Download Joe Corbo Briefly describe the function and component parts of a

JoeCorbo
Brieflydescribethefunctionandcomponentpartsofatranscriptionfactor.
Inabriefparagraph,describehowaneuralprogenitorpopulationcangiveriseto
differentneuronalcelltypesatdifferenttimepointsduringdevelopment.
Isneuronalcelltypeproductionprobabilisticordeterministic?
Describethelocationwithintheventricularepitheliumofaneuralprogenitoratthe
variousstagesofthecellcycle.Whatisthismovementprocesscalled?
AlbertKim
Explainthedistinctionbetweentheextrinsicandintrinsicpathwayofapoptosis.
Whatarekeydifferencesinthemorphologyandmechanismofapoptosisand
necrosis?
Whatisanexplanationforthefailureofcaspaseinhibitorstoprotectinjured
neuronsinstrokeorneurodegenerativediseases?
Co-receptorsystemsforneurotrophicfactorsareubiquitous.Nametwoexamples
neurotrophicfactorsthatuseco-receptors(nameligandandthereceptors).What
mightbeateleologicalreasonforhavingaco-receptorsystem?
ValeriaCavalli
Q1:Whataretheneuronalintrinsicstepsthatareelicitedbyinjuryinaperipheral
neuron?
Q2:Whyareoligodendrocytesnotabletoassistandpromoteaxonregenerationin
theinjuredcentralnervoussystem?
Q3:Whatlimitsaxonregenerationintheinjuredcentralnervoussystem?
JoeDougherty
Whatdoesinductionmean?Giveanexampleofinductionthatyoulearnedfromthis
class.
Whatisthedifferencebetweenfateandpotential?Giveanexampleofan
experimentthatdemonstratedthedifferencebetweenfateandpotentialfora
particularcelltypeortissue.
Drawadiagramforhowfeedbackfromadevelopingaxonmightsuppressaxonal
fateinotherneurites.Focusonprinciplesratherthanprecisemolecules.
Describeanexampleofablockingantibodybeingusedindevelopmentalbiology
research.Whatwaslearned?
Howcanyoufigureoutthebirthdayofaneuron?
Name3partsofagrowthcone.
JoshRubin
Herearetwoveryopen-endedstudyquestionsmeanttogetstudentsthinkingvery
broadlyaboutthetopic.
Whatcanbraintumorsteachyouaboutnormalbraindevelopmentandfunction,
andhowdotheydoit?
Inwhatwaysisbraintumorbiologyconstrainedbynormalbrainbiology?
TimMiller&PaulKotzbauer
Namethetwoproteins/peptidesthatpathologicallyaccumulateinAlzheimer’s
disease
LongerCAGrepeatlengthinHuntington’sdiseaseincreases/decreases/doesnot
affectageofdiseaseonset.
Youhavediscoveredmutationsinthenoseeingeneresponsiblefora
neurodegenerativediseaseinafamilythatdevelopsprogressivelossofvision.Your
geneticstudiessuggestautosomalrecessiveinheritance.Whichwouldbethebest
approachtogenerateamousemodelforthisdisorder.
A.TransgenicexpressionoftheWThumannoseeingene
B.Transgenicexpressionofmutanthumannoseeingene
C.Knockoutofthemousenoseeingene
JohnCirrito
Besidesamyloidplaquesandtauneurofibrillarytangles,Whatareearlypathological
changesintheAlzheimer'sdiseasebrain?
Whatare2therapeuticstrategiesthatwouldimpactADpathogenesisor
progression?HowdothesetherapiesworktolowerriskorpreventAD?