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Antimicrobial Resistance (AMR) - Joining Forces to Combat Antimicrobial Resistance – Thomas Ifland Senior Advisor Ministry of Health, Germany Antimicrobial Resistance is… …an increasing threat to Public Health. … affecting industrialized and devolping countries showing a complex global scope arising beyond boarders. …leading us straight back to a „pre-antibiotic era“ if no actions are taken NOW. ECDC: Data on resistant Klebsiella pneumoniae in Europe Antimicrobial Resistance is… …when we realize that we face prolongued treatment times, higher mortality and higher costs. …when common infectious diseases and minor injuries - easily treatable today - become major health threats tomorrow. …when you caught a simple lung infection and nothing can cure you. …when medicine once effective suddenly fails. …when individuals and health care systems have to carry an additional high burden. Main Drivers of AMR • extensive use of antibiotics > selfmedication, overprescribing, faulty advise/prescribing, wide use of broad-spectrum antibiotics, prophylactic use… • inappropriate use > non-compliance, nonknowledge, unreliable access to medication, unsafe medicine, financial aspects… • use of antibiotics and antimicrobial drugs in livestock, veterinary medicine and agriculture – resistance within the evironment Health Care Agriculture Livestock/ Veterinary Medicine Did you know…? • 80% - 90% of respiratory infections result from virusinfections which are non-treatable through antibiotics (WHO). • 85% of antibiotics are being prescribed in ambulant health care settings (Germany). • Up to 50% of antibiotics prescribed are not being needed or of optimal treatment effect (CDC). • Antibiotic development has not been sufficient within the last three decades. • Every 5th antibiotic prescription arises from uncertainty (US). • 2.5 million hospital days extra and costs of at least 1.5 billion €/year ( in the EU, 2007) result from AMR. Risks and Consequences • increase in mortality and disability • socioeconomic consequences and productivity loss • additional burden to health systems • especially high risk in industrialized countries for: cancer chemotherapy, complex surgery, dialysis for renal failure, rheumatoid arthritis, organ and bone marrow transplants… • cost increase through – prolongued and costlier treatment – extra health personnal – extra hospital days – costly medicine… Lessons learnt In May 2015 the World Health Assembly adopted the FIRST „Global Action Plan on Antimicrobial Resistance “ Thank you for your attention Quellen • Bundesministerium für Gesundheit(Hrsg.): DART – Deutsche AntibiotikaResistenzstrategie; 2011 • CDC - Centers for Disease Control and Prevention • ECDC European Centre for Disease Prevention and Control • Kassenärztliche Vereinigung Deutschland • Sosa, A. et al: Antimicrobial Resistance in Developing Countries; Springer 2010 • WHO: Antimicrobial Resistance. Global Report on Surveillance; World Health Organization, 2014 • WHO: Draft Global Action Plan http://www.who.int/drugresistance/amr_global_action_plan/en/