cataract and other anterior ocular surgeries, and
he performs research in intraocular lenses, ocular pathology,
and postoperative inflammation. Dr. Liliana Werner, MD,
PhD, co-director of the Intermountain Ocular Research Center,
specializes in biodevices research and lens design, including
materials, surface modifications, and interactions between
ocular implants and ocular tissue.
The two receive many honors and awards for their dynamic
work: Mamalis is the 2013 Binkhorst Medal winner, a
prestigious honor presented by the American Society of Cataract
and Refractive Surgery (ASCRS), and editor of the Journal of
Cataract and Refractive Surgery (JCRS). Werner is coeditor
of a column in EyeWorld magazine, member of the editorial
board of the JCRS, and consistently wins “Best-Paper” awards
for her studies and videos detailing the latest IOL research and
discoveries. Both are sought-after speakers worldwide.
Combined Experience
Lens manufacturers partner with the Intermountain Ocular Research Center because of the team’s
combined expertise: both Mamalis and Werner
specialize in lens design, materials, and surface
modifications, such as the shape and size of the
optics—the part of the lens that focuses on the
retina—and the haptics—small filaments connected to the optics that hold the lens in place in
the eye. Also, they look at how these materials
interact with ocular tissue.
Master Sleuths
Despite the technological advances in cataract
surgery, challenges of all kinds present themselves.
Lens design flaws—not to mention the occasional
baffling mystery—find their way to the Mamalis
Werner lab.
“While surgically removing an implant is relatively
uncommon—less than one percent—the impact
is still huge,” says Werner. “Since 2000, our lab
has received over 8000 explanted IOLs from all
over the world needing to be evaluated for flaws
or complications; some very puzzling.” The team
examines the history of each lens, identifies flaws
and successes, and prepares a report for every
lens. Findings help doctors around the world
make better surgical and lens choices for each
of their patients and help lens manufacturers
improve their designs.
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Never, Ever Routine
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The center also functions as a registry for removed
IOLs and eye tissue with lens-induced disease.
Packages arrive each week—malfunctioning lenses
from manufacturers, calcified lenses, opacified
lenses—even actual donated eyes with lenses still
in them. “We honestly don’t always know what the
day will bring. I may get a lens that is so interesting, I want to stop everything and dedicate myself
to that. It is so exciting,” says Werner. “One day,
we received a box with various explanted IOLs
that had mysteriously turned white. Scrupulous detective work led us to discover that the
lenses had been stored near pesticides and had
absorbed some of the chemicals. Another day, a
surgeon from Brazil actually flew to Moran with
an explanted corneal implant in her carry-on
luggage for me to evaluate. Our work is never,
ever routine. I think if I improve anything—
from developing future lenses to figuring out a
problem—it doesn’t just impact one patient, but
so many people, including manufacturers and
ophthalmologists. If we can change one surgeon’s
thinking, we have helped all of his patients. I’m
very proud of that.”
“Liliana is the workhorse that keeps the
center going. She puts a lot of time into
writing protocols and reports and doing
analyses—the center certainly couldn’t
function without her. She is delightful to
work with.”
—Nick Mamalis, MD
TASS Task Force
Cataract surgery is one of the safest surgeries
performed today, but some post-operative
complications can occur. One day, in the late
1980s, Dr. Randall J Olson, chairman of the
Moran Eye Center received a call from a baffled
and concerned doctor who said all of his
Friday cataract patients developed tremendous
inflammation after surgery, and he wasn’t sure
why. Dr. Olson immediately contacted Dr.
Mamalis, and upon investigating the matter, they
discovered a heat-resistant toxin in the ultrasound
bath in which the instruments soaked during the
week. By Friday, this bacterial toxin formed on
the instruments causing patients’ raging postsurgery eye inflammation. As a result of this
finding, the American Society of Cataract and
Refractive Surgery (ASCRS) asked the lab to help
®
The Next
Big Thing
Corrective cataract lenses
have developed from a single
distance-only monofocal
lens, to a multifocal, which
corrects vision for near and
far, eliminating the need for
glasses. The bulk of what
the lab is working on now
is designing a truly accommodating implant that will
give patients clear, near,
intermediate, and distance
vision without compromising
their vision or breaking up the
light as it comes in. There are
also designs for implants that
actually have separate optics
that come together and go
apart to allow people to see
both near and distance clearly.
In addition, the lab is working on a lens with silicone oil
®
The FluidVision lens (PowerVision ) as well as the Synchrony lens (Visiogen )
are just two examples of accommodating intraocular lens designs evaluated in
the Mamalis Werner laboratory.
inside its haptics. The silicone
moves to the center of the
lens when the patient focuses
up close, changing the curvature of the lens and providing
near vision. When the patient
focuses far away, the silicone
moves to the periphery of
the lens where it won’t affect
the curvature of the lens,
similar to the way the normal
human lens works. And they
are working on a lens that
can have its corrective power
modified by an exchangeable
optic or even changed by a
laser, designed for a child,
for example, whose eyesight
changes as he or she grows.
evaluate unexplained inflammatory complications
following cataract surgery. So they developed
the Toxic Anterior Segment Syndrome (TASS)
task force. The task force gets calls from surgeons
worldwide asking for help with cases of post-op
inflammation, 80 percent of which, to this day,
are caused by problems with instrument cleaning
and sterilization.
Ripple Effect
“As a physician, one of our primary goals is to
give patients the best possible vision and to prevent vision loss. This is why we go into ophthalmology. There is extensive research in blinding
eye diseases like macular degeneration and other
diseases of the retina, but we don’t want to forget
that we also want to treat preventable blindness,
and that’s where our research comes in—cataracts
are a tremendous cause of preventable blindness,” says Mamalis. “We can better our surgical
techniques and better the implants that go into
providing the best possible vision for our patients’
eyes. But we could not have been doing the work
we do in a different setting. Moran is really unique
for a major research institution, and it all starts
with Dr. Randall Olson. He gives us the necessary
resources and allows us the independence and latitude to do the work that we see fit. It is amazing.”
7
“The ambiance in our lab is so
great. I can count on Nick to
be very stable and calm—that
helps because sometimes it
is very stressful—we have so
much to do.”
—Liliana Werner, MD, PhD
Cataract Surgery Then and Now
From post-World War II through the 1970s, cataract
surgery required removing the natural lens by making
a large incision, removing the cataract in one piece,
and applying multiple sutures. Patients suffered a
lengthy recovery, and after it all, still had to wear
thick “Coke bottle” glasses.
8
Drs. Nick Mamalis and Liliana Werner with
pathology/research fellow Aabid Farukhi, MD.
Since the 1980s, cataract surgery has improved markedly.
Sophisticated intraocular lenses are now placed directly
in the eye after a cataract is removed, allowing people to
have functional vision without having to wear thick glasses.
Implants were originally made of a stiff Plexiglas-like material.
Now, we have foldable lenses that can go into the eye
through a miniscule incision that doesn’t require sutures.
Surgical techniques have improved as well, from removing
cataracts manually to using ultrasound and lasers. All of
these improvements allow the patient to rapidly go back to
normal activity, often the day after surgery.
Debra Cole
“For me, it is extraordinary to see someone you love have a whole new level of
enjoyment of the universe. We watched
the World Cup together. She was gobsmacked: for the first time in her life,
she could actually see the ball in play.” —Peter Cole, Debra’s husband
One of My Happiest Patients
“Debra Cole is one of the most nearsighted patients I’ve had—
legally blind in her right eye—20/500 and 20/950 in her left, and
then she developed cataracts,” says Dr. Nick Mamalis. “But, she
is now one of my happiest patients.”
Fifty-four-year-old Cole has worn glasses
since age four. Without corrective lenses, all she could
see of the eye chart was the shape, the white box. “My
lenses were so thick—I never wore them out in public,”
says Cole. “I was very self-conscious as a child and
now. It’s been this way for most of my adult life—you
learn to get by.”
As chief financial officer of Deer Valley Corporation,
Cole’s work requires hours at a computer proofing
thousands of numbers and figures. “At the end of the
day, my whole body was exhausted, and it began to
affect my work,” says Cole. “I used eye drops just to
keep my eyes moist, drank lots of liquids and exercised,
and converted to a larger computer screen. And I
always had this fear that I might be viewed as less competent because of my vision. I avoided driving at night.”
Finally, in June of 2014, Cole was a candidate for
cataract surgery. The results were immediate and
astonishing. “My vision is amazingly clear. I see things
I’ve never seen before: the veins in an aspen leaf; birds
in the trees, in the sky, the detail and the color in their
feathers and beak; and fish and turtles down in the
water. Colors are more vivid. I see people differently—
details in their faces, the color of their eyes. I see detail
in movies. I’m no longer fatigued at the end of the day.
I can drive at night. And I have a new-found passion
for photography, cooking, and painting. It is amazing,”
says Cole, “I feel this incredible joy and exploration in
my life now.”
Peter and Debra Cole
9
Hope in Sight Campaign 2012-2015
Goals Achieved!
Succeeded and Exceeded!
We Succeeded—and Even Exceeded—
Our Goal of Raising $22.3 Million in Just Three Years
$25.3 Million Total Raised!
$3 Million Beyond
$22.3 Million Goal Achieved!
Outreach
In 2012 when we launched our Hope in Sight
fundraising campaign, we had ambitious goals
in mind—goals at the heart of our belief that no
one facing vision loss should be without hope,
understanding, or treatment.
Goal—$2.1 Million
To expand our fight against preventable
blindness through international education
and global and local charity care
Research
Goal—$7.8 Million
To support and grow our visual
science research
Center for
Translational Medicine
Goal—$12.4 Million
To pioneer a new drug development model in the
Center for Translational Medicine (CTM)
We needed $22.3 million to meet these goals,
and we are thrilled and humbled to announce
that we succeeded—and even exceeded our
goals—thanks to our strong campaign leadership
and more than 3,400 amazing donors. With their
support, we have made significant advances in
science, in new AMD therapies, and in our efforts
to treat preventable blindness in Utah and around
the world.
Thanks to Our Volunteer Leaders!
10
We are particularly grateful to our campaign leadership who championed the Hope in
Sight campaign. They hosted round tables and parties, attended our galas, and introduced
friends and associates to the visionary work of the Moran Eye Center. With their support, in
three short years we grew our donor base by 62 percent and our average gift by 181 percent.
Campaign Co-chairs
Honorary Chairs
Thomas D. Dee, III
Lawrence T. Dee and Janet T. Dee Foundation
William H. and Patricia W. Child
Lisa E. Eccles
Sharon Steele-McGee
A. Scott Anderson
President and CEO, Zions Bank
John H. Firmage, III
President, Firmco Financial Inc. and BMW of Murray
3
Transformational Years
While the three-plus decades that preceded Moran’s Hope in Sight
campaign saw one great leap after another, the past three years have
been nothing short of remarkable.
CTM
Moran’s CTM was created in 2010 as an efficient model for new
drug development. Focused on age-related macular degeneration
(AMD), we used CTM-designated campaign funds to open a clinical
research center and enrolled more than 1,500 patients in a genetic
study of the disease. The eye repository—a globally unmatched collection of donated human eye tissue—grew by nearly 2,000 pairs.
And, pharmaceutical giant Allergan, Inc. entered into a powerful
research collaboration with the CTM designed to maximize our
unique resources and their drug development experience to hasten
the pace at which new therapies can be introduced into the market. The partnership is meeting or exceeding all milestones, and to date, we
have confirmed that AMD is at least two distinct diseases—and we are identifying new drug targets for each. Generous campaign support
has enabled the CTM to accomplish in 12 months what usually takes several years and millions of dollars. We are hopeful that within
three years, we will have a new AMD treatment in clinical trials.
Research
The Hope in Sight campaign launched at a time when traditional funding for
scientific research was at risk. While Moran is currently seventh nationwide
in National Institutes of Health funding for ophthalmic science, the federal
research budget has been shrinking for the last 10 years. Campaign support
has enabled our research program to remain fully funded and focused on
finding cures for blinding eye disease. Researchers in Moran’s 16 labs have
made vital breakthroughs in understanding diseases like glaucoma, AMD,
retinitis pigmentosa, and retinopathy of prematurity. They have created new
forms of drug delivery, improved key surgical tools, and been involved in
dozens of high-profile clinical trials. And last year, the top two vision science
awards in the world were awarded to Moran researchers.
Outreach
Hope in Sight support has also transformed Moran’s Outreach Program. What
began as a few passionate doctors traveling overseas has become a coordinated
effort to send more than 30 medical providers to dozens of countries to train
ophthalmic surgeons and staff, annually. We now provide desperately needed
eye care to underserved communities as we help build or improve their health
systems. The sustainability of our model resides in our commitment to train
local medical providers. Each year, more than 16 surgeons from around the
world come to Moran for advanced training and then return home with skills
to vastly increase their patient volumes and train their own residents. We also
made a long-term commitment to the Navajo Nation in 2013, bringing vision
screenings, eyeglasses, and surgical care to the Native Americans living in the
Four Corners region of Utah. In addition, we conduct a twice-yearly Charity
Surgery Day that has become the model for Operation Sight, a national effort
to coordinate organizations and volunteer surgeons who wish to end cataract
blindness in the US.
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Hope in Sight Foundation Supporters—A Lasting Legacy
Many charitable foundations are created as a way for donors to support future generations, as
well as their own. Their gifts are a perfect fit for Moran’s research and outreach programs, which
also focus on long-term goals of improved treatment options and sustainable care. Below are
foundations that have supported our campaign at a level of $2,500 or above.
ARCS Foundation Inc., Utah Chapter
ASCRS Foundation
Bamberger-Allen Health and Education Foundation
John I. and Toni F. Bloomberg Foundation
Brindle Foundation
Burningham Foundation
Robert S. Carter Foundation, Inc.
The Castle Foundation
Cumming Foundation
Lawrence T. and Janet T. Dee Foundation
Thomas and Candace Dee Family Foundation
Dream Weaver Foundation
George S. and Dolores Doré Eccles Foundation
Willard L. Eccles Charitable Foundation
William and Fern England Foundation
Henry W. and Leslie M. Eskuche Foundation
Thomas H. and Carolyn L. Fey Family Foundation, Inc.
John B. and Geraldine W. Goddard Family Foundation
Val A. and Edith D. Green Foundation
The Huntsman Foundation
Johnson Foundation
Helen K. and Arthur E. Johnson Foundation
Judelson Family Foundation
KAT Charitable Foundation, Inc.
Ben B. and Iris M. Margolis Foundation
Herbert I. and Elsa B. Michael Foundation
Larry H. and Gail Miller Family Foundation
The Mark and Kathie Miller Foundation
Mitchell and June Morris Foundation
John and Marcia Price Family Foundation
Rafati Foundation
Raymond James Charitable Endowment Fund
Retina Research Foundation
Rothman Family Foundation
Ruvo Family Foundation
Peter and Nancy Salter Family Foundation
The Semnani Family Foundation
Harris H. and Amanda P. Simmons Foundation
Sam and Diane Stewart Family Foundation
The Donald J. Trump Foundation, Inc.
Wattis Dumke Foundation
Stephen A. Wynn Foundation
“As a long-time member of the John A. Moran Eye Center Advisory
Board, I am pleased that our foundation was able to help create tailormade space for the outstanding work of Dr. Gregory S. Hageman and
his team. We are delighted that Dr. Hageman is part of the world-class
faculty associated with Moran, and we hope our support will hasten the
development of therapies to address age-related macular degeneration.”
—Spencer F. Eccles, Chairman and CEO, George S. and Dolores Doré Eccles Foundation
Julie Crandall; Alan S. Crandall, MD;
Elizabeth Green; Val Green.
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Craig J. Chaya, MD; Alan S. Crandall, MD; the late Elizabeth
Johnson; Randall J Olson, MD; Geoffrey Tabin, MD, at a 2013
Moran event.
“When it comes to Moran, we have a long and trusting
relationship, so we all know that whatever the needs are,
they are worthy. I don’t hesitate to tell people facing vision
challenges, ‘this is where you have to go—there is no better
place in the country—so put your eyes in their hands.’”
—Val Green, President, Val A. and Edith D. Green Foundation
Outreach supporters gather at Moran’s
“See the Difference” celebration, June 28, 2014.
Pamela Atkinson; Thomas Dee, III; Candace Dee;
Randall J Olson, MD; Ruth Olson.
The ALSAM Foundation—
Honoring One of Utah’s First Families
With the passing of L. Sam Skaggs in 2013 and Aline Skaggs
in 2015, the Moran Eye Center lost dear friends who were
instrumental in building the John A. Moran Eye Center. We are
grateful for their belief in our efforts, and we want to thank the
entire ALSAM foundation for their generous support.
Sharon Steele-McGee, Gregory S. Hageman, PhD.
13
L. Sam Skaggs
Aline Wilmot Skaggs
Ann Torrence, Margaret DeAngelis, PhD.
Awards 2014
Awards 2014
Visionary in Chief
14
Randall J Olson, MD, Professor and Chair,
Department of Ophthalmology and Visual
Sciences; CEO, John A. Moran Eye Center,
received the 2015 Philip M. Corboy, MD,
Memorial Award from the Hawaiian Eye
Foundation for distinguished service in
ophthalmology, and he delivered a keynote
lecture at the third largest annual educational
eye care meeting in the US—the Royal
Hawaiian Eye Meeting. On accepting the
award, Olson said that honoring him was also
honoring the faculty of the Moran Eye Center,
as well as his many mentors. Olson was also
named a “Top Ophthalmologist” by The
International Association of Ophthalmologists,
and he received the 2014 Charles D.
Kelman Innovator’s Lecture Award by the
American Academy of Ophthalmology.
As the award was presented, Olson was
enthusiastically referred to as “visionary
in chief.”
Paul S. Bernstein, MD, PhD, received the Utah Ophthalmology Society’s
Lewis A. Peterson Humanitarian Award for 2014. Bernstein, who specializes in
macular and retinal degeneration, vitreoretinal diseases, and retinal biochemistry, is
a skilled surgeon and educator, dedicated to bringing modern vitreoretinal services
to the developing world, where access to retinal care can be extremely limited. The
hands-on specialty training that he brings to local providers is key to expanding
available and quality care in a sustainable manner.
Mary Elizabeth Hartnett, MD, FACS, FARVO, received the 2014 Women in Ophthalmology
(WIO) Scientific Contribution Award and the Honorary Lecture Award. Dr. Hartnett, an
exceptional clinician who is passionate about improving care for pediatric retinal patients,
received WIO’s two highest honors in recognition of her research into retinopathy of prematurity
and other retinal diseases.
While perfecting a technology for imaging the metabolism of cells, the Marc Lab created this
color-coded map of part of a mouse kidney as it breaks down food to make energy through
chemical reactions. Colored red, blue, and green, molecules produced by some of these reactions
show how metabolism can vary between cells in the same organ at a given point in time.
Credit: Jefferson R. Brown, Robert E. Marc, Bryan W. Jones, Glen Prusky, and Nazia Alam.
“Metabolites in Mouse Kidney,” a collaborative effort from Moran’s Marc Lab, is a
2015 Wellcome Image Awards winner. Each year, the award recognizes the creators of
20 of the most informative, striking, and technically excellent images, which go on display
at science centers and public galleries across the United Kingdom, as well as additional
venues in Europe and the US. Jefferson R. Brown, MD, PhD, accepted the award on behalf
of the lab at the Wellcome Trust Headquarters in London in March, 2015.
Awards
Metabolites in Mouse Kidney
15
The Silent Thief
Glaucoma, often called the
silent thief of sight, gradually
robs patients of their peripheral
vision, often without warning.
Characterized by an increase
in eye pressure, which may
damage healthy retinal cells
and the optic nerve, glaucoma
can lead to blindness. Today,
glaucoma affects nearly 3
million people in the US. Early
detection, medication, or
surgery often can control the
increase in eye pressure.
David Krizaj, PhD, Discovers Glaucoma Treatments
May Also Help Soldiers with Blast Trauma
Pressure Kills Healthy Cells
16
While studying the mechanisms that cause pressure to damage the eye, Moran
researcher David Krizaj, PhD, and his team made exciting discoveries that relate
cell injury in glaucoma to that from blast pressure. When the head is subject to an
explosion, the eye’s cellular tissues distort and rupture due to the over-pressurized
wave that envelopes the body. This causes retinal detachment, death of retinal cells,
damage to the optic nerve, and vision loss. “In recent wars, massive explosives
targeting people and vehicles have exposed so many soldiers to blasts—it is alarming,”
says David Krizaj, PhD. “As a result, eye damage among infantry has skyrocketed.”
But How?
But How?
Collaborating with other departments from the
University of Utah and worldwide, Krizaj’s team
researched how cells communicate with each
other. They knew that pressure and inflammation
caused eye damage, and they knew that pressure
could be reduced with medication and surgery,
but they didn’t know how the eye senses pressure
and how that pressure kills cells. “We thought that
if we could find that mechanism, we could block
those pressure sensors with pressure-reducing
drugs, and we could protect cells from dying from
pressure. And we did it!”
The group identified the pressure sensors in
neuronal cells that die in glaucoma and found
that with new drugs that target pressure-sensitive
ion channels in their membranes, they could protect these cells. Importantly, they also discovered
that these sensors are localized to two other types
of retinal cells known to be impacted in glaucoma
and by blast injury: astrocytes and microglia—
amoeba-looking glial immune cells. Their job is
to feed neurons, remove metabolic waste, and get
rid of unhealthy cells; however, if they become
over activated, they start to release chemicals that
can be deadly to neurons.
Confused Astrocytes and
Microglia Cells
Krizaj’s team discovered that astrocytes and microglial cells get confused when strongly activated
by different types of mechanical stress, such as
intraocular or blast pressure, and they wreak
havoc in the surrounding brain tissue. “They sense
the pressure, think the healthy cell is dead and
that tissue is damaged, swarm like a pack of angry
wolves, release molecules meant to kill, and attack
it—literally eating our brain,” says Krizaj. “That is
what we want to stop. The over-active cells make
blast-induced cell damage worse. But we don’t
want to kill astrocytes or microglia cells; they are
critical in development. Ideally, we want to control
their activity—keep them quiet by controlling the
stress and the excessive swelling. Because excessive
swelling is the most immediate problem after the
blast, we hope our new therapies will help mitigate
injury by reducing pressure immediately following
blast impact in the field.”
Saving Sight—Saving Lives
David Krizaj, PhD, professor of ophthalmology and
visual sciences, specializes in retinal neurobiology,
calcium regulation, and glaucoma.
“Treating a serious disease is not something a
single person can do—it is a multidisciplinary endeavor
that involves and requires expertise from many different
branches of science, industry, and government. To succeed, all of them have to work together, which is not easy.
Moran is one of the few places in the world where this is
not only possible, it is happening.” —Dr. David Krizaj
Since finding that treatments to reduce pressure in
glaucoma are relevant to treatments for traumatic
blast injuries, Krizaj’s team has received a grant
from the Department of Defense to develop drugs
that could be administered onsite as an injection
or a pill for blast-trauma patients. Their goal is to
reduce immediate pressure-induced swelling and
inflammation and hopefully to prevent long-term
functional damage to the soldier. In the past year,
Krizaj’s team has developed and patented therapies
that will soon go to clinical trials.
17
The Krizaj lab team from left to right:
Tam Phuong, PhD; Peter Barabas, PhD;
Sarah Redmon; Andrew Jo; Maxim
Kozhemyakin, PhD; David Krizaj, PhD.
Game-changer for Gracie
Because three-year-old Gracie Jones of Kalispell, Montana, was
born with a collapsed lung, she spent a fair amount of time in a
neonatal intensive care unit. Naturally, doctors kept a close watch on
her once she was out. When she was about three months old, her
pediatrician noticed that one of her eyes wasn’t tracking quite right and
recommended that her parents, Jamie and Ryan, take her to Kalispell’s
Glacier Eye Clinic. Ophthalmologists there discovered that Gracie had
a detached retina in her left eye. They also saw problems looming
in her right eye. When Dr. Aaron Almy, the clinic’s retinal specialist,
examined Gracie, he suspected ‘familial exudative vitreoretinopathy,’
known as FEVR. “That was something we’d never heard of,” says
Ryan Jones. “He said she needed special treatment and scheduled
Gracie for surgery with Dr. Hartnett at the Moran Eye Center the next
day. It was a crazy time, right before Christmas—but we put everything
on hold, packed the car, and drove through the night in heavy wind
and snow. We hit Salt Lake at 4 am and got the last room at the
University Guest House. Later that day, Dr. Hartnett pretty much saved
our daughter’s vision. Talk about a game-changer.”
,
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18
“We’re all lucky that Gracie came to Moran when
she did,” says Hartnett. “I performed an urgent
exam under anesthesia that showed leakage
from the abnormal vessels in her right eye and
confirmed an inoperable retinal detachment in
the left. We also confirmed that she has a really
challenging case of FEVR—basically leaking and
hemorrhaging blood vessels in the retina. I treated
her with laser to stop the leakage and continued
to follow her every two weeks, then every two
months or so, continuing laser treatments.” FEVR
is rare—as are most pediatric retina diseases—and
it’s hereditary. It turns out that Jamie has the same
mutation as Gracie, but Jamie doesn’t manifest the
symptoms, so it’s not something the family would
have known about.
“That first year, we traveled back and forth at least
12 times,” says Ryan. “Everything was going well
until last June when Dr. Hartnett discovered that
Gracie’s right retina was starting to detach. She
ended up doing two ‘lens-saving’ vitrectomies, so
Gracie can still see. In fact, she has good close-up
vision. She likes to play catch and she can hit a
ball off a tee. All I can say is, we could not be in
better hands.”
“Gracie continues to have functional vision,” says
Hartnett. “We’ll keep monitoring her and preserve
as much vision as possible. Meanwhile, we need
to keep up the research to prevent or find a way
to slow down the activation of the vessels—it’s
so important.”
Gracie Jones, a favorite frog, and pediatric
retina specialist, Dr. Mary Elizabeth Hartnett.
Regional Center for PEDIATRIC RETINA
Rare eye diseases and conditions specific
to children require accurate, timely diagnosis and
treatment. They also demand that doctors and
parents act as constant advocates, staying on top
of patients’ treatment. These facts, along with the
area’s growing population, helped spur development of Moran’s Pediatric Retina Center, the only
such facility in the Intermountain West. Specializing in surgery, medical diagnosis and treatment,
and oncology, the center provides ongoing care
and guidance to the youngest—and tiniest—
patients and their families.
Rare Eye Disease Specialists
Healthy development and function of the retina,
a light-sensitive layer of tissue lining the back of
the eye, is critical for normal vision. The Pediatric Retina Center at Moran provides a range of
unique services and procedures to help prevent
and treat blinding retinal conditions in children
and infants. Specialists here have expertise in
diagnosing these conditions, including several rare
diseases—many involving genetic predisposition,
infection, trauma, or prematurity.
Services offered in conjunction with the Pediatric
Retina Center include pediatric imaging, genetic
counseling, and surgical care. Please visit the
Patient Care section at moraneyecenter.org for
details on these services and on a range of
pediatric eye conditions.
Mary Elizabeth Hartnett, MD, is the force behind
the Pediatric Retina Center’s development. A
vitreoretinal surgeon, her clinical interests include
vitreoretinal surgical diseases, pediatric vitreoretinopathies, trauma, retinal detachments, and diabetic eye disease. She is also a leading researcher
on retinopathy of prematurity, commonly known
as ROP—vision-threatening
abnormal blood vessel development in the eyes
of very premature babies. In addition, Hartnett
is the author of Pediatric Retina, the main industry
reference on the subject.
19
Specializing in PINT-SIZE PATIENTS
“When it comes to kids, the first pair of glasses is the most challenging,”
says Ellen Linde-Fagergren, American Board of Opticianry (ABO) Certified
Pediatric Specialist at the Moran Optical Shop. She’s been fitting children’s
glasses for all ages, including children with special needs, for 17 years.
20
Certified Pediatric Specialist
Ellen Linde-Fagergren
The stakes are incredibly high in the world of kids’
vision. Whether they have special needs or require
a slight correction, their vision is constantly
developing, so the wrong prescription or “slightly
off ” fit can actually cause further complications.
“The child’s world changes entirely when he or she
puts on glasses. It can change their depth perception,” Linde-Fagergren notes. “The brain and eyes
have to work together to force the eye muscles to
properly align. You don’t want kids to be looking
above or below their lenses, so it’s function first,
fashion second.” That’s precisely why Linde-Fagergren’s expertise in customizing every pair she fits
is so important. From her workbench stocked with
tools for creating special frames, tweaking, sewing
straps for proper fit, and fixing broken parts, she
creates miracles, big and small. She often works
with the smallest pair of glasses made: a 27mmeye size for babies born with conditions such as
retinopathy of prematurity or congenital cataracts.
Resembling tiny doll glasses, they have straight,
paddle-shaped arms to compensate for the
cartilage around the nose and ears that is not fully
developed. For each pair, Linde-Fagergren adds
a soft strap to go around the back of the head. In
other cases, special needs kids may be missing ears
or have head shapes that require customized solutions for keeping the glasses in place. Whatever the
need, she’s on it. She also follows up with regular
appointments, checking the child’s growth, making
sure the glasses still fit and are doing their job.
It’s not unusual to find Linde-Fagergren sitting on
the floor with her pint-size clients as she talks to
them and to their parents at the same time, reassuring everyone about the benefits of glasses and
schooling them in the challenges—from breaking
them in slowly to what to do when they break—to
the benefits, including important warranties. A
mom herself, she has a gentle but confidenceinspiring way of getting clients of all ages to listen—
and see.
Houston Gets Glasses
Houston Thompson was less than
a year old when his parents, Krystal
and Blake, met with Moran pediatric
optician Ellen-Linde Fagergren to fit
his first pair of glasses.
The event marked one more step in the process of
adjusting to Houston’s microtia—a congenital
condition affecting the outer ear where the ear does
not develop fully. As a result of microtia, he also
has “unilateral congenital ptosis”—in this case, a
slightly droopy eyelid on his right side and a fixation
preference for the left eye compared to the right.
“Houston’s depth perception is off on his right side,”
says his mom, “so until he started wearing glasses,
it was hard for him to even put objects into a bucket
if the objects fell behind him on his right side. He
has no hearing on his right side and that makes it
a little harder to hear noises that most people would
hear normally. Altogether, this has heightened his
other senses, and it can be hard for him to want to
wear glasses or gloves, as he feels it is taking another
sense away. But even though he has glasses and only
one ear, he can do all the things other children do.”
At a recent fitting, where Linde-Fagergren adjusted
a new customized hand-sewn T-strap on Houston’s
glasses, a few things were evident the moment he
put the glasses on. Clearly, he could see more of the
world around him as he looked around the shop; he is
a typically active, curious toddler who is still adjusting
to these corrective lenses and the T-strap in his
wavy brown hair; and he and Linde-Fagergren have
bonded. As Houston grows, she will be here for him,
possibly up until he is a young teenager. If he needs
protective sports glasses or ski goggles, she has
solutions for those, too.
A perfect fit!
“We chose Moran because it’s one of the only places
that have glasses to fit a child this young,” says
Krystal. “Also, we heard that Ellen was great to work
with, and that certainly turned out to be true.”
21
While Krystal Thompson holds her son, Houston, certified pediatric specialist Ellen Linde-Fagergren makes the
final adjustments to his new glasses and the strap that will keep them in place.
Guatemala
Changing Lives, TRANSFORMING COMMUNITIES
22
Traveling to some of the neediest areas of the world, the Moran Eye Center Outreach
team conducts nine major outreach medical eye camps each year. Most recently, they
have established vital local partnerships and made five-year commitments to Haiti,
Micronesia, and Guatemala.
In December, 2014, the team conducted its second outreach medical eye camp in
Salamá, Guatemala—a region with 700,000 people and only one ophthalmologist.
Here’s a day-by-day account of that experience.
Day 1
Day 2
Before the driver can turn off the engine, the team
Shuffling backwards, Lucia Pasqual glances over
her shoulder as she leads her mother by both hands into the
clinic. Local Lions Clubs have spread the word that Moran’s
surgeons are in Salamá, and Lucia has brought her mom,
blind in both eyes, for help. Like most of the patients, her
mother has cataracts from years working the fields under the
intense sun. Her family worries that her mom will fall or hurt
herself, so Lucia has quit work to care for her. The family is
now down two incomes.
is off the bus and unloading medical supplies. A singlefile line forms, and each person steps forward to receive
an equipment bag. As the final duffels are carried in, the
operating room team begins tearing down the existing clinic.
They move tables, clear shelves, and relocate equipment.
They want a clean canvas for their surgical supplies,
operating tables, and microscopes.
Before the week’s end, they will restore sight to more than
100 patients—a feat made possible by Moran’s many
dedicated professionals who have spent years creating and
refining best practices for delivering care to remote and
underserved regions. The support of dozens of volunteers
and hundreds of donors have made this mission, and others
like it, possible.
All morning, patients stream in. Most have blinding cataracts
in both eyes. They are brave and trusting as their families
navigate the organized chaos, leading them from check-in, to
scans and measurements, to registration and lens selection,
to dilation and surgery. The team completes
surgeries.
34
Day 3
Still wearing his post-surgical eye shield, Santiago is carefully
guided by his daughter to a seat in the waiting room. His head hangs and his
expression is empty. Santiago has been completely blind for years; he is used to
a world without sight. As the medical team works its way down the line of postoperative patients, Santiago waits patiently to have his patch removed. At last,
he is instructed to lift his head. A volunteer gently pulls the tape from his brow,
and his eye patch falls. Santiago stares vacantly for a minute before blinking
and moving his eye. Slowly, he turns toward his daughter and smiles. She
laughs and smiles back. Santiago can see! When asked what they are looking
forward to now that his vision is restored—“freedom”—they say in unison. The
family is free from the burden of having to care for him, and Santiago is free to
return to the fields to work. Today, the team restores sight to
patients.
Santiago
37
Cornelia
Day 4
Day 5
Today there are tears. Cornelia’s daughter, Marta, waits
anxiously for Cornelia’s patch to be removed. Yesterday, the doctors
told her there is nothing they can do for her mother’s right eye– the
damage is permanent; but they operated on the left eye hoping to
restore partial vision. When the patch comes off, Cornelia struggles
to open her eye. She is stoic, and it is unclear if the surgery has
worked. Marta asks if she can see, and Cornelia nods. She can
perceive light. The doctor comes. He tells them the surgery was
successful and she should gradually start to see more. They wait
quietly for the taxi that will take them home. When it arrives, Marta
prepares to lead her mom out of clinic, but Cornelia waves her off.
She wants to walk on her own. Mother and daughter both start
crying. Cornelia is seeing! They hug each other and the Moran staff.
Then, side by side and hand in hand, they walk to their taxi. “Thank
you, thank you,” they say the entire way.
Patients and their families are crammed in
the clinic. Busloads have arrived from Coban, a
rural village eight hours away. Others have come by
cart and oxen. Marta Morente Ixcopal has used the
family’s savings to hire a taxi to bring her mother,
Cornelia, for surgery. Cornelia is deaf and blind and
must be carried everywhere. Marta does not know
where they will stay for the night, but she trusts there
will be help. She is right. The local Lions Club has
arranged for patients who have traveled far distances
to stay in the locker room of a nearby soccer stadium
where they will be fed and given bedding. The team
completes
surgeries.
35
23
Micronesia
The team boarded the Caroline Voyager, a 180-foot merchant cargo ship, for an arduous 39-hour
journey across 300 miles of open sea from Pohnpei to the Satawan Atoll. Due to limited space,
half of the team had to sleep on the 30’ x 35’ deck of the cargo hold doors, covered with a tarp
as shelter from the ongoing mix of rain and blazing sun. Micronesian citizens, who rarely get the
opportunity to travel between islands, also climbed aboard the Caroline Voyager for the opportunity
to return to Satawan and its neighboring islands.
Summer 2014
Summer 2014: The Moran outreach team traveled 6,200 miles from Salt Lake
24
City, Utah, to their most remote destination yet—the islands of Pohnpei and Satawan
Atoll in the Federated States of Micronesia (FSM)—to conduct the first of many eye
camps over the next several years. Only 70 of the 607 tiny islands are inhabited, with
a population of 110,000 people living across 271 square miles of land. Not a single
ophthalmologist resides in the FSM, and the backlog of blindness is staggering. The
team conducted 500 screenings and performed 242 surgeries on their first trip and
will return in July, 2015. Change will happen gradually, but it has already started with
one Micronesian physician, Dr. Padwick P. Gallen, who is training to become the first
and only ophthalmologist in the FSM and will be practicing by the end of 2015. Each
year, Moran physicians will return to work with Dr. Gallen and other local medical
providers to conduct eye screenings, surgeries, and ophthalmic training, in keeping
with Moran’s model of sustainable eye care.
What it Takes
to Get an Outreach Medical Eye Camp off the Ground
Here’s a typical checklist,
starting three to four months
before each trip.
1
Each year, the Moran Eye Center Outreach Division meticulously plans and performs several
outreach medical eye camps (OMECs) around the world. Often, these camps take place in
remote, difficult-to-reach areas that offer few, if any, medical facilities, sanitation, or even
lodging. Each OMEC requires that the team lock down mountains of details well before the
trip. Here’s a typical checklist, starting three to four months before each trip.
Visas to
vaccinations
“Our trip is officially launched when we receive
a formal invitation from the country in need.”
Exactly what does every team
member need, and when?
Contact Centers for Disease
Control, local governments.
6
7
2
Do we need security?
If so, who provides it? What’s the cost?
3
Screening and
surgery situation
Number of patients?
What’s the facility like?
Does it have walls? Screens?
Operating tables? Sterilization?
What equipment do we need
to bring with us?
Team
Assemble medical and volunteer teams
based on need. Every professional must
be credentialed to work in the destination
country, each time they visit.
Ask teams to visit secure website for
credentialing all visa, passport, medical,
information and a long, long packing list:
imodium to head lamps, mosquito nets
to ear plugs.
Get copies of every team member’s CV,
diploma, licensing, extra passport photos,
travel insurance, emergency contacts,
and more. Plan to carry with you at
all times.
5
Incidentals
Exchange currency. Take cash.
(Might need it for tips or “special favors.”)
8
Equipment
Items such as operating room chairs,
IV poles, syringes, flashlight headlamps,
disposable surgical drapes, retinoscopes.
Double check: Do we know exactly
what we need to do to get equipment
through Customs?
Count and pack supply and pharmacy
lists. You may be looking at more than
200 items and have up to 300 cases.
Have a pizza party for packing 50-lb duffle
bags, and every team member must carry
at least one! Pack the content list in each
bag to expedite customs.
Lori McCoy
Outreach Division
Coordinator
Accommodations
4
Logistics
Distance of airport from the
OMEC? How to transport team
and equipment?
Hotel, houses, tents? Toilets, or not?
Do we need a site visit? Arrange
all lodging, take into account room sharing.
Where will patients stay?
Who’s feeding all of us?
Where does the food come from?
How’s it washed, prepped, served?
(Water must be boiled or bottled.)
Need to hire a local cook?
Need to truck food in?
Start planning and hiring now.
9
10
Team meeting Q&A
Is every team member prepped?
25
Meet at the airport
or gather for carpools,
and we’re off.
Dr. Craig Chaya and wife Michele with their three children, Malachi, Malia, and Micah.
Work & Family WITH A GLOBAL PERSPECTIVE
26
Craig John Chaya, MD, grew up in Southern California in a family of physicians and a world of medical
missions initiated by the Seventh-day Adventist Church. “The overseas work I did in high school was formative,”
he says. “Building schools, churches—even toilets—I developed a joy and passion for humanitarian work.” But
when the shifting of the earth’s plates in the Indian Ocean on December 26, 2004, caused a rupture more than
600 miles long, creating one of the world’s most devastating earthquakes and tsunamis, Chaya’s understanding of humanitarian outreach deepened even further. “I was just finishing up my residency in internal medicine
at the West Los Angeles VA Medical Center. A friend of mine, an ER doc, talked about going to Banda Aceh
to volunteer. In just over two weeks after the tsunami occurred, we headed to Indonesia and joined a medical
team from the Medan Adventist Hospital. Arriving in Banda Aceh was surreal. The city was completely leveled
as far as you could see. For 10 days, we provided disaster care—with no time to really process the magnitude
of what occurred. When I came home and started looking at the pictures from the trip, I started processing how
devastating the situation was, and I wondered, did we make a difference? I discovered that for many humanitarian groups, the impact of their work can be highly intense but also highly transient.”
Hope is the Seed for Good Things to Come
“When you are blind and living in a developing area, it’s a hopeless feeling. With hopelessness comes
depression, and sometimes, poverty. But if you can restore hope to a community through restoring sight,
that hope can be the seed for good things to come. Prior to coming to Moran, I understood the impact
you could have on one person’s life. What I didn’t realize is the ripple effect on the community. We have
the potential to be a major agent of social change.” —Craig J. Chaya, MD
aya
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“On a recent mission to Haiti, Craig was able to lower this 11-year-old
boy’s eye pressure to an acceptable range by doing an angle surgery under extremely
difficult conditions. It’s not easy to get a child to cooperate, which just demonstrates
his skill not only as a talented anterior segment surgeon, but as a compassionate person who could talk a terrified, non-English speaking child through an entire operation.
It was amazing to see how well the child did after surgery!”
—Sonya Dhar, MD, glaucoma and anterior segment surgeon and clinical instructor,
NYU School of Medicine; adjunct assistant professor, Moran Eye Center
That realization was key in drawing Chaya to
Moran’s global outreach work. “Moran’s model
is sustainable,” he says. “In addition to providing
sight-restoring surgeries in remote areas, we look
for local medical talent. We groom and support
them; we bring them here for training; and we
make long-term commitments, going back year
after year. People need to understand that it takes
time—and that you can’t just train an ophthalmologist—you have to train an entire health care
delivery system. In Haiti, for example, glaucoma
is a major challenge. Getting patients to agree to
surgery is a very hard sell. But really early screening and education can make a huge difference.”
Oncology to Ophthalmology
Chaya started out with aspirations to be an oncologist, but in his third year medical school surgical
rotation, he had some surgical elective time and
randomly decided to fill it with ophthalmology.
He first became acquainted with Moran as a medical student when he did an away-rotation with Dr.
Norm Zabriskie. “It was a great experience, and
I was enamored with Moran,” he recalls. “I was
immediately overwhelmed with the difference you
could make in someone’s life—with how precious
sight is to all of us, so I made a late career change,
shifted my aspirations. My long-time dream had
been to become an international doctor, and I
knew that Moran had two of the most recognized
leaders in that realm—Drs. Alan Crandall and
Geoff Tabin.
“My wife, Michele, is a nurse practitioner, and
after I graduated, we committed as a family to
doing full-time medical mission work overseas.
We were mainly in Guam, but I came back to
the US for a conference and ran into Dr. Randall
Olson. He suggested I come back to Moran, make
it my home base. At that time, we were very close
to moving to New Zealand, but Dr. Olson was
very compelling.”
Today, Chaya practices comprehensive ophthalmology and specializes in the medical and surgical
management of adult and pediatric cataracts,
glaucoma, and anterior segment surgery at Moran.
Michele homeschools their three children—Micah, Malia, and Malachi, ages eight, six, and three
respectively. Whenever possible, the family accompanies Chaya on his outreach missions. “We
like to think of our work as a team effort,” he says.
“We feel it’s important for our children to have a
global perspective—to see how other communities live, to understand the importance of helping
those who are less advantaged.”
27
Local Outreach IN A FORGOTTEN LAND
The Moran Eye Center, in partnership with Utah Navajo Health System, Inc.,
(UNHS) and Blue Mountain Hospital, is committed to bringing pediatric and
adult eye care to residents of the Utah Strip of the Navajo Nation, providing
surgical care and hundreds of eye screenings for patients monthly.
vision
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Sixty-year-old Betty Jelly tends sheep near Hovenweep, about an hour’s drive from Blue Mountain
28
Hospital in Blanding, Utah, where the Moran team performed her cataract surgery. To the Utes and Paiutes,
“Hovenweep” means “Deserted Valley.” To Betty, it’s the land she depends on to help maintain her
independence as she tends her flock. But, like so many citizens of the Navajo Nation, blindness threatened
to rob her of her livelihood. “With one eye, I see one sheep; with the other eye, I see two,” she told doctors,
speaking in Navajo translated by her son Charles. “It is very confusing.” When Betty and Charles came to
Blue Mountain, they each had cataracts in both eyes. At the time of his surgery, Charles was living with his
mother and unable to work at all. They depended on a driver to bring them to the hospital and to take them
home again. As both waited expectantly for surgery, tiny Betty, enveloped in surgical cap and gown and an
enormous-looking bed, nodded her head, smiled, and said, “I feel good about having eye surgery today.”
Betty and Charles are just two of the over 600 Navajo citizens within the past 12 months to receive free vision
screenings and exams by Moran volunteers.
Contrasts and Challenges
While southern Utah’s stunning red rock country is a coveted vacation destination for over 10 million
people each year and provides over 600 million dollars in economic benefit to the region’s economy,
it is also home to the Navajo Nation—one of the most underserved, isolated, and neglected areas in
the Lower 48. Citizens living in the remote Four Corners region, where Utah, New Mexico, Arizona,
and Colorado meet, struggle with some daunting obstacles: the remoteness of the land makes daily
transportation a challenge; the unemployment rate is around 50 percent; a lack of basic infrastructure
means that approximately 25 percent live without running water or electricity; and specialized health care
is limited. “The sheer vastness and remoteness makes access to health care difficult,” says Michael Yei,
Moran Outreach Division Manager. “Many folks fall through the cracks. It is hard for them to navigate the
system, to figure out how it all works.”
The high incidence of Type 2 Diabetes, UV exposure, and the overall impact of poverty has created an
urgent and critical need for eye-care delivery in the area. Unnecessary blindness from cataracts, lack
of vitamin A during pregnancy, diabetic retinopathy, and uncorrected refractive errors in children are
common, even though most of these eye conditions are either curable or preventable.
Partnerships and Commitment
Some Moran medical mission team members, left to right: Carolyn Hoffman,
Robert Hoffman, MD; Justin Beagley; Amy Beagley; Michael Yei; Julie Crandall;
Heidi Reid; Brynlie Reid; Marielle Young, MD; Tom Young, Laura Jane Pehrson,
Bryan Vincent, OD; Bonnie Vincent.
In addition to UNHS, Moran contracts with
Sight Path, a national organization that provides
specialized mobile ophthalmic equipment that
is not available at Blue Mountain Hospital, and
with Angel Flight, a volunteer nonemergency air
transportation service.
“We are only as good as our partners,” says Yei.
“We are so thankful for their ability to support
our efforts on this part of the Navajo Nation. I’ve
always believed that health care is a basic human
right. In areas where there is not access to it, the
burden of disease matches places in the developing world. We are committed to reaching populations that are the most underserved right here
in Utah. Because we have the resources and the
ability, I think we have an obligation and responsibility to provide that care.”
29
Charity Surgery Day
American Society of Cataract and Refractive Surgery
Looks to Moran as a National Model for Treating
Curable Blindness
Every day, thousands of people in the US have to put their lives and livelihoods
on hold because they suffer from treatable blinding conditions, most often caused
by cataracts. They are often forced to rely on others for everyday functioning
and care. In turn, many suffer from depression and low self-esteem. Many in this
population are too young for Medicare, earn low wages, or are underinsured or
uninsured. Through our semi-annual Charity Surgery Day, the Moran Eye Center
works to restore sight for people in our community.
Initiated three years ago by Moran residents, Charity Surgery
Day is an outgrowth of the volunteer eye care Moran residents provide
at Salt Lake City’s Fourth Street Clinic. As they saw a growing need to
follow up on cases where surgery could help patients get back to work
and live more independent lives, the residents took action. Today,
Charity Surgery Days are still organized by Moran residents and
have proven so successful and cost-efficient, the American Society of
Cataract and Refractive Surgery (ASCRS) Foundation’s new Operation
Sight network adopted Moran as a model in 2014. Moran is now one
of five founding members of the network, whose mission is to provide
a centralized approach for organizations and volunteer surgeons who
wish to end cataract blindness in the US.
Dr. Derek J. Sakata, MD, and Lavenita Mahanga.
A retired English school teacher, 63-year-old Lavenita
had cataracts in both eyes. She is the sole caretaker for
her husband, who is disabled from a stroke. Prior to her
surgery, she could only tell who some people were by their
voices; she couldn’t make out where to step up for a curb
or stairs—and she had fallen. She was excited to be at
Moran and to have her eyesight restored. After surgery,
Lavenita was all smiles as she beamed, “I can see out of
my right eye now. It is clear. I feel so happy.”
30
Volunteers Make it Happen
Through Moran’s low-cost charity surgery model,
physicians, nurses, anesthesiologists, technicians,
and staff volunteer their time to provide surgeries
to pre-screened patients at no cost. The operating room is staffed and run as it would be on any
other day, except patients are not billed for their
care. Donors and the Moran Eye Center’s annual
“Night for Sight” fundraiser event cover all the
costs. The October 2014 Charity Surgery Day
was underwritten by the Henry W. and Leslie M.
Eskuche Foundation and received additional
support from Operation Sight and ASCRS.
“Moran is a wonderful model for us,” says Don
Bell, ASCRS chief executive officer. “I’ve observed
two of their events, and the amount of work is
incredible, as is the remarkable caring and empathy. Last October, at the end of the day, 21 people
left with vision that will improve their lives.
Overall, there is an incredible socioeconomic
benefit, not only for patients, but for families and
the community as well.”
Don Bell, ASCRS chief executive officer, (l) discusses Moran’s Charity
Surgery Day operations with Nick Mamalis, MD, (r) Moran’s director
of Ophthalmic Pathology and co-director of the Intermountain Ocular
Research Center. Bell spent a day observing the Moran team in action.
For more on Operation Sight:
ascrsfoundation.org/operation-sight
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Former commercial truck driver, Ed Ylst is 64 years old. A friend drove him to
Moran for surgery, as he lost his commercial driver’s license because of his impaired
vision. Ed was also a journeyman carpenter until about 12 years ago, but lost his depth
perception, making that work extremely dangerous for him. He was continuing to do
handyman work, but really hoped to resume driving. “This whole cataract thing has really
had a severe financial impact on me,” he said. “I’ve also suffered a lot of depression.
When you can’t drive, can’t read, and can’t work, it just all adds up to some bad times.”
Ed’s surgery was a success, and he was able to resume driving within a few days.
31
The untold story
Moran’s resident training program is one of the elite
programs in the world
The term, “Moran model” continues to describe Moran’s
cutting-edge programs, from our sustainable outreach
model, to fast-tracking clinical trials and new therapeutics,
to quantifying surgical techniques that ensure safe and
efficient patient outcomes. While the term “model” can be
ambiguous, at Moran, it embodies a philosophy that begins
with Chair and CEO, Randall J Olson, MD, who supports a
culture of independence, creativity, and resourcefulness.
32
This philosophy is at the heart of Moran’s unique education
program, which allows residents the latitude to tailor their
own training. Jeff Pettey, MD, Director of the Education
and Residency Program at the John A. Moran Eye Center
describes it as a supportive culture, designed to help residents succeed. “When you bring in a spectacular group of
people—three applicants out of over 400 are selected—and
offer support rather than requirements and restrictions,
you allow them to accomplish great things,” says Pettey. “I
trust residents are going to work hard and study. I trust they
are going to be active and motivated learners. As we listen
and give them tools they need to succeed, they are able to
accomplish truly amazing things because we are getting out
of their way.”
How We Provide Support
International Outreach: Moran’s Outreach Division is
unparalleled in our mission to eradicate curable blindness
worldwide through a perpetual, sustainable model. Moran
pioneered international ophthalmology elective time for
residents who choose to take advantage of a three-week
rotation of humanitarian outreach. The opportunity to travel
out of the country to participate in training and education
has produced the next generation of leaders in international
ophthalmology.
Charity Surgery Days: Moran’s focus on supporting
residents in pursuing their unique passions produced
Charity Surgery Day. In 2012, Moran residents and
University of Utah medical students spearheaded a
volunteer program—now a national model—to provide
charitable surgery to a group of Utah’s underserved
population two Saturdays each year. Partnering with local
clinics, residents continue to drive the program that has
provided surgery for 75 patients in less than three years.
Patient Care: Under the supervision of a board certified
ophthalmologist, residents perform approximately 300
cataract extractions and almost 400 other major surgical
operations. During a weekly resident-staffed “Continuity
Clinic,” they learn how to become the key provider for each
of their patients with graduated levels of responsibility,
beginning day one.
Research: Residents who have a strong research interest
are given a half day a week of protected research time
throughout their residency. Beyond the commitment of
protected time, residents can become eligible for an
Achievement Rewards for College Scientists (ARCS) Award
of $15,000 for research the first year of their residency.
Thanks to generous donors, Moran is able to provide an
additional $15,000 dollars each year for the remainder of
their training to continue their research.
“I chose Moran for residency because
it provides the ideal training environment
to become a successful physician-scientist
within the field of ophthalmology. The
idea of the triple-threat physician is alive
and well here at Moran!”—First-year resident,
Rene Choi, MD, PhD.
Triple-threat physician: world-class researcher,
teacher, clinician.
Jeff Pettey, MD, director of the Education and Residency Program at the
John A. Moran Eye Center, and residents. From left to right, Brian Stagg,
MD; Russell Swan, MD; Adam Jorgensen, MD; Eileen Hwang, MD, PhD;
Program Director, Jeff Pettey, MD; Julia Byrd, MD; Zachary Joos, MD;
Trent Richards, MD; Rene Choi, MD, PhD; and Brian Zaugg, MD.
Education: Residents may tailor their elective opportunities to develop an expertise or passion such as creating a
library of educational cases and tools, authoring a text book
or oral boards manual, or developing and writing curriculum or clinical exam teaching sessions.
Moran Resident Brian C. Stagg, MD,
Honored to be Chosen to Represent All US
Ophthalmology Residents
Academic Fellowship: Residents from all over the
country apply for our fellowship programs. Our residents
have the opportunity to apply to stay on an extra year for
an academic fellowship. This can be devoted to research,
international ophthalmology, or to academic teaching/
training in ophthalmology.
Congratulations to Brian C. Stagg, MD, who was
appointed “resident representative” for ophthalmology’s Resident Review Committee (RRC) for
the Association of Graduate Medical Education
(ACGME), effective July 2014 through June 2016.
The RRC reviews and awards accreditation for all
specialties for the ACGME, which means Stagg
represents all ophthalmology residents in the United
States. This two-year appointment is an honor for
Stagg and for Moran. He also received the 2013
Achievement Rewards for College Scientists Foundation Inc. (ARCS) Award.
“Our mission is to cultivate an environment that stimulates
minds, develops critical thinking, and fosters personal
growth,” says Pettey. “I’m really proud of our training
program—it’s one of the elite programs in the world. My
hope is that our residents not only become superb physicians, but that they become leaders, change-agents, and
standard bearers of humanism in a global community.”
33
MORAN EYE CENTER
RESIDENTS AND FELLOWS
2014-2015
Consistently Ranked as One of the Top 10 Ophthalmology Education Programs in the Nation
For over 30 years, the ophthalmology program at the University of Utah School of Medicine has offered excellent didactic
training and extensive surgical experience. Each year, faculty from the Moran Eye Center provide ophthalmology training
to approximately 70-80 medical students and visiting residents as well as three interns, nine residents, seven to eight
fellows, and many international observers. As the only medical school in the Intermountain area, the University of Utah
plays an important role in training the region’s next generation of physicians and ophthalmologists.
R ES I D EN CY PR O G R A M 2 014 -2 015
FE LLOWS H I P PR O G R A M 2 014 -2 015
FIRST YEAR
Julia Byrd, MD
Rene Choi, MD, PhD
CORNEA
Eileen Hwang, MD, PhD
Carlton Fenzl, MD
SECOND YEAR
Adam Jorgensen, MD
Brian Stagg, MD
Jason Feuerman, MD
NEUROOPHTHALMOLOGY
Reuben Valenzuela, MD
RETINA
Russell Swan, MD
THIRD YEAR/CHIEF RESIDENTS
Nikhil Batra, MD
Jim Bell, MD
GLAUCOMA
MORAN
INTERNATIONAL
FELLOWSHIP
34
Zachary Joos, MD
Trent Richards, MD
Brian Zaugg, MD
Dan Bettis, MD
Hari Bodhireddy, MD
Anya Gushchin, MD
MORAN EYE CENTER
RESIDENTS AND FELLOWS
2014-2015
I NTER N S & O PHTHA LM I C PATH O LO GY / R ES EA R C H FE LLOWS 2 014 -2 015
INTERNS
A superb overall experience
With 11 locations and four state-of-the-art ophthalmic
surgery suites, over 40 ophthalmology specialists
carry out more than 6,500 surgeries per year at the
Moran Eye Center. This ensures that residents and
fellows have ample opportunity to participate in a full
spectrum of clinical and surgical experiences.
Ashlie Bernhisel, MD
Christopher Conrady,
MD, PhD
Richard “Reese”
Feist, Jr., MD
O P H T H A L M I C PAT H O L O G Y/ R E S E A R C H
Aabid Farukhi, MD
Gregory Kramer, MD
Located at the base of the spectacular Wasatch
Mountains, the University of Utah is the flagship
institution of higher education in Utah. Within reach
of seven major ski resorts, gorgeous desert country,
and a population known for its friendliness, Salt Lake
continues to rank among the top cities in which to live.
Kyle MacLean, MD
RESEARCH FELLOWS
Wyatt Messenger, MD
Ruju Rai, MD
Resident Alumni Day: One day each year, residents present an
overview of their interesting or unusual patient cases, treatments, and
results to faculty and community physicians and provide an update
on current research in the Department of Ophthalmology and Visual
Sciences. Designed to enhance and expand medical knowledge skills
of the residents, presentations are based on their interest, relevance,
and applicability to current ophthalmologic concerns and treatments.
In addition, a keynote speaker from an affiliate academic institution
presents the Robert H. Hales Memorial Lecture.
35
The Moran Eye Center offers ophthalmology fellowship programs in cornea and refractive surgery,
glaucoma, neuro-ophthalmology, retina, and international outreach. For more information, please
contact the Department of Ophthalmology and Visual Sciences Academic Office at 801-585-6701.
Moran’s Elite Resident Program
Attracts Award-winning Scholars from
Across the Nation
Meet Eileen Hwang, MD, PhD: Scientific, Curious, Independent
36
First-year resident Eileen Hwang, MD, PhD,
remembers that, at age nine, she read an article
about the origins of life and decided then and
there to become a molecular biologist. Never
wavering from that decision, she earned a PhD—
while in medical school—in molecular biology,
which was supported through a prestigious
National Institutes of Health F30 fellowship to
study hereditary diseases of collagen at Robert
Wood Johnson in New Jersey. In 2014, she
was honored with the Achievement Rewards
for College Scientists Foundation Inc. (ARCS)
“Randall J Olson Scholar Award,” including
a $15,000 unrestricted grant to continue her
research interests. “One of the things that
attracted me to Moran’s residency program is
that residents have time to research, to publish,
and to tailor our own training,” says Hwang.
“This is not the case in other programs. Here,
I don’t have to put my research on hold.”
Currently, Hwang is researching biophysical
techniques used to measure blood molecules in
relation to the genetic risk factors for advanced
age-related macular degeneration. And her
research won’t stop after her first year. Moran
builds on ARCS’ generosity by providing matching
funds for second- and third-year residents to
continue their research.
Hwang’s impressive scientific and exploratory
nature manifests in her other passions as well. She
describes being a ski patroller, EMT, mountain
biker, rock climber, and overall adventure-seeker.
One year, she “wanted to explore somewhere new,”
so she took a position as a park ranger and landed
in Furnace Creek, Death Valley National Park.
“Ophthalmology is a perfect fit for me. I really
love learning and exploring new places, concepts,
ideas; I enjoy hands-on surgery and patient care,”
says Hwang. “My dream for the future—I would
like to keep living in the west and become an
excellent clinician and researcher. I’m so glad I
chose to come to Moran and that they chose me!”
The ARCS foundation, committed to advancing science and
technology in the United States, provides financial awards to
academically outstanding US citizens studying to complete
degrees in science, engineering, and medical research. Only US
universities whose departments are ranked in the top 100 in the
country are eligible to receive ARCS Foundation Scholar Awards.
Cecinio “Nikko”Castillo Ronquillo Jr. PhD, (‘13), MD (‘15)
Research Prodigy to World Expert
While working as an MD/PhD student
in the lab of Moran’s Proctor-Awardwinning biochemist and genetic
researcher, Wolfgang B. Baehr, PhD,
Dr. Nikko Ronquillo became the world
expert on Senior-Loken syndrome
(SLS). A rare inherited disease caused
by a genetic mutation, SLS affects one
in one million people worldwide—350
in the US. Kids as young as seven start
developing subtle symptoms of retinitis
pigmentosa, a blinding eye disease.
By age 11, they develop cysts on the
kidneys and need a transplant, or the
kidneys fail.
“Good students are curious, have a strong work ethic, and
Sparking an Idea
“One day Wolfgang said, ‘Why don’t you start your
own project?’ I had no idea what I wanted to do,
except that I was interested in studying inherited
retinal diseases and developing animal models to
study these diseases,” says Ronquillo. “That’s the
expertise of Wolfgang’s lab worldwide—it is why
I came to the University of Utah and to Moran.”
Ronquillo found an ideal target for his project
when he read that people with mutations in the
gene Nephrocystin-5 (NPHP5) develop SLS.
“There are around five other known genes that
cause SLS, but NPHP5 is the most common cause.
This means when you are missing NPHP5, you
will always get SLS. That’s clean-cut genetics. I was
baffled that people were not doing anything about
this gene—so I started from there.”
Pursuing a Passion
Ronquillo wrote a proposal and received a
competitive grant from the National Institutes
of Health to create an NPHP5 knockout mouse
model, designed to be blind and develop kidney
problems. “The importance of this work is that
now we have a platform to delve deeper into how
NPHP5 mutations cause disease and to design
potential therapies that can be tested in the animal
model.” Ronquillo has also found three families
affected with SLS in Utah. For each person
affected in the SLS family, the goal is to identify
the ability to come up with their own ideas. With Nikko,
it was like opening up a gold mine. He is a great student who
has the talent and ability to move mountains in the future.”
—Wolfgang B. Baehr, PhD
Drs. Ronquillo and Baehr
new disease-causing genes. This information
will lead to better understanding this currently
incurable condition.
Fighting a Disease
He has already made a gene-therapy model and
is collaborating to make a virus to deliver normal
NPHP5, which should stop the progression of the
disease. And he is collaborating with the National
Eye Institute and an SLS family carrying the
NPHP5 mutation to research stem-cell therapy.
“SLS is a devastating disease. I design my studies
thinking about the patients I have met and what
that patient really needs. My dream is to stop the
progression of this disease,” says Ronquillo. “This
is a career-long endeavor.”
“Nikko is pretty impressive stuff. He discovered
a problem and researched how to solve it. He is going
to go on and do great things.”
—Randall J Olson, MD, CEO, Moran Eye Center
37
The Art of
Contact Lens Fitting
Babies born with cataracts, veterans with eye injuries, patients with corneal
disease, basketball and football players with astigmatism—anyone with
a special need or a simple desire to forgo eyeglasses and wear contact
lenses—is a candidate for a fitting with Moran’s Harald Olafsson, OD. His
career is a testament to dedication and a never-ending passion for learning
and teaching. His patients range in age from four weeks to 90-plus years,
and some of them have been with him since infancy.
Olafsson, who has been working
with Salt Lake’s Veterans Affairs Medical Center
(VA) and the Moran Eye Center since the mid1980s, was first drawn to specialty contact lens
fitting when he was stationed at a NATO hospital
in Belgium in the late 1970s. “A young German
officer came in with keratoconus, an eye disease
that affects the structure of the cornea causing it
to slowly change from the normal round shape to
a cone shape. He had been all over Europe trying
to get the right fit because his assignment required
sharp vison but didn’t allow eyeglasses. I worked
with him through lots of trial and error, because
at that time, I was learning, too,” recalls Olafsson.
“Finally, we found lenses that fit—and that actually
saved his career. He practically became a patient
for life, flying to Salt Lake to see me four or five
times for follow-up until I assured him he was
stable and didn’t have to come all this way. But
that experience really sparked it for me.”
Thanks to Olafsson’s efforts, Salt Lake’s VA offers
the only one-year accredited residency in the US
that combines cornea, contact lens, and disease
as well as general and primary eye care for ODs.
“Residents get to see patients at Moran—and at
the VA—where there is a huge need for specialty
care for veterans who have diseased or injured
eyes,” he says.
38
“The art of fitting lenses is almost as important as
the science,” notes Olafsson. “There is definitely an
intuitive element to it, a gut feeling of what might
work. After 30-plus years, I’m still constantly
evaluating new lens designs, but I know what
might work and why certain lenses may have
failed some patients. The key is you fit the lens to
the patient, not the patient to the lens.”
Utah Lions Eye Bank Moving into
Expanded, High-tech Space
on New Midvalley Campus
The Utah Lions Eye Bank is dedicated to restoring and preserving sight
through transplants, research, and education. Its mission is to consistently
provide surgeons and researchers with the highest quality eye tissue while
protecting the best interests and wishes of patients and donor families.
Executive Director Chris Hanna says, it’s a “delicate, complex” enterprise.
Chris Hanna, executive director Utah Lions Eye Bank
For the past seven years, 24 hours a day, seven days a week, the dedicated eye bank staff has performed remarkable work from a 1,464
square-foot space on the second floor of the Moran Eye Center at the University of Utah. But that space has its limitations in terms of
technical capacity and efficiency. In 2003, the eye bank received 710 eye tissue donations. In 2014, they received 2,810. “In 2003, we
had a staff of five or six people,” notes Hanna. “Today’s organizational chart calls for 39, so it’s no surprise we’ve outgrown the space in
more ways than one.” All of that will change when the group moves into a new 5,400 square-foot high-tech facility designed specifically
to enhance the eye bank’s technical capabilities, work flow, and capacity. Located adjacent to the new Midvalley Health Center, the new
facility will open later this year and include these features:
A fully enclosed, private Communications Center for sensitive
communication with donor families and healthcare workers.
Ample lab space for cutting-edge technology used
to process the tissue corneal surgeons need.
Improved storage.
An operating microscope.
Two International Standard for Organization (ISO)
Class 7 tissue-processing rooms.
A dedicated evaluation room.
An education/observation deck with a microphone and surgical
camera that make procedures visible and audible on a flat panel
display and from the break room. Residents and faculty will be
able to use the space to test new procedures and to train future
ophthalmologists on tissue that is not suitable for transplant or
used for research.
The ULEB received 2,810 eye
tissue donations in 2014 alone,
making it an all-time record year. This
incredible effort was only made possible
by the selfless actions of loving families
and donors and the help and cooperation
of many genuine and caring people.
An employee wellness center for around-the-clock staff.
Learn more at utaheyebank.org
Record Donations in 2014 Marked
Milestones for The Utah Lions Eye
Bank (ULEB) and Moran’s Center for
Translational Medicine (CTM)
Thanks to the concerted efforts and strong collaboration with
the ULEB, Moran’s Center for Translational Medicine (CTM)
reached a milestone in 2014, receiving eye tissue dedicated for
research purposes from over 2000 donors in four years, almost
doubling the donations that previously took over 20 years to
recover. Now at 6,000-plus pairs, this priceless collection is the
largest research eye tissue repository in the world.
39
The CTM’s Biological Resources Team, Norma Jean Miller, MPH,
and Marc Toso, PhD, senior laboratory specialists. Not pictured, Lisa
Nichols, program coordinator, is the liaison between the ULEB and
the CTM.
MORAN EYE CENTER
COMMUNIT Y CLINIC S
2015
A Brand New Moran Eye Center Location in Murray
On March 2, 2015, Moran and the University of Utah’s Department of Dermatology welcomed patients to the new Midvalley Health
Center—just north of the Fashion Place Mall at 243 East 6100 South. The 86,000 square-foot facility, with spectacular views of Mt.
Olympus to the east, is now home to full ophthalmology and dermatology clinics.
Moran patients are able to tap into a wide range of services at this convenient location. These include diagnostic testing and ocular
photography, full retina and glaucoma services, oculoplastic specialties, and a state-of-the-art laser center featuring the Alcon Wave Light
Refractive Suite for LASIK and PRK procedures. The center includes 35 exam lanes and full optometry and optical services, including
specialized and complex contact lens fitting. Faculty and fellows are now able to use this center for medical training as well.
Three of Moran’s former clinics in Rocky Mountain Ophthalmology, Old Mill Medical Center, and Greenwood Health Center have
relocated to this new, more centralized space at the south end of the valley.
40
Davis Vision Center
1492 West Antelope Drive
Layton
Farmington
15
Farmington Station
OPENING 2016
University of
Utah Hospital
Primary
Children’s
Hospital
Moran Eye Center
65 Mario Capecchi Drive
215
Park City
100 South
80
700 East
State Street
Dr
Tooele
hill
Redwood Road
Redstone
Health Center
1743 West
Redstone Center Drive
Suite 115
500 South
Salt Lake City
15
t
Foo
Stansbury Health Center
220 Millpond Road
Suite 100
400 South
80
2100 South
Redwood
Health Center
1525 West
2100 South
3500 South
West Valley City
South
Salt
Lake
State Street
215
Midvale
West Jordan
South Jordan Health Center
5126 West Daybreak Parkway
5200 West 11400 South
15
Murray
Midvalley
Health Center
243 East
6100 South
215
Redwood Road
Bangerter Highway
4700 South
Westridge
Health Center
3730 West
4700 South
3300 South
10600 South
South Jordan
11400 South
12600 South
Riverton
Moran Eye Center Clinic at
Intermountain Riverton Hospital
3773 West 12600 South
Suite 301
15
Parkway Health Center
145 West University Parkway
Orem
Hundreds attended Midvalley’s
grand opening February 23, 2015.
41
MORAN EYE CENTER
OPHTHALMOLOGISTS
2015
CEO of the John A. Moran Eye Center
Randall J Olson, MD, is the Chair of the Department of Ophthalmology and Visual Sciences and CEO of the
John A. Moran Eye Center. He specializes in research dealing with intraocular lens and cataract surgery. Dr. Olson
is the author of more than 300 professional publications and has given many named lectures all over the country
and worldwide. He was selected to receive the 2012 Binkhorst Medal by the American Society of Cataract and
Refractive Surgery, the 2014 Kelman Award by the American Academy of Ophthalmology, and the 2014 Rosenblatt
Prize for Excellence by the University of Utah.
Time constraints limit the number of patients Dr. Olson is able to see, yet he continues to enjoy patient care visits
on a regular basis.
specialt y
• Cataract Services and External Eye Diseases
Doctors in Alphabetical Order
William Barlow, MD,
Balamurali K Ambati,
MD, PhD, MBA,
specializes in cornea transplants,
cataract extraction, keratoprosthesis (artificial cornea), LASIK, and
other complex procedures of the
cornea and anterior segment of the
eye. He welcomes patients in these
areas as well as general ophthalmic
issues. Dr. Ambati also maintains a
dynamic research laboratory and
has authored more than 40 peerreviewed publications and
two books.
is an experienced comprehensive
ophthalmologist and ocular surgeon with a specific interest in cataracts, complex cataract surgery,
pterygium removal, and refractive
eye surgery such as LASIK and PRK.
He provides medical and surgical
care for these conditions as well as
general ophthalmic concerns. He
looks forward to welcoming you
to his practice and meeting your
ophthalmic needs.
specializes in comprehensive
ophthalmology with a focus on the
medical management of routine and
complex glaucoma.
specialties
• Comprehensive Ophthalmology
• Glaucoma
specialties
• Comprehensive Ophthalmology
• Cataract Services
• Refractive Surgery (LASIK,
Laser, and Non-laser)
Craig J Chaya, MD,
specialties
• Cornea
• Cataract Services
• Vision Correction Surgery
(LASIK, Laser, and Non-laser)
• Uveitis
Paul S Bernstein, MD, PhD,
42
James Beson, DO,
specializes in age-related macular
degeneration with special emphasis on the role of nutrition and
environment in its treatment and
prevention; inherited retinal and
macular dystrophies; and surgical
treatment of vitreoretinal disorders such as diabetic retinopathy
and retinal detachments.
specialties
• Vitreoretinal Diseases
and Surgery
• Retinal Biochemistry
• Macular and Retinal
Degeneration
practices comprehensive ophthalmology and specializes in the
medical and surgical management
of adult and pediatric cataracts,
glaucoma, and anterior segment
surgery. Dr. Chaya particularly
enjoys teaching and is actively
involved in Moran’s ophthalmology
resident and glaucoma fellow training programs. He is also passionate
about local and international outreach with his current work focusing on the advancement of eye care
delivery in Haiti, Guam, Micronesia,
Ghana, and the Navajo Nation
in southern Utah. His research
interests include the management
of cataracts and glaucoma in the
developing world and glaucoma
surgical techniques and devices.
specialties
• Comprehensive Ophthalmology
• Cataract Surgery
• Glaucoma
Susan Chortkoff, MD,
focuses on the management and
treatment of glaucoma as well as
comprehensive ophthalmology.
Dr. Chortkoff also has a special
interest in the management of dry
eye syndrome.
specialties
• Comprehensive Ophthalmology
• Glaucoma
MORAN EYE CENTER
OPHTHALMOLOGISTS
Alison Crum, MD,
Alan S Crandall, MD,
is the Senior Vice Chair of the
Department of Ophthalmology
and Visual Sciences, Director
of Moran’s Glaucoma and
Cataract Division, Co-director of
Moran’s International Outreach
Division, the Val A. and Edith
D. Green Presidential Endowed
Chair in Ophthalmology, and
past president of the American
Society for Cataract and Refractive Surgery. He focuses on the
medical and surgical management of glaucoma and cataracts.
Dr. Crandall has experience with
trabeculoplasty and laser cyclophotocoagulation. He is involved
in numerous clinical research
studies at the Moran Eye Center,
lectures throughout the world,
and was selected by Cataract
and Refractive Surgery Today as
one of 50 international opinion
leaders.
specialties
• Cataract Services
• Glaucoma
specializes in both oculoplastics
and orbital surgery—the reconstruction of the bones around
the eyes after traumas, correcting drooping eyelids, and
aesthetic surgeries, such as eyelid
lifts. She also practices neuroophthalmology, the study of how
the eye connects to the brain,
and provides medical and surgical
treatments for visual disorders.
Her interests include treatment of
Graves’ disease and treatment of
papilledema.
specialties
• Neuro-ophthalmology
• Oculoplastics and
Facial Plastic Surgery
• Ophthalmology
2015
Roger P Harrie, MD,
David C Dries, MD,
provides medical and surgical care
for a wide range of eye diseases
and visual impairments in children
as well as the evaluation and
management of strabismus in both
children and adults. His special
interests include amblyopia,
esotropia, exotropia, retinopathy
of prematurity, retinoblastoma,
infant and childhood cataracts,
and nasolacrimal duct obstruction.
practices comprehensive ophthalmology and ocular surgery
with a subspecialty in ophthalmic
ultrasound. He has been the senior
instructor in the ocular ultrasound
course at the annual American
Academy of Ophthalmology meeting and has published numerous
articles, book chapters, and two
textbooks. Dr. Harrie has made
more than 50 humanitarian trips,
mostly training doctors in developing countries in diagnostic and
therapeutic techniques. He directs
the outreach program in examining and giving glasses to residents
of the Salt Lake Valley Youth
Detention Center.
specialt y
• Comprehensive Ophthalmology
specialties
• Pediatric Ophthalmology
• Adult Strabismus
Kathleen B Digre, MD,
is a past president of the North
American Neuro-ophthalmology
Society. She specializes in neuroophthalmology and evaluates and
treats complex visual complaints
which can be due to optic nerve or
brain disease. Her interests include
gender differences in neuro-ophthalmic disorders, pseudotumor
cerebri, ischemic optic neuropathy,
temporal arteritis, papilledema,
episodic vision loss, headaches
and eye pain, diplopia, and Graves’
disease. She has worked with the
North American Neuro-ophthalmology Society and the University
of Utah Eccles Library to develop
a Neuro-ophthalmology Virtual
Educational Library (NOVEL) online
at http://novel.utah.edu. She
received the Rosenblatt Prize for
Excellence at the University of
Utah in 2012.
specialt y
• Neuro-ophthalmology
Mary Elizabeth Hartnett, MD,
Joseph L Hatch, MD,
provides expertise and experience
in all areas of ophthalmology and
has extensive experience in contact lens fitting. In 2008, Dr. Hatch
was asked to serve on the Church
of Jesus Christ of Latter-day Saints
Vision Initiative. This program
sends eye care professionals to
countries throughout the world.
specialt y
• Comprehensive Ophthalmology
is Director of Pediatric Retina. She
specializes in vitreoretinal surgery
and directs a pediatric retina
center, managing both pediatric
and adult retinal conditions at the
Moran Eye Center. She performs
surgery at both the Moran Eye
Center at the University of Utah
and the Moran Eye Center at
Primary Children’s Hospital.
specialt y
• Pediatric and Adult Retinal
Diseases and Surgery
43
MORAN EYE CENTER
OPHTHALMOLOGISTS
Bradley J Katz, MD, PhD,
specializes in neuro-ophthalmology, cataract, and comprehensive ophthalmology. He
evaluates patients with diseases
that affect the optic nerve and
diseases of the brain that affect
vision and eye movements. Dr.
Katz also conducts research in
the areas of giant cell arteritis,
photophobia and migraine, optic
neuritis, and multiple sclerosis.
Robert O Hoffman, MD,
is Chief of the Division of Pediatric
Ophthalmology and Eye Muscle
Disorders. He has special interests
in retinopathy of prematurity, ocular genetics, craniofacial disorders,
pediatric cataracts, and complicated strabismus.
specialties
• Cataract Services
• Neuro-ophthalmology
specialties
• Pediatric Ophthalmology
• Adult Strabismus
Amy Lin, MD,
specializes in the medical and
surgical treatment of corneal
and anterior segment diseases.
Her interests include corneal
transplantation, anterior segment reconstruction, cataract
surgery, refractive surgery, and
teaching residents and fellows.
Rachael Jacoby, MD,
specializes in medical and surgical
diseases of the retina and vitreous.
Her primary clinical and surgical
interests include retinal detachments, diabetic retinopathy, and
macular and retinal degeneration.
specialties
44
• Retinal Diseases and Surgery
• Macular and Retinal
Degeneration
specialties
• Corneal Transplantation
• Cataract Surgery (Advanced
Technology Intraocular
Lenses and Laser-assisted
Cataract Surgery)
• Vision Correction Surgery
(LASIK, PRK, Phakic
Intraocular Lenses)
2015
Mark D Mifflin, MD,
is Moran’s Director of Surgical
Services and the Medical Director
of the Utah Lions Eye Bank. He
specializes in the medical and
surgical treatment of corneal and
anterior segment eye diseases.
His expertise includes all types of
corneal transplantation, cataract
surgery, and refractive surgery.
Nick Mamalis, MD,
is Director of the Ophthalmic
Pathology Laboratory and evaluates all specimens submitted to
the laboratory. He focuses his
clinical practice on comprehensive
ophthalmology including cataract
and other anterior ocular surgeries. Dr. Mamalis is the editor of the
Journal of Cataract and Refractive
Surgery and is the author of 190
peer-reviewed publications, one
textbook, and 40 book chapters.
He is also Co-director of the
Intermountain Ocular Research
Center and is performing research
in the area of intraocular lenses
and postoperative inflammation.
Dr. Mamalis lectures throughout
the world and was selected by
Cataract and Refractive Surgery
Today as one of 50 international
opinion leaders. He was selected
as the Binkhorst Medal recipient
in 2013 by the American Society of
Cataract and Refractive Surgery.
specialties
• Cataract Services
• Ophthalmic Pathology
• Comprehensive Ophthalmology
specialties
• Cornea Transplant Surgery
(Penetrating Keratoplasty,
Lamellar Keratoplasty, Stem
Cell Transplantation, and
Eye Banking)
• Cataract Surgery (Premium
Intraocular Lenses, Monovision)
• Vision Correction Surgery (LASIK,
PRK, Phakic Intraocular Lenses)
Bhupendra C K Patel, MD,
FRCS, FRC,
is an expert in the management
of disorders involving eyelids,
periorbital tissues, the lacrimal
system, and facial bones, including
fractures. His clinical research
interests include thyroid disease,
optic nerve disorders, orbital and
eyelid tumors, blepharospasm,
lacrimal surgery, and facial
cosmetic surgery.
specialt y
• Oculoplastic and
Facial Plastic Surgery
MORAN EYE CENTER
OPHTHALMOLOGISTS
Akbar Shakoor, MD,
Jeff Pettey, MD,
is Director of the John A Moran
Eye Center Training and Residency
Program. He is also the Chief of
Ophthalmology at the Salt Lake
City VA Medical Center. Dr. Pettey
specializes in comprehensive
ophthalmology, complex cataracts,
and anterior segment surgery. He
coordinates teaching and training
of medical students, residents, international observers, and fellows
and is actively involved in local
outreach and international ophthalmology, working to develop
teaching and training collaborations with programs in developing
countries. He is actively involved in
research to make cataract surgery
safer and more efficient.
specialties
• Comprehensive Ophthalmology
• Cataract Services
Aparna Ramasubramanian, MD,
specializes in eye diseases in
children as well as evaluating and
treating strabismus in adults and
children, including adjustable
sutures. She is also trained in ocular
oncology and has a special interest
in pediatric eye tumors, especially
retinoblastoma.
specialties
• Pediatric Ophthalmology
• Ocular Oncology
• Adult and Pediatric Strabismus
specializes in diseases of the
retina and vitreous as well as
the diagnosis and treatment
of uveitis and other infectious
and inflammatory diseases of
the eye. His primary clinical and
surgical interests include retinal
detachments, diabetic retinopathy, epiretinal membranes and
macular holes, macular and
retinal degeneration, and the
medical and surgical treatment
of ocular inflammatory diseases
such as uveitis.
Jean Tabin, MD,
provides general vision care and
comprehensive ophthalmology services at the Moran Eye
Center. Dr. Tabin enjoys working
in Moran’s Triage Clinic treating
patients and teaching medical
students and residents who
are interested in learning more
about ophthalmology.
specialt y
• Comprehensive Ophthalmology
specialties
• Retinal Diseases and Surgery
• Uveitis and Ocular Immunology
Kim Taylor, MD,
Geoffrey Tabin, MD,
is the John E. and Marva M.
Warnock Presidential Endowed
Chair in Ophthalmology and Codirector of Moran’s International
Outreach Division. He specializes
in corneal transplantation,
keratoprosthesis (artificial cornea),
management of corneal disorders,
cataract extraction, LASIK,
inflammatory eye diseases, and
other complex procedures of the
cornea and anterior segment of the
eye. In addition to his work in Utah,
Dr. Tabin is working to develop
eye care delivery in developing
countries, including improving
cataract and corneal surgery.
specialties
• Cataract Services
• Vision Correction Surgery
(LASIK, Laser, and Non-laser)
2015
practices comprehensive ophthalmology and has extensive
experience in fitting contact
lenses. He has many years of
experience in diagnosing and
treating eye diseases of all kinds.
specialt y
• Comprehensive Ophthalmology
Albert T Vitale, MD,
is Director of Moran’s Uveitis
Division. He specializes in patients
with diseases of the retina and
vitreous. He is one of the only ophthalmologists in the Intermountain
West specializing in the diagnosis
and treatment of uveitis and
other infections and inflammatory
diseases of the eye. His research
interests include ocular manifestations of systemic diseases, novel
therapeutic agents, and new drug
delivery systems in the treatment
of ocular inflammatory disease,
retinal vascular disease, and the
pharmacotherapy of age-related
macular degeneration. He is one of
a few people in the country with
dual training in ocular immunology and inflammatory disease and
vitreoretinal surgery. Dr. Vitale is
co-author of the definitive text on
the subject, with Dr. C. Stephen
Foster, entitled, Diagnosis and
Treatment of Uveitis.
specialties
• Uveitis, Ocular Infections
• Retinal Diseases and Surgery
Michael P Teske, MD,
is Director of Vitreoretinal
Diseases and Surgery. Dr. Teske
specializes in medical and surgical
diseases of the retina and vitreous. His primary surgical interests include retinal detachment,
proliferative vitreoretinopathy,
diabetic retinopathy, retinopathy of prematurity, epiretinal
membranes, macular holes, and
posterior segment trauma.
specialt y
• Retinal Disease and Surgery
45
MORAN EYE CENTER
OPHTHALMOLOGISTS
2015
Ophthalmologists Continued
Judith E A Warner, MD,
is Chief of Neuro-ophthalmology.
She evaluates complex visual
complaints, which can be due
to optic nerve or brain disease,
and provides treatment for these
disorders. Her interests include
diplopia, giant cell arteritis, papilledema, optic neuritis, episodic
vision loss, idiopathic intracranial hypertension, ischemic optic
neuropathy, and unexplained
vision loss.
Barbara M Wirostko, MD,
has specialized fellowship training
in glaucoma, treats glaucoma and
comprehensive ophthalmology
patients, and specializes in clinical
research and drug development
for glaucoma pharmaceutical
therapies. Her research interest
is in sustained delivery of
therapeutics for ocular pathologies
and in approaching glaucoma
through non-intraocular pressure
mediated approaches.
specialt y
specialties
• Neuro-ophthalmology
• Comprehensive Ophthalmology
• Glaucoma
Marielle Young, MD,
provides medical and surgical
care for children with eye
disease as well as adults and
children with strabismus. Her
clinical expertise includes the
evaluation and treatment of
amblyopia, strabismus, infantile
and developmental cataracts, and
nasolacrimal duct obstruction.
specialties
• Pediatric Ophthalmology
• Adult and Pediatric Strabismus
Norm A Zabriskie, MD,
is Vice Chair and Medical Director
of Clinical Services and Director of
Clinical Operations at the John A.
Moran Eye Center. He specializes in
the medical and surgical treatment
of glaucoma and cataracts. He has
a research interest in the genetics
of glaucoma.
specialties
• Cataract Services
• Glaucoma
OTHER SPECIALTIES
Robert M Christiansen,
MD, FACS,
46
Donnell J Creel, PhD,
Lisa Ord, PhD, LCSW,
provides comprehensive vision
rehabilitation services through
Moran’s ophthalmology-based
Patient Support Program. A
nationally recognized expert in
low vision rehabilitation, he has
been recognized by the American
Academy of Ophthalmology with
the Achievement Award and the
Senior Achievement Award and
by other organizations for his
work with the partially sighted.
specialt y
specialt y
specialt y
• Electrophysiology
• General Anesthesiology
• Vision Rehabilitation
is Director of the ophthalmologybased Patient Support Program
for people with visual impairment
and their families. Services in
this program include counseling,
information and referral services,
support groups, and the Orientation to Vision Loss Program.
Derek J Sakata, MD,
is Director of the Electrophysiology
Service at the John A. Moran
Eye Center. The Electrophysiology
Service provides examinations
including visually evoked potentials, full-field electroretinograms,
auditory brainstem responses,
electrooculograms, multifocal
electroretinograms, and multifocal
visually evoked potentials. These
tests quantitate retinal, optic pathway, visual cortical, and brainstem
auditory pathway function.
specialt y
• Counseling Related to Vision Loss
is Medical Director for Anesthesia
Services at the John A. Moran
Eye Center. Dr. Sakata provides
and directs anesthesia care for
ophthalmic patients before, during, and after surgery. He also
has a background in engineering
and has been involved in medical
device design and subsequent
company startups. He continues to
be involved in research into new
medical device designs and drug
delivery.
Robert H Corry, OD,
specializes in ocular pathology,
pediatric and general optometry,
and contact lenses.
Redwood Health Center
South Jordan Health Center
Alan Morgan, OD,
specializes in contact lenses and
general optometry.
UUHC—Davis Vision Center
Timothy L Gibbons, OD,
specializes in contact lenses,
pediatrics, sports vision, and
ocular disease.
Stansbury Health Center
Westridge Health Center
Spencer D Mortensen OD,
FAAO
specializes in contact lenses,
sports vision, and general
optometry.
Westridge Health Center
Colleen S Schubach, OD,
offers full-scope optometric eye
care and contact lens services
for all ages. She specializes in
vision therapy with emphasis
on children and sports vision.
Redstone Health Center
2015
OPTOME TRISTS
Mark A McKay, OD,
specializes in full-scope optometric care, including adult
and pediatric care, contact
lenses and job- or hobby-related visual needs.
John A. Moran Eye Center
Redwood Health Center
Westridge Health Center
Harald E Olafsson, OD,
is the Director of Contact
Lens Services. He specializes
in fitting contact lenses with
particular interest in keratoconus, pediatrics, and fitting
traumatized eyes; eyes with
severe or irregular astigmatism; and he provides primary
eye care for those who do or
do not wear contact lenses.
John A. Moran Eye Center
Craig M Smith, OD,
specializes in children's vision,
sports vision, contact lenses,
and general optometry.
Midvalley Health Center
Clair R Palmer, OD,
specializes in contact lenses.
Parkway Health Center
South Jordan Health Center
Bryan H Vincent, OD,
specializes in ocular pathology
and contact lenses.
Midvalley Health Center
John A. Moran Eye Center
Optometrists
MORAN EYE CENTER
47
Research
MORAN EYE CENTER
2015
Balamurali K Ambati,
MD, PhD, MBA
Alessandra Angelucci,
MD, PhD
Wolfgang B Baehr, PhD
Professor of Ophthalmology
and Visual Sciences and
Adjunct Associate Professor of
Neurobiology and Anatomy
Professor, Ophthalmology
and Visual Sciences
Professor and Director, Michael
M. Wynn Center for Inherited
Retinal Diseases; Ralph and Mary
Tuck Professor of Ophthalmology
and Visual Sciences
specialties
specialt y
Visual Cortex Circuitry and Function
specialties
Ocular Angiogenesis and Corneal
Research
Phototransduction, the Retinoid
Cycle, and Membrane Protein
Transport in Photoreceptors;
Biochemistry, Molecular and
Cell Biology
Paul S Bernstein, MD, PhD
Paul Bressloff, PhD
Donnell J Creel, PhD
Karen Curtin, PhD, MStat
Director of Clinical Research
and Associate Director of
Research; Mary H. Boesche
Professor of Ophthalmology
and Visual Sciences
Adjunct Professor,
Ophthalmology and Visual
Sciences; Professor of
Mathematics
Research Professor,
Ophthalmology and Visual
Sciences; Neurobiology and
Anatomy; Neuroscience
Adjunct Professor,
Ophthalmology and Visual
Sciences, Moran Center for
Translational Medicine
specialties
specialt y
Modeling of Visual Cortex
specialt y
Electrophysiology
specialties
Genetic Epidemiology;
Age-relat­ed Macular
Degeneration
Margaret DeAngelis, PhD
Jeanne M Frederick, PhD
Yingbin Fu, PhD
Sabine Fuhrmann, PhD
Associate Professor, Ophthalmology and Visual Sciences
Research Associate Professor,
Ophthalmology and Visual
Sciences
Associate Professor, Ophthalmology and Visual Sciences
Associate Professor,
Ophthalmology and Visual
Sciences
specialt y
Macular and Retinal
Degeneration; Gene Therapy;
Phototransduction
Vitreoretinal Diseases and
Surgery; Retinal Biochemistry;
Macular and Retinal Degeneration
48
RESEARCH TEAM
specialt y
Genetics, Genomics, and Systems
Biology-based Approaches to
Pinpoint Disease Causality in Agerelated Macular Degeneration,
Glaucoma, Myopia, Diabetic Retinopathy, Retinopathy of Prematurity,
and Co-occurring Diseases
Retinal Cell and Molecular Biology
specialties
specialties
Ocular Development;
Retinal Pigment Epithelium
Cell Biology
Building bridges from research to patient care
Werner Gellermann, PhD
Gregory S Hageman, PhD
Mary Elizabeth Hartnett, MD
Bryan W Jones, PhD
Adjunct Professor,
Ophthalmology and Visual
Sciences; Research
Professor, Physics
John A. Moran Presidential
Professor, Department of Ophthalmology and Visual Sciences;
Executive Director, Moran Center
for Translational Medicine
Professor, Ophthalmology
and Visual Sciences
Research Assistant Professor,
Ophthalmology and Visual
Sciences
specialt y
specialt y
Retinal Angiogenesis Relating
to Retinopathy of Prematurity
and Age-related Macular
Degeneration
specialties
Retinal Degeneration Disorders;
Retinal Neurotransmission and
Neurocircuitry; Metabolomics
Spectroscopy of Living
Human Tissue
specialties
Li Jiang, MD, PhD
Bradley J Katz, MD, PhD
Julia Kleinschmidt, PhD,
LCSW
Helga E T Kolb, PhD
Research Assistant Professor,
Ophthalmology and Visual
Sciences
Associate Professor, Ophthalmology and Visual Sciences
Professor (Emerita), Ophthalmology and Visual Sciences
Professor (Emerita), Ophthalmology and Visual Sciences
specialties
specialties
specialt y
specialties
Retinal Diseases; Gene Therapy;
Molecular and Cell Biology
Giant Cell Arteritis; Photophobia
and Migraine; Optic Neuritis;
Multiple Sclerosis
Orientation and Support Services
for international ophthalmologists training under the Moran
Eye Center’s Outreach Division
Retinal Anatomy; Editor,
Webvision www.webvision.med.
utah.edu
David Krizaj, PhD
Edward M Levine, PhD
Nick Mamalis, MD
Robert E Marc, PhD
Professor, Ophthalmology and
Visual Sciences; Deputy Director
of Research
Associate Professor,
Ophthalmology and Visual
Sciences
specialties
specialt y
Professor, Ophthalmology
and Visual Sciences;
Co-director, Intermountain
Ocular Research Center
Director of Research and
Distinguished Professor of Ophthalmology; Cal and JeNeal Hatch
Presidential Endowed Chair in
Ophthalmology and Visual Sciences
Retinal Neurobiology;
Calcium Regulation; Glaucoma
The Genetics and Assessment of
Pathways Involved in the Etiology
of Age-related Macular Degeneration; Retinal Cell Biology
Retinal Neurogenesis and
Regeneration
specialties
Ocular Pathology; Comprehensive
Ophthalmology; Intraocular
Lens Research; Postoperative
Inflammation
specialties
Retinal Neurotransmission and
Networks; Retinal Degenerations;
Metabolomics
49
MORAN EYE CENTER
2015
Richard A Normann, PhD
Debra A Schaumberg, ScD,
OD, MPH
Jason Shepherd, PhD
Ning Tian, PhD
Professor (Emeritus),
Ophthalmology and Visual
Sciences; Distinguished
Professor of Bioengineering
Professor of Ophthalmology and
Visual Sciences; Associate Director for Clinical and Epidemiological Research, Moran Center for
Translational Medicine
Assistant Professor of
Neurobiology and Anatomy;
Adjunct Assistant Professor
of Ophthalmology and Visual
Sciences
Professor, Ophthalmology
and Visual Sciences; Adjunct
Professor, Neurobiology
specialt y
specialt y
Retinal Neurobiology
Artificial Vision/Neural
Prosthetics
specialties
Monica Vetter, PhD
Haibo Wang, MD, PhD
Liliana Werner, MD, PhD
Barbara M Wirostko, MD
Adjunct Professor,
Ophthalmology and Visual
Sciences; George and Lorna
Winder Professor of
Neuroscience; and Chair,
Neurobiology and Anatomy
Research Assistant Professor,
Ophthalmology and Visual
Sciences
Associate Professor, Ophthalmology and Visual Sciences;
Co-director, Intermountain Ocular
Research Center
Clinical Adjunct Associate
Professor, Ophthalmology and
Visual Sciences
Vascular Biology: abnormal
vessel growth implicated in
pathological neovascularization
in age-related macular degeneration, retinopathy of prematurity,
and diabetic retinopathy
specialties
Glaucoma; Drug and Device
Development
Larry A Wheeler, PhD
Lloyd Williams, MD, PhD
Jun Yang, PhD
Research Professor,
Ophthalmology and Visual
Sciences
Adjunct Research Assistant
Professor, Ophthalmology and
Visual Sciences
Associate Professor, Ophthalmology and Visual Sciences
specialties
specialties
specialties
Retinal Development; Glaucoma
50
RESEARCH TEAM
Epidemiology and the Joint
Influences of Genetic, Molecular, and Lifestyle Risk Factors in
Causing Eye Disease; Age-related
Macular Degeneration; and Dry
Eye Disease
specialt y
Ophthalmic Drug Discovery
and Development; Age-related
Macular Degeneration; Pharmacology of Glaucoma; Dry Eye and
Neuroprotection
specialties
Visual Cortex Function and Plasticity in vivo; Cellular and Molecular Mechanisms of Learning and
Memory; Cell Biology of Synapse
Ocular Biodevices Research; Different Intraocular Lens Designs;
Materials and Surface Modifications; Interactions between Ocular
Implants and Ocular Tissues
Genetics of Orphan Diseases;
International Eye Disease and
Population Studies; Cornea
specialties
specialties
Cell Biology of Photoreceptors;
Retinal Diseases
Moran Adjunct Volunteer Faculty 2015
From across the states and around the globe, adjunct volunteer faculty contribute as appreciated
members of our Moran team. They collaborate on research projects, participate in clinical studies,
attend teaching opportunities, and assist on our outreach medical missions.
Jason Ahee, MD
St. George, Utah
Robert C Kwun, MD
Murray, Utah
James Tweeten, MD
Boise, Idaho
Iqbal “Ike” Ahmed, MD
Mississauga, Ontario Canada
David P Lewis, MD
Brigham City, Utah
Albert Ungricht, MD
Salt Lake City, Utah
Rachel S Benator, MD
Salt Lake City, Utah
Corey Miller, MD
Salt Lake City, Utah
Jeremy Valentine, MD
Provo, Utah
John A Carver, MD
Provo, Utah
Valliammai Muthappan, MD
Sewickley, Pennsylvania
Charles H Weber, MD
Salt Lake City, Utah
Kevin H Charlton, MD
Salt Lake City, Utah
David B Petersen, MD
Salt Lake City, Utah
Robert C Welch, MD
Twin Falls, Idaho
Joseph Chen, MD
Ventura, California
Robert Rivera, MD
Draper, Utah
Brice J Williams, MD
Ogden, Utah
Robert J Cionni, MD
Salt Lake City, Utah
Sanduk Ruit, MD
Kathmandu, Nepal
Kirk S Winward, MD
Murray, Utah
Richard P Corey, MD
Salt Lake City, Utah
D Snow Slade, MD
St. George, Utah
Darcy Wolsey, MD
Salt Lake City, Utah
Sonya Dhar, MD
New York, New York
Robert E Smith, MD
West Valley City, Utah
Gilbert C Wong, MD
West Jordan, Utah
John B Fassio, MD
Heber City, Utah
R Doyle Stulting, MD, PhD
Atlanta, Georgia
Zachary J Zavodni, MD
Salt Lake City, Utah
William J Fishkind, MD
Tucson, Arizona
Scott O Sykes, MD
Salt Lake City, Utah
Roger C Furlong, MD
Butte, Montana
Robert L Treft, MD
Layton, Utah
Reeta Gurung, MD
Kathmandu, Nepal
James G Howard, MD
Murray, Utah
Krista Kinard, MD
Spokane, Washington
Victoria Knudsen, MD
Murray, Utah
51
Appendices
52
Contents
Donors53
Industry Leadership and Service
59
Awards, Honors, and Appointments63
Clinical Trials
64
Technology Commercialization
and Intellectual Property/Patents 66
Grand Rounds
70
Published Research
72
Research Grants and Contracts
77
National and
International Presentations
84
“From Darkness to Light”88
The following individuals and organizations contributed to the
Moran Eye Center from January 1, 2014 through December 31, 2014
Donors
2014
J O H N A . M O R A N E Y E C E N T E R D O N O R R E P O R T F O R 2014
gifts o f $1,000,000 a n d a b o v e
Marva M. and John E. Warnock, PhD
gifts o f $100,000 a n d a b o v e
William H. and Patricia W. Child | Edmund W. and Carol B. Dumke
The Huntsman Foundation | Helen K. and Arthur E. Johnson Foundation
Ray I. and Elizabeth A. Johnson Trust | Research to Prevent Blindness, Inc.
Sharon E. Steele-McGee | John C. and Carlene Williams | Stephen A. Wynn Foundation
gifts o f $50,000 a n d a b o v e
John and Toni Bloomberg | Lawrence T. and Janet T. Dee Foundation
Tim and Candace Dee | Willard L. Eccles Charitable Foundation
John B.* and Geraldine W.* Goddard | Val A. and Edith D. Green Foundation, Inc.
Margaret D. Hicks | Judelson Family Foundation
Noel and Florence Rothman Family | Peter and Nancy Salter Family Foundation
Wattis Dumke Foundation | Zions First National Bank
gifts of $ 2 5 ,00 0 a n d a bov e
Hoya Medical Singapore, PTE LTD
Utah Lions Foundation
Lance D. Alworth
Steven and Elizabeth Huish
Katrina vanden Heuvel
Bamberger-Allen Health and
Education Foundation
Stephen C. and Lynda M. Jacobsen
Gary and Sue Wingate
Nicole and Daniel C. Kline, MD
Terry L. Wright
Chip and Gayle N. Everest
Gordon and Marcia* Olch
Thomas H. and Carolyn L. Fey
George J. and Cynthia C. Petrow
gifts of $5, 000 an d above
Carol Holding
Thomas C. Praggastis and Michelle
Dumke Praggastis
Allan M. and Kay W. Lipman
MacuClear
Retina Research Foundation
James W. and Jeanne J. Welch
gifts of $ 1 0 ,00 0 a n d a bov e
Abbott Medical Optics
ASCRS Foundation
Lydia B. Barkley Charitable
Remainder Unitrust
Robert E. Hafey, JD
John and Marcia Price Family
Foundation
Ruvo Family Foundation
Adam and Tara G. Saucedo
The Semnani Family Foundation
Denise R. Sobel
Strazza Family Trust
Susan O. Taylor
The Donald J. Trump Foundation, Inc.
James P. Tweeten, MD
William and Sara Barrett
Scott Bergeson
Eveline Bruenger
Burningham Foundation
William H. Coles, MD and
Mary Elizabeth Hartnett, MD
Dustin Coupal
William K. and Fern H. England
Jill L. and Gregory S. Hageman, PhD
John Hoffman, MD
and Jane Durcan, MD
Paul Joos, MD
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J O H N A . M O R A N E Y E C E N T E R D O N O R R E P O R T F O R 2014
Edward M. and Beth A. McGill
Larry H. and Gail Miller
Family Foundation
FFKR Architects/Planners II
My Brother’s Keeper Foundation Trust
The Firmage Group, Inc.
Margaret D. Ordway
Teri and Dean Flanders Foundation
Frederick Quinn, PhD and
Carolyn Tanner Irish
Cecelia H. Foxley, PhD
Linda Rankin, PhD
Hazel I. M. Robertson
Sam and Diane Stewart
Family Foundation
Larry B. and Liane W. Stillman
Norman C.* and Barbara L. Tanner
James R. and Linda R. Wilson
gifts of $ 1 ,00 0 an d a bov e
Advanced Vision Care
Iqbal Ahmed, MD
George M. Ahn
Brock K. Bakewell, MD
Bonnie Barry
Paul L. Bartel and Marion DiRado
Raymond E. and Janette H. Beckham
Joseph C. and Gainor L. Bennett
Bennion Jewelers
Ann P. and Paul S. Bernstein, MD, PhD
BMW of Murray
Don F. and Jean W. Bradshaw
Rodney H. and Carolyn H.
(Mitzi) Brady
Laura D. Byrne
Cafe Trio Cottonwood
Irene G. Casper
The Castle Foundation
Helen and Robert Cionni, MD
Hal M.* and Aileen H. Clyde
Garry Condon
54
Henry W. and Leslie M. Eskuche
Foundation
F. Anthony and Joyce G. Crandall
Julie S. and Alan S. Crandall, MD
Lisa Z. and David A. Crandall, MD
Robert W. and Carol N. Culver
James R. and Rula B. Dickson
Anna M. and David C. Dries, MD
E. R. (Zeke) and Katherine W.* Dumke
EnergySolutions
Heidi and Roger Furlong, MD
David P. and Sheila S. Gardner
James H.* and Mary Ann Gardner
Paul E. Garland, MD
John R. and Andrea M. Hampshire
Orrin G. and Elaine Hatch
C. Charles and Elise Hetzel
Carolyn S. and Robert O. Hoffman, MD
Howard Rodney Horinbein
Hullinger Family Foundation
Theodore and Charlotte Jacobsen
The Fletcher Jones Foundation
Brad, Tracey, Sam, Jonah, and Zev Katz
Michelle Y. and Tae S. Kim, MD
Mike and Kris Kladis
Irving M. and Donna P. Raber
Richard F.* and Jan Rasmussen
Ronald and Carolyn C. Reaveley
Don B. Reddish
Alvin and Helene Richer
Ed and Carol Robinson
Gary W. Rodgers and Chris Filtz
Mickey Shapiro Charitable Trust
April Shell
Tueng T. Shen, MD and Jan H. Thjssen
Shiebler Family Foundation Trust
Lincoln V. Shurtz and Lisa Harrison
Shirley J. and Allan Evans Smith
Laura J. Springhetti
Howard S. Spurrier, DDS
John D. and Marilyn M. Stevens
Sun Lithographing Company
Gretchen and Michael P. Teske, MD
David B. Theobald
Utah Ophthalmology Society
Klintworth Family Foundation
Michael W. Varner, MD and
Kathleen B. Digre, MD
Peter G. and Geraldine S. Kypreos
The Vaughn Revocable Trust
Mihail Lari and Scott Murray
Sladjana Verkic
Lemon Grove LC
William and Karen Curtin Wegesser
Susan MacDonald, MD
Mitchell P. Weikert
Maurice F. Malouf
Luree and Robert C. Welch, MD
Mammco, LLC
Dan J. and Lisa J. Williamson
Milo S. and Jacqueline B. Marsden
David R. and Sharon Wilson
Mary Lou and Merrill Matzinger
Robert C. and Patience Ziebarth
John M. McQuillan
gifts of $100 an d abov e
Vicki B. Merchant
Herbert I. and
Elsa B. Michael Foundation
Moreton Family Foundation
Ruth A. Morey
Anna C. and Grant Morshedi, MD
George and Pauline Mulligan
Howard Munsell
Marilyn Neilson
Marilyn Olson
Ruth L. and Randall J Olson, MD
Jeff and Susan Polychronis
Printers Inc.
G. Howard Abplanalp
Curtis E. Ackerlind, Jr.
Kent M. and Jeanine H. Acomb
Hans G. Ahrens
Alcohol Servers Training of Utah LLC
Raymond H. and Ila Jane* Aldrich
Ray W. and Bonnie Lou Alvord
Balamurali K. Ambati, MD, PhD
Gabrielle D. Anderson
James and Carol Anderson
Milton M. and Dianne K. Anderson
Barry J. and Catherine F. Angstman
J O H N A . M O R A N E Y E C E N T E R D O N O R R E P O R T F O R 2014
Mary C. Argus
Timothy J. and Shelley A. Chambers
Curtis J. and Julie G. Drake
Melvin B. and Taunya L. Ashton
Michelle and Craig J. Chaya, MD
Bill G. and Sophia K. Drossos
Jeannine Athas
George A. and Pauline O. Childs
Gaye N. and R. Michael Duffin, MD
Pamela J. Atkinson
Don V. and Anne E. Christensen
Elwin J. and Lois Dutson
Shane R. Atkinson
Thayer S. and Sue D. Christensen
John S. and Evelyn B. Edwards
Ekhlas A. Attia
Kurt P. Christiansen
David E. Oberly and Karen Ehresman
June W. Austin
Joann Coyte Cissel
Robert* and LaDorna Eichenberg
Axis Reclamation & Construction Corp.
Glenn D. and Kara E. Clapp, PhD
Stephen and Lois Eisen
Charles Ayers, MD
G. Harlan and Mary J. Clark
Robert C. and Lisa B. Eixenberger
Karen S. Bachman
Joseph A. and Suzanne F. Clegg
Gary F. Evans
Barry and Ann C. Bagley
Blaine S. and Jacquelyn W. Clements
Dennis D. and Carma B. Ewing
Ramon C. Baird
Whitney O. and Frances R. Cluff
Fred W. and Christine A. Fairclough
Constance Baker
Janine B. Coles
Spencer P. Felt, Jr.
Leah A. Baker
Kenneth D. Collins
Susan Heiser Fenster
Margaret D. and Bryce G. Barker, MD
Joseph V. and Nancy C. Cook
Jack M. and Marianne Ferraro
J. Gene Barnes
Gerald W. and Ruth Y. Cooke
Carol W. and John H. Firmage, III
Richard P. Barnes Art Studio
Drury W. Cooper, III
Joan B. and John H. Firmage, II
Fern E. Bartholomew
Court House Fitness Center
Ethan K. and Kelly Belden Fisher
F. Robert and Jan L. Bayle
Margaret A. Cragin-Masarone
Russell F. and Barbara C. Fjeldsted
David W. Becker, Jr.
David L. Crandall
Keith A. and Cindy Hadden Fleming
Lawrence T. and Jane K. Bennett
David L. Croasdaile, MD
Paul Fleury
William F. and Victoria F. Bennion
Paul B. Crookston
Grant L. and Marjean P. Freeman
Kurt T. and Betsy Bernhisel
Ronald W. Crouch and
Elizabeth A. Nielson
Melvin R. Freeman
John A. and Dee Bianucci
Garth Bickmore
Eric R. and Maryann Biedermann
Carl M. Biehn
Bonnie B. Blanchard
Elmen D. and Monika Bloedel
Richard T. and Sharon D. Bretzing
Inge Jensen Brown
J. Steven and Susan J. Brown
Dolores Z. Buchanan
Grace Buck
William and Jean Buhl
David Burke
Ralph C. and Judy C. Burton
William L. and Sheral L. Calvin
Marilyn P. Cameron
Jo Ann Campbell
James D. Caras
Dean Cardinale
Robert S. Carter Foundation, Inc.
Alan S. and Joan E. Cruickshank
Culligan Water
John Romney and Inger Darden
Sujote David, MD
Milton L. and Margaret H. Davis
Craig W. Dayhuff
Nathan C and Linda Pearline Dean
Christine S. and Rodney W. Decker
Joel and Monica R. De La Cruz
Deer Valley Resort
Kevin W. and Susan H. Deesing
Stephen G. and Susan E. Denkers
Inci Irak Dersu, MD
Steven and Susan Dewey
Sonya Dhar, MD
Cameron and Rachel Diehl
John F. Dillon
Caren Dixon
Sean Douglas
Bernard I. and Margery G. Friedlander
D. Jay and Lynda S. Gamble
Vedha Priya Ganesan
Dietrich K. and LaDon M. Gehmlich
Deanna R. Gerber
Clark P. and Nancy L. Giles
Jeanette Giron
William A. Gislason
Mark D. and Dianne B. Glanville
Stephen V. and Leslie Goddard
Lawrence K. and Suzanne Goldsmith
William and Anne B. Goldstein
Robert and Rosanne Gordon
Steve Gottfredson
Julia Rae Grabendike
Mary H. Gracia
Carol-Anne Graff-Radford
Edward E. and Louise Graham
The Grand America Hotel
Adrienne Graves, PhD
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J O H N A . M O R A N E Y E C E N T E R D O N O R R E P O R T F O R 2014
Ann and James E. Gray, DDS
Thomas P. and Wendy A. Johnson
Collette Marthia
Neil J. and Stephanie D. Gray
G. Frank and Pamela M. Joklik
Norma W. Matheson
The Group Real Estate, LLC
Curt and Billie Jo Jones
George T. and Phyllis Mattena
Marjorie Riches Gunn
Ryan C. and Jaime L. Jones
Todd L. and Julie S. Maus
Gloria C. Gustin
Travis and Megan Jones
Les E. and Therese M. Mayes
Mark H. and Mildred M. Hafey
Howard A. and
Lou Ann B. Jorgensen, PhD
Mayfield Lions Club
Carol A. Jost
Daniel J. McInerney, PhD
William B. Hale
Barry K. Hanover and
Allison R. Brunvand
Guy E. Hanscom
Laurel D. Kay
Carol and
Ambrose P. McLaughlin, III, MD
Sandra Coggle Hanseen
Keller Family Foundation
Philip M. and Susan L. McLaughlin
James W. and Karen L. Hansen
Jemina A. Keller
James and Heather McVey
William E. and Roma O. Hansen
Paul D. Keller and
Robyn L. Carter Keller
Marvin A. and Renee B. Melville
Jean L. Kendall
Lloyd R. and Marjorie R. Merrill
Gerald D. and Betty Jo Hanson
Timothy R. and Gloria Jean Hanson
Brad D. and Jolie Coleman Hardy
Evelyn D. Hardy
Deborah Y. Harrison
Annette S. and Joseph L. Hatch, MD
Kellan and Lily Hatch
Douglas and Sharon Hender
Kirsten Henderson
Peggy N. Henrie
Ruth A. Hensel
R. Jeff Higgins
Einar B. and Madora I. Hoff
Kathleen S. Holley
HolPro Vision, Ltd.
Greg Hopkin
John T. and Anne C. Hopkin
Richard A. and Kathleen O. Kennedy
Beverly M. Kent
Paul and Geraldine Kilpatrick
Josephine S. Kimball
Michael and Tara Kisow
William M. and
Julia J. Kleinschmidt, PhD
Douglas Koch, MD
Fred H. and Christine M. Kraut
La Fleur Design
Jonathan S. and Deedra H. Lambert
Denise E. Landis
Jean M. Larsen, PhD
Mel and Wendy Lavitt
Frank S. and Georgie E. Lewis
Craig Alan Merrill, MD
Valerie A. and Mark D. Mifflin, MD
Gerald and Cyndee L. Miya
Moab Lions Club
Mark and Linda J. Moore
Edward B. and Barbara C. Moreton
Michael V. and Paula F. Morris
Allan and Elaine Muchin
Frances P. Muir
Margaret W. Mumford
Cynthia Marie Murphy
Mark J. and Katie Murphy
H. S. Nak
Tawny Nelson
Hans Nevaard
Hans and Geraldine M. Nievaard
David L. and Wendy Hopkins
Dr. Richard and
Jaci Lindstrom Foundation
Barbara Horwitz
Anthony F. and Jennifer Ann Lund
Carol P. Norton Revocable Trust
Jerry S. and Claudia F. Howells
David and Connie K. Lux
John P. and Lisa B. O’Brien
Edward L. Hughes and
Roberta L. Anner-Hughes
Joanna M. and Steven M. Lynch, MD
Joan J. Odd
Natasha Madsen
James and Sandra O’Hearn
Maher Live, Inc.
Bradley A. Olch
Margaret J. Malherbe
Stephen H. and Barbara J. Olchek
Atul and Kirsten Mallik
Todd S. and Debra Oldroyd
Mercy and Nick Mamalis, MD
Ferron A. and Donna Lee* Olson
ManagementPlus
Mary Lou Olson
Chris and Sharon C. Mancini
Lisa Marie Ord, PhD
Mantes Realty Company
Eugene and Jean Overfelt
Robert E. Marc, PhD and Ann Torrence
Anne Palmer
Alan E. and Drue B. Huish
56
Kanter Family Foundation
David A. and Laura McArthur
Harry D. and Norma W. Huston
Hyde Park Lions Club
Gilbert H. and Thelma P. Iker
Moodalgiriappa Jayaprakash, MD
Martha Lewis Jennings
Linda H. Jensen
Norman S. Jensen
Clay W. and Dianne R. Northrop
J O H N A . M O R A N E Y E C E N T E R D O N O R R E P O R T F O R 2014
J. James and Terry H. Palmer
Kathleen K. and Clough Shelton, MD
Judith E.A. Warner, MD
William and Jean Patsuris
Richard A. Shriver
Susan Weidner
Tamara R. Paul
John and Margaret M. Shuff
George P. and Adele W. Weiler
Craig and Dorothy A. Pedersen
David K. Sias
Weinberg Family Foundation
Elaine Peterson
Donald G. and Diane M. Siegel
Donald H. and Mary Jo Westien
Gretchen and Jeff Hale Pettey, MD
Arthur B. and Sandra P. Sleeper
Christopher C. and Deanna M. Wheeler
Warren S. Phillips
Smith Machinery Co., Inc
Bart L. and Marlene G. Wheelwright
Sheila and Howard Pizer
Florence G. Smith Foundation
Gordon C. and Barbara Whiting
William P. and Donna A. Poliz
Otto F. Smith, MD
Eileen Wilcox
Esther Pomeroy
Robert F. and Kathleen K. Smith
Stephen P. and Nancy Z. Williams
Jeanne A. Potucek
Jeffrey M. and Stacey K. Soinski
Gordon R.* and Georgia A. Wilson
Brent and Tina Price
Pierre and Susan B. Sokolsky
Ben and Suzanne J. Winchester
Probar
Speros Enterprises
Pamela and Robert W. Wing, MD
Gordon S. and Claire F. Prussian
Donald L. and Mary R. Stamberger
D. Bret Winn
Michael Puopolo
Marland L. and Rachel Stanley
Mark and Nancy Winski
Virginia Rainey
Ronald E. and Julie S. Steele
Wolf Eye Center, Inc.
Diana L. Ramirez
Sumner M. and Margaret R. Stewart
Elliott M.* and Judy Wolfe
V. Ramama and Elizabeth D. Rao
Deborah H. Stone
Lewis N. Wolff
Linda Rashkow
John R. and Helen B. Stone
Richard A. and Nancy S. Wolthuis
W. E. and Harriet R. Rasmussen
Dave Stout
Harry C. Wong, MD
Virginia Otterstom Ray Family Trust
Richard D. Stover
Taylor M. and Sherrie Wray
William R. Ray Family Trust
Linda Summers
Debra Yates
Debra S. and J. Scott Raymond, MD
Alan Sutton
John A. and Robbin Yee
Coleen M. Reardon
R. Anthony and Carol J. Sweet
Michael H. Yei and Jill A. Miller
Reay Family Trust
Thomas C. and Marsha Swegle
Ronald J. and Kay K. Yengich
Jeff, Heidi, Tyson, and Brynlie Reid
Jeannette F. Swent
Edward and Karen S. Yenne
Robert E. and Manda Robinson
Ronald and Kathleen H. Switzer, JD
Myrna and Steven R. Young, MD
P. Suzanne Rodriguez
Jean Tabin, MD
Gerard and Dominique Yvernault
Joan Forester Ross
Lary J. and Judy W. Talbot
Charles R. Zottnick
Fred C. and Kathleen M. Roth
William R. Tanner and Susan D. Heath
Joe and Cindy Rubal
Earl Tarver
IN HONOR OF
R. Mark and Margee M. Ruff
R. Burke Teichert
David E. and Lois P. Salisbury
Scott and LaNae Tennis
W. Gary and Darcy E. Sandberg
Henry A. Theurer, Jr., MD
Deidra S. Sarault-Sarjent
Austin B. and Elizabeth M. Thomas
Janet Bair
Paul F. and Janice W. Sargent
Mary E. Thompson
Kurt Bernhisel
Kurt B. and Victoria Scheider
Sally B. L. Thompson, MD
Paul S. Bernstein, MD, PhD
Gary Scholes and Pamela C. Skene
Berdine Tingey
Julie and Alan Crandall, MD
John F. Schroll
Douglas Unger
Brian Cull
Susan B. Schulman
Utah Jazz
LaVerne Diehl
David M. and Debra Reynolds Scott
D. Jesse and Ann T. Wagstaff
Michael R. Scott and
Loretta G. Falvo Scott
Jeffrey W. Walters
The doctors and staff of Moran Eye
Center International Ophthalmology
Matt and Lynn Ward
John and Carol Firmage
Those in whose honor gifts were made
to the Moran Eye Center from January 1,
2014 through December 31, 2014
Ralph Ashton
57
J O H N A . M O R A N E Y E C E N T E R D O N O R R E P O R T F O R 2014
Roger Furlong, MD
IN MEMORY OF
Sylvia Kirkland
Gregory Hageman, PhD
Those in whose memory gifts were made
to the Moran Eye Center from January 1,
2014 through December 31, 2014
Jay G. MacFarlane
Charles B. Hamner
Mary Elizabeth Hartnett, MD
Joseph L. Hatch, MD
Marth Enge Ahrens
Susan W. Hodgins
Arlin Anderson
Robert Hoffman, MD
Gerald Anderson
Jean Evans Holliday-Bryce
Noreen Arko
Jerry Howells
Robert K. Armour
Alan Huish
Ralph L. Ashton
Tom Johnson
Robert Ashton
Gracie Lynn Jones
Bradley Katz, MD, PhD
Bill and Kim Leslie
David R. Lewis and Kim Corbin-Lewis
Kirsten Mallik
Nick Mamalis, MD
Bonnie and Ernie Messerly
Mark Mifflin, MD
Magid Moshirfar, MD
Richard Ashworth
Cherie Ashworth Beazer
Elizabeth Beier
Ted Bernhisel
Maxie Biehn
Ruth Boe
Mary Bowen
Donald C. Cissel
Bianca Coppa
Patti Daly
The occasion of my cornea transplant
Kathleen Davies deBruyn
The occasion of my wife’s
cornea transplant
Nolan Davis
Randall J Olson, MD
Matthew Parsons
Senator Rand Paul
David Diehl
Bob Erickson
Rhea Anderson Fillmore
Elden R. Gardner
Charlie Pieper
Rose Mary Giron
Chris Reddish
Dorothy M. Hadden
Jon Reddish
Larry Hale
Patrick and Gwen Reddish
Suzette Hanscom
Heidi Reid
Darl and Wilma Hansen
Senti Sorenson
Clark Hardy
Thomas Starkovich
Mabelle F. Hays
Stubby, Dee, and Picabo Street
58
Rex Charles Ahlstrom
Michael Teske, MD
Charles Weber, MD
Marnie Widlund
Norm Zabriskie, MD
Susan Hodgins
Patricia Elaine Heninger Hopkin
Lois Horne
Jo Ellen Huston
In memory of the person whose
corneas I received
Norman C. Jensen
Joan Judelson
Russell J. Kelson
Casey Marble
Lloyd Marble
D. H. Marchant
Margaret Weber Martinez
Robert Phillip Morris
Dave Mumford
Verda S. Nelson
Mary Alice Newton
Steve J. Nichols
Mabel Orton
Pete G. Paulos
Darlene Phillips
Hal L. Potter
Virginia Palmer Rees
Kathryn Rowe
James Scallon
Bridget Gull Singleton
Clark T. Smith
Martha E. Streeter
Dona Thacker Sweat
Elton L. Varner
Walter and Barbara Weidner
Patricia Wessel
Paul Zabolotney
Greg Zenger
*Deceased
The Moran Eye Center is grateful
for the contributions made to support
our mission and goals. We have made
every effort to ensure that this 2014
Donor Report is as accurate as possible.
Should you find an error or wish to
change your listing, please contact us
at 801-585-9700.
JOHN A. MORAN EYE CENTER
Industry Leadership and Service
This is a partial list of Moran Industry Leadership and Service for 2014
Alessandra Angelucci, MD, PhD
2014
Lead Guest Editor, Special Issue for Vision Research, “The Function of Contextual Modulation”
Lead Guest Editor, Special Issue for Visual Neuroscience, “Controversies in Extrastriate
Cortex Mapping”
2008-Present Review Editor, Frontiers in Neuroanatomy
2007-Present Editorial Board, Visual Neuroscience
Review Editor, Frontiers in Systems Neuroscience
Wolfgang B Baehr, PhD
2013-Present
2004-Present
Editor, Journal of Ocular Biology, Diseases, and Informatics
Senior Editor, Vision Research, Elsevier Science
Paul S Bernstein, MD, PhD
2014
Editor, Special Issue, “Carotinoids,” Archives of Biochemistry and Biophysics
Karen Curtin, PhD
2011-Present
Associate Editor, BMC Gastroenterology
Editorial Board, Frontiers in Applied Genetic Epidemiology
Margaret DeAngelis, PhD
2014-Present
2013-Present
2012-Present
2011-Present
2010-Present
Guest Editor, Journal of Clinical Medicine-Special Issue, Age-related Macular Degeneration
Chair, Seminar Series Committee, Moran Eye Center, Department of Ophthalmology,
School of Medicine
Editorial Board, Journal of Biophysical Chemistry
Editorial Board, BioMed Central Genetics
Executive Board, Women’s Eye Health Organization, International
Co-chair, Development, Women’s Eye Health Organization, International;
Chapter Head, Utah
Executive Committee, International Consortium for Refractive Error and Myopia, sponsored
by the NEI/NIH
Editorial Board, International Scholarly Research Network Genetics
Editorial Board, PLoS One
Board of Trustees, Fourth Street Clinic
Senior Executive Steering Committee, Age-related Macular Degeneration Gene Consortium,
sponsored by the NEI/NIH
Director, Ocular Genomics and Systems Biology Laboratory, Moran Eye Center, University of
Utah School of Medicine
Kathleen B Digre, MD
2004-Present 2002-Present
1998-Present
1995-Present
Chairman, Board of Directors, North American Neuro-Ophthalmologic Society
Chair, Publications Committee, American Headache Society
Review Board, American Headache Society
Board of Directors, North American Neuro-Ophthalmology Society
Editorial Board, Journal of Neuro-Ophthalmology
59
JOHN A. MORAN EYE CENTER
Sabine Fuhrmann, PhD
2014-Present 2004-Present Co-chair, Recruitment Committee, Molecular Biology Graduate Program
Editorial Board, Developmental Dynamics
Gregory S Hageman, PhD
2013-Present
2012-Present 2009-Present Advisory Board, Merck Sharp and Dohme Corporation
Scientific Advisory Board, Applied Genetic Technologies Corporation
Chief Scientific Officer, Co-founder, Voyant Biotherapeutics LLC
Clinical Advisory Board, Sequenom, Inc.
Board of Directors, AMD Alliance International
Mary Elizabeth Hartnett, MD
2012-Present
2011-Present 2009-Present Editor, American Academy of Pediatric Ophthalmology and Strabismus
Editor, Molecular Vision and Molecular Vision Scientific Review
Board, Women's Eye Health.org
Honorary Editorial Board, Patient Related Outcome Measures, Dove Press
Honorary Editorial Board, Eye and Brain
Editorial Board, Clinical Ophthalmology
Robert O Hoffman, MD
2011-Present
2007-Present
2003-Present Medical Executive Committee, Primary Children's Medical Center
Legislative Committee, American Association for Pediatric
Ophthalmology and Strabismus
Alumni Board and Executive Committee, Ophthalmology and
Visual Sciences, School of Medicine
Rachael S Jacoby, MD
2012-Present Board, Institutional Review Board, University of Utah
Bryan W Jones, PhD
2002-Present Editor/Webmaster, Webvision http://webvision.med.utah.edu
Bradley J Katz, MD, PhD
2007-Present 2006-Present Medical Director, Utah Eye Care Initiative, University of Utah
Chair, Department of Ophthalmology Committee for Indigent Care
David Krizaj, PhD
2009-Present Editorial Board, Journal of Open Access Animal Physiology
Edward M Levine, PhD
2007-Present 2004-Present Editor, Journal of Ocular Biology, Diseases, and Informatics
Editorial Board, Developmental Dynamics
Nick Mamalis, MD
60
2007-Present 1998-Present Editor, Journal of Cataract and Refractive Surgery
Editorial Board, Review of Ophthalmology
Robert E Marc, PhD 2013-Present Editorial Board, Journal of Comparative Neurology, Society for Neuroscience
JOHN A. MORAN EYE CENTER
Mark D Mifflin, MD 2005-Present Faculty Executive Committee, Ophthalmology and Visual Sciences
Randall J Olson, MD
2014
2012-Present 2002-Present 2001-Present 1983-Present Advisory Board, American Academy of Ophthalmology
Editorial Advisory Board, EyeNet
Executive Editor, American Journal of Ophthalmology
Editorial Board, Ophthalmologica
Advisory Boards, Advanced Medical Optics, Inc., Surgical Global, and Healon V
Chair, Advisory Board, Calhoun Vision
Executive Committee, Department Chairs’ Collateral Group and Sciences Council, School
of Medicine
Bhupendra C K Patel, MD, FRCS, FRC 2007-Present 2006-Present 2005-Present 2003-Present 2002-Present 2000-Present 1999-Present 1996-Present 1991-Present Chief Section Editor, Plastic Surgery, British Journal of Ophthalmology
Chief Section Editor, Plastic Surgery, EYE
Chief Coeditor, ORBIT
Editorial Board, Evidence Based Eye Care
Editor, USA ORBIT
Editorial Board, Aesthetique
Editorial Board, Journal of Cranio-Maxillofacial Trauma
Medical Advisory Board, American Society of Ocularists
Editorial Board, Abstracts from the Literature for Ophthalmic, Plastic, and
Reconstructive Surgery
Jeff Pettey, MD
2014-Present 2013-Present Associate Editor, American Academy of Ophthalmology
Associate Editor, American Academy of Ophthalmology Global Ophthalmology Guide
Debra Schaumberg, ScD, OD, MPH
2013-2014
2008-Present 1999-Present Treasurer, Board of Directors, Tear, Film, and Ocular Surface Society
Editorial Board Guest Member, Optometry and Vision Science
Editorial Board Guest Member, Investigative Ophthalmology and Vision Science
Jason D Shepherd, PhD
2014-Present Editorial Board, Frontiers in Molecular Neuroscience
Geoffrey Tabin, MD 2006-Present Editor, Stedman’s Medical Dictionary
Monica Vetter, PhD 2014-Present
2013-Present
2011-Present
Chair, Executive Board, University of Utah Neuroscience Initiative
Chair, Neuroscience Strategic Planning Committee, University of Utah
Scientific Advisory Board, “Catalyst for a Cure 2,” Glaucoma Research Foundation
61
JOHN A. MORAN EYE CENTER
Albert T Vitale, MD 2014
President-elect, American Uveitis Society, 2015
Co-director, American Academy of Ophthalmology, Uveitis Sub-specialty Day,
AAO Annual Meeting
2006-Present
Faculty Executive Committee, Ophthalmology and Visual Sciences
Editorial Board, Editorial and Writing Committee for Practicing Ophthalmologists,
American Academy of Ophthalmology
Editor, Basic Science Course: Intraocular Inflammation, Uveitis, and Tumors for Focal
Points, American Academy of Ophthalmology
Faculty Executive Committee, John A. Moran Eye Center
Advisory Boards, Genentech, Inc. and Lucentis
2004-Present Uveitis Advisory Board, Aciont Inc.
Uveitis Advisory Board, Bausch & Lomb
2003-Present Judith E A Warner, MD 2004-Present Editorial Board, Neuro-Ophthalmology
Liliana Werner, MD, PhD
2013-present
Coeditor, Quarterly Column, “Cataract/IOL Complications: Moran CPC Reports,”
EyeWorld International
Editorial Board, Brazilian Journal of Ophthalmology
2011-present
Chair, Continuing Medical Education Advisory Committee, American Society of Cataract
and Refractive Surgery
2009-present
Scientific Advisory Board of Powervision Inc., USA
2004-present
Editorial Board, Journal of Cataract and Refractive Surgery
Editorial Board, EyeWorld Magazine
Barbara M Wirostko, MD
2011-Present
2010-Present
2007-Present 62
Chief Medical Officer Retained Consultant, Altheos, Inc.
Executive Team, Lead Clinical Development Program and Glaucoma Strategy,
Novel Rho Kinase Inhibitor, Currently in Phase 2
Medical Advisory Board, Ophthalmology Consultant, Premier Research LTD
Editorial Board, Acta Ophthalmologica
Associate Editor and Peer Reviewer, Acta Ophthalmologica
JOHN A. MORAN EYE CENTER
Awards, Honors, and Appointments
2014
Other awards, honors, and appointments are highlighted in FOCUS content
Awards and Appointments
Iqbal “Ike” K Ahmed, MD, PhD, received the Binkhorst Medal
and presented the Binkhorst Lecture during the American
Society of Cataract and Refractive Surgery Symposium and
Congress in Boston on April 26, 2014. With this announcement, a Moran physician or alumni has received this honor
three years in a row.
Balamurali K Ambati, MD, PhD, MBA, was honored with the
2014 Ludwig von Sallmann Clinician-Scientist Award by the
Association for Research in Vision and Ophthalmology (ARVO)
Foundation for Eye Research. Ambati was also honored with
the 2014 Arnold P. Gold Humanism in Medicine Award by the
student body of the University of Utah School of Medicine.
Wolfgang B Baehr, PhD, was honored with the international
2014 Proctor Medal, awarded by the Association for Research
in Vision and Ophthalmology (ARVO), for his lifetime
achievement and many significant discoveries regarding
retina disease.
Alan S Crandall, MD, was honored with the 2014 Dr. Clark
Lowe Rich Distinguished Surgeon and Mentor Award
recognizing an outstanding surgeon who has demonstrated
exceptional skill and dedication in the fields of surgery,
including teaching, advising, and mentoring medical students,
interns, residents, or fellows at the University of Utah.
Margaret DeAngelis, PhD, was appointed to the editorial
board of the Journal of Biophysical Chemistry. And DeAngelis
published a study in the journal Investigative Ophthalmology
and Visual Science that ranked fourth among the ten most
read research studies in 2014. DeAngelis led a team that
included her staff and Drs. Owen, Baehr, and Ambati. The
study titled “FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic
FLT1 Expression” was funded by the ALSAM Foundation.
Kathleen B Digre, MD, broke new ground as the first Hedi
Fritz-Niggli Visiting Professor at the University of Zurich.
Gregory S Hageman, PhD, received the 2014 Achievement
Award, American Association of Ophthalmology (AAO).
Robert E Marc, PhD, received the Retina Research Foundation’s 2014 Paul Kayser International Award in Retina Research
for his lifetime achievement and significant contributions to
the understanding of vitreoretinal diseases or disorders.
Randall J Olson, MD, Professor and Chair, Department of
Ophthalmology and Visual Sciences; CEO, John A. Moran Eye
Center, was named the 2014 recipient of the Rosenblatt Prize
for Excellence, the University of Utah’s most prestigious award
for a faculty member who displays excellence in teaching,
research, and administrative efforts. Olson was also appointed
to the Board of Directors of Jade Therapeutics, Inc.
Geoffrey Tabin, MD, was celebrated as the first John E.
and Marva M. Warnock Presidential Endowed Chair in
Ophthalmology, May 30, 2014.
Monica Vetter, PhD, was appointed member of the
National Advisory Eye Council for the National Eye Institute,
National Institutes of Health, January 2014.
Barbara M Wirostko, MD, was appointed to the Scientific
Advisory Board of the Glaucoma Foundation.
Liliana Werner, MD, PhD; Nick Mamalis, MD; and
Alan S Crandall, MD, were awarded first prize in the category
“Cataract,” for their video “Watch Out for the Zonules!” at the
XIII International Congress of Cataract and Refractive Surgery
Video Festival, Rio de Janeiro, Brazil, April 2014.
Amercian Society of Cataract and
Refractive Surgery (ASCRS) Awards, 2014
BEST PAPER OF SESSIONS AWARDS
Brian E Zaugg, MD; Cecinio Ronquillo Jr., PhD; Kevin Kirk;
Brian C Stagg, MD; Jeff H Pettey, MD; William R Barlow, MD;
Mohammed A. Farukhi MD; Isha Gupta; Randall J Olson, MD.
Determining Optimal Longitudinal Power Setting for Torsional
Phacoemulsification Using Ex Vivo Porcine Lens Model.
Jeff H Pettey, MD; Randall J Olson, MD; William R Barlow,
MD; Brian E Zaugg, MD; Brian C Stagg, MD; Kevin Kirk;
Cecinio Ronquillo Jr., PhD; Jason D Jensen; Mohammed A
Farukhi, MD; Isha Gupta. Efficiency of Micropulse On-time
Duty Cycle Settings.
Justin C Kohl, MD; Joshua Ford, MD; Scott Cole, MD; Shail Vasavada, DO, DNB, FICO; Gareth Gardiner; Liliana Werner, MD,
PhD; Nick Mamalis, MD. Long-term Uveal and Capsular
Biocompatibility of a New Accommodating Intraocular Lens.
Joshua Ford, MD; Justin Kohl, MD; Scott Cole, MD; Gareth
Gardiner; Shail Vasavada, DO, DNB, FICO; Liliana Werner, MD,
PhD; Nick Mamalis, MD. Long-term Uveal and Capsular
Biocompatibility and Stability after Nd:YAG Laser Posterior
Capsulotomy of a New Disc-shaped Intraocular Lens.
SCIENTIFIC POSTER, HONORABLE MENTION,
INTRAOCULAR SURGERY:
Liliana Werner, MD, PhD; Caleb Morris; Erica Liu, MD;
Shannon Stallings, MD; Anne Floyd, MD. Light Transmittance
of Cadaver-eye Explanted Single-piece Hydrophobic Acrylic
IOLs with Surface Light Scattering.
BEST OF SHOW, THE EYE AS ART:
James Gilman, CRA, FOPS. Retinal Canopy.
63
CLINIC AL TRIAL S
2014
Currently, more than 70 clinical research trials are being carried out at the Moran Eye Center
CATARACT
Accuracy of the Holladay 2 Formula Using Lenstar Biometry
Principal Investigator: James Bell, MD
Clinical Study of the ARTISAN Aphakia Lens for the Correction
of Aphakia in Adults
Principal Investigator: Alan S Crandall, MD
Clinical Study of the ARTISAN Aphakia Lens for the Correction
of Aphakia in Children
Principal Investigator: Alan S Crandall, MD
Impact of AcrySof Glistenings on Visual Quality
Principal Investigator: Randall J Olson, MD
Driving with Pseudophakia
Principal Investigator: Randall J Olson, MD
GLAUCOMA
Safety and Effectiveness of the Hydrus Aqueous Implant for
Lowering Intraocular Pressure in Glaucoma Patients Undergoing
Cataract Surgery; A Prospective, Multicenter, Randomized,
Controlled Clinical Trial (Hydrus 4 Study)
Principal Investigator: Alan S Crandall, MD
NEURO-OPHTHALMOLOGY
Prospective Assessment of Photophobia in Moran Eye Center Patients
Principal Investigator: Kathleen B Digre, MD
Evaluation of Optic Neuropathies with Imaging
Principal Investigator: Kathleen B Digre, MD
Long-term Follow-up of the Cohort from the Idiopathic Intracranial
Hypertension Treatment Trial (IIHTT)
Principal Investigator: Kathleen B Digre, MD
CORNEA
Retrospective Review of Primary and Secondary Causes of
Pseudotumor Cerebri
Principal Investigator: Kathleen B Digre, MD
Subconjunctival IVIg (Gamunex-C) Injection for Corneal
Neovascularization and Inflammatory Conditions
Principal Investigator: Balamurali K Ambati, MD, PhD, MBA
Measurement of Critical Flicker Fusion Frequency
Principal Investigator: Bradley J Katz, MD, PhD
Subconjunctival Aflibercept Injection for Corneal Neovascularization
Principal Investigator: Balamurali K Ambati, MD, PhD, MBA
Effect of Corneal Preservation Time on Long-term Graft Success (CPTS)
Principal Investigator: Mark D Mifflin, MD
Efficacy and Safety of Loteprednol 0.5% Gel for Routine Prophylaxis
after Phototrefractive Keratectomy Compared to Prednisolone
Acetate 1% Suspension and Fluorometholone 0.1% Suspension
Principal Investigator: Mark D Mifflin, MD
Retrospective Study of Descemet’s Stripping Automated Endothelial
Keratoplasty Outcomes
Principal Investigator: Mark D Mifflin, MD
Evaluation of the Safety and Efficacy of Corneal Collagen Crosslinking
in Eye with Keratoconus or Corneal Ectasia after Refractive Surgery
Principal Investigator: Majid Moshirfar, MD, FACS
Biomechanical Changes in the Cornea after Laser Assisted in situ
Keratomileusis (LASIK) and Photorefractive Keratectomy (PRK)
Principal Investigator: Majid Moshirfar, MD, FACS
Topical Proparacaine vs Tetracaine in Photorefractive Keratectomy
(PRK)
Principal Investigator: Majid Moshirfar, MD, FACS
70 versus 110 Degrees Side-cut Angles in Femtosecond Laser-assisted
in situ Keratomileusis
Principal Investigator: Majid Moshirfar, MD, FACS
64
GENERAL
Proteomics and Genomics of Giant Cell Arteritis
Principal Investigator: Bradley J Katz, MD, PhD
Prospective Study to Evaluate the Possible Association Between
the Use of PDE5 Inhibitors and the Risk of Acute Nonarteritic
Anterior Ischemic Optic Neuropathy
Principal Investigator: Bradley J Katz, MD, PhD
Predictive Value of Optic Nerve MRI Measurements at Onset of
Optic Neuritis for Two-year MS Outcomes
Principal Investigator: Bradley J Katz, MD, PhD
Thin Film Spectacle Coatings to Reduce Light Sensitivity and
Headaches in Patients with Migraine
Principal Investigator: Bradley J Katz, MD, PhD
Benign Essential Blepharospasm in Children
Principal Investigator: Judith E A Warner, MD
Posterior Cortical Atrophy
Principal Investigator: Judith E A Warner, MD
Observational Study Assessing Various Novel Vascular and
Diagnostic Parameters and Their Relationship to Glaucoma
Principal Investigator: Barbara M Wirostko, MD
PEDIATRIC
Genetics of Pediatric Retinal Disorders
Principal Investigator: Mary Elizabeth Hartnett, MD
Potential for Vision Loss Following Blast Exposure
Principal Investigator: Jason Goldsmith, MD
Preeclampsia and Retinopathy of Prematurity
Principal Investigator: Mary Elizabeth Hartnett, MD
Experience in an Ophthalmology Clinic for Homeless Patients
Principal Investigator: Brian Stagg, MD
Genetic Associations in Preterm Infants at Risk of Retinopathy
of Prematurity
Principal Investigator: Mary Elizabeth Hartnett, MD
Spectral Domain OCT Imaging of Eyes: a Practical Diagnostic Tool
and Methodology
Principal Investigator: Mary Elizabeth Hartnett, MD
Postnatal Growth and Retinopathy of Prematurity Study (G-ROP)
Principal Investigator: Robert O Hoffman, MD
Phase 3 Randomized, Double-masked, Controlled Trial to Establish
the Safety and Efficacy of Intravitreous Administration of FovistaTM
(anti-PDGF-B pegylated aptamer) Administered in Combination with
Lucentis® Compared to Lucentis® Monotherapy in Subjects with
Neovascular Age-related Macular Degeneration
Principal Investigator: Paul S Bernstein, MD, PhD
Retrospective Analysis of Neurofibromatosis Type 1-associated Optic
Glioma Outcome after Treatment
Principal Investigator: Robert O Hoffman, MD
Natural History Observation and Registry Study of Macular
Telangiectasia Type 2: the MacTel Study
Principal Investigator: Paul S Bernstein, MD, PhD
Telemedicine Approaches to Evaluating Acute-phase Retinopathy
of Prematurity (eROP)
Principal Investigator: Robert O Hoffman, MD
Effects of Maternal Nutrition and Intrauterine Growth Restriction
on Infant Carotenoid Status
Principal Investigator: Paul S Bernstein, MD, PhD
Prevalence of Autism Spectrum Disorders in Patients with
Oculocutaneous Albinism
Principal Investigator: Marielle Young, MD
Genetic and Epidemiological Study of Diseases of the Posterior Eye
Principal Investigator: Margaret DeAngelis, PhD
Pediatric Cataract Surgery Outcomes Registry
Principal Investigator: Marielle Young, MD
Clinical Phenotypes of Inherited Retinal Disease
Principal Investigator: Marielle Young, MD
RETINA
Subretinal Versus Intravitreal TPA for Subretinal Hemorrhage
Principal Investigator: James Bell, MD
Macular Pigment Imaging in Infants Using the RetCam
Principal Investigator: Paul S Bernstein, MD, PhD
Clinical Interventions Against Stargardt Macular Dystrophy: DHA
Supplementation in Patients with STGD3
Principal Investigator: Paul S Bernstein, MD, PhD
Phase 3 Trial to Establish the Safety and Efficacy of Intravitreous
Administration of Fovista Administered in Combination with Lucentis
Principal Investigator: Paul S Bernstein, MD, PhD
National Ophthalmic Genotyping Network (eyeGENE)
Principal Investigator: Paul S Bernstein, MD, PhD
Genetic Analysis of Coats’ Disease Patients and Correlation of
Phenotypic and Imaging Data
Principal Investigator: Mary Elizabeth Hartnett, MD
Post-approval Study of VisionCare’s Implantable Miniature Telescope
in Patients with End-stage Age-related Macular Degeneration
Principal Investigator: Majid Moshirfar, MD, FACS
Value of Genetic Counseling and Testing for Patients Who Would Like
to Know More About Their Personal Risk of AMD
Principal Investigator: Briana Sawyer, CCGC
Birdshot Chorioretinopathy OCT Study
Principal Investigator: Albert T Vitale, MD
UVEITIS
Multicenter Study of the Efficacy and Safety of the Human anti-TNF
Monoclonal Antibody Adalimumab in Subjects with Inactive Uveitis
Principal Investigator: Albert T Vitale, MD
Long-term Follow-up of Patients Participating in the Multicenter
Uveitis Steroid Treatment (MUST) Trial
Principal Investigator: Albert T Vitale, MD
Utah Center for the Collaborative Study of the Role of Macular
Pigment Carotenoids in the Pathogenesis and Treatment of MacTel
Principal Investigator: Paul S Bernstein, MD, PhD
Multicenter Study of the Long-term Safety and Efficacy of the
Human anti-TNF Monoclonal Antibody Adalimumab in Subjects
with Noninfectious Uveitis
Principal Investigator: Albert T Vitale, MD
Phase 2 Study to Investigate the Safety, Tolerability, Efficacy,
Pharmacokinetics, and Pharmacodynamics of GSK 933775 in Patients
with Geographic Atrophy
Principal Investigator: Paul S Bernstein, MD, PhD
Multicenter Study of the Efficacy and Safety of the Human anti-TNF
Monoclonal Antibody Adalimumab as Maintenance Therapy
in Subjects Requiring High-dose Corticosteroids for Active Uveitis
Principal Investigator: Albert T Vitale, MD
Phase 2 Multiple-site Randomized, Placebo-controlled Trial of Oral
Valproic Acid for Retinitis Pigmentosa
Principal Investigator: Paul S Bernstein, MD, PhD
Utah Center for MacTel Genetics
Principal Investigator: Paul S Bernstein, MD, PhD
Efficacy and Safety of Emixustat Hydrochloride (ACU-4429) with
Placebo for the Treatment of Geographic Atrophy Associated with
Dry Age-related Macular Degeneration
Principal Investigator: Paul S Bernstein, MD, PhD
Natural History of the Progression of Atrophy Secondary to Stargardt
Disease: a Prospective Longitudinal Study (ProgSTAR)
Principal Investigator: Paul S Bernstein, MD, PhD
65
JOHN A. MORAN EYE CENTER
Technology Commercialization and
Intellectual Property/Patents
2014
Patents, Patents Pending, Industry & Technology, Technological, and Other Scientific Innovations
Balamurali K Ambati, MD, PhD, MBA
2014-Present
“Intraceptors—Novel
Intracellular Anti-VEGF Therapy,” US patent.
Pat e n t Gra n t ed :
2011-Present
“Ambati Phaco D-Tip, Surgical
Instrument for Cataract Surgery,” Developed by
Pat e n t I ss u ed :
Microsurgical Technologies.
2010-Present
“Intraocular Drug Delivery
Device and Associated Methods,” US, Australian,
Pat e n t Gra n t ed :
and Japanese patent.
9/18/14
“Point-of-Care Test to
Monitor for the Progression of ‘Dry’ to ‘Wet’ Agerelated Macular Degeneration,” Balamurali K Ambati,
Pat e n t I n t er n a l Revi ew:
Swomitra K Mohanty, Jason R Young, Younghwan Kim,
Jules J Magda, Keith Prisbrey, Manoranjan Misra and
Hironori Uehara.
Gregory S Hageman, PhD
“Methods
of Predicting the Development of Complementmediated Disease,” Singapore application 201308050-2;
Patent Application P ublish ed:
publication 0194235 (19398).
1/2/14
“Variants in Complement
Regulatory Genes Predict Age-related Macular
Degeneration,” Australia patent 2007215218 (2420AU).
Patent Issued:
1/22/14
“Methods
of Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,”
Patent Application P ublish ed:
European application 12757910.0; publication 2686007
(19399).
1/22/14
“Methods of
Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,” European
Patent Application P ublish ed:
application 12757806.0; publication 2686446 (19400).
2/5/14
Scientific Advisory Board, Applied Genetic Technologies
Corporation.
Patent Application P ublish ed: “Methods of
Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,” China
Principal Investigator, Voyant Biotherapeutics/Allergan
Collaboration.
3/12/14
2013-Present
2012-Present
Co-founder and Chief Scientific Officer, Voyant
Biotherapeutics LLC.
Clinical Advisory Board, Sequenom, Inc.
2009-Present
66
1/1/14
Executive Director, Moran Center for Translational Medicine,
John A. Moran Eye Center.
2014 PATENT ACTIVITY
1/1/14
“Methods and Reagents for
Treatment and Diagnosis of Vascular Disorders
and Age-related Macular Degeneration,”
Pat e n t Al low ed :
European patent application 12152177.7 (2122EP).
application 2012800233585; publication 103562408 (19400).
“Methods of
Predicting the Development of Complement-mediated Disease,” European application 12776262.3; publica-
Patent Application P ublish ed:
tion 2704800 (19398).
3/20/14
“Methods of
Predicting the Development of AMD Based on
Chromosome 1 and Chromosome 10,” US application
Patent Application P ublish ed:
2013/59789; publication WO2014/043558 (19444).
JOHN A. MORAN EYE CENTER
3/20/14
7/8/14
Paten t App l i c at i on Pu b l i s he d :
Patent Issued:
“Methods of
Predicting Survival in a Subject Based on the
Presence of Single Nucleotide Polymorphisms,”
US application 2013/59778; publication WO2014/043550
(19472).
4/28/14
“Variants in
Complement Regulatory Genes Predict Agerelated Macular Degeneration,” European application
Paten t Al low ed/ Not Ye t I ss u e d :
7750527.9 (2420EP).
5/15/14
Paten t App l i c at i on S u b mi t t e d / Pe nd i ng:
“Methods and Reagents for Treatment
and Diagnosis of Vascular Disorders and Agerelated Macular Degeneration,” US application
14/279,235 (2150US).
5/15/14
Paten t App l i c at i on S u b mi t t e d / Pe nd i ng:
“Genes and Polymorphisms Associated with
AMD,” US application 14/279,228 (2250US).
5/28/14
“Use of Complement Factor H
Polymorphisms in Treatment and Diagnosis of
Age-related Macular Degeneration,” Canada patent
Paten t I ss u ed :
2,597,411 (1220CA).
6/4/14
“Methods and Reagents for
Treatment and Diagnosis of Age-related Macular
Degeneration,” Mexico patent 320809 (1221MX).
Paten t I ss u ed :
6/4/14
Paten t App l i c at i on Pu b l i s he d : “Methods of
Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,” China
“Protective Complement Proteins
and Age-related Macular Degeneration,”
Canada patent 2,638,759 (2430CA).
7/13/14
Patent Cl a im s Allowed/Not Yet Issued:
“Methods and Reagents for Treatment
and Diagnosis of Vascular Disorders and
Age-related Macular Degeneration,”
Australia application 2007272335 (2120AU).
7/14/14
Patent Application Filed/P ending :
“Assessing Susceptibility to Vascular Disorders,”
US patent application 14/331,173 (2241US).
7/22/14
Patent Application Subm itted/P ending:
“RCA Locus Analysis to Assess Susceptibility to
AMD and MPGNII,” US application 14/493080 (2211US).
7/31/14
“Methods and Reagents for Treatment and Diagnosis of Age-related Macular Degeneration,” Mexico patent MX/a/2011/013528 (1222MX).
Patent Issued:
8/19/14
Patent G ra nted/Not Yet Issued: “A Method of
Screening for Susceptibility to Developing Agerelated Macular Degeneration,” Israel application
185219 (1220IL).
9/19/14
Patent Allowed/Not Yet Issued: “Predicting
AMD with SNPs within or near C2, FACTOR B,
PLEAKHA1, HETRA1, PRELP, or LOC387715,”
Canada application 2,704,447 (2220CA).
10/9/14
6/16/14
“Methods of
Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,” US applica-
Paten t App l i c at i on S u b mi t t e d / Pe nd i ng:
tion 14/005,226; publication 20140303013 (19400).
application 2012800236687; publication 103841991 (19399).
“Methods and Reagents for Treatment and
Diagnosis of Age-related Macular Degeneration,”
Patent Application P ublish ed:
10/16/14
6/18/14
Patent G ra nted/Not Yet Issued: “Methods
and Reagents for Treatment and Diagnosis of
Age-related Macular Degeneration,” New Zealand
Paten t App l i c at i on Pu b l i s he d :
application 608860 (1223NZ).
Japan application 2012-123102 (1223JP).
“Methods of
Predicting the Development of Complementmediated Disease,” China application 2012800312356;
publication 103874526 (19398).
10/24/14
“Methods of
Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,” Hong Kong
Patent Application P ublish ed:
application 14108008.7; publication 1194770A (19400).
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JOHN A. MORAN EYE CENTER
Gregory S Hageman, PhD
Bradley J Katz, MD, PhD
10/30/14
2013 – Present
“Compositions
for Treatment of Age-related Macular
Degeneration,” Israel application 225204 (1221IL).
Pat e n t Gra n t ed /Not Ye t I ss u e d :
10/30/14
“Methods of
Diagnosing and Treating Vascular Associated
Maculopathy and Symptoms Thereof,” US applica-
Pat e n t App l i c ati on Pu b l i s he d :
tion 14/005,231; publication 20140323413 (19399).
11/10/14
Pat e n t Al low ed /Not Ye t I ss u e d : “Methods and
Reagents for Treatment and Diagnosis of Agerelated Macular Degeneration,” Israel application
Patent Incorporated into Anoth er Tech :
“Methods, Systems, and Apparatus for Reducing
the Frequency and/or Severity of Photophobic
Response,” Bradley J Katz, Steven Blair.
Founder and CEO of Axon Optics, www.axonoptics.com.
Joined with Tecport Optics to develop a ground-breaking
optical interference filter coating process for plastic spectacle lenses. The process blocks the specific wavelengths of
light that have been implicated as the cause of photophobic
symptoms, particularly those associated with triggering and
exacerbating debilitating migraine headaches. The University
of Utah has registered the existing proprietary property.
225203 (1222IL).
David Krizaj, PhD
11/18/14
6/18/14 – Present
Hold For More Data From Inventor(s):
“Methods and
Reagents for Treatment and Diagnosis of Vascular
Disorders and Age-related Macular Degeneration,” European application 12152172.8 (2121EP).
“Epilepsy Treatment Using Novel Ion Channel
Targets.”
11/25/14
Salcantay Vision Solutions, LLC, CEO.
Pat e n t Al low ed /Not Ye t I ss u e d :
Pat e n t App l i c ati on Fi l e d : “Variants in Complement Regulatory Genes Predict Age-related
Macular Degeneration,” US application 12/645,272
(2431US).
12/4/14
“Methods of
Predicting the Development of Complementmediated Disease,” US application 14/114,751;
Pat e n t App l i c ati on Pu b l i s he d :
publication 20140357732 (19398).
Mary Elizabeth Hartnett, MD
2014
Pat e n t P en d i n g : “Methods and Compositions for
Inhibiting Retinopathy of Prematurity,” US patent.
Bryan W Jones, PhD; Robert E Marc, PhD
2012 – Present
“Oncological Application of
Computational Molecular Phenotyping.”
Pat e n t P en d i n g :
2013 – Present
Asha Vision, LLC, Founder and CEO.
Entrepreneurial Faculty Scholars, University of Utah.
Center for Translational Medicine, University of Utah.
3/14/13 – Present
“Compounds with TRPV4 Activity,
Compositions and Associated Methods Thereof,”
Patent Filed:
Priority date May 10, 2012.
5/10/12 – Present
“Role of TRPV4 Antagonists in
Ocular Disease,” docket no. 00846-U5301, Krizaj D, Rys-
Patent P ending :
kamp DA, Barabas P. Inventor of a novel method for
treatment of glaucoma and other ocular diseases associated
with abnormal mechanical environment within the eye.
The method has been validated in animal models and has
the potential for a wide impact on clinical care, as there are
currently no treatments that regulate intraocular pressure
and protect retinal ganglion neurons in glaucoma.
10/16/12 – Present
“Mechanosensory Channel
Antagonists in Glaucomatous Neuroprotection,”
Patent P ending :
68
D Krizaj, P Barabas, Y Xu, G Prestwich, DA Ryskamp, 00846US01. Priority date May 10, 2012.
JOHN A. MORAN EYE CENTER
Randall J Olson, MD
7/7/2014
Paten t L i c en s ed, Exclu s i ve :
2013 – Present
“A Safer Knife Blade.”
2012 – Present
“A Vision Correction System to
Minimize Intraocular Lens Rotation.”
Paten t S u b m i tt ed :
Paten t P en d i n g : “A Vision Correction System,”
patent 5087, International.
“Hypodermic Needle System
and Method to Reduce Infection,” patent 4826,
Paten t P en d i n g :
International.
2011 – Present
Paten t S u b m i tt ed : “Multi-functional Second
Instrument for Cataract Removal,” US patent
7883521, Washington.
Ning Tian, PhD
04/21/2014
Paten t R el eas ed to I nve ntor : “Dual Imaging
Chamber,” Ning Tian, PhD, and Brent Young.
P ublish ed: “HGH for Ocular Diseases,” PCT/US serial
no. is 61/956,070, provisional.
2012 – Present
Patent Filed:
no. 61/58,1845.
“Dermal Wound Healing,” US patent
Patent Filed: “Corneal Reinnervation,” US submitted patent no. 3246-005, provisional.
2011 – Present
Patent Application Filed: “Corneal Wound
Healing,” US patent no. 61/62,4730.
2011 – Present
Co-founder/ Chief Scientific Officer of Jade Therapeutics,
Inc, Drug Development Company focusing on developing
sustained delivery drugs and products via a novel propriety
cross-linked hyaluronic acid polymer for ophthalmic areas
of high unmet need. Recently received two Utah State
Technology Commercialization and Innovation (TCIP) grants
through USTAR, for $ 40,000 each, a Phase I and II NSF SBIRs,
and a Phase I DOD SBIR grant. Jade is currently being awarded
a Phase II DOD SBIR (2/2015).
Liliana Werner, MD, PhD
1996-Present
“Procédé de Revêtement de Matériaux
et Produits Ainsi Obtenus. Téflon AF pour Implant
Intraoculaire,” Legeais JM, Legeay G, Werner L, Renard G,
Pat en t:
French patent number FR 9604267, registered on April 4th,
1996, Paris.
Barbara M Wirostko, MD
2014 – Present
Paten t Fi l ed : “Ocular Composition and Method,”
US patent application serial no. 14/584,787. Will publish
April 2015.
2013 – Present
Pub l i s h ed : “Ocular Drug Delivery System,”
PCT/US2013/036807, WO/2013/158661.
An ocular drug delivery system including a composition in
which a formulation having an active agent (e.g., HGH, rHGH
or an HGH mimic) that increases insulin growth factor (IGF) or
that alters insulin growth factor binding protein (IGFBP) in a
subject is dispersed in a pharmaceutical carrier. The composition is configured for placement in, around, or on an eye of
the subject, and the composition provides controlled release
of an amount of the active agent to the eye effective to
promote ocular surface and corneal neural regeneration and
wound healing.
69
Grand Rounds
D AT E
P R E S E N T E R
January 15
Meg DeAngelis, PhD, Faculty
70
2014
T O P I C
O R
T I T L E
Integrated Analysis of Gene Expression,
Genetics, and Epigenetics Suggest a Role for
Lipid Metabolism is Involved in Age-related
Macular Degeneration
January 22
Bloomberg Library Committee: Kathleen B. Digre, MD; Bryan Jones, PhD;
Christy Jarvis, MLIS
Library Update
January 29 R. Rand Allingham, MD, Professor of Ophthalmology, Chief Glaucoma Services, Duke University
Exfoliation Glaucoma: Common,
Inherited, and Curable
February 5
Marilyn McKasson, MD, Neurology Resident; Alicia Bennet, MD, Neurology Resident
Chronic Relapsing Inflammatory
Optic Neuropathy
February 12
Julia Byrd, MD, Ophthalmology Intern
Ocular Manifestations of Arthropod
Vector-borne Diseases
February 19
Albert T. Vitale, MD, Faculty
Infectious and Neoplastic
Masquerades in Uveitis
Paul S. Bernstein, MD, PhD, Faculty
February 26
Update on AREDS2 and the MacTel
Genetics Project
March 5
M.E. Hartnett, MD, Faculty
Update of VEGF Neuroprotection in ROP
March 12 Joseph L. Hatch, MD, Faculty
Thermal Wedge Resection
March 19
Luis Santiago-Caban, MD, Cornea Fellow
LASIK Enhancement: PRK on the Flap vs. Flap
Re-lift. Case Presentation: The Patient with
Bilateral Corneal Edema
March 26
Crystalline Retinopathy
Ronald Hobbs, MD, Retina Fellow
April 9
Brian Zaugg, MD, Resident Intracameral Antibiotics for
Endophthalmitis Prophylaxis
Kelsey Juster-Switlyk, MD,
Neurology Resident
Optic Nerve Head Drusen
April 16
Jian-zing Ma, MD, PhD, Laureate Professor and Chairman, Department of Physiology, University of Oklahoma
Fenofibrate Effect on Diabetic Retinopathy:
Its Target and Mechanism of Action
Krista Kinard, MD, Neuro-ophthalmology Fellow
Corneal Nerves in Migraine
May 7
Jeff H. Pettey, MD, Faculty
Residency Training Just Got Better
May 21
Brian Stagg, MD, Resident
Paraneoplastic Syndromes in the Eye
May 28
Jay Jacobson, MD, Intermountain Medical Center,
Salt Lake City, Utah
Ethics Conference: Off-label Use of
Medications and Devices
June 4
Russell Swan, MD, Resident
This Looks Fishy
Adam Jorgensen, MD, Resident
Bilateral Optic Nerve Edema
Leah Owen, MD, PhD, Resident
Central Retinal Artery Occlusion and Branch
Retinal Vein Occlusion in a Patient with
CNS Vasculitis
June 11
Craig J. Chaya, MD, Faculty
SICS is to Cataract as ??? is to Glaucoma?
July 16
Randy “Chris” Bowen, MSIV, University of Utah
Bench to Bedside: Ocular Drug Delivery
Isha Gupta, MSIV, University of Utah
Optimizing Phaco Emulsification
Matthew Kliethermes, MSIV, University of Missouri
Acute Onset Esotropia
July 23
Majid Moshirfar, MD, FACS, ABES, Faculty Refractive Surgical Complications
July 30
Kimberly Lavin, MSIV, Creighton University, SOM-Phoenix Regional Campus
Advantages and Disadvantages of Small-gauge
Vitrectomy
Samuel Passi, MSIV, University of Utah SOM
Band Keratopathy and Interstitial Keratitis
Zhan Li, MSIV, University of Nevada SOM
Differentiating Retinopathy from Optic
Neuropathy in Acute Vision Loss
Grand Rounds
D AT E
P R E S E N T E R
2014
T O P I C
O R
T I T L E
August 13
Kevin Garff, MSIV, University of Utah
Measuring Ocular Blood Flow in Glaucoma
Michael Jordan, MSIV, University of North Dakota
Two-year Old with Leukocoria
Tara Tae, MSIV, University of Tennessee
Shallow Anterior Chamber in a Post-operative
Patient
August 20
Nikko Ronquillo, PhD, University of Utah
A New Animal Model of Senior-Løken Syndrome:
Insights to Disease Mechanism
Nigel Stippa, MSIV, Stony Brook University
The Role of Optical Coherence Tomography of the
Optic Nerve in the Evaluation of Central Retinal
Vein Occlusions
Michael Taggert, University of Utah SOM
The Use of Serum Biomarkers in NVAMD
August 27
Alan S. Crandall, MD, Faculty
Case Presentation: Complex Cataract
September 3
Aabid Farukhi, MD, University of Utah Mastering TASS: An Updated Review of the
Common Causes, Evaluation, and Treatment of a
Post-operative Complication
Gregory Kramer, MD, University of Utah
Prevention of Post-operative Capsular Bag
Opacification by Intraocular Lenses and
Endocapsular Devices Maintaining the Capsular
Bag Open or Expanded
Kyle MacLean, MD, University of Utah
Multicomponent Lens Technology
September 10
Wyatt Messenger, MD, Research Fellow Comp-Ang1: A Novel Treatment for CRAO
Ruju Rai, MD, Research Fellow
Case Presentation: Neuro-ophthalmology
September 17
Joshua Atkinson, MSIV, UT Medical School Houston Back to Basics: Illumination Techniques
Bradley Henricksen, MSIV, University of Utah SOM
Examining the Effects of Maternal Nutrition on
Macular Development. Case Presentation:
Neuro-ophthalmology Visual Distortions
Christopher Ricks, MSIV, UT Medical School
Houston
A Brief Review of Oculocutaneous Albinism
September 24
Aaron Barnett, MSIV, University of Arkansas COM
High IOP after Intravitreal Anti-VEGF
Cullen Ryburn, MSIV, Texas Tech University HSC
Case Presentation: Headache
Daniel Tervee MSIV, University of South Dakota, Sanford SOM
Four-point Scleral Fixation of a Hydrophilic Acrylic
PC IOL
October 1
Maria Grant, MD, FARVO, Eugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University SOM
Stem/Progenitor Cells: Do They Have a Future in
Retinal Vascular Repair?
October 8
Christopher Conrady, MD, PhD, Intern
Innate Recognition of HSV-1: A View from within
the Cornea
October 15
Rene Choi, MD, PhD, Resident
Seeing is Believing in Retinal Regeneration
Carey Wilson, MD, Pediatric Neuro-ophthalmology Resident
Case Presentation: Double Blind
October 22
Ty Dickerson, MD, MPH, FFAP, Assistant Dean of Global Health Ed, University of Utah
Global Health Governance: The Players, the
Process, and the Problem
October 29
Jay Jacobson, MD, Intermountain Medical Center, Salt Lake City, Utah
Ethics Conference: International Teaching
November 12
Majid Moshirfar, MD, FACS, ABES, Faculty; Carlton Fenzl, MD, Cornea Fellow
Cornea
November 19
Brian Zaugg, MD; Rene Choi, MD, PhD, Residents
A Case of Unilateral Optic Nerve Swelling
71
PUBLISHED RESEARCH
A sample of more than 130 published and presented materials by Moran faculty members
between January 1 and December 31, 2014
ACS Chemical Neuroscience
2014; Part A, 164A(9), 2250-5.
Cancers (Basel). 2014; 6(4), 2330-42.
Marc RE, Pfeiffer R, Jones B. Retinal prosthetics, optogenetics, and chemical photoswitches.
ACS Chem Neuro. 2014 Oct; 5(10):895-901.
American Journal of Ophthalmology
Case Reports in Ophthalmological
Medicine
Acta Biomaterialia
Zarembinski T, Doty NJ, Erickson IE, Srinivas R,
Wirostko BM, Tew WP. Thiolated hyaluronanbased hydrogels crosslinked using oxidized
glutathione: An injectable matrix designed for
ophthalmic applications. Acta Biomater. 2014
Jan; 10 (1): 94-103.
Advanced Ocular Care
Ambati B, Messenger W. Customizing
cataract surgery. Advanced Ocular Care. 2014;
(12), 70-74.
Creel DJ. Evaluating hydroxychloroquine
toxicity with multifocal electroretinography.
Advanced Ocular Care. 2014; 5(6), 63-66.
Moshifar M, McCaughey M. The relevance of
angle kappa in refractive surgery. Advanced
Ocular Care. 2014; (7), 89-90.
Advances in Experimental
Medical Biology
Zhang H, Frederick JM, Baehr W. Unc119 gene
deletion partially rescues the GRK1 transport
defect of Pde6d (- /-) cones. Adv Exp Med Biol.
2014; 801, 487-93.
Fu Y, Zhang T. Pathophysiological mechanism
and treatment strategies for Leber congenital
amaurosis. Adv Exp Med Biol. 2014; 801,791796.
American Journal of Human Genetics
Cheng CY; Consortium for Refractive Error and
Myopia; Fuchs’ Genetics Multi-Center Study
Group; Diabetes Control and Complications
Trial/Epidemiology of Diabetes Interventions,
and Complications Research Group; Baird
PN, et al. DeAngelis MM. Nine loci for ocular
axial length identified through genome-wide
association studies, including shared loci with
refractive error. Am J Hum Genet. 2013 Aug 8;
93(2):264-77.
American Journal of Medical Genetics
72
Venkatramani R, Spector LG, Georgieff
M, Tomlinson G, Krailo M, Malogolowkin
M, Kohlmann W, Curtin K, Fonstad RK,
Schiffman JD. Congenital abnormalities
and hepatoblastoma: A report from the
Children’s Oncology Group (COG) and the Utah
Population Database (UPDB). Am J Med Genet.
Uchino M, Uchino Y, Dogru M, Kawashima
M, Yokoi N, Komuro A, Sonomura Y, Kato H,
Kinoshita S, Schaumberg DA, Tsubota K. Dry
eye disease and work productivity loss in
visual display users: The Osaka study. Am J
Ophthalmol. 2014 Feb; 157(2):294.
Amparo F, Jin Y, Hamrah P, Schaumberg DA,
Dana R. What is the value of incorporating tear
osmolarity measurement in assessing patient
response to therapy in dry eye disease?
Am J Ophthalmol. 2014; 157(1), 69-77.e2.
Uehara H, Mamalis C, McFadden M, Stagg B,
Passi S, Earle P, Taggart M, Hogg R, Chakravarty
U, Ambati BK. The reduction of serum soluble
Flt-1 in patients with neovascular age-related
macular degeneration. Am J Ophthalmol. 2014.
Ronquillo Jr CC, Zaugg B, Stagg B, Kirk KR,
Gupta I, Barlow Jr WR, Pettey JH, Olson RJ.
Determining optimal torsional ultrasound
power for cataract surgery with automatic
longitudinal pulses at maximum vacuum ex
vivo. Am J Ophthalmol. 2014 Dec; 158:12621266.
American Journal of Pathology
Yang Z, Wang H, Jiang Y, Hartnett ME.
VEGFA activates erythropoietin receptor and
enhances VEGFR2-mediated pathological
angiogenesis. Am J Pathol. 2014; 184(4), 1230-9.
Annals of Pharmacotherapy
Sleath BL, Blalock SJ, Muir KW, Carpenter DM,
Lawrence SD, Giangiacomo AL, Goldsmith JA,
Hartnett ME, Slota C, Robin AL. Determinants
of self-reported barriers to glaucoma medicine
administration and adherence: A multisite
study. Ann Pharmacother. 2014 Apr; 48(7):856862.
Biomedical Papers of the Medical
Faculty of the University Palacký
Jiraskova N, Werner L, Mamalis N,
Rozsival P. Histologic evaluation of AlphaCor
keratoprosthesis explanted following various
complications. Biomed Pap Med Fac Univ
Palacky Olomouc Czech Repub. 2014; 158(1):505.
Brain
Schankin CJ, Maniyar FH, Digre KB, Goadsby
PJ. Visual snow—a disorder distinct from
persistent migraine aura. Brain. 2014 May;
137:1419-28.
Cancers (Basel)
Stagg BC, Uehara H, Lambert N, Rai R, Gupta
I, Radmall B, Bates T, Ambati BK. Morpholinomediated isoform modulation of vascular
endothelial growth factor receptor-2 (VEGFR2)
reduces colon cancer xenograft growth.
Gupta I, Oakey Z, Ahmed F, Ambati BK.
Spectacle independence after cataract
extraction in post-radial keratotomy patients
using hybrid monovision with ReSTOR®
multifocal and TECNIS® monofocal intraocular
lenses. Case Rep. Ophthalmol. 2014; 5:157-161.
Taggart MG, Morshedi RG, Ambati BK.
Trimanual anterior vitrectomy: A novel
technique to manage vitreous loss during
phacoemulsification. Case Rep Ophthalmol.
2014; 5(3), 373-9.
Vejdani AH, Khakshoor H, McCaughey MV,
Moshirfar M. Partial and total Descemet’s
detachments in a patient with severe Terrien’s
marginal degeneration and juvenile idiopathic
arthritis. Case Rep Ophthalmol Med. 2014;
(10), 1155.
Cells
Ryskamp DA, Redmon S, Jo AO, Krizaj D. TRPV1
and endocannabinoids: Emerging molecular
signals that modulate mammalian vision.
Cells. 2014 Sep; 3(3):914-38.
Clinical Ophthalmology
Zacharaki F, Hadjigeorgiou GM, Koliakos
GG, Morrison MA, Tsezou A, Chatzoulis DZ,
Almpanidou P, Topouridou C, Karabatsas
CH, Pefkianaki M, DeAngelis MM, Tsironi EE.
Plasma homocysteine and genetic variants of
homocysteine metabolism enzymes in patients
from central Greece with primary open-angle
glaucoma and pseudoexfoliation glaucoma.
Clin Ophthalmol. 2014 Sep 11; 8:1819-25.
Fenzl DR, Gess AJ, Moshirfar M. Accuracy of
corneal trephination depth using the Moria
single-use adjustable depth vacuumm trephine
system. Clin Ophthalmol. 2014; 8, 2391-6.
Moshirfar M, Smedley JG, Muthappan V,
Jarsted A, Ostler EM. Rate of ectasia and
incidence of irregular topography in patients
with unidentified preoperative risk factors
undergoing femtosecond laser-assisted LASIK.
Clin Ophthalmol. 2014; 8:35-42.
Moshirfar M, Mifflin MD, McCaughey MV, Gess
AJ. Prospective, randomized contralateral eye
comparison of tetracaine and proparacaine for
pain control in laser in situ keratomileusis and
photorefractive keratectomy. Clin Ophthalmol.
2014; 8(6), 1213-19.
Moshirfar M, Imbormoni LM, Ostler EM,
Muthappan V. Incidence rate and occurrence
of visually significant cataract formation and
corneal decompensation after implantation
of Verisyse/Artisan phakic intraocular lens.
Clin Ophthalmol. 2014; (8), 711-6.
Moshirfar M, Pierson K, Hanamaikai Km
Santiago-Caban L, Muthappan V, Passi SF.
Artificial tears potpourri: A literature review.
Clin Ophthalmol. 2014; 8(4), 1-15.
Clinics in Mother Child Health
Frost CJ, Murphy PA, Shaw JM, Jones KP, Varner
M, Mihalopouls N, Lake E, Patrick S, Johnston
L, Digre KB. Reframing the view of women’s
health in the United States: Ideas from a
multidisciplinary National Center of Excellence
in Women’s Health demonstration project
clinics in mother and child health. Clinics
Mother Child Health. 2014 Feb; 11(1):1000156.
Clinics in Perinatology
Hartnett ME. Vascular endothelial growth
factor antagonist therapy for retinopathy of
prematurity. Clin Perinatol. 2014 Dec; 41(4):
925-43.
Cold Spring Harbor Perspectives
in Medicine
light responses of the inner retina. Eur J
Neurosci. 2014; 41:17-30.
study in Utah. Gastroenterology. 2014; 147(4),
814-821.e5; quiz e15-6.
Experimental Eye Research
Glaucoma Today
Fuhrmann S, Zou C, Levine EM. Retinal pigment
epithelium development, plasticity, and tissue
homeostasis. Exp Eye Res. 2014 Jun; 123:141-50.
Zabriskie N. IOL selection considerations in
glaucoma patients. Cover Story. Glaucoma
Today. 2014; (5), 39-41.
Singh V, Jaini R, Torricelli AA, Santhiago MR,
Singh N, Ambati BK, Wilson SE. TGFβ and PDGF-B
signaling blockade inhibits myofibroblast development from both bone marrow-derived and
keratocyte-derived precursor cells in vivo.
Exp Eye Res. 2014 Apr; 121:35-40.
Graefes Archive for Clinical and
Experimental Ophthalmology
Cahoon JM, Olsono PR, Nielson S, Miya TR,
Bankhead P, McGeown JG, Curtis TM, Ambati BK.
Acridine orange leukocyte fluorography in mice.
Exp Eye Res. 2014; 12(3), 15-9.
Eye (London)
Morgan DJ, DeAngelis MM. Differential
gene expression in age-related macular
degeneration. Cold Spring Harb Perspect Med.
2014 Oct 23; pii: a017210.
Bernstein PS, Johnson EJ, Neuringer M, Schalch
W, Schierle J. Comment on: What is meso-zeaxanthin, and where does it come from?
Eye (Lond). 2014; 28(2), 240-2.
Cornea
The FASEB Journal
Cho YK, Archer B, Ambati BK. Dry eye
predisposes to corneal neovascularization and
lymphangiogenesis after corneal injury in a
murine model. Cornea. 2014; 33(6), 621-7.
Wang H, Jiang Y, Shi D, Quilliam LA,
Chrzanowska-Wodnicka M, Wittchen ES, Li
DY, Hartnett ME. Activation of Rap1 inhibits
NADPH oxidase-dependent ROS generation
in retinal pigment epithelium and reduces
choroidal neovascularization. FASEB J. 2014
Jan; 28(1):265-74.
Moshirfar M, Imbornoni LM, Muthappan V,
Williams L, Khalifa YM, Jarstad A, Sikder S.
In vitro pilot analysis of uniformity, circulatiry,
and concentricity of DSAEK donor endothelial
grafts prepared by a microkeratome.
Cornea. 2014 Feb; 33(2):191-6.
Current Eye Research
Križaj D, Ryskamp DA, Tian N, Tezel G, Mitchell
CH, Slepak VZ, Shestopalov VI. From mechanosensitivity to inflammatory responses: New
players in the pathology of glaucoma.
Curr Eye Res. 2014; 39:105-19.
Current Neuropharmacology
Uzunova G, Hollander E, Shepherd JD. The role
of ionotropic glutamate receptors in childhood
neurodevelopmental disorders: Autism spectrum disorders and fragile x syndrome. Curr
Neuropharmacol, 2014 Jan; 12(1):71-98.
Environmental Research
Wu EW, Schaumberg DA, Park SK. Environmental cadmium and lead exposures and agerelated macular degeneration in US adults: The
National Health and Nutrition Exam Survey.
Environ Res. 2014; 133:178-84.
European Journal of Neuroscience
Tian N, Xu HP, Wang P. Dopamine D2 receptors
preferentially regulate the development of
Focal Points
Crandall AS, Slade DS. Placement of
endocapsular IOLs in eyes with zonular
compromise. Focal Point. 2014; 32(7), 1-8.
Frontiers in Cellular Neuroscience
Obana A, Gohto Y, Tanito M, Okazaki S,
Gellermann W, Bernstein PS, Ohira A. Effect
of age and other factors on macular pigment
optical density measured with resonance
Raman spectroscopy. Graefes Arch Clin Exp
Ophthalmol. 2014; 252(8), 1221-8.
Health Communication
Sleath B, Sayner R, Blalock SJ, Carpenter DM,
Muir KW, Hartnett ME, Tudor G, Lawrence S,
Giangiacomo AL, Robin AL. Patient questionasking about glaucoma and glaucoma
medications during videotaped medical visits.
Health Commun. 2014 Jul; 25:1-9.
Human Molecular Genetics
Zhang T, Enemchukwu N, Jones A, Wang S,
Dennis E, Watt, C, Pugh E, and Fu Y.
Genetic deletion of S-opsin prevents rapid
cone degeneration in a mouse model of Leber
congenital amaurosis. Hum Mol Genet. 2014
Nov 20. pii: ddu588.
Zou J, Zheng T, Ren C, Askew C, Liu X, Pan B,
Holt JR, Wang Y, Yang J. Deletion of PDZD7
disrupts the Usher syndrome type 2 protein
complex in cochlear hair cells and causes
hearing loss in mice. Hum Mol Genet. 2014;
23(9), 2374-2390.
Chen M, Krizaj D, Thoreson WB. Intracellular
stores drive sustained non-ribbon vesicle
release from rod photoreceptors. Front Cell
Neurosci. 2014; 8:20.
Ratnapriya R, Schaumberg DA, Swaroop A, et
al. Rare and common variants in extracellular
matrix gene fibrillin 2 (FBN2) are associated
with macular degeneration. Hum Mol Genet.
2014 Jun; 23(21):5827-37.
Frontiers in Molecular Neuroscience
Human Mutation
Jiang L, Frederick JM, Baehr W. RNA
interference gene therapy in dominant retinitis
pigmentosa and cone-rod dystrophy mouse
models caused by GCAP1 mutations. Front Mol
Neurosci. 2014; 7: 25.
Marc RE, Anderson JR, Jones BW, Sigulinsky CL,
Lauritzen JS. The all amacrine cell connectome:
A dense network hub. Front Neural Circuits.
2014 Sep; 8(104):1-13.
Thomas S, Wright K, Le Corre S, Micalizzi A,
Romani M, Abhyankar A, Saada J, Perrault I,
Amiel J, Litzler J, Filhol E, Elkhartoufi N, Kwong
M, Casanova J-L, Boddaert N, Baehr W, Lyonnet
S, Munnich A, Burglen L, Chaissaing N, EnchaRavazi F, Vekemans M, Gleeson JG, Valente
EM, Jackson PK, Drummond IA, Saunier S,
Attié-Bitach T. A homozygous PDE6D mutation
in Joubert syndrome impairs targeting of
farnesylated INPP5E protein to the primary
cilium. Hum Mutat. 2014; 35(1):137-46.
Gastroenterology
IEEE
Samadder NJ, Curtin K, Tuohy TM, Pappas L,
Boucher K, Provenzale D, Rowe KG, Mineau GP,
Smith K, Pimentel R, Kirchhoff AC, Burt RW.
Characteristics of missed or interval colorectal
cancer and patient survival: A populationbased study. Gastroenterology. 2014; 146(4),
950-60.
Loizos K, Lazzi G, Lauritzen JS, Anderson J, Jones
BW, Marc R. A multi-scale computational
model for the study of retinal prosthetic
Frontiers in Neural Circuits
Samadder NJ, Curtin K, Tuohy TM, Rowe KG,
Mineau GP, Smith KR, Pimentel R, Wong J,
Boucher K, Burt RW. Increased risk of colorectal
neoplasia among family members of patients
with colorectal cancer: A population-based
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Feb; 55(2):737-44.
5 long-term studies. JAMA Ophthalmol. 2014
Jan; 132(1):84-95.
Investigative Ophthalmology and
Visual Sciences
Meyers KJ, Mares JA, Igo RP Jr, Truitt B, Liu Z,
Millen AE, Klein M, Johnson EJ, Engelman CD,
Karki CK, Blodi B, Gehrs K, Tinker L, Wallace R,
Robinson J, LeBlanc ES, Sarto G, Bernstein PS,
SanGiovanni JP, Iyengar SK. Genetic evidence
for role of carotenoids in age-related macular
degeneration in the Carotenoids in AgeRelated Eye Disease Study (CAREDS). Invest
Ophthalmol Vis Sci. 2014; 55(1), 587-99.
Ahmed F, Kamae KK, Jones DJ, DeAngelis MM,
Hageman GS, Gregory MC, Bernstein PS.
Temporal macular thinning associated with
x-linked alport syndrome. JAMA Ophthalmol.
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Baehr, W. Membrane protein transport in
photoreceptors: the function of PDEδ: the
Proctor lecture. Invest Ophthalmol Vis Sci. 2014
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Fu Y. A functional approach to examine the role
of HTRA1 vs ARMS2 in AMD. Invest Ophthalmol
Vis Sci. 2014; 55, 6524.
Wang F, Wang Y, Zhang B, Zhao L, Lyubasyuk V,
Wang K, Xu M, Li Y, Wu F, Wen C, Bernstein PS,
Lin D, Zhu S, Wang H, Zhang K, Chen R.
A missense mutation in HK1 leads to
autosomal dominant retinitis pigmentosa.
Invest Ophthalmol Vis Sci. 2014 Nov;
55(11):7159-64.
Vitale AT. Birdshot retinochroidopathy.
Iranian Journal of Medical Sciences. 2014; (7).
Oakley GM, Curtin K, Layfield L, Jarboe E,
Buchmann LO, Hunt JP. Increased melanoma
risk in individuals with papillary thyroid
carcinoma. JAMA Otolaryngology—Head &
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JAMA Internal Medicine
JCRS Online Case Reports
Ambati B. Gender income disparities can be
explained by alternative factors. JAMA Intern
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Ambati BK, Cahoon J. Rejuvenating clinicianscientist training. Invest Ophthalmol Vis Sci.
2014 Mar; 55(3):1853-5.
JAMA Ophthalmology
Messenger WB, Ambati BK. Unilateral
implantation of a pseudoaccommodating
toric intraocular lens in 2 patients after radial
keratotom. JCRS Online Case Reports. 2014 Aug;
2(4):73-77.
Das SK, Gupta I, Cho YK, Zhang, Uehara H,
Muddana SK, Bernhisel AA, Archer B, Ambati
BK. Vimentin knockdown decreases corneal
opacity. Invest Ophthalmol Vis Sci. 2014 May;
55(7):4030-40.
Hartnett ME, Morrison MA, Smith S, Yanovitch
TL, Young TL, Colaizy T, Momany A, Dagle
J, Carlo WA, Clark EAS, Page G, Murray J,
DeAngelis MM, Cotton M. Genetic variants
associated with severe retinopathy of
prematurity in extremely low birth weight
infants. Invest Ophthalmol Vis Sci. 2014 Aug;
55(10):6194-203.
Jiang Y, Wang H, Culp D, Yang Z, Fotheringham
L, Flannery J, Hammond S, Kafri T, Hartnett
ME. Targeting Muller cell-derived VEGF164 to
reduce intravitreal neovascularization in the
rat model of retinopathy of prematurity. Invest
Ophthalmol Vis Sci. 2014 Feb; 55(2):824-31.
Kumar S, Berriochoa Z, Ambati BK, Fu Y.
Angiographic features of transgenic
mice with increased expression of human
serine protease HTRA1 in retinal pigment
epithelium. Invest Ophthalmol Vis Sci. 2014; Jun;
55(6):3842-50.
Owen LA, Morrison MA, Ahn J, Woo SJ, Sato H,
Robinson R, Morgan DJ, Zacharaki F, Simeonova
M, Uehara H, Chakravarthy U, Hogg RE, Ambati
BK, Kotoula M, Baehr W, Haider NB, Silverstri
G, Miller JW, Tsironi EE, Farrer LA, Kim IK, Park
KH, DeAngelis MM. FLT1 genetic variation
predisposes to neovascular AMD in ethnically
diverse populations and alters systemic FLT1
expression. Invest Ophthalmol Vis Sci. 2014 Jun;
55(6):3543-54.
74
JAMA Otolaryngology—
Head & Neck Surgery
Wang H, Yang Z, Jiang Y, Flannery J, Hammond
S, Kafri T, Vemuri SK, Jones B, Hartnett ME.
Quantitative analyses of retinal vascular
area and density after different methods to
reduce VEGF in a rat model of retinopathy of
Iranian Journal of Medical Sciences
Finger RP, Wu Z, Luu CD, Kearney F, Ayton LN,
Lucci LM, Hubbard WC, Hageman JL, Hageman
GS, Guymer RH. Reticular pseudodrusen: A
risk factor for geographic atrophy in fellow
eyes of individuals with unilateral choroidal
neovascularization. JAMA Ophthalmol. 2014;
121(6), 1252-6.
Age-related Eye Disease Study 2 (AREDS2)
Research Group, Chew EY, Clemons TE,
Sangiovanni JP, Danis RP, Ferris FL 3rd, Elman
MJ, Antoszyk AN, Ruby AJ, Orth D, Bressler SB,
Fish GE, Hubbard GB, Klein ML, Chandra SR,
Blodi BA, Domalpally A, Friberg T, Wong WT,
Rosenfeld PJ, Agron E, Toth CA, Bernstein PS,
Sperduto RD. Secondary analyses of the effects
of lutein/zeaxanthin on age-related macular
degeneration progression: AREDS2 report no.
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Schaumberg DA. Serum carboxymethyllysine,
an advanced glycation end product, and agerelated macular degeneration: The age, gene/
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JAMA Ophthalmol. 2014 Apr; 132(4):464-70.
Schaumberg DA, Rose L, DeAngelis MM, Semba
RD, Hageman GS, Chasman DI. Prospective
study of common variants in CX3CR1 and risk
of macular degeneration: Pooled analysis from
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Young MP, Sawyer BL, Hartnett ME.
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2014; 18(2):205-7.
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are both required to form the quaternary
protein complex associated with Usher
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Journal of Cataract and
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Mamalis N. Long-term uveal and capsular
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Barra D, Werner L, Costa JL, Morris C, Ribeiro
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and light transmittance in a series of calcified
single-piece hydrophilic acrylic intraocular
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Refract Surg. 2014 Feb; 40(2):323-6.
Morris C, Werner L, Barra D, Liu E, Stallings
S, Floyd A. Light scattering and light
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Werner L, Morris C, Liu E, Stallings S, Floyd
A, Ollerton A, Leishman L, Bodnar Z. Light
transmittance of 1-piece hydrophobic acrylic
intraocular lenses with surface light scattering
removed from cadaver eyes. J Cataract Refract
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Owen LA, Hartnett ME. Current concepts
of oxygen management in retinopathy of
prematurity. J Ophthalmic Vis Res. 2014 Jan;
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Jacobo SM, DeAngelis MM, Kim IK, Kazlauskas
A. Age-related macular degenerationassociated silent polymorphisms in HtrA1
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MP, Kieburtz K, Kupersmith M, Stoutenburg A,
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Joos ZP, Adesina OO, Katz BJ. Posterior
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Federer F, Williams D, Ichida JM, Merlin S,
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2 is required for mouse olfactory ciliary
McCaughey MV, Mifflin TR, Fenzl CR, Goldsmith
JA, Moshirfar M. Pseudophacomorphic
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Journal of Visual Experiments
Kumar S, Berriochoa Z, Jones A, and Fu Y. Detecting abnormalities in choroidal
vasculature in a mouse model of age-related
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Bosco A, Romero CO, Ambati BK, Vetter ML.
In vivo dynamics of retinal microglial
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Moshirfar M. Last issue of: Interesting
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Neurobiology of Aging
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DM, Muir KW, Hartnett ME, Robin AL. Provider
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JOHN A. MORAN EYE CENTER
Research Grants and Contracts
RESEARCH GRANTS
The Role of Soluable Flt-1 and Raver2
in Ocular Vascular Demarcations
Balamurali K Ambati, MD, PhD, MBA
Strategic in Silico Discovery
NA
National Institutes of Health
07/01/12–06/30/17
Biocompatible Novel Ocular Drug
NA
National Institutes of Health
07/01/12–05/01/14
Compang1 in Diabetic Retinopathy
NA
National Institutes of Health
07/01/12–06/30/16
The Comp-Ang1
NA
$250,000
National Eye Institute
08/01/13–07/31/17
Vascular Normalization
NA
Interference of VEGFNA
National Eye Institute
04/01/13–03/31/18
NA
$18,000
National Institutes of Health
07/01/13–06/30/14
AHAF-Glaucoma
American Heart Association
Western States Affiliate
01/01/14–12/31/14
Intraceptor Interference of VEGF
in Ocular Angiogenesis
Retinal Health Analyzer for Novel Therapy and Early Diagnostics for AMD $392,028
$20,000
Carl Marshall Reeves & Mildred Almen
Reeves Foundation
12/01/12–08/31/14
Parallel Pathways in Visual Cortex: Functional Connectivity of Output
Pathways from Area V1 to Area V2
$365,050
National Eye Institute
08/01/13–07/31/16
Parallel Pathways in Visual Cortex: Functional Connectivity of Output
Pathways From Area V1 to Area V2
Parallel Pathways in Visual Cortex: Functional Connectivity of Output
Pathways from Area V1 to Area V2
NA
$50,039
A Novel Approach for Mapping Single-cell Long-range
Connections in the Cerebral Cortex
$38,500
$206,808
$409,750
National Eye Institute
05/01/12–07/31/15
Regeneron Pharmaceuticals Inc.
08/29/13–03/31/15
Epcs in Diabetic Retinopathy $94,000
Equipment Supplement National Eye Institute
08/01/14–07/31/15
Admin Supplement National Eye Institute
08/01/14–07/31/15
American Health Assistance Foundation
07/01/13–06/30/15
Eyelea for Corneal Neo The Role of Soluable Flt-1 and Raver2 in Ocular Vascular Demarcations
Equipment Supplement National Eye Institute
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National Institutes of Health
04/01/13–03/31/18
Defining the Mechanism of Ang1
National Eye Institute
08/01/13–07/31/17
Alessandra Angelucci, MD, PhD
Juvenile Diabetes Research Foundation
03/01/13–02/28/14
Caltech Wound Healing
NA
National Eye Institute
01/01/14–12/31/17
American Diabetes Association
01/01/13–12/31/16
Role of sFlt in Corneal Avascularity
2014
$365,050
Computation of Visual Context Information in the Primary
Visual Cortex
National Science Foundation
09/01/14–08/31/17
77
$200,000
Wolfgang B Baehr, PhD
ProgStar Prospective Study
Nephrocystin-5 in Retinal Degeneration (Baehr; Ronquillo)
Foundation Fighting Blindness
01/01/13–02/29/16
$33,695
National Institutes of Health
08/01/12–07/31/14
Core Vision Research Grant (Baehr; Bernstein)
ProgStar Prospective Study $173,129
$372,500
$365,050
Retina Research Foundation
01/01/14–12/31/14
$75,000
Research to Prevent Blindness
07/01/14–06/30/19
NA
Paul S Bernstein, MD, PhD
$1,696
Roche Translational and Clinical
Research Center
04/01/14–05/30/14
Oph1002 Acu-4429
Acucela, Inc.
03/01/13–12/31/16
$100,000
Arnold and Mabel Beckman Foundation
07/01/13–12/30/14
$315,712
Nanosized Carotenoid Complexes with Plant Metabolities and
Potential Delivery System for
Treatment of Ocular Disorders
$5,000
US Civilian Research and Development
03/22/13–3/21/15
Alan S Crandall, MD
Hydrus 4 $110,417
Ophthotech Corporation
09/01/13–12/31/15
78
$395,050
Lowy Medical Research Institute
02/15/14–3/31/15
Abbott Medical Optics
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Roche Bp28935
$168,000
National Eye Institute
03/01/13–02/28/17
Collaborative Study of the Role of the Macular Pigment Carotenoids in the
Pathogenesis and Treatment
William Barlow, MD
$628,276
Emmes Corporation/National Eye Institute
6/01/06–Present
VLC-PUFAS in Dry AMD $100,000
$234,887
National Neurovision Research Institute
06/01/10–Present
Biochemistry and Pharmacology of Macular Cartenoids
Foundation for Retinal Research
11/01/13–10/31/14
A Comparative Study of Venturi vs. Peristaltic Vacuum Regarding
Efficiency and Chatter
$40,219 GlaxoSmithKline
05/01/11–12/31/14
Age-related Eye Disease (AREDS) Study II
Therapy for a Mouse Model SLS$30,000
Gene Therapy for Retinitis Pigmentosa Animal Models
Bam114341 VPA Protocol
National Eye Institute
05/01/12–04/30/16
Therapies for Retinal Degeneration Caused by NPHP5 Mutations
Intuitive Retinal System (Abbott; Bernstein)
Intuitive Surgical, Inc.
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National Eye Institute
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Photoreceptor Ciliopathies: RP2, KIF17 and NPHP5 (Baehr; Frederick)
$24,600
Foundation Fighting Blindness
01/01/13–12/31/16
National Eye Institute
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Membrane Protein Transport in Photoreceptors
$174,800
Cypass Glaucoma Implant $254,842 $130,700
Ivantis, Inc.
04/17/14–12/31/19
$110,289
Transcend Medical, Inc.
1/01/11–12/31/14
Karen Curtin, PhD, MStat
Genetic Epidemiology of Chronic Lymphocytic Leukemia (Curtin; Camp) National Cancer Institute
12/01/09–11/30/14
$385,646
Sequencing in High-risk Multiple Myeloma Pedigrees (Curtin; Camp) $80,795
Utah Genome Project Partnership Grant Program
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Identification of High-risk Genes for Childhood Cancer through the Utah
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Utah Genome Project Partnership Grant Program
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Margaret DeAngelis, PhD
Human Eye Repository for Studies of
Age-related Macular Degeneration
$60,000
$14,924
Program of Research to Understand the Genetic Epidemiology of Glaucoma
and Co-occurring Diseases
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Department of Defense
09/01/12–08/31/16
Mechanisms and Treatment Strategies
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$365,050
$372,500
A New Treatment Strategy for Age-related Macular Degeneration $20,000
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National Eye Institute
02/01/14–01/31/15
$40,000
Carl Marshall Reeves & Mildred Almen
Reeves Foundation
12/01/12–08/31/14
Sabine Fuhrmann, PhD
Mechanisms Controlling RPE Development NA
National Eye Institute
01/01/10–12/31/14
$20,000
Gregory S Hageman, PhD
Carl Marshall Reeves & Mildred Almen
Reeves Foundation
12/01/12–08/31/14
Identification of Pathways, Targets, and Therapies for Age-related
Macular Degeneration
To Continue to Build a Repository of Human Eyes from the Utah Lions Eye
Bank of Tissue for Studies of Age-related
Macular Degeneration for the Purpose
of Gene Expression Assays and Functional
Studies (DeAngelis; Hartnett)
Voyant Biotherapeutics LLC
12/15/13–12/31/17
Carl Marshall Reeves & Mildred Almen
Reeves Foundation
12/01/14–08/31/15
$240,000
E. Matilda Ziegler Foundation for the Blind
07/01/11–06/30/14
Mechanisms and Treatment Strategies for Polypoidal Choroidal Vasculopathy
Equipment Supplement The University of Utah Center on Aging
01/01/14 –01/31/15
To Continue to Build a Repository of Human Eyes from the Utah Lions Eye
Bank of Tissue for Studies of Age-related
Macular Degeneration for the Purpose
of Gene Expression Assays and Functional
Studies (DeAngelis; Hartnett)
$181,009
National Eye Institute
02/01/14–01/31/17
The ALSAM Foundation
03/16/12–08/31/15
Elucidating Functional Mechanisms in the Normal Aging Retina and AMD
Temporal Progression of Visual
Injury from Blast Exposure
National Eye Institute
09/30/12–08/31/17
L. J. Skaggs & Mary C. Skaggs Foundation
08/01/14–3/31/17
Research to Understand the Genetic Epidemiology of Blinding Diseases of
the Posterior Eye among Federally
Recognized Native American Tribes of
the Intermountain West
Yingbin Fu, PhD
Cone Opsins in Photoreceptor Degeneration
Massachusetts Eye and Ear Infirmary
03/24/14–12/31/15
$750,000
Edward N. & Della L. Thome
Memorial Foundation
01/01/09–10/31/14
Mechanisms and Treatment Strategies for Leber Congenital Amaurosis Carl Marshall Reeves & Mildred Almen
Reeves Foundation
12/01/14–8/31/15
Molecular Analyses of UVEAL Melanoma
Identifying Underlying Mechanisms of Age-related Macular Degeneration for
the Development of Appropriate Preventive
and Therapeutic Interventions
Genetic Susceptibility to Age-related Macular Degeneration
$60,000
Columbia University
09/01/14–8/31/15
$7,750,000
79
$55,963
Gregory S Hageman, PhD
David Krizaj, PhD
Improved Characterization of High-risk
Phenotypes in Early AMD, Employing
Novel Imaging and Functional Modalities
(Guymer; Hageman)
Glaucoma Drugs2
$400,000
Macular Degeneration Foundation
of Australia
10/04/11–10/04/14
$20,200
$381,608
NA
Utah Governor’s Office of
Economic Development
02/28/14–02/28/15
NA
RGC Mechanotransduction as a Target in Glaucoma Jaeb Center For Health Research
01/01/13–12/31/14
Endothelial Transmigration in Neovascular Age-related
Macular Degeneration
$365,050
Regulation of Retinal Progenitor
Cell Properties
$90,000
March of Dimes
06/1/13–5/31/16
$19,024
University of Pennsylvania
09/30/12–8/31/14
$88,411
Bradley J Katz, MD, PhD
$93,635 Quark Pharmaceuticals, Inc.
09/1/12–08/31/16
US Army Medical Research
Acquisition Activity
09/01/12– 08/31/16
$87,287
$372,500
National Eye Institute
04/01/14–3/31/18
Evaluation of Biocompatibility and Capsular Bag Opacification with a
New Foldable Intraocular Lens in the
Research Eye Model (TO#8)
$718,099
$19,797
ANEW Optics Inc.
01/01/14–09/30/14
Evaluation of the Uveal and Capsular Bag Biocompatibility with a New
Foldable Intraocular Lens in a
Research Eye Model (TO#12)
University of Pennsylvania
07/01/10–06/30/14
Blast Ocular Injury
(Coats; Fu; Goldsmith; Monson; Katz) $40,000
Nick Mamalis, MD and Liliana Werner, MD, PhD
Robert O Hoffman, MD
80
Core Vision Research Grant Studies on Angiogenic Mechanisms and Safety Regarding Erythropoietin
in Retinopathy of Prematurity: Seeking
a Safe Treatment
Quark 007
$40,000
Edward M Levine, PhD
National Eye Institute
07/01/10–06/30/15
E-Rop
$322,788
Glaucoma Research Foundation
03/01/14–02/28/15
National Eye Institute
04/01/12– 3/31/17
G-Rop
$335,250
Army Medical Research Acquisition Activity
08/15/12–08/14/16
Glaucoma Drugs
Duke University
04/01/13–03/31/18
Protocol T
$84,187
National Institutes of Health
12/01/12–11/30/16
Characterization of Molecular Mechanisms of Ocular Blast Trauma
National Eye Institute
09/01/14–8/31/19
Neonatal Sdoct
Core Vision Research Grant
Role of Mechanosensation in the Retina
Jack McGovern Coats’ Disease Foundation
03/15/14–03/31/15
Mechanisms of Angiogenesis in Retinopathy of Prematurity
State of Utah
02/04/14–02/04/15
National Eye Institute
07/1/10–06/30/15
Mary Elizabeth Hartnett, MD
Genetics of Coats’ Disease
$40,000
$25,718
Abbott Medical Optics
01/01/14–04/30/14
Evaluation of the Biocompatibility of a New Coating Material for Intraocular
Lens Inserter Cartridges in a Research
Eye Model (TO#13)
Abbott Medical Optics
04/01/14–07/31/14
$17,334
Evaluation of Stability and Capsular Bag Opacification with a New
Foldable Intraocular Lens in a
Research Eye Model (TO#2)
$21,804
PhysIOL
10/23/13–01/31/14
Evaluation of the Aqua Sense Y PAL Intraocular Lens in a Research Eye Model
$27,706
Evaluation of Stability and Capsular Bag Opacification with a New Foldable Intraocular
Lens in a Research Eye Model (TO#1)
$12,483
HOYA Medical Singapore PTE. LT
10/01/13–01/31/14
$14,473
Powervision INC.
01/22/14–3/31/14
Evaluation of the FluidVision Accommodating IOL in a Research
Eye Model (TO#36)
Evaluation of the Surgical Technique to Implant the Harmoni IOL in a Research
Eye Model (TO#1)
$26,944
Evaluation of Stability and Capsular Bag Opacification with a New Foldable
Intraocular Lens in a Research Eye
Model (TO#2)
$26,944
Evaluation of the Surgical Technique to Implant the Harmoni IOL
in a Research Eye Model (TO#3)
Clarvista Medical
06/25/14–9/30/14
Evaluation of Stability and Capsular Bag Opacification with a Foldable
Intraocular Lens Coupled with a
Patterned Protective Membrance
in a Research Eye Model (TO#1)
Evaluation of the Surgical Technique
to Implant the Omega 3D IOL
in a Research Eye Model (TO#1)
$7,603
Sharklet Technologies INC.
01/01/14–Current
Sharklet Technologies INC.
04/15/14–6/30/14
$15,408
$3,506
$17,344
Clarvista Medical
05/15/14–9/30/14
HOYA Medical Singapore PTE. LT
07/01/14–Current
Evaluation of Stability and Capsular
Bag Opacification with a Foldable
Intraocular Lens Coupled with a
Protective Membrance in a Research Eye Model (TO#2)
$3,426
Clarvista Medical
01/31/14–5/31/14
HOYA Medical Singapore PTE. LT
07/01/14–Current
Evaluation of a Biocompatibility and Capsular Bag Opacification with a New
Foldable Intraocular Lens (SP2 Clear) in
a Research Eye Model (TO#4)
Evaluation of New Surgical Techniques to Implant the FluidVision Intraocular Lens
in a Research Eye Model (TO#35)
Powervision INC.
11/05/14–Current
HOYA Medical Singapore PTE. LT
10/01/13–01/31/14
Evaluation of a Biocompatibility and Capsular Bag Opacification with a New
Foldable Intraocular Lens (SP2 Yellow)
in a Research Eye Model (TO#3)
$30,488
Sharklet Technologies INC.
05/7/14–10/31/14
Aaren Scientific Inc.
05/20/13–03/01/14
Evaluation of the Stability of a New Foldable Intraocular Lens in a
Research Eye Model after Nd: YAG
Laser Posterior Capsulotomy (TO#2)
Evaluation of Stability and Capsular Bag Opacification with a Foldable
Intraocular Lens Coupled with a
Protective Membrance in a Research
Eye Model (TO#3)
$2,603
$4,647
OMEGA Ophthalmics
07/15/14–11/30/14
Power Adjustment and Biocompatibility, Amend #21
NA
Calhoun Vision, Inc.
05/04/07–07/31/17
$7,603
Evaluation of a New Solution for Prevention of Capsular Bag Opacification
in a Research Eye Model (TO#1)
Genisphere LLC
01/15/14–5/31/14
81
$27,985
Nick Mamalis, MD and Liliana Werner, MD, PhD
Mark D Mifflin, MD
Evaluation of a New Solution for Prevention of Capsular Bag Opacification
in a Research Eye Model (TO#2)
CPTS
$22,603
Genisphere LLC
08/01/14–12/31/14
Evaluation of Biocompatibility of a Silicone Fluid in a Research Eye Model (TO#1)
$12,603
$3,506
$32,756
$3,101
Structural Neurochemistry of Retinal Circuits $509,797
National Eye Institute
12/01/11–11/30/16
$498,849
National Eye Institute
4/01/12–03/31/16
$167,337
National Eye Institute
07/01/10–06/30/15
Core Vision Research Grant (Main)
$29,743
Vision Research Training Grant at the University of Utah (Marc; Krizaj)
National Eye Institute
07/01/10–06/30/15
$20,000
Debra A Schaumberg, ScD, OD, MPH
Randomized Trial of Vit D & Omega-3 Fatty Acids for Diabetic Kidney Disease
$19,144
Effects of Vitamin D and Omega-3 Fatty
Acids on Infectious Diseases and hCAP18
$31,644
National Eye Institute-Subaward from
Brigham & Womens Hospital
04/01/13–05/31/17
Vital AMD: Prevention of AMD in the Vitamin D and Omega-3 Trial
$136,502
National Eye Institute-Subaward from
Brigham & Womens Hospital
4/01/13–08/31/17
Systemic Complement and Age-related Macular Degeneration
$37,418
National Eye Institute-Subaward from
Johns Hopkins University
09/01/14–8/31/15
Omega-3 Fatty Acids for Prevention of Dry Eye Disease: Vital AMD
$373,156
National Eye Institute
04/01/13–8/31/17
National Eye Institute
07/01/10–6/30/15
82
Evaluation of Topical Antibiotics/Risk of Endophthalmitis with Intravitreal
Injection
National Eye Institute-Subaward from
University of Washington
04/01/13–08/31/15
Robert E Marc, PhD
Core Vision Research Grant
$20,000
Allergan, Inc.
04/01/07–Present
MYNOSYS
09/01/14–Current
Retinal Remodeling
Evaluation of Topical Antibiotics/Risk of Endophthalmitis with Intravitreal
Injection
Allergan, Inc.
01/01/09–Present
Lensgen Inc.
10/15/14–Current
Evaluation of an Automated Capsulorhexis Technique for
Phacoemulsification and Intraocular
Lens Implantation in a Research Eye
Model (TO#1)
$109,350
Jaeb Center for Health Research
03/01/12–06/30/17
Lensgen Inc.
06/01/14–11/30/14
Evaluation of Biocompatibility of a Silicone Fluid in a Research Eye
Model (TO#3)
Jaeb Center for Health Research
07/01/12–06/30/17
CPTS
Lensgen Inc.
02/11/14 –05/31/14
Evaluation of Biocompatibility of a Silicone Fluid in a Research Eye
Model (TO#2)
$51,800
Jason Shepherd, PhD
$214,991
Role of Arc in Synaptic/Experience-
dependent Plasticity in Mouse
Visual Cortex
National Institutes of Health
04/01/11–04/01/16
$166,450
Investigating the Causal Role of Arc in Angelman Syndrome
$80,101
Angelman Syndrome Foundation
07/01/13–07/01/15
Michael P Teske, MD
Utah Women’s Health Information Network (Digre; LaCoursiere; Teske) $500,000
Utah Department of Health
09/01/07–Present
Ning Tian, PhD
Development of Synaptic Pathways
in Retina (Supplement) $365,050
National Eye Institute
04/01/11–03/31/16
NA
National Institutes of Health
12/01/14–11/30/16
The Role of Microglia in
Experimental Glaucoma NA
National Institutes of Health
07/01/10–06/30/15
Inhibitory Regulation of Microglia
in Glaucoma NA
NA
NA
Aciont Inc.
12/01/14–12/31/15
Centre for Eye Research Australia
01/01/13–12/31/16
NA
Stop-Uveitis Study NA
Genentech Inc.
12/01/12–12/31/14
NA
Genentech Inc.
06/01/12–04/30/14
Must Follow Up Study
Johns Hopkins University
05/01/12–04/30/15
Bausch & Lomb
01/01/03–Present
Formation and Function(s) of the Usher 2 Protein Complex in Photorecptors
$68,811
$328,545
National Eye Institute
04/01/11–03/31/16
Research to Prevent Blindness Special Scholar Award
$100,000
Research to Prevent Blindness
7/01/13–12/31/14
$27,273
Hearing Health Foundation
07/01/14–06/30/15
$22,727
Hearing Health Foundation
07/01/13–06/30/14
Involvement of C8orf37 in Inherited Retinal Degenerations and Ciliopathies
Albert T Vitale, MD 2U10EY014660: Multicenter Uveitis
Steroid Treatment (MUST) Trial A Multicenter Randomized Controlled
Study to Evaluate the Safety and Efficacy of
an Intravitreal Flucinolone Acetonide (0.5mg)
Implant Compared to Standard Therapy in
Patients with Noninfectious Uveitis
Affecting the Posterior Segment of the Eye NA
Function of Pdzd7
Research to Prevent Blindness,
Innovative Ophthalmic Research Award
01/01/13–12/31/15
Dsp-Visulex
Lux Biosciences, Inc.
04/01/07–Present
Pdzd7 Function
National Institutes of Health
07/01/13–06/30/18
Regulation of Axon Degeneration
in Glaucoma NA
Jun Yang, PhD Monica Vetter, PhD
Role of Microglia During
Retinal Neurogenesis Double-mass, Placebo-controlled,
Multi-centered, Dose-ranging Study to
Assess the Efficacy and Safety of LX211
as Therapy Clinically Quiescent Sight
Threatening, Noninfectious Uveitis $28,000
University of Utah Research Foundation
Seed Grant
07/01/13–06/30/14
Analysis of Interactions-Qian Chen
$60,000
Knights Templar Eye Foundation
07/01/13–06/30/14
Ush2 Complex in Cochlear Hair
$20,000
National Organization for Hearing Research
07/01/13–06/30/14
83
N AT I O N A L A N D I N T E R N AT I O N A L P R E S E N TAT I O N S
2014
This is a partial list of Moran National and International Presentations
Balamurali K Ambati, MD, PhD, MBA
Talks at Kyoto Cornea Club, Nagoya and Tokyo University.
Nagoya and Tokyo,
Japan
Alessandra Angelucci, MD, PhD
Keynote Speaker, Corticocortical Connections in the Primate Visual
Cortex: Structure and Function.
Brazilian Society for Neuroscience,
2013.
Belo Horizonte, Brazil
Invited Speaker, Department of Morphology, Autonoma University
Medical School, 2013.
Madrid, Spain
Invited Speaker, Department
of Neuroscience, University of
Pennsylvania, 2013.
Philadelphia, PA
Department of Physiology, University of Rome.
La Sapienza, Italy
Wolfgang B Baehr, PhD
Proctor Medal Lecture. Membrane Protein Transport in Photoreceptors:
the Function of PDE-Delta. Poster and
Platform Presentations. ARVO.
Orlando, FL
Invited Presentation, The Function of PDE-Delta in Photoreceptors. UC Davis.
Davis, CA
Paul S Bernstein, MD, PhD
Inter-relationships of Human Retinal VLD-PUFAS with Biomarkers of Dietary
Lipid Intake. ISER.
San Francisco, CA
Invited Speaker, University of Sao Paulo, Brazil.
Sao Paulo, Brazil
Alan S Crandall, MD
84
The Topical Problems, Current Trends, and Technologies in Surgery of
Cataract Associated with Glaucoma.
Microinvasive Approach in Glaucoma
and Cataract Surgery: The Paradigm’s
Changing. New Technologies in
Cataract Surgery and Intraocular
Correction (with Live Surgery
Demonstration). The XV Scientificpractical Conference with International
Participation: Modern Technologies in
Cataract and Refractive Surgery.
Moscow, Russia
The Management of Exfoliative Glaucoma. Pseudoexfoliation Cataract
Technique to Reduce Zonule Stress.
Use of Capsule Devices in Different
Stages of Complex Cataracts.
27th APACRS.
Jaipur, India
Empowering Women to Be Involved and Create Charitable Organizations.
Women in Ophthalmology.
Washington, DC
Schlemm Canal Surgery: From the Outside In. ‘Catarocks’ and the Crowded
Anterior Chamber. Cataract Surgery in
the Setting of Ocular Comorbidities and
High-risk Features for Intraoperative
and Postoperative Complications.
Advanced Refractive Cataract Surgery
and Anterior Segment Reconstruction.
A Video Symposium of Challenging
Cases and the Management of
Intraoperative Complications During
Cataract Surgery. Tackling Weak
Zonules and Using Capsular Tension
Devices. IOL Exchange. AAO.
Chicago, IL
Secondary and Sutured IOLs. Complicated Cataracts. Nebraska
Academy of Eye Physicians and
Surgeons Annual Fall Meeting.
Omaha, NE
Prevent Blindness. Women in Ophthalmology.
Leesburg, VA
Moderator, Industry Panel Discussion: Glaucoma Devices; Glaucoma 360;
New Horizons Forum. Glaucoma
Research Foundation.
San Francisco, CA
Phaco Prechop by Hand, Ultrasound and Laser. Cataract Surgery Special
Cases II. Management of Cataract in
Challenging Cases. Surgical
Management of Malpositioned Lenses.
XXXII Congress, ESCRS.
London, England
Phaco Small Incision Cataract Surgery Gainesville, FL
in International Ophthalmology.
Ensuring Excellent Outcomes in Third
World Countries. Managing
Complicated Cataracts and Glaucoma.
International Eye Care Conference,
Center for Vision Research, U of Florida.
IOL Solutions for Posterior Capsular Tears. Surgical Skill Development
Through the Perfect Balance: Practice
and ‘Just in Time’ Education. World
Ophthalmology Congress.
Tokyo, Japan
Boston, MA
Surgery for Coexisting Cataract and Glaucoma, Uneasy Relationship. Intraocular Surgery Presbyopia-correcting
IOLs. Video-based Complex Cataract
Surgery: Complications Reviewed—
Learning from Our Mistakes.
Surgical Management of Subluxated
Lenses. Phaco Prechop: By Hand,
Ultrasound, and Laser. Intraocular Lens
Exchange and Repositioning Techniques.
Management of Iris Deficiencies.
Managing the Malpositioned IOL.
Effective Use of Capsular Tension
Devices. Toxic Anterior Segment
Syndrome following Cataract Surgery.
Management of Difficult Cataracts
and Challenging Situations.
Phacoemulsification in Difficult and
Challenging Cases. Use of Femtosecond
Laser for Complex Cataract Surgery:
Cases That I Could Not Have Done
without the Femtosecond Laser. ASCRS.
Donnell J Creel, PhD
Using Electroretinography to Detect Cobalt Toxicity from Artificial Hips
Affecting Retinal Function. 17th AfroAsia Congress of Ophthalmology.
Xi’an, China
Clinical Electrophysiology. Zhongshan Ophthalmic Center, Sun Yat-sen
University.
Guangzhou, China
Electro-oculograms and Visually Evoked Potentials. Electroretinograms.
Tilganga Institute of Ophthalmology.
Kathmandu, Nepal
Margaret M DeAngelis, PhD
Genetic and Epigenetic Evidence for a Pathway Involving Lipid
Metabolism and HTRA1 in AMD
Pathophysiology. ARVO.
Orlando, FL
Bridging the Gap Between Gene Association Studies and Disease
Mechanism in AMD. International
Biennial Symposium on AMD, Harvard
Medical School.
Boston, MA
Sabine Fuhrmann, PhD
Requirement of the Rho GTPase Cdc42 Denver, CO
during Optic Cup Morphogenesis in
Mouse. ARVO.
Roles of Porcn/Wnt Signaling During Eye Development. XXI. International
Society for Eye Research.
San Francisco, CA
Third International Retinal Development Workshop, IRCM.
Mont-Tremblant,
Canada
Nationwide Children’s Hospital Research Institute.
Columbus, OH
Invited Speaker, Genetics, Pharmacogenomics, and Histology.
Applied Genetic Technologies, Corp.
Chicago, IL
Invited Speaker, New Insights into the Causes of AMD. Blinded Veterans
Association Convention.
Reno, NV
Invited Speaker, Toward a Refined Understanding of the Genetics and
Biology of AMD. Macula Vision
Research Foundation.
Atlanta, GA
Invited Speaker, Partnership to Identify Pathways and Targets Associated with Diabetic Retinopathy.
Novo Nordisk,
Copenhagen
Invited Speaker, Can Genetics Provide the Answer to Optimal Wet AMD
Treatment? Towards a Deeper
Understanding of Wet AMD Therapy:
Optimizing Benefits, Managing Risks,
and Individualizing Care. World
Ophthalmology Congress.
Tokyo, Japan
Invited Speaker, Research and Early Development Projects, Academic
and Industry Perspectives. Vision
Research Day.
Zurich, Switzerland
Invited Speaker, New Insights into the Causes of AMD. Blinded Veterans
Association Convention.
Reno, NV
Mary Elizabeth Hartnett, MD
Targeted Knockdown of VEGF164 Safely and Effectively Inhibits
Intravitreal Neovascularization. APRS.
Cabo San Lucas, Mexico
Targets Knockdown of Muller Cell VEGF 164 Safely and Effectively
Inhibits Intravitreal Neovascularization
in Rat ROP Model. The Macula Society.
Key Largo, FL
Symposium Presentation, Studying Mechanisms in ROP. RPE Barriers in
AMD. SIG Presentation. ARVO.
Orlando, FL
VEGF Receptor Activates and Interactswith Erythropoietin Receptor
to Cause Pathologic Angiogenesis.
Retina Society.
Philadelphia, PA
Raleigh, NC
Keynote Speaker, Genotype-
phenotype Correlation in AMD.
Coimbra Ophthalmology International
Congress.
Coimbra, Portugal
Physiologic Retina Vascular Development and ROP: What Went
Wrong? 11th Annual Dialogues in
Neonatal-Perinatal Medicine
Conference, Duke University.
Milwaukee, WI
Keynote Speaker, Are There More Forms of AMD than Wet and Dry?
International Congress of German
Ophthalmic Surgeons.
Nuremberg, Germany
Mechanisms of Retinopathy of Prematurity. Vision Science Distinguished Lecture Series, Medical
College of Wisconsin.
Detroit, MI
Keynote Speaker, Toward a Deeper Understanding of Wet AMD Therapy:
Optimizing Benefits, Managing Risks,
and Individualizing Care. Novartissponsored Symposium, World
Ophthalmology Congress.
Tokyo, Japan
Keynote Speaker, Retinopathy of Prematurity: The Effects of VEGF in
Health and Pathology. Clinical
Translational Lectureship, Kresge Eye
Institute, Wayne State University.
Retinopathy of Prematurity: The Effects of VEGF in Development and
Disease. 8th Annual OU Vision
Workshop. Oklahoma University.
Norman, OK
Gregory S Hageman, PhD
85
Mary Elizabeth Hartnett, MD
Genetic Variants Associated with ROP in Extremely Low Birth Weight
Infants. Duke University Department
of Ophthalmology.
Durham, NC
Update on Oxygenation and Risk of Retinopathy of Prematurity. Jules Stein
Eye Institute Leonard Apt Meeting:
Advanced Topics in Pediatric
Ophthalmology and Strabismus. UCLA.
Los Angeles, CA
Retinopathy of Prematurity: The Role of VEGF in Pathogenesis and Health.
WIO Summer Symposium.
Leesburg, VA
Genetic Variants Associated with Severe Retinopathy of Prematurity in
Extremely Low Birth Weight Infants,
Poster. Pediatric Retina Disease.
Retina Subspecialty Day, AAO.
Chicago, IL
Inhibition of Vascular Endothelial Growth Factor Splice Variant Inhibits
Pathologic Neovascularization Safely
in Model of Retinopathy of
Prematurity, Poster. AAO.
New York, NY
Overview of Utilization of Bevacizumab Orlando, FL
(Avastin) for ROP. Orange County
Convention Center. AAO.
Bryan W Jones, PhD
Adult Neural Plasticity Revealed in Retinal Degenerative Disease.
University of Tennessee, Memphis.
Memphis, TN
Plasticity in the Adult Degenerate Retina, Implications for Retinal Rescue.
University of Tübingen.
Tübingen, Germany
Retinal Remodeling. University of Louisville.
Louisville, KY
Vision Rescue Strategies in the Context
of Retinal Disease. HHMI Janelia Farm.
Ashburn, VA
Bradley J Katz, MD, PhD
Photophobia: What’s New? Blepharospasm in the Pediatric
Population. A Comparison of Clinical
Features of Pseudotumor Cerebri
Secondary to Tetracyclines and
Idiopathic Intracranial Hypertension.
Chronic Migraine is Associated with
Reduced Corneal Nerve Fiber Density
and Length. NANOS.
Rio Grande, Puerto Rico
David Krizaj, PhD
86
fMRI Study of Architecturally-induced Contemplative States. ANFA.
La Jolla, CA
Calcium Signaling from Basic to Bedside, TRP Channels and
Neuroprotection in the Retina.
Stockholm, Sweden
TRPV Channels Regulate Neuronal and Glial Physiology in the Mammalian
Retina. The Role of TRPC1 and TRPV1
Channels in Retinal Calcium
Homeostasis and Visual Signaling.
Role of Mechanosensitive TRP
Channels in Retinal Pathology. ISER.
San Francisco, CA
Nonretrograde Endocannabinoid Signaling Modulates Retinal Ganglion
Cell Calcium Homeostasis through the
Trpv1 Cation Channel. ARVO.
Orlando, FL
Nick Mamalis, MD
New IOL Technology: The Next Generation. Toxic Anterior Segment
Syndrome. Prevention of Posterior
Capsule Opacification. Faco y Algo Más:
Faco y Presbicia. Jornadas Argentinas
de Oftalmologia, Consejo Argentino
de Oftalmologia.
Buenos Aires, Argentina
Long-term Uveal and Capsular Biocompatibility and Stability
after Nd:YAG Laser Posterior
Capsulotomy of a New Disc-shaped
IOL. Pathological Evidence of
Pseudoexfoliation in Cases of In-theBag IOL Subluxation/Dislocation.
Update on Adjustable IOL Power
Technologies. XXXII Congress, ESCRS.
London, England
Long-term Uveal and Capsular Biocompatibility of New Accommodating IOL. ASCRS-ESCRS Survey on
Foldable IOLs Requiring Explantation
or Secondary Intervention: 2013
Update. Long-term Uveal and Capsular
Biocompatibility and Stability of New
Disc-shaped IOL after Nd:YAG Posterior
Capsulotomy. Update of Adjustable IOL
Power Technologies. Intraocular
Polyimide IOL Haptic Breakage Longterm Postoperatively: Report of Two
Cases. Pathologic Evidence of Pseudoexfoliation in Cases of In-the-Bag IOL
Subluxation/Dislocation. Effective
Communication Skills: Tips for Public
Speaking, Writing, and Publishing.
Capsulorhexis Phimosis with Anterior
Flexing of Accommodating IOL: Case
Report and Laboratory Analyses.
Microsheathed Coaxial Phaco/Microphaco Techniques and Biaxial
Microphaco in Challenging Cataracts:
Video Course. Toxic Anterior Segment
Syndrome Following Cataract Surgery.
Management of Difficult Cataracts and
Challenging Situations. ASCRS.
Boston, MA
ASCRS/ESCRS Survey of Foldable IOLs Requiring Explanation or Secondary
Intervention: 2013 Update. Phacoemulsification and Advanced
Techniques: The Core Curriculum.
Cataract Surgery in the Setting of
Ocular Comorbidities and High-risk
Features for Intraoperative and
Postoperative Complications. Toxic
Anterior Segment Syndrome Following
Cataract Surgery. Cataract Surgery
Crisis Management 101. AAO.
Chicago, IL
Robert E Marc, PhD
Plenary Lecture, Mapping Retinal Cells and Networks. Retina Research
Foundation’s 2014 Paul Kayser
International Award in Retina
Research. ISER.
Geoffrey Tabin, MD
San Francisco, CA
Impossible Dreams—Everest and the Eradication of World Blindness.
Frontiers in Vision Research, Bascom
Palmer Eye Institute.
Miami, FL
Albert T Vitale, MD
Majid Moshirfar, MD, FACS
Infectious and Noninfectious Keratitis after Refractive Surgery. Academy of
American Ophthalmologists.
Chicago, IL
Infectious and Noninfectious Keratitis after Refractive Surgery: Diagnosis,
Management, and Treatment. Incidence
Rate and Occurrence of Cataract/or
Corneal Decompensation after
Implantation of Anterior Chamber
pIOL: 14 Year Review. ASCRS.
Boston, MA
Current Concepts in Post-LASIK Ectasia. UCSF.
San Francisco, CA
Randall J Olson, MD
Entrepreneurship in Clinical Research, Charles D. Kelman Fund
Lecture. AAO Courses: Learning Phaco
Chop: Pearls and Pitfalls; Toxic Anterior
Segment Syndrome; Advanced Phaco
Technique. AAO.
Chicago, IL
Moderator, Intraocular Surgery: Phaco Techniques and Technology; Learning
Phaco Chop: Pearls and Pitfalls; Toxic
Anterior Segment Syndrome Following
Cataract Surgery. ASCRS.
Boston, MA
How to Manage the Transition from Service to Risk-based Contracting.
AUPO.
Miami, FL
Panel Discussion, Surgical Complications: Cataract/IOL: Advances
in Techniques and Technology to
Improve Patient Outcomes; What’s
More Important in Phaco: Fluidics or
Ultrasound Modulation? Hawaiian Eye.
Kauai, HI
Understanding Wound Burn. Ultrasound Modulation: Does it
Make a Difference? UW.
Seattle, WA
Treating Pseudophakic Dysphotopsia.
Understanding Pseudophakic
Dysphotopsia. Washington State
Ophthalmology Society.
Seattle, WA
Phaco Tip Motion: Deciphering Fact from Fiction. Can a Rounded Phaco Tip
Make a Difference? Post-surgical
Endophthalmitis Update. Wound Burn:
The Complete Story. Bascom Palmer
Eye Institute.
Miami, FL
Pseudophakic Dysphotopsia: More than an Annoyance? Understanding
Wound Burn. UNC.
Chapel Hill, NC
Diagnostic Vitreoretinal Surgery in Management of Infectious and Uveitis
Masquerades. Foster Ocular
Immunology Society Dinner, AAO.
Chicago, IL
Fluoroscein Angiography Imaging in
Uveitis. Noninfectious Posterior
Uveitis: Birdshot Chorioretinopathy.
12th International Ocular Inflammation
Society Congress.
Valencia, Spain
Pediatric Uveitis. Washington University, SOM.
St. Louis, MO
How to Interpret Fundus Fluorescein Angiography and Autofluorescence.
Medical and Surgical Therapy and
Diagnosis of Uveitis. Puzzling White
Dots: What’s a Doctor to Do? AAO.
Chicago, IL
Haibo Wang, MD, PhD
Thy-1 Regulates VEGF-induced Chor-
oidal Endothelial Cell Migration. ARVO.
Orlando, FL
Liliana Werner, MD, PhD
XIII International Congress on Cataract and Refractive Surgery.
Rio de Janeiro, Brazil
Journée Annuelle de la Recherche en Ophtalmologie. JARO.
Québec City, Canada
International Course on Refractive Cataract Surgery and Intraocular
Implants. FACOFEST, Puerto
de Veracruz.
Boca del Rio, Mexico
Guest Lecture. Department of Ophthalmology, Wakayama Medical
University.
Wakayama, Japan
Barbara M Wirostko, MD
Invited Panelist/Speaker, Education Course: Early‐stage Startup
Companies—Strategies for Entrepreneurship in Ophthalmology. ARVO.
Orlando, FL
Jun Yang, PhD
The Usher Syndrome Type 2 Protein Complex in Hair Cells and
Photoreceptors. International
Symposium of Usher Syndrome.
Boston, MA
Deletion of PDZD7 Disrupts the Usher Syndrome Type 2 Protein Complex in
Cochlear Hair Cells and Causes Hearing
Loss in Mice. ARVO.
San Diego, CA
Norm A Zabriskie, MD
Jason Shepherd, PhD
Hospital for Sick Children, Neuro-
sciences, Mental Health Program.
Toronto, Canada
Cataract and Glaucoma Cases and Open Discussion, IOLs: Present and
Future Considerations. Alyson E. Braley
Lecture, Iowa Eye Association.
Iowa City, IA
87
“It was the end of a surgery day and we had wandered into the village of
Duk Payuel to check on a few patients. The children would always run to
us to play or have their picture taken. This little one walked up to me and
just took hold of my hand. No words…we just walked.” —Alan S. Crandall
“From Darkness to Light,” an oil and
acrylic painting by Brazilian artist Nilma
Pacini Werner, is an inspired tribute to the
volunteer work Moran’s Dr. Alan Crandall
and his wife, Julie, have done to cure
blindness in Africa and around the world.
Nilma lives in the state of Minas Gerais,
Brazil, and is the mother of our own Dr.
Liliana Werner. Last year, when Nilma
saw a photograph of Dr. Crandall with
a beautiful African boy in South Sudan,
she was quite moved and felt compelled
to create the painting. In addition to
applications of shimmering gold leaf, the
painting contains text fragments from the
Book of Genesis, written in a language
spoken in Ghana (Asante Twi). The painting
was presented to the Crandalls by Dr.
Werner at the Moran Eye Center in October,
2014, before Dr. Crandall was awarded
the “Outstanding Humanitarian Service
Award” by the American Academy of
Ophthalmology in Chicago.
“From Darkness to Light”
88
The artist, Nilma Pacini Werner, in her
studio in Brazil.
Dr. Liliana Werner, center, presenting the painting to Dr. Alan
Crandall and Julie Crandall.
John A. Moran Eye Center
Visit our website moraneyecenter.org
2015 FOCUS
The John A. Moran Eye Center is an integral part of University of Utah
Health Care, which for five years running has won the University Health
System Consortium’s Quality Leadership Award and continues to rank
among the nation’s top academic medical centers. This winning streak
is matched by only one other health system in the US.
John A. Moran Eye Center | University of Utah Health Care
John A. Moran Eye Center
65 Mario Capecchi Drive
Salt Lake City, UT 84132
801-581-2352
University of Utah Health Care