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HEALTHAMERICA PENNSYLVANIA MANAGEMENT OF ASTHMA PRACTICE RECOMMENDATIONS INTRODUCTION The following information was developed by the National Asthma Education and Prevention Program Expert Panel Report II: Guidelines for the Diagnosis and Management of Asthma [The Expert Panel is a multidisciplinary group of clinicians and scientists with an expertise in asthma management. The Panel includes health professionals in the areas of general medicine, family practice, pediatrics, emergency medicine, allergy, pulmonary medicine, nursing, pharmacy and health education]. HealthAmerica endorses the information contained in these recommendations. RECOMMENDATIONS Patient History at time of initial diagnosis should include: Symptoms (cough, wheezing, shortness of breath, chest tightness, sputum production) Pattern of symptoms (perennial, seasonal or both; continual, episodic, or both; onset, duration, frequency; diurnal variations-especially nocturnal and on awakening in early morning) Precipitating and/or aggravating factors Development of disease and treatment (age of onset & diagnosis, history of early life injury to airways, progress of disease, present management and response, need for oral corticosteroids, comorbid conditions). Family history/Social history Profile of typical exacerbation Impact of asthma on patient and family Assessment of patient's and family's perceptions of disease Periodic Assessment and Monitoring The purpose of periodic assessment and ongoing monitoring is to determine whether the goals of a sthma therapy are being achieved. The goals of asthma therapy include the following: Prevent chronic and troublesome symptoms (coughing or breathlessness in the night, early morning or after exertion) Maintain (near) "normal" pulmonary function Maintain normal activity levels (including exercise and other physical activity) Prevent recurrent exacerbations of asthma and minimize the need for emergency department visits or hospitalizations Provide optimal pharmacotherapy with minimal or no adverse effects Meet patients' and families' expectations of and satisfaction with asthma care The Expert Panel recommends ongoing monitoring in the following areas to determine whether the goals of asthma therapy are being met: HEALTHAMERICA PENNSYLVANIA MANAGEMENT OF ASTHMA PRACTICE RECOMMENDATIONS INTRODUCTION The following information was developed by the National Asthma Education and Prevention Program Expert Panel Report II: Guidelines for the Diagnosis and Management of Asthma [The Expert Panel is a multidisciplinary group of clinicians and scientists with an expertise in asthma management. The Panel includes health professionals in the areas of general medicine, family practice, pediatrics, emergency medicine, allergy, pulmonary medicine, nursing, pharmacy and health education]. HealthAmerica endorses the information contained in these recommendations. RECOMMENDATIONS Patient History at time of initial diagnosis should include: Symptoms (cough, wheezing, shortness of breath, chest tightness, sputum production) Pattern of symptoms (perennial, seasonal or both; continual, episodic, or both; onset, duration, frequency; diurnal variations-especially nocturnal and on awakening in early morning) Precipitating and/or aggravating factors Development of disease and treatment (age of onset & diagnosis, history of early life injury to airways, progress of disease, present management and response, need for oral corticosteroids, comorbid conditions). Family history/Social history Profile of typical exacerbation Impact of asthma on patient and family Assessment of patient's and family's perceptions of disease Periodic Assessment and Monitoring The purpose of periodic assessment and ongoing monitoring is to determine whether the goals of asthma therapy are being achieved. The goals of asthma therapy include the following: Prevent chronic and troublesome symptoms (coughing or breathlessness in the night, early morning or after exertion) Maintain (near) "normal" pulmonary function Maintain normal activity levels (including exercise and other physical activity) Prevent recurrent exacerbations of asthma and minimize the need for emergency department visits or hospitalizations Provide optimal pharmacotherapy with minimal or no adverse effects Meet patients' and families' expectations of and satisfaction with asthma care The Expert Panel recommends ongoing monitoring in the following areas to determine whether the goals of asthma therapy are being met: • Monitoring signs and symptoms of asthma: patients with asthma should be taught to recognize symptoms of inadequate control and they should be assessed at the time of each health care visit. Assessment should include the following: Monitoring pulmonary function: Daytime asthma symptoms Nocturnal awakening as a result of asthma symptoms Asthma symptoms early in the morning that are not improved 15 minutes after inhaling a short acting beta 2agonist Spirometry: at the time of initial assessment, after treatment is initiated and symptoms and peak expiratory flow (PEF) have stabilized and at least every 1-2 years to assess the maintenance of airway function. Peak flow monitoring: Used as a tool for ongoing monitoring, not diagnosing. Patients with moderate to severe persistent asthma should learn how to monitor their PEF and have a peak flow at home. Long term daily peak flow monitoring for patients with mild intermittent or mild persistent asthma is not required unless the patient, family or physician finds it useful in guiding therapeutic decisions. Monitoring quality of life/functional status: The following areas should be periodically assessed: Any missed work or school due to asthma Any reduction in usual activities (either home/work/school or recreation/exercise) Any disturbance in sleep due to asthma Any change in caregiver's activities due to a child's asthma (for caregivers of children with asthma) Monitoring history of asthma exacerbations: It is important to evaluate the frequency, severity and causes of exacerbation. Monitoring pharmacotherapy: The following factors should be monitored: Patient adherence to the regime Inhaler technique Level of usage of as-needed inhaled short-acting beta 2 -agonist Frequency of oral corticosteroid "burst" therapy Changes in dosage of inhaled anti-inflammatory or other long-term control medications Side effects of medications Monitoring patient-provider communication and patient satisfaction: Two aspects of patient satisfaction should be monitored: Satisfaction with asthma control Satisfaction with the quality of care Referral for consultation or care to a specialist in asthma care is recommended when: Patient has life-threatening asthma exacerbation Patient is not meeting the goals of asthma therapy • Signs and symptoms are atypical or there are problems in differential diagnosis Other conditions complicate asthma or its diagnosis Additional diagnostic testing is indicated Patient requires additional education and guidance on complications of therapy, problems with adherence, or allergen avoidance Patient is being considered for immunotherapy Patient has severe persistent asthma Patient requires continuous oral corticosteroid therapy or high-dose inhaled corticosteroids or has required more that two bursts of oral corticosteroids in one year Patient requires confirmation of a history that suggests that an occupational or environmental inhalant or ingested substance is provoking or contributing to asthma Patient is pregnant Controlling Factors Contributing to Asthma Severity, • It is essential to identify and reduce exposure to relevant allergens and irritants including inhalant allergens, occupational exposures, non-allergic factors and other factors Intranasal corticosteroids are recommended for the treatment of chronic rhinitis in patients with persistent asthma Treatment of sinusitis includes medical measures to promote drainage and the use of antibiotics when complicating bacterial infection is present Medical management of gastroesophageal reflux should be instituted for any patients with asthma complaining of frequent heartburn or pyrosis, particularly those with frequent episodes of nocturnal asthma Adult patients with asthma should be questioned regarding precipitation of bronchoconstriction by aspirin and other nonsteroidal anti-inflammatory drugs Patients who have asthma symptoms associated with eating processed potatoes, shrimp, or dried fruit or with drinking beer or wine should avoid these products Nonselective beta-blockers, including those in ophthalmological preparations, can cause asthma symptoms and should be avoided by asthma patients Annual influenza vaccinations are recommended for patients with persistent asthma One lifetime Pneumococcal Vaccination, with possible revaccination after 65 years is recommended. Pharmocologic Therapy Pharmocologic therapy is used to prevent and control asthma symptoms, reduce the frequency and severity of asthma exacerbations and reverse airflow obstruction. Asthma medications are categorized into two general classes: long-term control medications and "quick relief' medications. Patients with persistent asthma require both classes of medication. Long-term control medications * Corticosteroids: Inhaled form is used for the long-term control of asthma. Systemic corticosteroids are often used to gain prompt control of the disease when initiating long-term therapy and are the medications of choice. * Cromolyn sodium and nedocromil: Mild-moderate anti-inflammatory medications. May be used as initial choice for long-term control therapy for children. Can also be used as preventive treatment prior to exercise or unavoidable exposure to allergens. • Long-acting beta 2 -agonists: Long-acting bronchodilator used concomitantly with anti inflammatory medications for long-term control of symptoms, especially nocturnal symptoms. Also prevents exercise induced bronchospasm. Methylxanthines: Sustained-release theophylline is a mild-moderate bronchodilator used principally as an adjuvant to inhaled corticosteroids for prevention of nocturnal asthma symptoms. May have mild antiinflammatory effect. Leukotriene modifiers: May be used alone and with low-to-medium dose inhaled corticostoroids in mild persistent asthma. Quick relief medications Short-acting beta 2 -agonists: Therapy of choice for relief of acute symptoms and prevention of exercise-induced bronchospasm Anticholinergics: Ipratropium bromide may provide some additive benefit to inhaled beta 2 agonists in severe exacerbations. May be an alternative bronchodilator for patients who do not tolerate inhaled short acting beta 2 -agonists. Systemic corticosteroids: Used for moderate to severe exacerbations to speed recovery and prevent recurrence of exacerbations. Managing exacerbations of asthma: Early treatment of asthma exacerbation is the best strategy for management. Important elements of early treatment include: Written action plan to guide patient self-management of exacerbation at home, especially for a patient with moderate-to-severe persistent asthma Recognition of early signs of worsening asthma Appropriate intensification of therapy Prompt communication between patient and physician regarding serious deterioration in symptoms or peak flow Inhaled beta 2 -agonists to provide prompt relief of airflow obstruction Systemic corticosteroids, for moderate-to-severe exacerbations or for patients who fail to respond promptly and completely to an inhaled beta 2 -agonist, to suppress and reverse airway inflammation Oxygen to relieve hypoxia for moderate-to-severe exacerbations Monitoring response to therapy with serial measurements of lung function with spirometry or peak flow meters for FEVI/PEF. Patient Education Patient education should begin at the time of diagnosis and be integrated into every step of clinical asthma care It is essential that education be provided by all members of the health care team. Patient education should include asthma self-management, tailoring the approach to meet the needs of each patient The following should be taught/reinforced at every opportunity: • Basic facts about asthma * Roles of medications Skills: inhaler, spacer, holding chamber use, self-monitoring Environmental control measures Asthma patients should not smoke or be exposed to environmental tobacco smoke. Tobacco smoke is the most important environmental indoor irritant and is a major precipitant of asthma symptoms in children and adults. Asthma patients should avoid exertion or exercise outside to the extent possible when levels of air pollution are high. When and how to take rescue action Jointly develop treatment goals All patients should be provided with a written daily self-management plan and an action plan for exacerbations Encourage adherence by promoting open communication, emphasizing goals and outcomes and encouraging family involvement HealthAmerica's Wellness and Health Education Programs, PLUS SERVICES, offers assistance and support groups through the America Lung Association. Footnote: * A meter dose inhaler should be used with a spacer device when appropriate * Osteoporosis evaluation should be done inappropriate patients. REFERENCES: 1 Gilbert, Ileen A., MD, McFadden, E.R.,MD. Asthma. New England Journal of Medicine. 1992;327:19281937. 2. National Education Program, Expert Panel Report II. Guidelines for the Diagnosis and Management of Asthma. Bethesda, MD: US Dept. of Health and Human Services; July 2002. 3. Shapiro, Gail G., MD. Childhood Asthma: Update. Pediatrics in Review. 1992;13,11: 403 -412. 4. The American Academy of Pediatrics, JCQIP Ambulatory Care Quality Improvement Program, 279 -92. 5. The American Academy of Family Physicians , The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention. Quality Standards for Immunization. IDSA National Guideline Clearinghouse March 1999 The Expert Panel Report is a valuable resource for office practices. It contains numerous aids for providers and education handouts for patients. The full report can be obtained from: NHLBI Information Center P.O. Box 30105 Bethesda, MD 20824-0105 or http://www.nhlbi.nih.gov/nhlbi/lung/astlnna/prof/asthgdln.htm APPENDICES: l. Asthma Severity Classification 2. Flowchart for the management of asthma in infants and children 5 years of age and younger 3. Flowchart for the management of asthma inpatients older than five years of age Original date 5/1997 First Revision 3/99 Second Revision 10/01 Third Revision 10/02 Asthma Health Management Team 10/14/02 UM/01 10/29/02 Asthma Health Management Team 10/15/04 UM/QI 10/26/04 Updated 6/27/05 UM/QI 6/28/05