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Basic Histology Primary Tissues By Mrs. Bailey 1. Epithelial Tissue 2. Connective Tissue 3. Muscle Tissue 4. ervous Tissue Epithelium • Very cellular • Supported by underlying connective tissue Covering/Lining Epithelium • Faces a space such as the lumen of a blood vessel or intestine. • Epithelial & connective tissue are separated by a basement membrane, which is produced by both tissues. Apical surface = adjacent • Packed together tightly & orderly. Tight junctions may occur between cells. Basal surface = adjacent to lumen to basement membrane • Avascular. Receives its nutrients Hint: These surfaces are “places” ”, not “things” ”. by diffusion from the underlying connective tissue. • Two types: a. Covering/Lining b. Glandular • Mucous membranes - line organs and cavities - secretion of mucous from glands Serous membranes - cover and protect organs 1 Glandular Epithelium a. Exocrine secretions enter ducts b. Endocrine secretions enter bloodstream Epithelial Tissue Types Layers : Simple - single layer – provides a selective barrier allowing diffusion, filtration, secretion, and absorption. Stratified - several layers – subject to wear and tear – forms a protective barrier. Pseudostratified – appears to be several layers, but is actually only a single layer. Shapes • Squamous - flattened Cuboidal - cube Columnar - cylindrical • Transitional – change shape • • Types of Epithelial Tissue They are rounder when the tissue is relaxed and flatter when the tissue is stretched. OTE: When viewed from the apical surface, all epithelial cells have a similar shape. 2 Simple CUBOIDAL Epithelium Simple COLUMNAR Epithelium ame those parts! 5 What would this area be called? Pseudostratified Ciliated Columnar Epithelium Connective Tissue • Most abundant tissue in the body. 4 3 2 1 • Supports epithelial tissue and connects it to other tissues. Provides coverings that support and protect muscle and nervous tissue. • Most are not very cellular, usually containing more matrix than cells. • Most are vascular and regenerate easily. EXCEPTIOS: Tendons – poorly vascularized; do OT heal easily Cartilage – avascular - does OT heal easily Cells: Fibroblasts, Macrophage, Plasma cells, Mast cells, Adipocytes, WBC's 3 Connective Tissue Matrix Ground substance + Fibers (Composition is used in classifying connective tissue) Ground Substance = polysaccharides + proteins Fibers: • Collagen - most abundant protein in body • Elastic fibers - stretchable (in skin, BV, lungs) • Reticular fibers - support and strength Types of Connective Tissue • Loose • Dense Loose Connective Tissue • Fibers are loosely arranged. • Collagen, elastic, and reticular fibers provide strength, elasticity, and support. • Fibroblasts and adipocytes permanently reside here. • Subcutaneous layer of skin. • Cartilage Areolar • Bone Reticular • Blood Adipose 4 Areolar Connective Tissue ow you try ……………. Refer to page 136 Fibroblast nucleus Mast cell Elastic fiber Collagen fiber Ground substance ow you try ……………. Dense Connective Tissue • Matrix is packed with fibers and contains very little ground substance and few fibroblasts. • Tendons, Ligaments, Skin dermis, Artery wall Dense Regular Dense Irregular Dense Regular Elastic 5 ow you try ……………. ow you try ……………. HIT: This is an ARTERY, which contains dense regular elastic CT. • Peach • Blue outlines? arrows? • Green arrow? • Grey block arrow? • Yellow block arrow? ow you try ……………. Cartilage Contains cells called chondrocytes housed in spaces called "lacunae". Some lacunae contain more than one chondrocyte ... these are daughter cells formed after division. Hyaline - ends of bone; support rings of respiratory tubes Elastic – elastin fibers; epiglottis; nose Fibrocartilage - much collagen; intervertebral discs 6 Bone ow you try ……………. • Dense - middle portion (osteon); Spongy – ends (trabeculae) 1. 2. 3. Bone • Haversian Canal - extends the length of each osteon through its center; contains blood vessels, lymphatic vessels, and nerves. • Volkmann’ ’s Canals – connect Haversian canals to each other; communication; contain nerves and vessels that carry blood and lymph from the exterior bone surface to the osteons. • Canaliculi – tiny canals radiating in all directions from the lacunae and connecting them to each other as well as to the Haversian canal. • Bone tissue is unlike other connective tissues in that the extracellular matrix becomes calcified. • Lamellae – layers of matrix; concentric = within osteons; interstitial = in between osteons. • Contains cells called osteocytes housed in lacunae. Bone Osteon Volkmann’ ’s canals Concentric lamellae Interstitial lamellae Haversian canal Lacunae Refer to page 140 7 Canaliculi ow you try ……………. 1. 2. 3. 4. What do you refer to each of the “larger circles” ”? Muscle Tissue Blood Platelets White blood cells (Leukocytes) Red blood cells (Erythrocytes) Plasma matrix Refer to page 142 • Contains muscle cells and connective tissue. Thin layers of connective tissue surround muscle cells to protect and support them. • Very cellular. Muscle cells = muscle fibers. Fibers contain many microfilaments (myofilaments) - cause muscle cells to shorten (contract) when stimulated. Skeletal (striated; voluntary; multinucleated cells) Cardiac (striated; involuntary; multinucleated cells; branching cells; intercalated disks) Smooth (non-striated; involuntary; uninucleated cells; tapered cells) 8 Nervous Tissue • Forms the brain, spinal cord, and nerves. • Two basic categories of nervous tissue cells: a. eurons – receive and send information; amitotic REVIEW: axon, dendrite, cell body Glial cells b. euroglial cells – support the neurons; divide and replace themselves • Highly vascularized Refer to page 146 ow you try ……………. 1. 2. 1&2 3 3. 9