Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
JoeCorbo Brieflydescribethefunctionandcomponentpartsofatranscriptionfactor. Inabriefparagraph,describehowaneuralprogenitorpopulationcangiveriseto differentneuronalcelltypesatdifferenttimepointsduringdevelopment. Isneuronalcelltypeproductionprobabilisticordeterministic? Describethelocationwithintheventricularepitheliumofaneuralprogenitoratthe variousstagesofthecellcycle.Whatisthismovementprocesscalled? AlbertKim Explainthedistinctionbetweentheextrinsicandintrinsicpathwayofapoptosis. Whatarekeydifferencesinthemorphologyandmechanismofapoptosisand necrosis? Whatisanexplanationforthefailureofcaspaseinhibitorstoprotectinjured neuronsinstrokeorneurodegenerativediseases? Co-receptorsystemsforneurotrophicfactorsareubiquitous.Nametwoexamples neurotrophicfactorsthatuseco-receptors(nameligandandthereceptors).What mightbeateleologicalreasonforhavingaco-receptorsystem? ValeriaCavalli Q1:Whataretheneuronalintrinsicstepsthatareelicitedbyinjuryinaperipheral neuron? Q2:Whyareoligodendrocytesnotabletoassistandpromoteaxonregenerationin theinjuredcentralnervoussystem? Q3:Whatlimitsaxonregenerationintheinjuredcentralnervoussystem? JoeDougherty Whatdoesinductionmean?Giveanexampleofinductionthatyoulearnedfromthis class. Whatisthedifferencebetweenfateandpotential?Giveanexampleofan experimentthatdemonstratedthedifferencebetweenfateandpotentialfora particularcelltypeortissue. Drawadiagramforhowfeedbackfromadevelopingaxonmightsuppressaxonal fateinotherneurites.Focusonprinciplesratherthanprecisemolecules. Describeanexampleofablockingantibodybeingusedindevelopmentalbiology research.Whatwaslearned? Howcanyoufigureoutthebirthdayofaneuron? Name3partsofagrowthcone. JoshRubin Herearetwoveryopen-endedstudyquestionsmeanttogetstudentsthinkingvery broadlyaboutthetopic. Whatcanbraintumorsteachyouaboutnormalbraindevelopmentandfunction, andhowdotheydoit? Inwhatwaysisbraintumorbiologyconstrainedbynormalbrainbiology? TimMiller&PaulKotzbauer Namethetwoproteins/peptidesthatpathologicallyaccumulateinAlzheimer’s disease LongerCAGrepeatlengthinHuntington’sdiseaseincreases/decreases/doesnot affectageofdiseaseonset. Youhavediscoveredmutationsinthenoseeingeneresponsiblefora neurodegenerativediseaseinafamilythatdevelopsprogressivelossofvision.Your geneticstudiessuggestautosomalrecessiveinheritance.Whichwouldbethebest approachtogenerateamousemodelforthisdisorder. A.TransgenicexpressionoftheWThumannoseeingene B.Transgenicexpressionofmutanthumannoseeingene C.Knockoutofthemousenoseeingene JohnCirrito Besidesamyloidplaquesandtauneurofibrillarytangles,Whatareearlypathological changesintheAlzheimer'sdiseasebrain? Whatare2therapeuticstrategiesthatwouldimpactADpathogenesisor progression?HowdothesetherapiesworktolowerriskorpreventAD?