Download Apoptosis - stephen fleenor

Warm-Up (1/17)
Describe how a cell differentiates
during development.
UNIT
Last Thursday’s Picture
4A
A
B
A
C
Apoptosis
UNIT
4A
2E.1c: Programmed cell death (apoptosis) plays a role in the normal
development and differentiation.
Illustrative example: Morphogenesis of fingers and toes
4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic
enzymes, which are important in intracellular digestion, the recycling of a
cell’s organic materials and programmed cell death (apoptosis).
Lysosomes carry out intracellular digestion in a variety of ways.
4A.3c: Environmental stimuli can affect gene expression in a mature cell.
UNIT
Apoptosis
4A
Apoptosis =
programmed cell death used
for normal development.
1.
2.
3.
UNIT
Apoptosis
4A
Apoptosis =
programmed cell death used
for normal development.
Lysosomes are organelles
filled with acid and enzymes
which digest cellular waste.
Lysosome
nucleus
UNIT
Apoptosis
4A
Apoptosis =
programmed cell death used
for normal development.
receptor
Lysosomes are apoptosis
signal
organelles
filled with acid
and enzymes
which digest
cellular waste.
Apoptosis
results when
lysosomes are
triggered to
release their
contents.
P
LYSOSOME
ACTIVATOR
PROTEIN
2nd
messenger
Lysosome
TF
nucleus
UNIT
Apoptosis
4A
Apoptosis =
programmed cell death used
for normal development.
receptor
Lysosomes are apoptosis
signal
organelles
filled with acid
and enzymes
which digest
cellular waste.
P
2nd
messenger
Lysosome
Apoptosis
results when
lysosomes are
triggered to
release their
contents.
nucleus
Apoptosis
Apoptosis =
programmed cell death used
for normal development.
UNIT
MR.
CELL
Lysosomes are
organelles
filled with acid
and enzymes
which digest
cellular waste.
4A
Lysosome
Apoptosis
results when
lysosomes are
triggered to
release their
contents.
nucleus
UNIT
Apoptosis
4A
Apoptosis =
programmed cell death used
for normal development.
Lysosomes are
organelles
filled with acid
and enzymes
which digest
cellular waste.
Apoptosis
results when
lysosomes are
triggered to
release their
contents.
1.
Cells that
are going
to die
Cells that
did die
2.
3.
2E.1c: Programmed cell death (apoptosis) plays a role in the normal
development and differentiation.
Illustrative example: Morphogenesis of fingers and toes
4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic
enzymes, which are important in intracellular digestion, the recycling of a
cell’s organic materials and programmed cell death (apoptosis).
Lysosomes carry out intracellular digestion in a variety of ways.
4A.3c: Environmental stimuli can affect gene expression in a mature cell.
Apoptosis
UNIT
4A
Apoptosis occurs in diseased
or cancerous cells of mature
organisms.
Cancer cell undergoing apoptosis
Apoptosis
UNIT
4A
Apoptosis occurs in diseased
or cancerous cells of mature
organisms.
White blood cell consuming an apoptotic cell
UNIT
Apoptosis
Apoptosis occurs in diseased
or cancerous cells of mature
organisms.
4A
Environmental stimuli can affect
gene expression in a mature cell.
cell membrane
nucleus
melanin
RNA
UV damage
melanin gene
UNIT
Apoptosis
Apoptosis occurs in diseased
or cancerous cells of mature
organisms.
4A
Environmental stimuli can affect
gene expression in a mature cell.
cell membrane
nucleus
melanin
RNA
UV damage
melanin gene
UNIT
CTQ #1
Describe how apoptosis plays a role in
development. (LO 2.34)
4A
UNIT
CTQ #2
4A
The model below shows a cell with a receptor that is un-activated. Redraw this
model and revise it to show how signals from other cells can promote apoptosis.
(LO 4.7)
Closure
Describe how processes occurring in the
nucleus affect the lysosome when a cell
undergoes apoptosis. (LO 4.5)