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STEPS OF MITOSIS
STEPS OF MITOSIS
 STEP ONE 1: Prophase
 In early prophase…
 The chromatin changes into chromosomes
 The nuclear membrane breaks down
 Parts called centrioles move to the ends of
the cell
PROPHASE CONTINUED…
 In Late Prophase
 Spindle fibers appear (made of microtubules)
 Polar spindles go across the entire cell
 Kinetochore fibers meet at the chromosomes
 Chromosomes are randomly positioned
PROPHASE DIAGRAM
 Draw Diagram
  Color the
chromosomes red &
blue – like this diagram
 Label
 Chromosomes
 Spindle fibers
(microtubules)
 Polar spindles
 Nuclear Membrane
METAPHASE
 Kinetochore fibers move the chromosomes
 Chromosomes line up at the center of the cell
METAPHASE DIAGRAM
 Draw Diagram
 Color the
chromosomes
red & blue –
like this
diagram
 Label
 Kinetochore
fibers
 Chromosomes
 Polar Spindles
 Centromere
ANAPHASE
 Centromere is pulled apart
 (this is where accidents can happen!)
 Sister chromatids are pulled to opposite ends of
the cell
ANAPHASE DIAGRAM
 Draw Diagram
 Color the
chromosomes red
& blue – like this
diagram
 Label
 Sister
Chromatids
 Kinetochore
fibers
 Polar spindles
REVIEW – COPY & ANSWER ON THE
LEFT SIDE OF YOUR SIN
 In what phase do chromosomes first appear?
 In what phase do chromosomes separate into
sister chromatids?
TELOPHASE
 Chromatids are at opposite ends of the cell
 Chromosomes unwind back into chromatin
 Nuclear membrane re-forms
 Spindle vanishes
 “Clean-up phase”
TELOPHASE DIAGRAM
 Draw Diagram
 Color the
chromosomes red &
blues – like this
diagram
 Label
 Chromatids ->
Chromatin
 Nuclear membrane
 Polar Spindles
CYTOKINESIS
 Cytoplasm divides, one cell becomes two
 Plant cells make a cell plate between new cells
 Animal cells form a cleavage furrow
CYTOKINESIS DIAGRAMS
 Draw Diagram
 Label
 Plant Cell
 Animal Cell
 Cleavage Furrow
 Cell Plate
 Nucleus
 Chromatin
 Cytoplasm
VIDEOS
  Cell Cycle and Mitosis
  https://www.youtube.com/watch?v=JcZQkmooyPk
  Cell Division & The Cell Cycle
  https://www.youtube.com/watch?v=Q6ucKWIIFmg
  Mr. Parr- Cell Division
  https://www.youtube.com/watch?v=IlV9hExXZnM
  YES, 20 points of extra credit if you write out all the lyrics
by hand and turn in within 3 days of reading this.
SIDE NOTE: MITOSIS GONE WRONG!
 During the cell cycle, there are a lot of
checkpoints.
 Think of them like stoplights.
 Sometimes a mutation happens that turns
these stoplights off.
 What happens then?
 Cells grow uncontrollably, also known as
cancer.
CANCER CELLS VS. NORMAL CELLS
 Cancer cells never stop growing
 Cancer cells never die, unless they run out of
resources.
HELA CELLS
 In 1951, cells were taken from Henrietta Lacks
and used for many years in research.
Henrietta did not give permission for her
cells to be used, the law did not require
that. These cells have been used in over
60,000 research projects, but Henrietta's family
has not received any compensation for
contribution to the research. Do you think the
law should be changed? Should people be
compensated for donating their cells to
science?