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ホームページではパンフレットに収載されていない化合物,試薬のスケールアップのご用命を受け付けております。 www.tokyokasei.co.jp/jutaku/synthesis Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Nucleosides and Their Analogs Genetic information is stored in DNA as combinatorial codes held in nucleosides and nucleotides, in which form it is passed from parents to their offspring. Analogs of nucleosides and nucleotides are used clinically as medicinal agents such as reverse transcriptase inhibitors. Therefore, the preparation and development of these species as effective, selective and nontoxic antiviral and antitumor agents has been the subject of intense research.1) In addition to this, the development of Polymerase Chain Reaction (PCR) methodology has brought a dramatic change and rapid development in studies of DNA. At the current time the draft version in decoding and mapping human genome has been almost completed, and the functional analyses of genome and analyses of “Single Nucleotide Polymorphism” (SNP) are being vigorously pursued. Discovery of the RNAi process has facilitated the fast progression of studies of RNA. At the same time, chemically synthesized oligoDNA and oligoRNA have been studied as potential antisense DNAs, siRNAs and DNA aptamers, as oligonucleotide therapeutic agents, primers for PCR method, and elements of DNA computers. Nucleosides and Their Analogs A2052 1g 5g A2073 5g 25g Nucleosides are glycosylamines made by attaching a nucleobase to a ribose or 2’-deoxyribose, which can be phosphorylated producing nucleotides. Nucleoside analogues are an established class of clinically useful medicinal agents possessing a wide range of antiviral and anticancer activities. Consequently, extensive modifications have been made to both the heterocyclic base and the sugar moiety. Some representative examples of these are 9-[(2-hydroxyethoxy) methyl]guanine (acyclovir) developed by Elion in 1977, which shows antiviral activity; 3'-azido-3'-deoxythymidine (AZT) discovered by Mitsuya et al. in 1985 and used for the treatment of HIV infection; and cytosine β-D-arabinofuranoside (cytarabine) approved by the FDA in 1969 and which has been shown to display a range anticancer activities. In addition, modified nucleosides such as 2’-deoxy-5-methylcytidine are ubiquitous in living systems, and their functions have received due attention from the scientific community.2) Protected nucleosides, in which reactive amino and hydroxyl groups have been masked, e.g. N6-benzoyl-5'-O-(4,4'dimethoxytrityl)-2'-deoxyadenosine (Bz-DMT-dA), have been used for chemical synthesis of DNA and RNA. A055910mg A2033 6-Azauridine[54-25-1] 5-Azacytidine[320-67-2] A2356 1g 5g A24311g 100mg 1g Pyrimidine Nucleosides A2232 20mg 100mg NH2 N HO O N N O Azidothymidine [30516-87-1] 1-(3,5-Anhydro-2-deoxyβ-D -threo-pentofuranosyl)thymine[7481-90-5] 5-Aza-2'-deoxycytidine [2353-33-5] 1-β- D -Arabinofuranosyluracil[3083-77-0] 2,2'-O-Anhydro5-methyluridine [22423-26-3] A252850mg A2942 B0666 B1575 B3087 25mg 100mg O N HO NH2 O OH Acadesine 2 100mg 1g 1g 5g 1g 5g O C NH2 N OH HN HO O N O OH OH [2627-69-2] 4 N3 2'-Azido-2'-deoxyuridine [26929-65-7] 5-Bromouridine[957-75-5] 5-Bromo-2'-deoxyuridine [59-14-3] Please inquire for pricing and availability of listed products to our local sales representatives. N -Benzoyl-5'-O(4,4'-dimethoxytrityl)-2'deoxycytidine[67219-55-0] Nucleosides, Nucleotides, Nucleic Acids and Related Reagents B3094 1g 5g B3102 100mg 1g B3404 100mg 1g B3631 1g 5g C0522 1g 5g 25g 4 4 N -Benzoyl-2'-deoxycytidine [4836-13-9] C0525 C20355g 100mg 1g Brivudine[69304-47-8] N -Benzoyl-3',5'-O-(1,1,3,3tetraisopropyl-1,3-disiloxanediyl)cytidine [69304-43-4] Cytidine[65-46-3] C2207 C2208 C2878 4 N -Benzoylcytidine [13089-48-0] 1g 5g 5g 25g 1g 5g O NH C O(CH2)4CH3 F N H3C O N O OH OH Cytidine Sulfate [32747-18-5] Cytarabine[147-94-4] 2,2'-O-Cyclocytidine Hydrochloride[10212-25-6] 2,2'-O-Cyclouridine [3736-77-4] Capecitabine[154361-50-9] D0048 D0060 1g 5g 25g D2235 100mg 500mg 1g D3566 D3579 2'-Deoxycytidine Hydrochloride[3992-42-5] 2'-Deoxyuridine [951-78-0] 2'-Deoxy-5-fluorouridine [50-91-9] 5'-O-(4,4'-Dimethoxytrityl)thymidine[40615-39-2] 5'-Deoxy-5-fluorouridine [3094-09-5] D3580 D3583 1g 5g D3610 100mg 500mg 5g D36141g D3615 [3056-17-5] 2'-Deoxycytidine [951-77-9] 2'-Deoxy-5-methylcytidine [838-07-3] 2'-Deoxy-2'-fluorocytidine Hydrate[10212-20-1] 2'-Deoxy-2'-fluorouridine [784-71-4] 1g 5g D420010mg D4220 D4342 D4823 5g 25g 1g 5g Stavudine D3642 50mg 200mg O O F O 2'-Deoxy-5-fluorocytidine [10356-76-0] E1057 50mg 200mg I HO O CH2OH N N HO OH N H3C O N O 1g 5g 200mg 1g O F N HN HO O O OH OH OH O H3C O OH N F Fialuridine[69123-98-4] 2'-Deoxy-5-(hydroxymethyl)cytidine [7226-77-9] 5'-Deoxy-5-fluorocytidine [66335-38-4] (2'R)-2'-Deoxy-2'-fluoro-2'methyluridine[863329-66-2] E1093 F05341g F0635 F0636 50mg 200mg O 5g 25g 1g 5g NH2 C CH HN 1g 5g 1g 5g NH2 NH2 HN HO 5g 25g N C CH N HO N O O O OH OH 5-Ethynyl-2'-deoxyuridine [61135-33-9] 5-Ethynyl-2'-deoxycytidine [69075-47-4] 5-Fluorocytidine [2341-22-2] Tegafur G0367 I0258 I08821g L0217 100mg 1g 1g 5g 25g [17902-23-7] 100mg 1g 5-Fluorouridine[316-46-1] M1405 1g 5g 25g NH2 I N HO N O O OH Gemcitabine Hydrochloride [122111-03-9] Idoxuridine M19311g M2290 [54-42-2] 1g 5g 5-Iodo-2'-deoxycytidine [611-53-0] Lamivudine [134678-17-4] 5-Methyluridine [1463-10-1] M2317 M2399 R0077 200mg 1g O HN HO O N OH HO O OCH3 2'-O-Methyluridine [2140-76-3] OH C NH2 N N O 100mg 500mg O N O 5-Methylcytidine [2140-61-6] 50mg 250mg NH2 N HO OH O OCH3 2'-O-Methylcytidine [2140-72-9] OH OH Mizoribine [50924-49-7] Please inquire for pricing and availability of listed products to our local sales representatives. Ribavirin[36791-04-5] 3 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents T0233 1g 5g 25g T2511 100mg 1g T2549 5g 25g U0020 5g 25g Z0022 200mg 1g N HO N O O OH Thymidine[50-89-5] OH Trifluorothymidine [70-00-8] 2',3',5'-Tri-O-acetyluridine [4105-38-8] Uridine[58-96-8] Zebularine[3690-10-6] A0152 A1915 A2054 A2135 5g 25g 100g 1g 5g 25g 1g 5g 5g 25g Purine Nucleosides A2414 100mg 1g Adenosine[58-61-7] Acyclovir[59277-89-3] 2-Amino-6-chloropurine Riboside [2004-07-1] 2-Aminoadenosine [2096-10-8] A2739 B3093 B3101 B3103 10mg 50mg 1g 5g 100mg 1g 100mg 1g O NH N HO HO O N N NH2 6 . xH2O OH N -Benzoyladenosine [4546-55-8] N -Benzoyl-2'deoxyadenosine Hydrate [206752-42-3] N -Benzoyl-5'-O(4,4'-dimethoxytrityl)2'-deoxyadenosine [64325-78-6] B4002 C2192 C2206 6 Adefovir Dipivoxil [142340-99-6] 9-β- D Arabinofuranosylguanine Hydrate [38819-10-2] Hydrate B3460 B4001 100mg 1g 200mg 1g 6 1g 5g N HO Br N NH2 HO Br N N NH2 O O 6 1g 5g NH N NH N 100mg 1g O O . xH2O N -Dibenzoyladenosine 2',3'-Dibenzoate [58463-04-0] 8-Bromo-2'-deoxyguanosine [13389-03-2] Hydrate 8-Bromoguanosine [4016-63-1] 2-Chloroadenosine Hydrate [146-77-0] 6-Chloropurine Riboside [5399-87-1] C249950mg C2500 C268925mg C281525mg D0046 OH 20mg 100mg OH OH NH2 NH2 N N N N N HO N N HO Cl N N N O . xH2O OH OH OH N N HO O O 5g 25g NH2 [4291-63-8] Clofarabine[123318-82-1] Cordycepin from Cordyceps militaris [73-03-0] Cordycepin Hydrate [73-03-0] Monohydrate[16373-93-6] 1g 5g 25g D3065100mg D3066 D3584 1g 5g D41375g 2'-Deoxyguanosine Hydrate [961-07-9] 2',3'-Dideoxyadenosine [4097-22-7] Didanosine[69655-05-6] 2'-Deoxyinosine[890-38-0] 2'-Deoxyadenosine Anhydrous[958-09-8] D422825mg D4256 D4292 E0899 F0656 Cladribine D0052 O CH3 N N O N N CH3 Cl N N O CH2CH2OCH2 P O 50mg 200mg 200mg 1g O N N O O P O ONa 100mg 1g NH2 HN N 1g 5g 100mg 500mg 2'-Deoxyadenosine N HO OCH2CH3 Cl HN H2N N N O N . H2O CH2 OCH2CH3 Dibutyryl cAMP Sodium Salt[16980-89-5] Diethyl [[2-(6-Amino-9Hpurin-9-yl)ethoxy]methyl]phosphonate[116384-53-3] 5,6-Dichlorobenzimidazole 1-β-D -Ribofuranoside[53-85-0] Entecavir Monohydrate [209216-23-9] 2-Fluoroadenosine [146-78-1] F0842 G0171 G0315 H1290 H1291 O 500mg 5g 5g 25g 100g OH OH 5g 25g HO CH2OH 5g 25g O N H2N N N CH2CH2CH NH2 HN N O H2N CH2O C CH3 CH2O C CH3 N N . xH2O N N 4 Guanosine[118-00-3] CH2OH CH2OCH CH OH 2 Ganciclovir Hydrate [82410-32-0] N N N CH3 O Famciclovir[104227-87-4] 1g 5g 9-(2-Hydroxyethyl)adenine[707-99-3] Please inquire for pricing and availability of listed products to our local sales representatives. OH (R)-9-(2-Hydroxypropyl)adenine[14047-28-0] Nucleosides, Nucleotides, Nucleic Acids and Related Reagents I0037 25g 500g I0697 [58-63-9] N -Isobutyryl-5'O-(4,4'-dimethoxytrityl)-2'deoxyguanosine[68892-41-1] N -Isobutyrylguanosine Monohydrate[64350-24-9] N -Isobutyryl-2'-deoxyguanosine[68892-42-2] 2',3'-O-Isopropylideneadenosine[362-75-4] I07035g I07045g I0759 M22911g M2318 1g 5g I0699 100mg 1g I0700 100mg 1g I0702 5g 25g 2 Inosine 2 200mg 1g 5g 2 200mg 1g O NH2 N N N N HO N NH2 O O OH NH N HO N OH OCH3 OCH3 . xH2O 2',3'-O-Isopropylideneguanosine[362-76-5] 2',3'-O-Isopropylideneinosine [2140-11-6] 2-Iodoadenosine [35109-88-7] 2'-O-Methyladenosine [2140-79-6] Hydrate[2140-71-8] O0401 P2164 P2311 T26901g T2691 2',3',5'-Tri-O-acetyl-2-amino6-chloropurine Riboside [16321-99-6] 2',3',5'-Tri-O-acetyl6-chloro-2-iodopurine [5987-76-8] Riboside X0008 200mg 1g HN HO O N N N N N N CH2OH CH3O CH2OH OH N O NH2 NH O OH . 2HCl 8-Oxoadenosine [29851-57-8] Penciclovir[39809-25-1] Puromycin Dihydrochloride[58-58-2] T2692 V0098 V0111 1g 5g 2',3',5'-Tri-O-acetylguanosine [6979-94-8] 1g 5g Vidarabine Monohydrate [24356-66-9] 1g 5g CH3 N N HO N CH2CH2CH O OH 25mg 100mg CH3 HN H2N N 200mg 1g O NH2 2'-O-Methylguanosine 100mg 1g Valacyclovir Hydrochloride Hydrate [124832-27-5] 100mg Xanthosine Dihydrate [146-80-5] Nucleotides and Their Analogs Nucleotides are formed from the condensation of nucleoside which is either ribose (RNA) or 2’-deoxyribose (DNA). and a phosphate group. The nucleosides themselves are Nucleotides are the minimum structural units of DNA and RNA, formed from a nucleobase (see below) and a sugar moiety and serve as important cofactors in metabolism. C0523 Nucleotides and Their Analogs Pyrimidine Nucleotides 10mg 100mg 1g C0524 1g 5g Cytidine 5'-Diphosphate Trisodium Salt Hydrate [34393-59-4] Cytidine 5'-Monophosphate Disodium Salt Hydrate [6757-06-8] C16755g D3673 100mg 1g T0845100mg U0021 5g 25g U0022100mg Cytidine 5'-Monophosphate [63-37-6] 2'-Deoxycytidine 5'-Monophosphate Hydrate [1032-65-1] Thymidine 5'-Monophosphate Disodium Salt Hydrate [33430-62-5] Uridine 5'-Monophosphate Disodium Salt Hydrate [3387-36-8] Uridine 5'-Triphosphate Trisodium Salt Hydrate [19817-92-6] Please inquire for pricing and availability of listed products to our local sales representatives. 5 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents A0157 Purine Nucleotides A2381 1g 5g 1g 5g 25g Adenosine 5'-Triphosphate Disodium Salt Hydrate [34369-07-8] F0913 25mg 100mg A0158 1g 5g 25g A0626 100mg 1g A2112 100mg 1g 5'-Adenylic Acid [61-19-8] Adenosine 5'-Diphosphate Disodium Salt Hydrate [16178-48-6] Adenosine 3',5'-Cyclic Monophosphate Sodium Salt Hydrate[37839-81-9] G0172 G0173 I0036 25g 100g 1g 5g 1g 5g 25g NH2 N N O HO P O HO O OH N N F Adenosine 3',5'-Cyclic Monophosphate Hydrate [60-92-4] Fludarabine Monophosphate [75607-67-9] I0038100mg I0039100mg Inosine 5'-Triphosphate Trisodium Salt Hydrate [35908-31-7] Inosine 5'-Monophosphate Barium Salt Hydrate [3249-92-1] OH Nucleic Acids Guanosine 5'-Monophosphate Disodium Salt Hydrate [5550-12-9] R002225g Deoxyribonucleic Acid Ribonucleic Acid not highly polymerized from Herring sperm [9007-49-2] D3545 5g 25g R002425g Ribonucleic Acid Sodium Salt from Yeast D1140100mg P0251100mg Bovine Spleen [9003-98-9] D0920 100mg 1g 5g β-NADH Disodium Salt Hydrate, reduced form [606-68-8] T2980100mg T2979100mg β-NADPH Tetrasodium Salt reduced form [2646-71-1] Thionicotinamide Adenine Dinucleotide Disodium Salt reduced form Thionicotinamide Adenine Dinucleotide oxidized form [4090-29-3] Nucleobases and Their Analogs Nucleobases, usually simply called “bases”, are a vital sense component of DNA and RNA. The bases can be divided into two groups based on the structure: purines such as adenine and guanine; and pyrimidines such as cytosine, thymine and uracil. Other nucleobases can be created by the modification Inosine 5'-Monophosphate Disodium Salt Hydrate [4691-65-0] from Yeast Deoxyribonucleic Acid Sodium Salt from Salmon Milt [9007-49-2] T0521100mg 6 (2'-,3'- mixture) from Yeast[5550-12-9] D005425g Deoxyribonuclease from Enzymes and Coenzymes related to Nucleic Acids Guanylic Acid Sodium Salt Phosphatase, Acid from C0379 100mg 1g β-NADP Sodium Salt Wheat Germ [9001-77-8] Hydrate, oxidized form [1184-16-3] N0943100mg D0919 β-NADP β-NAD Hydrate, oxidized form [53-84-9] [53-59-8] 1g 5g of these basic structures. For example, hypoxanthine and xanthine are generated in living systems through deamination of adenine and guanine, respectively. Furthermore, nucleobase analogue 5-fluorouracil (5-FU) is used as an anticancer agent. Derivatives of 2-fluoroadenine have been widely reported as prodrug forms of anticancer agents. Please inquire for pricing and availability of listed products to our local sales representatives. Nucleosides, Nucleotides, Nucleic Acids and Related Reagents A2089 5g 25g A2670 1g 5g O Pyrimidine Nucleobases and Their Analogs Nucleobases CH3 O C NH N H O 4 A2136 1g 5g A21255g A2449 5g 25g N -Acetylcytosine [14631-20-0] 5-Acetyluracil[6214-65-9] A094725g A0898 5g 25g O O H2N NH H2N N NH O O N H CH3 4-Amino-6-chloropyrimidine [5305-59-9] 4-Amino-5-fluoro2-methoxypyrimidine [1993-63-1] 6-Amino-1-methyluracil [2434-53-9] 5-Aminoorotic Acid [7164-43-4] 5-Aminouracil[932-52-5] A0658 A0558 B31695g B066525g C1057 25g 250g 1g 5g 5g 25g O O NH NH H2N N H ClCH2 O 4 6-Aminouracil[873-83-6] 6-Azauracil[461-89-2] N -Benzoylcytosine [26661-13-2] 5-Bromouracil C2300 C0969 C2093 C0528 5g 25g 5g 25g 5g 25g [51-20-7] 5g 25g 100g N H O 6-Chloromethyluracil [18592-13-7] D1136 1g 5g O CH3 NH CH3 6-Chloro-3-methyluracil [4318-56-3] 5-Chlorouracil[1820-81-1] 6-Chlorouracil[4270-27-3] Cytosine D09485g E0807 E1096 F0321 1g 5g 200mg 1g [71-30-7] 1g 5g 25g N H O 5,6-Dimethyluracil [26305-13-5] F0382 100mg 1g O S HC C NH N H NH N H S O 2,4-Dithiopyrimidine [2001-93-6] 5-Ethyluracil [4212-49-1] 5-Ethynyluracil [59989-18-3] 5-Fluorocytosine [2022-85-7] Monohydrate[703-95-7] F0151 I0531 I0219 I08145g M0204 5g 25g 1g 5g 5g 25g 5-Fluoroorotic Acid 100mg 1g 5g O N 5-Fluorouracil [51-21-8] M2506 1g 5g 5-Iodo2,4-dimethoxypyrimidine [52522-99-3] 5-Iodouracil M2355 M0994 O O2N CH3 N H 1g 5g Isocytosine [108-53-2] 5-Methylcytosine Hydrochloride[58366-64-6] M0443 25g 500g M0454 [696-07-1] 10g 25g N H N O NH NH N O 25g 500g O OH NH NH2 CH3 SCH3 N H N H CH3 S O 6-Methyl-5-nitrouracil [16632-21-6] 2-Methylthio-4-pyrimidinol [5751-20-2] 5-Methyl-2-thiouracil [636-26-0] 6-Methyl-2-thiouracil [56-04-2] 6-Methyluracil [626-48-2] N0281 O0065 P0236 P053325g T0224 5g 25g 25g 100g 500g 1g 5g O O2N N H 5-Nitrouracil O O NH NH NH O [611-08-5] 25g 250g CH3CH2CH2 Orotic Acid Monohydrate [50887-69-9] 6-Phenyl-2-thiouracil [36822-11-4] N H S 6-Propyl-2-thiouracil [51-52-5] Please inquire for pricing and availability of listed products to our local sales representatives. N H 2-Thiouracil S [141-90-2] 7 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents T27571g T0234 5g 25g 100g T1622 1g 5g U0013 25g 100g 500g Purine Nucleobases 4-Thiouracil[591-28-6] Thymine[65-71-4] 5-(Trifluoromethyl)uracil [54-20-6] Uracil[66-22-8] A0149 A0150 A0151 25g 100g A05551g A06251g 25g 250g 5g 25g Adenine[73-24-5] Adenine Hydrochloride Hemihydrate [2922-28-3] Adenine Sulfate Dihydrate [6509-19-9] 8-Azahypoxanthine [2683-90-1] 8-Azaguanine[134-58-7] A0907 A1041 A1111 A1248 A1407 25g 250g 100mg 1g 5g 200mg 1g 1g 5g 1g 5g NH2 N N N H N Allopurinol[315-30-0] 4-Aminopyrazolo [3,4-d]pyrimidine[2380-63-4] 2-Aminopurine[452-06-2] 2-Acetamido-6hydroxypurine[19962-37-9] 2-Amino-6-chloropurine [10310-21-1] A2068 A2069 A2699100mg A2805 B1088 5g 25g 5g 25g NH2 N H N N N O N CH3 H2N NH2 N H 2 6 2-Amino-6-iodopurine [19690-23-4] Azathioprine [446-86-6] AHPP B3344 B3355 B3456 5g 25g N H 5g 25g O CH3 N O 25g 100g 5g 25g [5472-41-3] Aminophylline [317-34-0] N -Benzyladenine [1214-39-7] 1g 5g B41341g B4454 O O HN HN N N O 200mg 1g N H Br N N O N CH2 C C CH3 Br CH3 N -Benzoyladenine [4005-49-6] 6-Benzyloxypurine [57500-07-9] 8-Bromotheophylline [10381-75-6] 8-Bromo-3-methylxanthine[93703-24-3] 8-Bromo-7-(2-butyn-1-yl)3-methylxanthine [666816-98-4] C0278 C0293 25g 250g C22211g C2306 C2575 6-Chloropurine[87-42-3] 8-Chlorotheophylline [85-18-7] 6-Chloro-2-fluoropurine [1651-29-2] 6-Chloro-7-deazapurine [3680-69-1] 2-Chloroadenine [1839-18-5] C2845200mg1g C3130 D1625 D2470 1g 5g 25g D360425g 6 5g 25g 1g 5g 5g 25g CH3 1g 5g 1g 5g Cl N Cl N N I N N N O N H 2 6-Chloro-9-(tetrahydropyran2-yl)purine [7306-68-5] 6-Chloro-7-iodo-7deazapurine [123148-78-7] 2,6-Diaminopurine Hydrate [1904-98-9] 2,6-Dichloropurine [5451-40-1] N ,9-Diacetylguanine [3056-33-5] D3894 D4284 D4295 D43241g F0647 1g 5g 1g 5g 1g 5g Cl O Cl N Cl 6-(Dimethylamino)purine [938-55-6] 8 N 200mg 1g N H 2,6-Dichloro-7deazapurine[90213-66-4] Cl N . HCl N H 5,6-Dichlorobenzimidazole Hydrochloride[1087737-96-9] HN N N H 7-Deazahypoxanthine [3680-71-5] Please inquire for pricing and availability of listed products to our local sales representatives. 2-Fluoroadenine [700-49-2] Nucleosides, Nucleotides, Nucleic Acids and Related Reagents G0168 1g 25g G0169 Guanine Sulfate Dihydrate [10333-92-3] Guanine I0370100mg I0941 1g 25g 250g G017025g H0311 [73-40-5] Guanine Hydrochloride Hydrate [635-39-2] Hypoxanthine [68-94-0] 9-(2-Hydroxyethyl)adenine [707-99-3] K0009 M0063 M1925 1g 5g 1g 5g 5g 25g 1g 5g H1290 5g 25g 1g 5g NH2 I N N Isoguanine M2073 [3373-53-3] 5g 25g N H N 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine [151266-23-8] Kinetin[525-79-1] 6-Mercaptopurine Monohydrate[6112-76-1] 6-Methoxypurine [1074-89-1] M2432 M2518 N0958 T0212 50mg 200mg O CH3 O NH2 N N N H 200mg 1g N N N 1-Methylxanthine [6136-37-4] H2N T0225 1g 5g X000425g 2-Thioxanthine [2487-40-3] Xanthine[69-89-6] 3-Methyladenine [5142-23-4] Pharmacologically-Active Nucleosides and Nucleobases for Research and Experimental Use N CH3 3-Methylxanthine [1076-22-8] 1g 5g OCH2 N N H 20mg 100mg NU 2058 N N N H [161058-83-9] 6-Thioguanine[154-42-7] research are shown below., and serve as important cofactors in metabolism. Typical nucleosides and nucleobases used in pharmacology Pharmacologically-Active Nucleosides and Nucleobases for Research and Experimental Use A2052 1g 5g A2069 5g 25g A0907 25g 250g A1915 1g 5g 25g A2033 100mg 1g Allopurinol[315-30-0] Acyclovir[59277-89-3] 5-Azacytidine[320-67-2] A2232 A2414 A252850mg 20mg 100mg 100mg 1g O NH2 N HO O N N OH Azathioprine[446-86-6] Decitabine[2353-33-5] N HO O Azidothymidine [30516-87-1] C NH2 N NH2 O Adefovir Dipivoxil [142340-99-6] Please inquire for pricing and availability of listed products to our local sales representatives. OH Acadesine OH [2627-69-2] 9 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents A2694 1g 5g A2699100mg A2737 200mg 1g A2739 10mg 50mg NH2 NH2 NH N N H2N N N N N H O N N HO Abacavir[136470-78-5] AHPP[5472-41-3] 4-Amino1-phenylpyrazolo [3,4-d]-pyrimidine[5334-30-5] B1575 B3404 C20355g HO 1g 5g HO O N N H 100mg 1g 25g 100g O NH N N N A2805 O N N CH3 NH2 O . xH2O OH N N H2N NH2 N H N CH3 2 Ara-G Hydrate [38819-10-2] Aminophylline [317-34-0] C2042 C249950mg 25g 500g NH2 O CH3 N O N Brivudine[69304-47-8] Cytarabine C2500 C268925mg C281525mg [147-94-4] NH2 N N HO N N N O N O . xH2O D2235 100mg 500mg 1g 1g 5g O NH C O(CH2)4CH3 N N N O F N CH2CH2Cl H3C O N O N CH3 OH OH Clofarabine [123318-82-1] CH3 [4291-63-8] C2878 O N HO Cordycepin from Cordyceps militaris [73-03-0] 5g 25g OH Cladribine NH2 N Cl O [58-08-2] C2748 N N HO N Caffeine N N CH3 CH3 5-Bromo-2'-deoxyuridine [59-14-3] 20mg 100mg N OH OH Cordycepin Hydrate [73-03-0] 7-(2-Chloroethyl)theophylline [5878-61-5] Capecitabine[154361-50-9] D3065100mg D3066 D3579 D3580 2'-Deoxy-5-fluorouridine [50-91-9] 2',3'-Dideoxyadenosine [4097-22-7] Didanosine[69655-05-6] Doxifluridine[3094-09-5] Stavudine D3600 D422825mg D4292 D4302 D4342 25g 500g 100mg 500mg 100mg 1g 1g 5g 1g 25g 1g 5g [3056-17-5] 1g 5g O CH3 HN OH O N N NH2 N CH2 CH CH2OH N O CH3 N HO N O O N N O P O ONa CH3 O D4823 E0899 F0151 50mg 200mg OH N HN H3C O 5g 25g N N N H2N HO CH2OH 5-Fluorouracil F0636 F0842 F0913 1g 5g 500mg 5g N H2N [51-21-8] 25mg 100mg F0321 F0635 N O N CH2O C CH3 CH2O C CH3 HO P O HO O OH O N N OH 5-Fluorouridine[316-46-1] Famciclovir[104227-87-4] H0402 H1430 H1542 25g 500g 5g 25g 1g 5g O H 2N CH3 10 5g 25g 5-Fluorocytosine [2022-85-7] Tegafur [17902-23-7] G0315 G0367 100mg 1g O N CH3 OH N N CH2 CH CH3 CH3CH3 O CH3 O N CH3 H O N CH2CH2OH [519-37-9] N CH3 CH3 NH . xH2O N CH2OH CH2OCH CH OH 2 Ganciclovir Hydrate [82410-32-0] Gemcitabine Hydrochloride [122111-03-9] I0258 K0009 1g 5g 25g 1g 5g O N NH2 CH3 O CH3 CH3 O NH2 O CH3 O CH3 O P O HO N CH3 O HO Proxyphylline[603-00-9] N H 2N N CH3 N N N Co N O H2N O NH2 H 2N 5g 25g HN F Fludarabine Monophosphate [75607-67-9] Etofylline 1g 5g 25g O N N O N CH2CH2CH O OH Doxofylline [69975-86-6] NH2 N OH 5'-Deoxy-5-fluorocytidine [66335-38-4] . H2O PSI-6206[863329-66-2] CH3 N O CH2 F N H3C O O N CH3 [53-85-0] Entecavir Monohydrate [209216-23-9] O O O HN O N N O F N N OH OH DRB HO Cl CH3 O Diprophylline[479-18-5] O CH3 O Dibutyryl cAMP Sodium Salt [16980-89-5] 200mg 1g O Cl N N O Hydroxocobalamin Acetate[22465-48-1] Idoxuridine [54-42-2] Please inquire for pricing and availability of listed products to our local sales representatives. Kinetin[525-79-1] Nucleosides, Nucleotides, Nucleic Acids and Related Reagents L0217 100mg 1g M0063 1g 5g M2399 50mg 250mg M27421g N HO H2N C NH2 N O CH3 H2N CH3 O H CH3CH3 OH O CH3 OH CH3 CH3 NH N O O P O HON O O HO OCH2 O NH2 CH3 CH3 N NH2 O CH3 H2N CH3 . xH2O Lamivudine [134678-17-4] 6-Mercaptopurine Monohydrate[6112-76-1] Mizoribine [50924-49-7] Methylcobalamin Hydrate [288315-09-3] NU 2058 P2164 P2311 R0077 T0179 T0212 200mg 1g 25mg 100mg O CH3 HN H2N N N N N CH2CH2CH CH2OH CH3O CH2OH 100mg 500mg 25g 100g 500g N N N H [161058-83-9] 1g 5g CH3 N N N HO 20mg 100mg O NH2 N CH3 N Co N N H2 N O OH N0958 O O N O NH2 NH O OH . 2HCl Penciclovir[39809-25-1] Puromycin Dihydrochloride[58-58-2] Ribavirin[36791-04-5] Theophylline[58-55-9] 6-Thioguanine[154-42-7] T2511 T2744 T294125g V0098 V0111 100mg 1g 500mg 5g O CH3 N 100mg 1g O N N O 1g 5g CH2 C OH N CH3 Trifluorothymidine [70-00-8] Temozolomide[85622-93-1] Theophylline-7-acetic Acid[652-37-9] Nucleic Acid Synthesis Agents Silylation converts insoluble nucleobases into lipophilic trimethylsilyled derivatives, which are readily soluble in organic solvents, permitting homogenous chemical reactions. The trimethylsilylated nucleobases react with protected sugars to afford nucleosides. The procedure is commonly referred to as the Hilbert-Johnson reaction modified by Vorbrüggen et al. Phosphorylating and phosphorothioating agents, condensing agents and protecting agents for hydroxy and amino groups are of importance in the synthesis of DNA and RNA chains. Active research on chemical synthesis of DNA and RNA is being conducted, and a variety of synthetic methods using these agents are being developed. Nucleic Acid Synthesis Agents B0105 25mL 500mL Benzoyl Chloride [98-88-4] B0511 10mL 100mL BSA[10416-59-8] TBSCl Valacyclovir Hydrochloride Hydrate [124832-27-5] The dicyclohexylcarbodiimide (DCC) method exemplified by the Khorana group, the phosphotriester method and phosphitetriester method by the team of Letsinger and the phosphoramidite method by the Caruthers group are examples of the various synthetic methods. Recently, the phosphoramidite method has been used frequently in tandem with the penetration of DNA synthesizers, thus 2-cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite has been the reagent of frequent choice for the phosphitylation due to its ease in handling and safety.3) 1,2,4-Triazole and 1H-tetrazole are also used for chemical conversion of uridines into cytidines. Chemically synthesized DNA is becoming important as a primer for the PCR method, an antisense molecule, or an element of the DNA computer. Protecting Agents for Hydroxy and Amino Groups B0995 Vidarabine Monohydrate [24356-66-9] A0082 100g 500g B0078 25g 100g 500g Acetyl Chloride [75-36-5] Benzoic Anhydride [93-97-0] 5g 25g 100g B11515g B1223 [18162-48-6] 1,3-Benzodithiolylium Tetrafluoroborate [57842-27-0] tert-Butyldiphenylchlorosilane[58479-61-1] Please inquire for pricing and availability of listed products to our local sales representatives. 5mL 25mL 100mL 11 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents C0306 25mL 100mL 500mL C0308 25g 100g 500g C0832 25g 100g 500g D1293 25mL 100mL 500mL D1608 5g 25g [76-83-5] 4-Chlorophenoxyacetyl Chloride[4122-68-3] N,N-Dimethylformamide Dimethyl Acetal[4637-24-5] 1,3-Dichloro-1,1,3,3tetraisopropyldisiloxane [69304-37-6] 5g 25g D24695g D250425g D3135 4,4'-Dimethoxytrityl Chloride [40615-36-9] 1,3-Dichloro-1,1,3,3tetramethyldisiloxane [2401-73-2] Di-tert-butyldichlorosilane [18395-90-9] 2-Chlorotrityl Chloride [42074-68-0] Di-tert-butylsilyl Bis(trifluoromethanesulfonate) [85272-31-7] H0089 25mL 100mL 500mL I0115 M0721 M0790 N0404 HMDS [999-97-3] Isobutyryl Chloride [79-30-1] 4-Methoxybenzoyl Chloride [100-07-2] 4-Methoxytrityl Chloride [14470-28-1] 2-Nitrobenzyl Bromide [3958-60-9] P0113 25g 500g P0677 T0459 T0512 T0871 Chlorotrimethylsilane [75-77-4] Trityl Chloride D1612 D2334 5g 25g 25g 100g 500g 25mL 500mL Phenoxyacetyl Chloride [701-99-5] Pivaloyl Chloride [3282-30-2] T1071 T15261g 5g 25g 4,4',4''-Tris(benzoyloxy)trityl Bromide[86610-66-4] 4,4',4''-Tris(4,5-dichlorophthalimido)trityl Bromide [91898-93-0] C0976 C0977 5g 25g 5g 25g 25g 100g 500g 25g 500g 2,4,6-Triisopropylbenzenesulfonyl Chloride [6553-96-4] Phosphorylating and Phosphorothioating Agents C0978 5g 25g 25g 250g 25g 100g 1g 5g 5g 25g 5g 25g 250g Trityl Bromide [596-43-0] Trimethylsilyl Trifluoromethanesulfonate [27607-77-8] B3125 B3623 1g 5g 5g 25g O S S O 3H-1,2-Benzodithiol-3-one 1,1-Dioxide[66304-01-6] Bis(phenylacetyl) Disulfide [15088-78-5] C1210 5g 25g C121525g 2-Chlorophenyl Phosphorodichloridate [15074-54-1] 4-Chlorophenyl Phosphorodichloridate [772-79-2] Barium 2-Cyanoethylphosphate Hydrate [5015-38-3] 2-Chloro-4H-1,3,2benzodioxaphosphorin4-one[5381-99-7] 2-Chloro-1,3,2-dioxaphospholane[822-39-9] C1250 C2228 D0624 25g 500g D076425g D1059 5g 25g 1g 5g 25g 100g 500g 2-Chloro-2-oxo1,3,2-dioxaphospholane [6609-64-9] 2-Cyanoethyl N,N,N',N'Tetraisopropylphosphordiamidite [102691-36-1] Diethyl Chlorothiophosphate [2524-04-1] Dimethyl Chlorothiophosphate [2524-03-0] Diphenyl Chlorophosphate [2524-64-3] D26245g D288325g D4211 D42521g M0904 1g 5g CH3 CH3 (CH3)3CO Dibenzyl N,N-Diisopropylphosphoramidite [108549-23-1] 12 Diphosphoryl Chloride [13498-14-1] N P 5g 25g 100g CH3 CH3 CH3 OC(CH3)3 (CH3)3CO Di-tert-butyl N,NDiisopropylphosphoramidite [137348-86-8] N P CH3 OC(CH3)3 Di-tert-butyl N,NDiethylphosphoramidite [117924-33-1] Please inquire for pricing and availability of listed products to our local sales representatives. Methyl Phosphorodichloridate [677-24-7] Nucleosides, Nucleotides, Nucleic Acids and Related Reagents M090510g P0209 25g 500g P12231g B302025g Condensing Agents Methyl Dichlorophosphite [3279-26-3] Phenyl Dichlorophosphate [770-12-7] Tetrabenzyl Pyrophosphate[990-91-0] C2325 5g 25g C24215g D0436 1,1'-Carbonyldi(1,2,4-triazole)[41864-22-6] 1-(Cyanomethyl)piperidinium Tetrafluoroborate [434937-12-9] E0670 M0071 5-(Benzylthio)-1Htetrazole[21871-47-6] 25g 250g D379225g N,N'-Dicyclohexylcarbodiimide (= DCC) [538-75-0] 4,5-Dicyanoimidazole [1122-28-7] N,N'-Dicyclohexyl-4morpholinecarboxamidine [4975-73-9] 25g 500g M06251g M1186 5g 25g N04775g 5-(Ethylthio)-1H-tetrazole [89797-68-2] 2-Mesitylenesulfonyl [773-64-8] Chloride 1-(2-Mesitylenesulfonyl)[50257-39-1] imidazole 2,4-Mesitylenedisulfonyl Dichloride [68985-08-0] 3-Nitro-1,2,4-triazole [24807-55-4] P0677 T0340 T0459 T1017 T1410 1g 5g 25mL 500mL 25g 100g 500g 25g 400g 25g 500g Pivaloyl Chloride [3282-30-2] 1,2,4-Triazole[288-88-0] 2,4,6-Triisopropylbenzenesulfonyl Chloride [6553-96-4] T15625g T1985 T2951 5g 25g D2026 5g 25g 1H-Tetrazole[288-94-8] 1-(2,4,6-Triisopropylbenzenesulfonyl)imidazole[50257-40-4] D0059 1g 5g 5g 25g 5g 25g N N CH3 CH3 N SO2 CH CH CH CH3 CH3 CH3 CH3 2,4,5,6-Tetramethylbenzenedisulfonyl Dichloride [97997-76-7] 1-(p-Toluenesulfonyl)imidazole [2232-08-8] 1-(2,4,6-Triisopropylbenzenesulfonyl)1,2,4-triazole[54230-60-3] D4207 D4594 M1965 1g 5g F BzO O 1g 5g BzO O O 1g 5g Riboses and 2'-Deoxyriboses 2-Deoxy- D -ribose [533-67-5] R0025 25g 250g R0026 100mg 1g F OBz OBz F OBz 2-Deoxy-2,2-difluoro-D -erythropentonic Acid γ-Lactone 3,5-Dibenzoate[122111-01-7] 2-Deoxy-2-fluoro-1,3,5-tri-Obenzoyl-α-D -arabinofuranose [97614-43-2] Methyl β-D -Ribofuranoside [7473-45-2] D -(-)-Ribose[50-69-1] Ribose-5-phosphate Barium Salt Hydrate [15673-79-7] R0066 R0067 R0068 1g 5g 25g R00801g R00825mg β-L-Ribofuranose 1-Acetate 2,3,5-Tribenzoate [3080-30-6] α-D -Ribose 1,5-Bis(phosphate) Tetrasodium Salt [113599-17-0] 5g 25g 5g 25g Tetra-O-acetylβ- D -ribofuranose [13035-61-5] β-D -Ribofuranose 1-Acetate 2,3,5-Tribenzoate [6974-32-9] L-Ribose[24259-59-4] R0083 T2607 T2641 お問い合わせください β-D -Ribose 1,5-Bis(phosphate) Tetrasodium Salt 5g 25g 1,2,3-Tri-O-acetyl-5-deoxyβ-D -ribofuranose [62211-93-2] 5g 25g 1,3,5-Tri-O-benzoylα- D -ribofuranose [22224-41-5] Please inquire for pricing and availability of listed products to our local sales representatives. 13 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Magaña, K. Wrobel, Y. Alvarado Caudillo, S. Zaina, G. Lund, K. Wrobel, References Anal. Biochem. 2008, 374, 378; M. Münzel, D. Globisch, T. Brückl, M. 1) H. Vorbrüggen, C. Ruh-Pohlenz, in Handbook of Nucleoside Synthesis, Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell, Wiley-Interscience, New York, 2001; H. Vorbrüggen, C. Ruh-Pohlenz, Angew. Chem. Int. Ed. 2010, 49, 5375. in Organic Reactions, ed. by L. A. Paquette et al., John Wiley & Sons, 3) I. Okamoto, K. Shohda, K. Seio, M. Sekine, J. Org. Chem. 2003, 68, 2000, Vol. 55; D. M. Huryn, M. Okabe, Chem. Rev. 1992, 92 , 1745; E. 9971; A. Misra, S. Mishra, K. Misra, Bioconjugate Chem. 2004, 15, 638.; Ichikawa, K. Kato, Curr. Med. Chem. 2001, 8, 385. R. Gukathasan, M. Massoudipour, I. Gupta, A. Chowdhury, S. Pulst, S. 2) Z. Liu, S. Liu, Z. Xie, W. Blum, D. Perrotti, P. Paschka, R. Klisovic, J. Byrd, K. K. Chan, G. Marcucci, Nucleic Acids Res. 2007, 35, e31; A. Alcázar 14 Ratnam, Y. S. Sanghvi, S. A. Laneman, J. Organomet. Chem. 2005, 690, 2603. Please inquire for pricing and availability of listed products to our local sales representatives. L3014E 20160317