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Warm-Up (1/17) Describe how a cell differentiates during development. UNIT Last Thursday’s Picture 4A A B A C Apoptosis UNIT 4A 2E.1c: Programmed cell death (apoptosis) plays a role in the normal development and differentiation. Illustrative example: Morphogenesis of fingers and toes 4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important in intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways. 4A.3c: Environmental stimuli can affect gene expression in a mature cell. UNIT Apoptosis 4A Apoptosis = programmed cell death used for normal development. 1. 2. 3. UNIT Apoptosis 4A Apoptosis = programmed cell death used for normal development. Lysosomes are organelles filled with acid and enzymes which digest cellular waste. Lysosome nucleus UNIT Apoptosis 4A Apoptosis = programmed cell death used for normal development. receptor Lysosomes are apoptosis signal organelles filled with acid and enzymes which digest cellular waste. Apoptosis results when lysosomes are triggered to release their contents. P LYSOSOME ACTIVATOR PROTEIN 2nd messenger Lysosome TF nucleus UNIT Apoptosis 4A Apoptosis = programmed cell death used for normal development. receptor Lysosomes are apoptosis signal organelles filled with acid and enzymes which digest cellular waste. P 2nd messenger Lysosome Apoptosis results when lysosomes are triggered to release their contents. nucleus Apoptosis Apoptosis = programmed cell death used for normal development. UNIT MR. CELL Lysosomes are organelles filled with acid and enzymes which digest cellular waste. 4A Lysosome Apoptosis results when lysosomes are triggered to release their contents. nucleus UNIT Apoptosis 4A Apoptosis = programmed cell death used for normal development. Lysosomes are organelles filled with acid and enzymes which digest cellular waste. Apoptosis results when lysosomes are triggered to release their contents. 1. Cells that are going to die Cells that did die 2. 3. 2E.1c: Programmed cell death (apoptosis) plays a role in the normal development and differentiation. Illustrative example: Morphogenesis of fingers and toes 4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important in intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways. 4A.3c: Environmental stimuli can affect gene expression in a mature cell. Apoptosis UNIT 4A Apoptosis occurs in diseased or cancerous cells of mature organisms. Cancer cell undergoing apoptosis Apoptosis UNIT 4A Apoptosis occurs in diseased or cancerous cells of mature organisms. White blood cell consuming an apoptotic cell UNIT Apoptosis Apoptosis occurs in diseased or cancerous cells of mature organisms. 4A Environmental stimuli can affect gene expression in a mature cell. cell membrane nucleus melanin RNA UV damage melanin gene UNIT Apoptosis Apoptosis occurs in diseased or cancerous cells of mature organisms. 4A Environmental stimuli can affect gene expression in a mature cell. cell membrane nucleus melanin RNA UV damage melanin gene UNIT CTQ #1 Describe how apoptosis plays a role in development. (LO 2.34) 4A UNIT CTQ #2 4A The model below shows a cell with a receptor that is un-activated. Redraw this model and revise it to show how signals from other cells can promote apoptosis. (LO 4.7) Closure Describe how processes occurring in the nucleus affect the lysosome when a cell undergoes apoptosis. (LO 4.5)