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COST-EFFICIENCY OF NATIONAL DRUG INFORMATION CENTER THROUGH MINISTRY OF HEALH HOTLINE CALLING SERVICES (937) IN SAUDI ARABIA: APPLICATION OF A MERCIAN MODEL Alomi YA1, Almudaiheem HY1, Alarnous T1, Alshurei S1, Alsharafa A2, Alzahrani T1, Albassri H1, Alenizi K1, Alreshedi M1, Alathan M1, Aljohany N1 1Ministry of Health, Saudi Arabia, Riyadh, Saudi Arabia, 2Ras Tanoura Hospital, Saudi Arabia, Riyadh, Saudi Arabia Background National Drug Information Hotline was established in December 2013 and it’s a work joint with Health Emergency General Department and General Pharmaceutical Care Department. It’s a 24/7 active service throughout the year covering holidays as well, receiving calls from public and professional health care providers all around the Kingdom, this service was operated with only 11 Clinical Pharmacist and trained Pharmacist whom providing Drug Information to public as Phase I, this service expand to have providers throughout the Kingdom (Riyadh, Jeddah, Almadinah, Tabouk, Eastern Region, Northern Region, Jazan, Hail, Alqarayat & Alhassa ), having 47 Clinical Pharmacist and trained pharmacist answering public and professional calls Phase II on 2015. Objectives National Drug Information Center (NDIC) has started providing services since January 2013; and answering public and professional inquires through MOHHotline Calling Services (937) since December 2013. The objective of this study was to estimate cost-efficiency of NDIC in Saudi Arabia using American model of drug information inquires cost avoidance. Methods Simulation including all 12-month 2014 of receiving adults and pediatrics drug information inquiries through MOH-Hotline Calling Services (937). Ten on-call clinical Pharmacists and expert trained pharmacists were receiving calls from public and professional asking about drug information, through manual documentation system of drug information inquiries by data collecting form. Using international Study Model (Kinky et al, Ann Pharmacotherapy 1999), the cost considered were the expected results of drug related problems sequel of drug information inquires if not existing drug information services and were not answered; starting from Physician visit, additional treatment, hospital admission to death stage. Results The total number answered calls were 976 calls, with 264 (27%) answered calls were documented; the average costs avoidance per each answered call was (415.78 USD), and total cost was (109,768 USD) with partial documentation, the estimated total cost with complete documentation was (405,801 USD) per year. The cost avoidance of answering public inquiries was (80,806.5 USD) and Professional inquires was (28,961.5 USD). The highest cost avoidance based on type of inquires was dose standardization (34,195 USD), drug administration (21,324 USD) followed by drugs in pregnancy (15,826 USD) and Adverse a Drug reaction (12,793 USD). The highest cost avoidance was Antibacterial expected related problem (33,454.5 USD). Reference: 1. American Society of Health-System Pharmacists 2014, Medication Therapy and Patient Care: Specific Practice Areas–Guidelines. 2. Asiri YA , AlArifi, MN, AlSultan MS, Gubara OA. Evaluation of drug and poison information center in Saudi Arabia during the period 2000-2002. Saudi Med J. 2007 Apr;28(4):6179. 3. Taher EntezariMaleki, Mohammad Taraz, Mohammad Reza Javadi, Mir Hamed Hajimiri, Kaveh Eslami, Iman Karimzadeh, Maysam Esmaeili, and Kheirollah Gholami. A two year utilization of the pharmacist operated drug information center in Iran. J Res Pharm Pract. 2014 OctDec;3(4): 117–122. 4.Shadnia S, Soltaninejad K, Sohrabi F, Rezvani M, Barari B, Abdollahi M. The performance of Loghman-Hakim drug and poison information center from 2006 to 2008. Iran J Pharm Res. 2011;10:647–52. [PMCID: PMC3813026] Inquiry classification Public Professional % % Dose standardization Drug Administration Drug in pregnancy ADR Drug availability/ formulary Drug Identification Drug-drug interaction Others Compatibility Drugs in breast feeding Compounding Drug- Nutrition interaction pharmacokinetic Total N (180( 27.77 16.11 12.7 9.47 9.4 7.22 6.66 5 1.66 1.11 0.55 0.55 0.55 100 N (120( 25.83 14.16 8.33 15 5 9.16 10.83 5 1.66 2.5 2.5 0 0 100 Medication category Inquiry % Antibacterial 20.3 Vitamins 12 Antihypertensive 5 Analgesia 4.3 rheumatic disease and gout Antihistamine 4 4 Contraceptives 3.3 Anticonvulsants 3.3 Immunosuppressant Agent and Corticosteroid Antidepressant 3 2.6 Discussion In this study we tried to estimate cost-efficiency of NDIC in Saudi Arabia during 12 months, the most frequent question was about dose standardization (27.77% and 25.83%) for public and professional respectively while in Loghman-Hakim drug and poison information center in Iran, Drug identification was the most frequent question by (23.9%), in Southern Illinois University and College of Pharmacy and Nutrition, University of Saskatchewan the most frequent question was related to Drug therapy by (24.19%, 13% )Respectively. we encountered some limitations during our evaluation as the rate of documentation was just (27%), online network of Drug information around the kingdom was not activated and finally the number of the hotline staff was inadequate in the first year of operation. Online documentation was activated and the staff was increased by 30% . CONCLUSIONS In this National Drug Information Center cost-efficiency simulation for Saudi Arabia, hotline line calling services - Drug Information associated with cost savings per each receiving call. expanding the answering drug information services with electronic documentation, and available elibrary resources considering the associated preventing drug related problems and Healthcare Improvement and better care, better patient outcomes, and reduced costs.