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Nucleosides, Nucleotides, Nucleic Acids
and Related Reagents
Nucleosides and Their Analogs
Genetic information is stored in DNA as combinatorial codes
held in nucleosides and nucleotides, in which form it is passed
from parents to their offspring. Analogs of nucleosides and
nucleotides are used clinically as medicinal agents such as
reverse transcriptase inhibitors. Therefore, the preparation and
development of these species as effective, selective and
nontoxic antiviral and antitumor agents has been the subject
of intense research.1)
In addition to this, the development of Polymerase Chain
Reaction (PCR) methodology has brought a dramatic change
and rapid development in studies of DNA. At the current time
the draft version in decoding and mapping human genome
has been almost completed, and the functional analyses of
genome and analyses of “Single Nucleotide Polymorphism”
(SNP) are being vigorously pursued. Discovery of the RNAi
process has facilitated the fast progression of studies of RNA.
At the same time, chemically synthesized oligoDNA and
oligoRNA have been studied as potential antisense DNAs,
siRNAs and DNA aptamers, as oligonucleotide therapeutic
agents, primers for PCR method, and elements of DNA
computers.
Nucleosides and Their Analogs
A2052
1g 5g
A2073
5g 25g
Nucleosides are glycosylamines made by attaching a
nucleobase to a ribose or 2’-deoxyribose, which can be
phosphorylated producing nucleotides. Nucleoside analogues
are an established class of clinically useful medicinal agents
possessing a wide range of antiviral and anticancer activities.
Consequently, extensive modifications have been made to
both the heterocyclic base and the sugar moiety. Some
representative examples of these are 9-[(2-hydroxyethoxy)
methyl]guanine (acyclovir) developed by Elion in 1977, which
shows antiviral activity; 3'-azido-3'-deoxythymidine (AZT)
discovered by Mitsuya et al. in 1985 and used for the treatment
of HIV infection; and cytosine β-D-arabinofuranoside
(cytarabine) approved by the FDA in 1969 and which has been
shown to display a range anticancer activities. In addition,
modified nucleosides such as 2’-deoxy-5-methylcytidine are
ubiquitous in living systems, and their functions have received
due attention from the scientific community.2)
Protected nucleosides, in which reactive amino and hydroxyl
groups have been masked, e.g. N6-benzoyl-5'-O-(4,4'dimethoxytrityl)-2'-deoxyadenosine (Bz-DMT-dA), have been
used for chemical synthesis of DNA and RNA.
A055910mg
A2033
6-Azauridine[54-25-1]
5-Azacytidine[320-67-2]
A2356
1g 5g
A24311g
100mg 1g
Pyrimidine
Nucleosides
A2232
20mg 100mg
NH2
N
HO
O
N
N
O
Azidothymidine
[30516-87-1]
1-(3,5-Anhydro-2-deoxyβ-D -threo-pentofuranosyl)thymine[7481-90-5]
5-Aza-2'-deoxycytidine
[2353-33-5]
1-β- D -Arabinofuranosyluracil[3083-77-0]
2,2'-O-Anhydro5-methyluridine
[22423-26-3]
A252850mg
A2942
B0666
B1575
B3087
25mg 100mg
O
N
HO
NH2
O
OH
Acadesine
2
100mg 1g
1g 5g
1g 5g
O
C NH2
N
OH
HN
HO
O
N
O
OH
OH
[2627-69-2]
4
N3
2'-Azido-2'-deoxyuridine
[26929-65-7]
5-Bromouridine[957-75-5]
5-Bromo-2'-deoxyuridine
[59-14-3]
Please inquire for pricing and availability of listed products to our local sales representatives.
N -Benzoyl-5'-O(4,4'-dimethoxytrityl)-2'deoxycytidine[67219-55-0]
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
B3094
1g 5g
B3102
100mg 1g
B3404
100mg 1g
B3631
1g 5g
C0522
1g 5g 25g
4
4
N -Benzoyl-2'-deoxycytidine
[4836-13-9]
C0525
C20355g
100mg 1g
Brivudine[69304-47-8]
N -Benzoyl-3',5'-O-(1,1,3,3tetraisopropyl-1,3-disiloxanediyl)cytidine
[69304-43-4]
Cytidine[65-46-3]
C2207
C2208
C2878
4
N -Benzoylcytidine
[13089-48-0]
1g 5g
5g 25g
1g 5g
O
NH C O(CH2)4CH3
F
N
H3C O
N
O
OH
OH
Cytidine Sulfate
[32747-18-5]
Cytarabine[147-94-4]
2,2'-O-Cyclocytidine
Hydrochloride[10212-25-6]
2,2'-O-Cyclouridine
[3736-77-4]
Capecitabine[154361-50-9]
D0048
D0060
1g 5g 25g
D2235 100mg 500mg 1g
D3566
D3579
2'-Deoxycytidine
Hydrochloride[3992-42-5]
2'-Deoxyuridine [951-78-0]
2'-Deoxy-5-fluorouridine
[50-91-9]
5'-O-(4,4'-Dimethoxytrityl)thymidine[40615-39-2]
5'-Deoxy-5-fluorouridine
[3094-09-5]
D3580
D3583
1g 5g
D3610 100mg 500mg 5g
D36141g
D3615
[3056-17-5]
2'-Deoxycytidine
[951-77-9]
2'-Deoxy-5-methylcytidine
[838-07-3]
2'-Deoxy-2'-fluorocytidine
Hydrate[10212-20-1]
2'-Deoxy-2'-fluorouridine
[784-71-4]
1g 5g
D420010mg
D4220
D4342
D4823
5g 25g
1g 5g
Stavudine
D3642
50mg 200mg
O
O
F
O
2'-Deoxy-5-fluorocytidine
[10356-76-0]
E1057
50mg 200mg
I
HO
O
CH2OH
N
N
HO
OH
N
H3C O
N
O
1g 5g
200mg 1g
O
F
N
HN
HO
O
O
OH
OH
OH
O
H3C
O
OH
N
F
Fialuridine[69123-98-4]
2'-Deoxy-5-(hydroxymethyl)cytidine
[7226-77-9]
5'-Deoxy-5-fluorocytidine
[66335-38-4]
(2'R)-2'-Deoxy-2'-fluoro-2'methyluridine[863329-66-2]
E1093
F05341g
F0635
F0636
50mg 200mg
O
5g 25g
1g 5g
NH2
C CH
HN
1g 5g
1g 5g
NH2
NH2
HN
HO
5g 25g
N
C CH
N
HO
N
O
O
O
OH
OH
5-Ethynyl-2'-deoxyuridine
[61135-33-9]
5-Ethynyl-2'-deoxycytidine
[69075-47-4]
5-Fluorocytidine
[2341-22-2]
Tegafur
G0367
I0258
I08821g
L0217
100mg 1g
1g 5g 25g
[17902-23-7]
100mg 1g
5-Fluorouridine[316-46-1]
M1405
1g 5g 25g
NH2
I
N
HO
N
O
O
OH
Gemcitabine Hydrochloride
[122111-03-9]
Idoxuridine
M19311g
M2290
[54-42-2]
1g 5g
5-Iodo-2'-deoxycytidine
[611-53-0]
Lamivudine [134678-17-4]
5-Methyluridine
[1463-10-1]
M2317
M2399
R0077
200mg 1g
O
HN
HO
O
N
OH
HO
O
OCH3
2'-O-Methyluridine
[2140-76-3]
OH
C NH2
N
N
O
100mg 500mg
O
N
O
5-Methylcytidine
[2140-61-6]
50mg 250mg
NH2
N
HO
OH
O
OCH3
2'-O-Methylcytidine
[2140-72-9]
OH
OH
Mizoribine [50924-49-7]
Please inquire for pricing and availability of listed products to our local sales representatives.
Ribavirin[36791-04-5]
3
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
T0233
1g 5g 25g
T2511
100mg 1g
T2549
5g 25g
U0020
5g 25g
Z0022
200mg 1g
N
HO
N
O
O
OH
Thymidine[50-89-5]
OH
Trifluorothymidine
[70-00-8]
2',3',5'-Tri-O-acetyluridine
[4105-38-8]
Uridine[58-96-8]
Zebularine[3690-10-6]
A0152
A1915
A2054
A2135
5g 25g 100g
1g 5g 25g
1g 5g
5g 25g
Purine
Nucleosides
A2414
100mg 1g
Adenosine[58-61-7]
Acyclovir[59277-89-3]
2-Amino-6-chloropurine
Riboside
[2004-07-1]
2-Aminoadenosine
[2096-10-8]
A2739
B3093
B3101
B3103
10mg 50mg
1g 5g
100mg 1g
100mg 1g
O
NH
N
HO
HO
O
N
N
NH2
6
. xH2O
OH
N -Benzoyladenosine
[4546-55-8]
N -Benzoyl-2'deoxyadenosine Hydrate
[206752-42-3]
N -Benzoyl-5'-O(4,4'-dimethoxytrityl)2'-deoxyadenosine
[64325-78-6]
B4002
C2192
C2206
6
Adefovir Dipivoxil
[142340-99-6]
9-β- D Arabinofuranosylguanine
Hydrate
[38819-10-2]
Hydrate
B3460
B4001
100mg 1g
200mg 1g
6
1g 5g
N
HO
Br
N
NH2
HO
Br
N
N
NH2
O
O
6
1g 5g
NH
N
NH
N
100mg 1g
O
O
. xH2O
N -Dibenzoyladenosine
2',3'-Dibenzoate
[58463-04-0]
8-Bromo-2'-deoxyguanosine
[13389-03-2]
Hydrate
8-Bromoguanosine
[4016-63-1]
2-Chloroadenosine Hydrate
[146-77-0]
6-Chloropurine Riboside
[5399-87-1]
C249950mg
C2500
C268925mg
C281525mg
D0046
OH
20mg 100mg
OH
OH
NH2
NH2
N
N
N
N
N
HO
N
N
HO
Cl
N
N
N
O
. xH2O
OH
OH
OH
N
N
HO
O
O
5g 25g
NH2
[4291-63-8]
Clofarabine[123318-82-1]
Cordycepin from Cordyceps
militaris
[73-03-0]
Cordycepin Hydrate [73-03-0]
Monohydrate[16373-93-6]
1g 5g 25g
D3065100mg
D3066
D3584
1g 5g
D41375g
2'-Deoxyguanosine Hydrate
[961-07-9]
2',3'-Dideoxyadenosine
[4097-22-7]
Didanosine[69655-05-6]
2'-Deoxyinosine[890-38-0]
2'-Deoxyadenosine
Anhydrous[958-09-8]
D422825mg
D4256
D4292
E0899
F0656
Cladribine
D0052
O
CH3
N
N
O
N
N
CH3
Cl
N
N
O
CH2CH2OCH2 P
O
50mg 200mg
200mg 1g
O
N
N
O
O P O
ONa
100mg 1g
NH2
HN
N
1g 5g
100mg 500mg
2'-Deoxyadenosine
N
HO
OCH2CH3
Cl
HN
H2N
N
N
O
N
. H2O
CH2
OCH2CH3
Dibutyryl cAMP Sodium
Salt[16980-89-5]
Diethyl [[2-(6-Amino-9Hpurin-9-yl)ethoxy]methyl]phosphonate[116384-53-3]
5,6-Dichlorobenzimidazole
1-β-D -Ribofuranoside[53-85-0]
Entecavir Monohydrate
[209216-23-9]
2-Fluoroadenosine
[146-78-1]
F0842
G0171
G0315
H1290
H1291
O
500mg 5g
5g 25g 100g
OH
OH
5g 25g
HO
CH2OH
5g 25g
O
N
H2N
N
N
CH2CH2CH
NH2
HN
N
O
H2N
CH2O C CH3
CH2O C CH3
N
N
. xH2O
N
N
4
Guanosine[118-00-3]
CH2OH
CH2OCH CH OH
2
Ganciclovir Hydrate
[82410-32-0]
N
N
N
CH3
O
Famciclovir[104227-87-4]
1g 5g
9-(2-Hydroxyethyl)adenine[707-99-3]
Please inquire for pricing and availability of listed products to our local sales representatives.
OH
(R)-9-(2-Hydroxypropyl)adenine[14047-28-0]
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
I0037
25g 500g
I0697
[58-63-9]
N -Isobutyryl-5'O-(4,4'-dimethoxytrityl)-2'deoxyguanosine[68892-41-1]
N -Isobutyrylguanosine
Monohydrate[64350-24-9]
N -Isobutyryl-2'-deoxyguanosine[68892-42-2]
2',3'-O-Isopropylideneadenosine[362-75-4]
I07035g
I07045g
I0759
M22911g
M2318
1g 5g
I0699
100mg 1g
I0700
100mg 1g
I0702
5g 25g
2
Inosine
2
200mg 1g 5g
2
200mg 1g
O
NH2
N
N
N
N
HO
N
NH2
O
O
OH
NH
N
HO
N
OH
OCH3
OCH3
. xH2O
2',3'-O-Isopropylideneguanosine[362-76-5]
2',3'-O-Isopropylideneinosine
[2140-11-6]
2-Iodoadenosine
[35109-88-7]
2'-O-Methyladenosine
[2140-79-6]
Hydrate[2140-71-8]
O0401
P2164
P2311
T26901g
T2691
2',3',5'-Tri-O-acetyl-2-amino6-chloropurine Riboside
[16321-99-6]
2',3',5'-Tri-O-acetyl6-chloro-2-iodopurine
[5987-76-8]
Riboside
X0008
200mg 1g
HN
HO
O
N
N
N
N
N
N
CH2OH
CH3O
CH2OH
OH
N
O
NH2
NH
O
OH
. 2HCl
8-Oxoadenosine
[29851-57-8]
Penciclovir[39809-25-1]
Puromycin
Dihydrochloride[58-58-2]
T2692
V0098
V0111
1g 5g
2',3',5'-Tri-O-acetylguanosine
[6979-94-8]
1g 5g
Vidarabine Monohydrate
[24356-66-9]
1g 5g
CH3
N
N
HO
N
CH2CH2CH
O
OH
25mg 100mg
CH3
HN
H2N
N
200mg 1g
O
NH2
2'-O-Methylguanosine
100mg 1g
Valacyclovir Hydrochloride
Hydrate
[124832-27-5]
100mg
Xanthosine Dihydrate
[146-80-5]
Nucleotides and Their Analogs
Nucleotides are formed from the condensation of nucleoside
which is either ribose (RNA) or 2’-deoxyribose (DNA).
and a phosphate group. The nucleosides themselves are
Nucleotides are the minimum structural units of DNA and RNA,
formed from a nucleobase (see below) and a sugar moiety
and serve as important cofactors in metabolism.
C0523
Nucleotides and Their Analogs
Pyrimidine
Nucleotides
10mg 100mg 1g
C0524
1g 5g
Cytidine 5'-Diphosphate
Trisodium Salt Hydrate
[34393-59-4]
Cytidine 5'-Monophosphate
Disodium Salt Hydrate
[6757-06-8]
C16755g
D3673
100mg 1g
T0845100mg
U0021
5g 25g
U0022100mg
Cytidine
5'-Monophosphate
[63-37-6]
2'-Deoxycytidine
5'-Monophosphate Hydrate
[1032-65-1]
Thymidine 5'-Monophosphate
Disodium Salt Hydrate
[33430-62-5]
Uridine 5'-Monophosphate
Disodium Salt Hydrate
[3387-36-8]
Uridine 5'-Triphosphate
Trisodium Salt Hydrate
[19817-92-6]
Please inquire for pricing and availability of listed products to our local sales representatives.
5
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
A0157
Purine
Nucleotides
A2381
1g 5g
1g 5g 25g
Adenosine 5'-Triphosphate
Disodium Salt Hydrate
[34369-07-8]
F0913
25mg 100mg
A0158
1g 5g 25g
A0626
100mg 1g
A2112
100mg 1g
5'-Adenylic Acid [61-19-8]
Adenosine 5'-Diphosphate
Disodium Salt Hydrate
[16178-48-6]
Adenosine 3',5'-Cyclic
Monophosphate Sodium
Salt Hydrate[37839-81-9]
G0172
G0173
I0036
25g 100g
1g 5g
1g 5g 25g
NH2
N
N
O
HO P O
HO
O
OH
N
N
F
Adenosine 3',5'-Cyclic
Monophosphate Hydrate
[60-92-4]
Fludarabine Monophosphate
[75607-67-9]
I0038100mg
I0039100mg
Inosine 5'-Triphosphate
Trisodium Salt Hydrate
[35908-31-7]
Inosine 5'-Monophosphate
Barium Salt Hydrate
[3249-92-1]
OH
Nucleic Acids
Guanosine 5'-Monophosphate
Disodium Salt Hydrate
[5550-12-9]
R002225g
Deoxyribonucleic Acid
Ribonucleic Acid
not highly polymerized from
Herring sperm [9007-49-2]
D3545
5g 25g
R002425g
Ribonucleic Acid Sodium
Salt from Yeast
D1140100mg
P0251100mg
Bovine Spleen
[9003-98-9]
D0920
100mg 1g 5g
β-NADH Disodium Salt
Hydrate, reduced form
[606-68-8]
T2980100mg
T2979100mg
β-NADPH Tetrasodium
Salt reduced form
[2646-71-1]
Thionicotinamide Adenine
Dinucleotide Disodium
Salt reduced form
Thionicotinamide Adenine
Dinucleotide oxidized form
[4090-29-3]
Nucleobases and Their Analogs
Nucleobases, usually simply called “bases”, are a vital sense
component of DNA and RNA. The bases can be divided into
two groups based on the structure: purines such as adenine
and guanine; and pyrimidines such as cytosine, thymine and
uracil. Other nucleobases can be created by the modification
Inosine 5'-Monophosphate
Disodium Salt Hydrate
[4691-65-0]
from Yeast
Deoxyribonucleic Acid
Sodium Salt from
Salmon Milt
[9007-49-2]
T0521100mg
6
(2'-,3'- mixture)
from Yeast[5550-12-9]
D005425g
Deoxyribonuclease from
Enzymes and Coenzymes
related to Nucleic Acids
Guanylic Acid Sodium Salt
Phosphatase, Acid from
C0379
100mg 1g
β-NADP Sodium Salt
Wheat Germ
[9001-77-8]
Hydrate, oxidized form
[1184-16-3]
N0943100mg
D0919
β-NADP
β-NAD Hydrate, oxidized
form
[53-84-9]
[53-59-8]
1g 5g
of these basic structures. For example, hypoxanthine and
xanthine are generated in living systems through deamination
of adenine and guanine, respectively. Furthermore, nucleobase
analogue 5-fluorouracil (5-FU) is used as an anticancer agent.
Derivatives of 2-fluoroadenine have been widely reported as
prodrug forms of anticancer agents.
Please inquire for pricing and availability of listed products to our local sales representatives.
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
A2089
5g 25g
A2670
1g 5g
O
Pyrimidine
Nucleobases and Their Analogs
Nucleobases
CH3
O
C
NH
N
H
O
4
A2136
1g 5g
A21255g
A2449
5g 25g
N -Acetylcytosine
[14631-20-0]
5-Acetyluracil[6214-65-9]
A094725g
A0898
5g 25g
O
O
H2N
NH
H2N
N
NH
O
O
N
H
CH3
4-Amino-6-chloropyrimidine
[5305-59-9]
4-Amino-5-fluoro2-methoxypyrimidine
[1993-63-1]
6-Amino-1-methyluracil
[2434-53-9]
5-Aminoorotic Acid
[7164-43-4]
5-Aminouracil[932-52-5]
A0658
A0558
B31695g
B066525g
C1057
25g 250g
1g 5g
5g 25g
O
O
NH
NH
H2N
N
H
ClCH2
O
4
6-Aminouracil[873-83-6]
6-Azauracil[461-89-2]
N -Benzoylcytosine
[26661-13-2]
5-Bromouracil
C2300
C0969
C2093
C0528
5g 25g
5g 25g
5g 25g
[51-20-7]
5g 25g 100g
N
H
O
6-Chloromethyluracil
[18592-13-7]
D1136
1g 5g
O
CH3
NH
CH3
6-Chloro-3-methyluracil
[4318-56-3]
5-Chlorouracil[1820-81-1]
6-Chlorouracil[4270-27-3]
Cytosine
D09485g
E0807
E1096
F0321
1g 5g
200mg 1g
[71-30-7]
1g 5g 25g
N
H
O
5,6-Dimethyluracil
[26305-13-5]
F0382
100mg 1g
O
S
HC C
NH
N
H
NH
N
H
S
O
2,4-Dithiopyrimidine
[2001-93-6]
5-Ethyluracil [4212-49-1]
5-Ethynyluracil
[59989-18-3]
5-Fluorocytosine
[2022-85-7]
Monohydrate[703-95-7]
F0151
I0531
I0219
I08145g
M0204
5g 25g
1g 5g
5g 25g
5-Fluoroorotic Acid
100mg 1g 5g
O
N
5-Fluorouracil
[51-21-8]
M2506
1g 5g
5-Iodo2,4-dimethoxypyrimidine
[52522-99-3]
5-Iodouracil
M2355
M0994
O
O2N
CH3
N
H
1g 5g
Isocytosine
[108-53-2]
5-Methylcytosine
Hydrochloride[58366-64-6]
M0443
25g 500g
M0454
[696-07-1]
10g 25g
N
H
N
O
NH
NH
N
O
25g 500g
O
OH
NH
NH2
CH3
SCH3
N
H
N
H
CH3
S
O
6-Methyl-5-nitrouracil
[16632-21-6]
2-Methylthio-4-pyrimidinol
[5751-20-2]
5-Methyl-2-thiouracil
[636-26-0]
6-Methyl-2-thiouracil
[56-04-2]
6-Methyluracil [626-48-2]
N0281
O0065
P0236
P053325g
T0224
5g 25g
25g 100g 500g
1g 5g
O
O2N
N
H
5-Nitrouracil
O
O
NH
NH
NH
O
[611-08-5]
25g 250g
CH3CH2CH2
Orotic Acid Monohydrate
[50887-69-9]
6-Phenyl-2-thiouracil
[36822-11-4]
N
H
S
6-Propyl-2-thiouracil
[51-52-5]
Please inquire for pricing and availability of listed products to our local sales representatives.
N
H
2-Thiouracil
S
[141-90-2]
7
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
T27571g
T0234
5g 25g 100g
T1622
1g 5g
U0013
25g 100g 500g
Purine
Nucleobases
4-Thiouracil[591-28-6]
Thymine[65-71-4]
5-(Trifluoromethyl)uracil
[54-20-6]
Uracil[66-22-8]
A0149
A0150
A0151
25g 100g
A05551g
A06251g
25g 250g
5g 25g
Adenine[73-24-5]
Adenine Hydrochloride
Hemihydrate [2922-28-3]
Adenine Sulfate Dihydrate
[6509-19-9]
8-Azahypoxanthine
[2683-90-1]
8-Azaguanine[134-58-7]
A0907
A1041
A1111
A1248
A1407
25g 250g
100mg 1g 5g
200mg 1g
1g 5g
1g 5g
NH2
N
N
N
H
N
Allopurinol[315-30-0]
4-Aminopyrazolo
[3,4-d]pyrimidine[2380-63-4]
2-Aminopurine[452-06-2]
2-Acetamido-6hydroxypurine[19962-37-9]
2-Amino-6-chloropurine
[10310-21-1]
A2068
A2069
A2699100mg
A2805
B1088
5g 25g
5g 25g
NH2
N
H
N
N
N
O
N
CH3
H2N
NH2
N
H
2
6
2-Amino-6-iodopurine
[19690-23-4]
Azathioprine [446-86-6]
AHPP
B3344
B3355
B3456
5g 25g
N
H
5g 25g
O
CH3
N
O
25g 100g
5g 25g
[5472-41-3]
Aminophylline [317-34-0]
N -Benzyladenine
[1214-39-7]
1g 5g
B41341g
B4454
O
O
HN
HN
N
N
O
200mg 1g
N
H
Br
N
N
O
N
CH2 C C CH3
Br
CH3
N -Benzoyladenine
[4005-49-6]
6-Benzyloxypurine
[57500-07-9]
8-Bromotheophylline
[10381-75-6]
8-Bromo-3-methylxanthine[93703-24-3]
8-Bromo-7-(2-butyn-1-yl)3-methylxanthine
[666816-98-4]
C0278
C0293
25g 250g
C22211g
C2306
C2575
6-Chloropurine[87-42-3]
8-Chlorotheophylline
[85-18-7]
6-Chloro-2-fluoropurine
[1651-29-2]
6-Chloro-7-deazapurine
[3680-69-1]
2-Chloroadenine
[1839-18-5]
C2845200mg1g
C3130
D1625
D2470
1g 5g 25g
D360425g
6
5g 25g
1g 5g
5g 25g
CH3
1g 5g
1g 5g
Cl
N
Cl
N
N
I
N
N
N
O
N
H
2
6-Chloro-9-(tetrahydropyran2-yl)purine
[7306-68-5]
6-Chloro-7-iodo-7deazapurine [123148-78-7]
2,6-Diaminopurine Hydrate
[1904-98-9]
2,6-Dichloropurine
[5451-40-1]
N ,9-Diacetylguanine
[3056-33-5]
D3894
D4284
D4295
D43241g
F0647
1g 5g
1g 5g
1g 5g
Cl
O
Cl
N
Cl
6-(Dimethylamino)purine
[938-55-6]
8
N
200mg 1g
N
H
2,6-Dichloro-7deazapurine[90213-66-4]
Cl
N
. HCl
N
H
5,6-Dichlorobenzimidazole
Hydrochloride[1087737-96-9]
HN
N
N
H
7-Deazahypoxanthine
[3680-71-5]
Please inquire for pricing and availability of listed products to our local sales representatives.
2-Fluoroadenine
[700-49-2]
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
G0168
1g 25g
G0169
Guanine Sulfate Dihydrate
[10333-92-3]
Guanine
I0370100mg
I0941
1g 25g 250g
G017025g
H0311
[73-40-5]
Guanine Hydrochloride
Hydrate
[635-39-2]
Hypoxanthine [68-94-0]
9-(2-Hydroxyethyl)adenine
[707-99-3]
K0009
M0063
M1925
1g 5g
1g 5g
5g 25g
1g 5g
H1290
5g 25g
1g 5g
NH2
I
N
N
Isoguanine
M2073
[3373-53-3]
5g 25g
N
H
N
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
[151266-23-8]
Kinetin[525-79-1]
6-Mercaptopurine
Monohydrate[6112-76-1]
6-Methoxypurine
[1074-89-1]
M2432
M2518
N0958
T0212
50mg 200mg
O
CH3
O
NH2
N
N
N
H
200mg 1g
N
N
N
1-Methylxanthine
[6136-37-4]
H2N
T0225
1g 5g
X000425g
2-Thioxanthine
[2487-40-3]
Xanthine[69-89-6]
3-Methyladenine
[5142-23-4]
Pharmacologically-Active Nucleosides and Nucleobases
for Research and Experimental Use
N
CH3
3-Methylxanthine
[1076-22-8]
1g 5g
OCH2
N
N
H
20mg 100mg
NU 2058
N
N
N
H
[161058-83-9]
6-Thioguanine[154-42-7]
research are shown below., and serve as important cofactors in
metabolism.
Typical nucleosides and nucleobases used in pharmacology
Pharmacologically-Active
Nucleosides and Nucleobases
for Research and
Experimental Use
A2052
1g 5g
A2069
5g 25g
A0907
25g 250g
A1915
1g 5g 25g
A2033
100mg 1g
Allopurinol[315-30-0]
Acyclovir[59277-89-3]
5-Azacytidine[320-67-2]
A2232
A2414
A252850mg
20mg 100mg
100mg 1g
O
NH2
N
HO
O
N
N
OH
Azathioprine[446-86-6]
Decitabine[2353-33-5]
N
HO
O
Azidothymidine
[30516-87-1]
C NH2
N
NH2
O
Adefovir Dipivoxil
[142340-99-6]
Please inquire for pricing and availability of listed products to our local sales representatives.
OH
Acadesine
OH
[2627-69-2]
9
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
A2694
1g 5g
A2699100mg
A2737
200mg 1g
A2739
10mg 50mg
NH2
NH2
NH
N
N
H2N
N
N
N
N
H
O
N
N
HO
Abacavir[136470-78-5]
AHPP[5472-41-3]
4-Amino1-phenylpyrazolo
[3,4-d]-pyrimidine[5334-30-5]
B1575
B3404
C20355g
HO
1g 5g
HO
O
N
N
H
100mg 1g
25g 100g
O
NH
N
N
N
A2805
O
N
N
CH3
NH2
O
. xH2O
OH
N
N
H2N
NH2
N
H
N
CH3
2
Ara-G Hydrate [38819-10-2]
Aminophylline [317-34-0]
C2042
C249950mg
25g 500g
NH2
O
CH3
N
O
N
Brivudine[69304-47-8]
Cytarabine
C2500
C268925mg
C281525mg
[147-94-4]
NH2
N
N
HO
N
N
N
O
N
O
. xH2O
D2235 100mg 500mg 1g
1g 5g
O
NH C O(CH2)4CH3
N
N
N
O
F
N
CH2CH2Cl
H3C O
N
O
N
CH3
OH
OH
Clofarabine [123318-82-1]
CH3
[4291-63-8]
C2878
O
N
HO
Cordycepin from Cordyceps
militaris
[73-03-0]
5g 25g
OH
Cladribine
NH2
N
Cl
O
[58-08-2]
C2748
N
N
HO
N
Caffeine
N
N
CH3
CH3
5-Bromo-2'-deoxyuridine
[59-14-3]
20mg 100mg
N
OH
OH
Cordycepin Hydrate [73-03-0]
7-(2-Chloroethyl)theophylline [5878-61-5]
Capecitabine[154361-50-9]
D3065100mg
D3066
D3579
D3580
2'-Deoxy-5-fluorouridine
[50-91-9]
2',3'-Dideoxyadenosine
[4097-22-7]
Didanosine[69655-05-6]
Doxifluridine[3094-09-5]
Stavudine
D3600
D422825mg
D4292
D4302
D4342
25g 500g
100mg 500mg
100mg 1g
1g 5g
1g 25g
1g 5g
[3056-17-5]
1g 5g
O
CH3
HN
OH
O
N
N
NH2
N
CH2 CH CH2OH
N
O
CH3
N
HO
N
O
O
N
N
O P O
ONa
CH3
O
D4823
E0899
F0151
50mg 200mg
OH
N
HN
H3C
O
5g 25g
N
N
N
H2N
HO
CH2OH
5-Fluorouracil
F0636
F0842
F0913
1g 5g
500mg 5g
N
H2N
[51-21-8]
25mg 100mg
F0321
F0635
N
O
N
CH2O C CH3
CH2O C CH3
HO P O
HO
O
OH
O
N
N
OH
5-Fluorouridine[316-46-1]
Famciclovir[104227-87-4]
H0402
H1430
H1542
25g 500g
5g 25g
1g 5g
O
H 2N
CH3
10
5g 25g
5-Fluorocytosine
[2022-85-7]
Tegafur
[17902-23-7]
G0315
G0367
100mg 1g
O
N
CH3
OH
N
N
CH2 CH CH3
CH3CH3
O
CH3
O
N
CH3
H
O
N
CH2CH2OH
[519-37-9]
N
CH3 CH3
NH
. xH2O
N
CH2OH
CH2OCH CH OH
2
Ganciclovir Hydrate
[82410-32-0]
Gemcitabine Hydrochloride
[122111-03-9]
I0258
K0009
1g 5g 25g
1g 5g
O
N
NH2
CH3
O
CH3
CH3
O
NH2
O CH3
O
CH3
O P O HO N
CH3
O
HO
Proxyphylline[603-00-9]
N
H 2N
N
CH3
N
N
N
Co
N
O
H2N
O
NH2
H 2N
5g 25g
HN
F
Fludarabine Monophosphate
[75607-67-9]
Etofylline
1g 5g 25g
O
N
N
O
N
CH2CH2CH
O
OH
Doxofylline [69975-86-6]
NH2
N
OH
5'-Deoxy-5-fluorocytidine
[66335-38-4]
. H2O
PSI-6206[863329-66-2]
CH3
N
O
CH2
F
N
H3C O
O
N
CH3
[53-85-0]
Entecavir Monohydrate
[209216-23-9]
O
O
O
HN
O
N
N
O
F
N
N
OH
OH
DRB
HO
Cl
CH3
O
Diprophylline[479-18-5]
O
CH3
O
Dibutyryl cAMP Sodium
Salt
[16980-89-5]
200mg 1g
O
Cl
N
N
O
Hydroxocobalamin
Acetate[22465-48-1]
Idoxuridine
[54-42-2]
Please inquire for pricing and availability of listed products to our local sales representatives.
Kinetin[525-79-1]
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
L0217
100mg 1g
M0063
1g 5g
M2399
50mg 250mg
M27421g
N
HO
H2N
C NH2
N
O
CH3
H2N
CH3
O H
CH3CH3
OH
O
CH3
OH
CH3 CH3
NH
N
O
O P O HON
O
O
HO
OCH2
O
NH2
CH3
CH3
N
NH2
O CH3
H2N
CH3
. xH2O
Lamivudine [134678-17-4]
6-Mercaptopurine
Monohydrate[6112-76-1]
Mizoribine [50924-49-7]
Methylcobalamin Hydrate
[288315-09-3]
NU 2058
P2164
P2311
R0077
T0179
T0212
200mg 1g
25mg 100mg
O
CH3
HN
H2N
N
N
N
N
CH2CH2CH
CH2OH
CH3O
CH2OH
100mg 500mg
25g 100g 500g
N
N
N
H
[161058-83-9]
1g 5g
CH3
N
N
N
HO
20mg 100mg
O
NH2
N CH3 N
Co
N
N
H2 N
O
OH
N0958
O
O
N
O
NH2
NH
O
OH
. 2HCl
Penciclovir[39809-25-1]
Puromycin
Dihydrochloride[58-58-2]
Ribavirin[36791-04-5]
Theophylline[58-55-9]
6-Thioguanine[154-42-7]
T2511
T2744
T294125g
V0098
V0111
100mg 1g
500mg 5g
O
CH3
N
100mg 1g
O
N
N
O
1g 5g
CH2 C OH
N
CH3
Trifluorothymidine
[70-00-8]
Temozolomide[85622-93-1]
Theophylline-7-acetic
Acid[652-37-9]
Nucleic Acid Synthesis Agents
Silylation converts insoluble nucleobases into lipophilic
trimethylsilyled derivatives, which are readily soluble in organic
solvents, permitting homogenous chemical reactions. The
trimethylsilylated nucleobases react with protected sugars to
afford nucleosides. The procedure is commonly referred to as
the Hilbert-Johnson reaction modified by Vorbrüggen et al.
Phosphorylating and phosphorothioating agents, condensing
agents and protecting agents for hydroxy and amino groups are of
importance in the synthesis of DNA and RNA chains. Active research
on chemical synthesis of DNA and RNA is being conducted, and a
variety of synthetic methods using these agents are being developed.
Nucleic Acid Synthesis Agents
B0105
25mL 500mL
Benzoyl Chloride
[98-88-4]
B0511
10mL 100mL
BSA[10416-59-8]
TBSCl
Valacyclovir Hydrochloride
Hydrate
[124832-27-5]
The dicyclohexylcarbodiimide (DCC) method exemplified by the
Khorana group, the phosphotriester method and phosphitetriester
method by the team of Letsinger and the phosphoramidite method
by the Caruthers group are examples of the various synthetic
methods. Recently, the phosphoramidite method has been used
frequently in tandem with the penetration of DNA synthesizers, thus
2-cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite has been
the reagent of frequent choice for the phosphitylation due to its ease
in handling and safety.3) 1,2,4-Triazole and 1H-tetrazole are also used
for chemical conversion of uridines into cytidines.
Chemically synthesized DNA is becoming important as a
primer for the PCR method, an antisense molecule, or an
element of the DNA computer.
Protecting
Agents for
Hydroxy and
Amino Groups
B0995
Vidarabine Monohydrate
[24356-66-9]
A0082
100g 500g
B0078
25g 100g 500g
Acetyl Chloride [75-36-5]
Benzoic Anhydride
[93-97-0]
5g 25g 100g
B11515g
B1223
[18162-48-6]
1,3-Benzodithiolylium
Tetrafluoroborate
[57842-27-0]
tert-Butyldiphenylchlorosilane[58479-61-1]
Please inquire for pricing and availability of listed products to our local sales representatives.
5mL 25mL 100mL
11
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
C0306
25mL 100mL 500mL
C0308
25g 100g 500g
C0832
25g 100g 500g
D1293
25mL 100mL 500mL
D1608
5g 25g
[76-83-5]
4-Chlorophenoxyacetyl
Chloride[4122-68-3]
N,N-Dimethylformamide
Dimethyl Acetal[4637-24-5]
1,3-Dichloro-1,1,3,3tetraisopropyldisiloxane
[69304-37-6]
5g 25g
D24695g
D250425g
D3135
4,4'-Dimethoxytrityl Chloride
[40615-36-9]
1,3-Dichloro-1,1,3,3tetramethyldisiloxane
[2401-73-2]
Di-tert-butyldichlorosilane
[18395-90-9]
2-Chlorotrityl Chloride
[42074-68-0]
Di-tert-butylsilyl
Bis(trifluoromethanesulfonate)
[85272-31-7]
H0089 25mL 100mL 500mL
I0115
M0721
M0790
N0404
HMDS
[999-97-3]
Isobutyryl Chloride
[79-30-1]
4-Methoxybenzoyl Chloride
[100-07-2]
4-Methoxytrityl Chloride
[14470-28-1]
2-Nitrobenzyl Bromide
[3958-60-9]
P0113
25g 500g
P0677
T0459
T0512
T0871
Chlorotrimethylsilane
[75-77-4]
Trityl Chloride
D1612
D2334
5g 25g
25g 100g 500g
25mL 500mL
Phenoxyacetyl Chloride
[701-99-5]
Pivaloyl Chloride
[3282-30-2]
T1071
T15261g
5g 25g
4,4',4''-Tris(benzoyloxy)trityl
Bromide[86610-66-4]
4,4',4''-Tris(4,5-dichlorophthalimido)trityl Bromide
[91898-93-0]
C0976
C0977
5g 25g
5g 25g
25g 100g 500g
25g 500g
2,4,6-Triisopropylbenzenesulfonyl Chloride [6553-96-4]
Phosphorylating
and
Phosphorothioating
Agents
C0978
5g 25g
25g 250g
25g 100g
1g 5g
5g 25g
5g 25g 250g
Trityl Bromide [596-43-0]
Trimethylsilyl
Trifluoromethanesulfonate
[27607-77-8]
B3125
B3623
1g 5g
5g 25g
O
S
S
O
3H-1,2-Benzodithiol-3-one
1,1-Dioxide[66304-01-6]
Bis(phenylacetyl) Disulfide
[15088-78-5]
C1210
5g 25g
C121525g
2-Chlorophenyl
Phosphorodichloridate
[15074-54-1]
4-Chlorophenyl
Phosphorodichloridate
[772-79-2]
Barium 2-Cyanoethylphosphate
Hydrate
[5015-38-3]
2-Chloro-4H-1,3,2benzodioxaphosphorin4-one[5381-99-7]
2-Chloro-1,3,2-dioxaphospholane[822-39-9]
C1250
C2228
D0624
25g 500g
D076425g
D1059
5g 25g
1g 5g
25g 100g 500g
2-Chloro-2-oxo1,3,2-dioxaphospholane
[6609-64-9]
2-Cyanoethyl N,N,N',N'Tetraisopropylphosphordiamidite
[102691-36-1]
Diethyl
Chlorothiophosphate
[2524-04-1]
Dimethyl
Chlorothiophosphate
[2524-03-0]
Diphenyl Chlorophosphate
[2524-64-3]
D26245g
D288325g
D4211
D42521g
M0904
1g 5g
CH3
CH3
(CH3)3CO
Dibenzyl N,N-Diisopropylphosphoramidite
[108549-23-1]
12
Diphosphoryl Chloride
[13498-14-1]
N
P
5g 25g 100g
CH3
CH3
CH3
OC(CH3)3
(CH3)3CO
Di-tert-butyl N,NDiisopropylphosphoramidite
[137348-86-8]
N
P
CH3
OC(CH3)3
Di-tert-butyl N,NDiethylphosphoramidite
[117924-33-1]
Please inquire for pricing and availability of listed products to our local sales representatives.
Methyl
Phosphorodichloridate
[677-24-7]
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
M090510g
P0209
25g 500g
P12231g
B302025g
Condensing
Agents
Methyl
Dichlorophosphite
[3279-26-3]
Phenyl Dichlorophosphate
[770-12-7]
Tetrabenzyl
Pyrophosphate[990-91-0]
C2325
5g 25g
C24215g
D0436
1,1'-Carbonyldi(1,2,4-triazole)[41864-22-6]
1-(Cyanomethyl)piperidinium Tetrafluoroborate
[434937-12-9]
E0670
M0071
5-(Benzylthio)-1Htetrazole[21871-47-6]
25g 250g
D379225g
N,N'-Dicyclohexylcarbodiimide
(= DCC)
[538-75-0]
4,5-Dicyanoimidazole
[1122-28-7]
N,N'-Dicyclohexyl-4morpholinecarboxamidine
[4975-73-9]
25g 500g
M06251g
M1186
5g 25g
N04775g
5-(Ethylthio)-1H-tetrazole
[89797-68-2]
2-Mesitylenesulfonyl
[773-64-8]
Chloride
1-(2-Mesitylenesulfonyl)[50257-39-1]
imidazole
2,4-Mesitylenedisulfonyl
Dichloride [68985-08-0]
3-Nitro-1,2,4-triazole
[24807-55-4]
P0677
T0340
T0459
T1017
T1410
1g 5g
25mL 500mL
25g 100g 500g
25g 400g
25g 500g
Pivaloyl Chloride
[3282-30-2]
1,2,4-Triazole[288-88-0]
2,4,6-Triisopropylbenzenesulfonyl Chloride [6553-96-4]
T15625g
T1985
T2951
5g 25g
D2026
5g 25g
1H-Tetrazole[288-94-8]
1-(2,4,6-Triisopropylbenzenesulfonyl)imidazole[50257-40-4]
D0059
1g 5g
5g 25g
5g 25g
N
N
CH3
CH3
N
SO2
CH
CH
CH
CH3
CH3
CH3
CH3
2,4,5,6-Tetramethylbenzenedisulfonyl Dichloride
[97997-76-7]
1-(p-Toluenesulfonyl)imidazole
[2232-08-8]
1-(2,4,6-Triisopropylbenzenesulfonyl)1,2,4-triazole[54230-60-3]
D4207
D4594
M1965
1g 5g
F
BzO
O
1g 5g
BzO
O
O
1g 5g
Riboses and
2'-Deoxyriboses
2-Deoxy- D -ribose
[533-67-5]
R0025
25g 250g
R0026
100mg 1g
F
OBz
OBz F
OBz
2-Deoxy-2,2-difluoro-D -erythropentonic Acid γ-Lactone
3,5-Dibenzoate[122111-01-7]
2-Deoxy-2-fluoro-1,3,5-tri-Obenzoyl-α-D -arabinofuranose
[97614-43-2]
Methyl β-D -Ribofuranoside
[7473-45-2]
D -(-)-Ribose[50-69-1]
Ribose-5-phosphate
Barium Salt Hydrate
[15673-79-7]
R0066
R0067
R0068
1g 5g 25g
R00801g
R00825mg
β-L-Ribofuranose 1-Acetate
2,3,5-Tribenzoate
[3080-30-6]
α-D -Ribose 1,5-Bis(phosphate)
Tetrasodium Salt
[113599-17-0]
5g 25g
5g 25g
Tetra-O-acetylβ- D -ribofuranose
[13035-61-5]
β-D -Ribofuranose
1-Acetate 2,3,5-Tribenzoate
[6974-32-9]
L-Ribose[24259-59-4]
R0083
T2607
T2641
お問い合わせください
β-D -Ribose 1,5-Bis(phosphate)
Tetrasodium Salt
5g 25g
1,2,3-Tri-O-acetyl-5-deoxyβ-D -ribofuranose
[62211-93-2]
5g 25g
1,3,5-Tri-O-benzoylα- D -ribofuranose
[22224-41-5]
Please inquire for pricing and availability of listed products to our local sales representatives.
13
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents
Magaña, K. Wrobel, Y. Alvarado Caudillo, S. Zaina, G. Lund, K. Wrobel,
References
Anal. Biochem. 2008, 374, 378; M. Münzel, D. Globisch, T. Brückl, M.
1) H. Vorbrüggen, C. Ruh-Pohlenz, in Handbook of Nucleoside Synthesis,
Wagner, V. Welzmiller, S. Michalakis, M. Müller, M. Biel, T. Carell,
Wiley-Interscience, New York, 2001; H. Vorbrüggen, C. Ruh-Pohlenz,
Angew. Chem. Int. Ed. 2010, 49, 5375.
in Organic Reactions, ed. by L. A. Paquette et al., John Wiley & Sons,
3) I. Okamoto, K. Shohda, K. Seio, M. Sekine, J. Org. Chem. 2003, 68,
2000, Vol. 55; D. M. Huryn, M. Okabe, Chem. Rev. 1992, 92 , 1745; E.
9971; A. Misra, S. Mishra, K. Misra, Bioconjugate Chem. 2004, 15, 638.;
Ichikawa, K. Kato, Curr. Med. Chem. 2001, 8, 385.
R. Gukathasan, M. Massoudipour, I. Gupta, A. Chowdhury, S. Pulst, S.
2) Z. Liu, S. Liu, Z. Xie, W. Blum, D. Perrotti, P. Paschka, R. Klisovic, J. Byrd,
K. K. Chan, G. Marcucci, Nucleic Acids Res. 2007, 35, e31; A. Alcázar
14
Ratnam, Y. S. Sanghvi, S. A. Laneman, J. Organomet. Chem. 2005, 690,
2603.
Please inquire for pricing and availability of listed products to our local sales representatives.
L3014E 20160317