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ROUTES OF MEDICATION ADMINISTRATION Route Indications Time of Onset (Action) Oral Safest and least invasive method of administration. Requires an intact Gag reflex 30 - 60 minutes Sublingual Used when rapid effect is required Avoid diluting the dosage by not drinking for 30-minutes after administration Several minutes Buccal Limited number of medications available for use of this route Convenient. Can cause local irritation to buccal lining as tablet/lozenge retained in cheek for up to one-hour Several minutes Transdermal Convenient dosage form. Provides continuous systemic absorption over extended time (hours, days) 30 – 60 minutes Rectal Useful when patient unable to tolerate oral medication and parenteral route is not indicated. Good absorption and avoids first pass metabolism. 15 – 30 minutes Examples (Provide Two for each) Route Indications Time of Onset (Action) Vaginal For local effect 15 – 30 minutes Topical For local effects on the skin and mucous membrane of the eye, ear, nose and mouth Within one hour Inhalation Used for local effect within the respiratory Within one tract minute Subcutaneous Used for drugs that may be inactivated by Within several the gastrointestinal tract minutes Intramuscular Used for drugs that have poor oral absorption, when a faster rate of action is Within several required than other routes. minutes Blood concentrations achieved quickly. Intravenous Used in emergency situations for immediate effect. Also used where large volumes of a medication are required to be administered (ie. Infusion) Within one minute Examples (Provide Two for each)