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CURRICULUM VITAE
Vesna Mandušić (maiden name Vranić), PhD,
Molecular biologist,
Date of Birth:
09.07.1966
Martial status: married, two children (14 and 17 years)
Professional Address:
Institute for Nuclear Sciences “Vinča”
Department for Radiobiology & Molecular Genetics
Mike Alasa 12-14, Vinča, P.O. Box 522, Belgrade, Serbia,
Institute’s web site: www.vinca.rs
Phone: +381-64-2088835,
E-mails: [email protected],
THE RESUME OF SCIENTIFIC AND EDUCATIONAL ACTIVITIES
 Over 20 years of scientific experience in the area of cancer research and therapy; familiar
with main molecular biology techniques and its application in biomedical research.
 From 1994 to 2002 participating in the preclinical study within collaboration of our
Institute with ICN Pharmaceuticals, Galenika – Belgrade. Within this project, my activities
was
related
to
optimizing
the
protocols
for
detection
of
tiazofurin-induced
erythrocytotoxicity by standard hematological methods and by scanning probe
microscopy. As a result of in vivo and in vitro hematological toxicity studies of new drugs
and chemotherapeutic regimens, the output was several publications and abstracts of
scientific meetings.
 In 1998 and 2001 I made two short pauses in the scientific work due to parental leaves.
 From the 2002, I have started collaboration with a research group at the Institute of
Oncology and Radiology of Serbia, Belgrade (the largest oncology Clinic in Serbia). In the
scope of this collaboration, I analyzed the expression of estrogen receptor β (ERβ)
isoforms, by real time RT-PCR (with TaqMan probes) and Western blot methodology. The
results of this study, on breast cancer samples were a major part of my PhD thesis.
Moreover, three publications were ensued from this collaboration. Some of the results
were presented at scientific conferences.
 From academic year 2002/03 until 2006, I have been engaged as associate lecturer in
School for persons professionally exposed to radiation, which is part of Vinca’s Institute
Continuous Training Courses. Study subject was the “Biological Effects of Radiation”..
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 As a postdoctoral fellow at German Cancer Research Center (DKFZ), Heidelberg,
Germany (July, 2007 – October, 2008), my research was focused on quantitative
expression analyses of the isoforms and splice variants of estrogen receptors (ERα and
ERβ) in the clinical samples of early- and late-onset breast cancer.
 Ongoing projects and activities are related to defining the new and emerging predictive
and prognostic markers in human malignancies (mainly carcinomas and sarcomas) at
DNA, RNA and protein level by using an up-to-date methodology. In present position, I
was supervising three PhD students who successfully defended their thesis during last
two years.
Further research activities of my team will be focused on the role of
alternatively spliced isoforms of ERs’ and members of their signaling pathways, which
play important role in cancer biology and may represent the novel target in cancer
therapy.
EDUCATION
2006
PhD degree, PhD of Biological Sciences, Faculty of Biology, University of
Belgrade. Title of PhD thesis: “Quantitative analysis of the estrogen receptor
ß mRNA expression in the pathogenesis of breast cancer”
1997
Master of Science degree, Master of Biological sciences, Faculty of Biology,
University of Belgrade. Title of M.Sc. thesis: "Hematological effects of
nucleotide analog tiazofurin"
1991
Bachelor of Science degree, Faculty of Biology, University of Belgrade. Title
of undergraduate thesis: “Protein extract of K-562 cells as a model for
analyzing of mismatch repair in eukaryotic cells"
EMPLOYMENTS AND PROFESSIONAL EXPERIENCE
2009 - now
Research Associate Institute “Vinča”, Department for Radiobiology and
Molecular Genetics, Belgrade, Serbia
2007 - 2008
Postdoctoral Fellow at DKFZ, Heidelberg Germany Department: Molecular
Genetics of Breast Cancer
2004-2006
Research Associate
Institute “Vinča”, Department for Radiobiology and Molecular Genetics,
Belgrade, Serbia
1997-2003
Research Associate
Institute “Vinča”, Department for Radiobiology and Molecular Genetics,
Belgrade, Serbia
2002-2006
Associate Lecturer
Associate lecturer at the Center for Permanent Education, Institute “Vinča”,
Belgrade. Serbia, Subject: “Biological Effects of Radiation”
2001-2002
Parental leave
2000
Research Assistant
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Institute of Nuclear Sciences “Vinča”, Department for Radiobiology and
Molecular Genetics, Belgrade, Serbia
1997-1999
Parental leave
1994-1997
Research Assistant
Institute of Nuclear Sciences “Vinča”, Department for Radiobiology and
Molecular Genetics, Belgrade, Serbia
1993-1994
Fellowship from Ministry for Science and Technology of Republic of Serbia for
18 months for master degree thesis preparation
GRANTS AND AWARDS
2012- now
Participant in collaborative project between The Institute for Nuclear
Sciences “Vinča” and Noguchi Thyroid Clinic and Hospital Foundation, Bepu
Japan: “Search for new X hormone of anorexia”.
2009
"Expression profiling and quantification of hormone receptors isoforms and
splice variants in early- and late-onset breast cancers", Grant Number: MA
4554/2-1; DFG (Deutsche Forschungsgemeinschaft), three-year-position for
principal investigator at DKFZ, Heidelberg, Germany.
2007-2008
UICC American Cancer Society International Fellowship at the German
Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer,
B055, Heidelberg, Germany; Project: “Methylation Status of Estrogen and
Progesterone Receptor Genes and Expression Profiling of their Isoforms in
Early-Onset Breast Cancer” (ACSBI No: ACS/07/014).
WORKSHOPS
EMBO practical course on “Quantification of Gene Expression by real-time qRT-PCR", June
17-22, 2006, EMBL, Heidelberg, Germany
EPPENDORF “PCR workshop”, May 27, 2004, Belgrade, Serbia
UNIVERSITY OF BRISTOL & UNIVERSITY OF BELGRADE, SCHOOL OF MEDICINE
Course of Continuing Medical Education “Functional Genomic”, April, 1-8,
2004, Belgrade, Serbia
BASIC RESEARCH AREAS
2002 to now: Breast and Thyroid Cancer: Expression profiling of estrogen receptors’
isoforms in breast cancer. Targeted therapy
1994-2001: Experimental
antineoplastic agents
Oncology:
Chemotherapy
and
hematological
toxicity
of
1993-1997: Mutation research: Molecular causes of colorectal, urogenital and oral
carcinomas; mutational analysis of K-ras and H-ras oncogenes in human tumors
COMPUTER SKILLS
MS Ofice, Word, Excel, Statistica, Systat, SigmaPlot, Sequence Navigator, PowerPoint,
PhotoShop,
LANGUAGE SKILLS:
English – fluent, German – beginner, Serbian – native language.
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MEMBERSHIPS:
European Association for Cancer Research
Serbian Association for Cancer Research
Serbian Biological Society
Yugoslav Biochemical Society
Serbian Society of Geneticist
Vesna Mandusic
Belgrade, November, 2015