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A Comparative Analysis of Several Corrected Vectoreardiographic Leads By DANIEL A. BRODY, M.D., AND ROBERT C. ARZBAECHER, PH.D. With the technical assistance of Harry A. Phillips Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 DURING the past decade a great deal of attention has been devoted to the development and application of one or more vectorcardiographic lead systems possessing certain highly desirable physical characteristics. The overriding design consideration has been that the lead system provide a truly Cartesian frame of reference for the display of cardiac vectors. Achievement of this goal requires that the axes of the three component leads be mutually orthogonal, that their individual electrocardiographic sensing abilities be equally scaled, and that both of the preceding properties remain essentially invariant throughout the cardiac region. Sets of electrocardiographic connections that attempt to satisfy these basic requirements are frequently referred to as corrected lead systems. They appear to be gaining increasing acceptance in vectorcardiographic practice. The ultimate test of a vectorcardiographic system lies in the demonstration of its reliability as a clinical diagnostic tool. Pending such clinical testing and confirmation, however, the special merits of corrected lead systems are predicated on their adherence to the specific design principles referred to above. Therefore it is of interest to examine the physical properties of such leads in detail and to determine how closely their parameters approximate the ideal situation. There is nothing basically new in the idea of exploring the physical properties of lead connections. Indeed, it was in this way that the design of corrected lead systems was achieved. The experimental methods applied to this purpose, however, have been somewhat deficient in a number of technical and conceptual respects. During the past 3 years we have developed a method of measuring and analyzing the physical characteristics of lead connections in a manner that is designed to eliminate or, at least, greatly minimize many of the limitations of previously employed methods.' Our new method embraces certain fundamental concepts that were not comprehensively treated in earlier reports on corrected lead systems. An important technical feature of the experimental method employed in this study is its largely automatic mode of data acquisition, and the extensive use of the electronic digital computer in data processing and analysis. In this present report we re-examine the physical characteristics of three corrected lead systems as determined by the newer experimental method. In addition, we shall deal with three potentially valuable single leads whose quantitative characteristics have not previously been recorded in the electrophysiologic literature. Theoretical Foundations According to one of the newer concepts of the interrelationships between leads and the electromotive forces of the heart2' 3 the potential difference, V, which appears across the terminals of a vectorcardiographic lead, can be expressed mathematically as (1) V = FiMi + FijM!' + FijkMiik + In this equation the successive F symbols are covariant tensors of the first, second, third, etc., rank, respectively. The corresponding M symbols are contravariant tensors of like rank. The contravariant tensors express the equiv- From the Section of Cardiology, University of Tennessee, Memphis, Tennessee. Supported in part by Grants HE-0132-11, HE-K610432, FR-00001, National Institutes of Health, U. S. Public Health Service; Grant GP-706 of the National Science Foundation; and a grant from the West Tennessee Heart Association. Circulation, Volume XXIX, April 1 964 533 BRODY, ARZBAECHER 5-34 Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 alent cardiac generator behavior of the heart; the covariant tensors express the intrinsic characteristics of the given lead connection. The form of the equation indicates that the cardiac and lead parameters can be treated as two experimentally independent sets even though there is an inextricable conceptual linkage between them. It is this ability to divorce cardiac properties from lead characteristics that makes possible a comprehensive, quantitative analysis of lead behavior. Vectors are tensors of the first rank. Accordingly, the set, Mi: M 1, M 2-, M3, of equation 1 represents, respectively, the X, Y, and Z components of the heart vector. By strict definition it is these components alone that the vectorcardiogram is intended to display. Since it is highly probable that heart tensor components above the first rank do exist,4- " the desired purity of heart-vector display lies in the development of registration systems in which lead tensor components above the first rank vanish. It is the achievement of this condition which is, in essence, the goal of most corrected lead systems. Experimental evaluation of such systems in the biophysics laboratory requires not only determination of the first rank parameters, but also verification that the magnitudes of higher rank parameters are acceptably small. The F symbols of equation 1 are parameters of the electrocardiographic lead field, which, by definition, is the potential field generated in the body when one unit of current from an external electromotive source is caused to flow from the positive to the negative terminal of a given lead connection.7 The specific tensor characteristics of the lead field, including their relationship to the canonical or analytic treatment of lead-field potentials, have been described in detail elsewhere.'29 In devising an experimental approach to lead-field analysis the analytic form has proved more rewarding. This is particularly true when the field is treated as a series of spherical harmonics components of the form u1 = p.o( rn (n1-7m)! (n+m)! P,' / P,"r (y (2) cos mO \ sin m0/ p Equations 2 are referred to conventional spherical coordinates, r, 0, 0, with g = cos 0. Other symbols indicate: u, the scalar potential of a given component; n and m, the degree and order, respectively, of the component; pllo Ppnm, and qnm, coefficients that characterize the vectorcardiographic sensitivity of each component; Pl1m ( pt), associated Legendre functions of nth degree and mth order. In ideal systems all sensitivity coefficients except plo, pl, and q1l vanish. The appraisal of nonideal behavior, then, rests in large measure upon quantitative evaluation of sensiti.vity coefficients other than these three. Experimental determination of the coefficients, Pnm and qtlIn, in torso models of the human body does not require sampling of lead-field potentials throughout the cardiac region. WVhat is required, rather, is measurement at a number of spherically arrayed sampling points that contain the cardiac region.1 9 The sampling procedure should be extensive enough to permit accurate interpolation of lead-field potentials at all intervening points. Having thus measured the potential function, us, over a spherical sampling surface, the desired coefficients can be determined from the relationships, 1 2n+ 1 2r J u usco mO 110()d (3) pno1 pniin qnm / _ 'Sr 2n +- 1 2 J 1 u, MO </c.os \sin > d0 m0 d1 0 Pill--" ( ) dp- Methods and Materials Three corrected vector systems, Frank's,1'( Schmitt's SVEC-JII,"1 and McFee's 12 axial, were studied in an electrolyte-filled torso model having cross sectional dimensions of 20.8 by 35.7 cm. at the midventricular transverse level, and measuring 50.9 cm. from the symphysis pubis to the suprasternal notch. Either tap water or dilute sodium chloride solution was employed as the electrolyte. Precordial electrodes consisted of 30mm. diameter disks of pure silver foil temporarily cemented to the internal surface of the model at C,r(:;ulation. VolIz-)ne XXIX, April 1964 535 CORRECTED VECTORCARDIOGRAPHIC LEADS Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 the appropriate locations. Larger rectangles of the silver foil (approximately 5 by 8 cm.) were cemented to the extremity stumps of the model to serve as the right and left arm, and left leg electrodes. The soldered connections of the lead wires to the electrodes were carefully sealed with Glyptal lacquer in order to minimize the possibility of unstable contact potential due to local electrolytic effect. Lead fields were generated within the model by reciprocally energizing each connection with 1.000 cycle per second altemating current. By means of the previously described device,' leadfield potentials were systematically and automatically measured at 425 spherically arrayed sampling locations. Additional measurements were made at the north and south poles of the sampling sphere, the radius of which was 8.52 cm. Write-out of data observations was in both analog and digital (punch card) form at a rate of six observations per minute. The individual sampling sites were located at 25 equiangular intervals of azimuth on 17 circles of latitude. The sampling circles included the equator of the spherical array and eight latitudes to either side of the equator, arranged in equiangular steps of 7.2 degrees of elevation. The device that measured the lead-field potentials was essentially an impedance bridge that balanced itself by means of two servo mechanisms. The axis of rotation of the sampling mechanism was parallel to the sagittal plane of the model. As viewed from the left side, the vertical axis of the model was tilted forward 9.3 degrees in a counterclockwise direction from the rotational axis of the mechanism. This tilt permitted the center of the spherical sampling pattern to be located at the centroid of the ventricular mass without the necessity of having an excessively large port in the cervical region of the model. A computer program was employed that first reduced the input data to millivolts of lead-field potential, referred to a standard medium resistivity of 1,000 ohm-cm. Next, the Fourier coefficients of the potential function around each sampling circle were computed. This step amounted to performance of the integration indicated in the brackets of equation 3. Since the sampling circles were disposed symmetrically to either side of the equator, they were sorted into odd and even functions of the spherical surface and thereafter referred to the upper hemisphere alone. The 10 values of each odd and even set of the Fourier coefficients in the upper hemisphere were smoothly connected as ninth-degree polynomial functions of g. By means of these polynomial functions interpolated values of the Fourier coefficients were determined for the argument, u taken in steps of 0.02 from zero to one. At this Circulation, Volume XXIX, April 1964 juncture pre-computed tables of associated Legendre functions for equal steps of argument were read in, and the remaining integration indicated in equation 3 was performed according to Simpson's rule. Due allowance was made for the fact that the range of argument, g, had been limited to the upper hemisphere. In addition to the three complete systems the properties of two anteroposterior grid-type of lead connections were studied. In each case a square array of 16 equally weighted, 1.0-cm. diameter circular electrodes was applied to the anterior and posterior walls of the model in the region of the heart. In the first case, equivalent to the MeFee-Johnston grid,7 the individual electrode centers were spaced 6.25 cm. apart as measured on the body surface of the model. In the second case the electrodes were so relocated that it was their projections on the frontal plane, rather than the electrodes themselves, which formed the square grid pattern.13 Two individual vertical leads were also studied. One of these was lead aVI. The other was the "<symmetrical" lead, which we proposed a few years ago.14 It consists simply of two pairs of equally weighted electrodes which are applied, respectively, to the sides of the neck and the two lower extremities. Quantitative Results In each case the lead vector components are the first-degree coefficients, plo, pi,, and q1l, divided by the factor, 8.52, which is the radius in centimeters of the sampling sphere. Table 1 lists the lead vector magnitudes and their direction cosines with respect to an anatomically oriented Cartesian coordinate system. The axes of this reference frame are those ordinarily employed in vectorcardiography: X axis transverse and positive to the left; Y axis vertical and positive toward the feet; Z axis anteroposterior and positive toward the back. The triple scalar product of the unit base vectors was computed for each of the complete lead systems studied. A geometric interpretation of the triple scalar product is that it is the volume of the parallelopiped the sides of which correspond to the unit base vectors. The departure of triple scalar product from unity is one measure of non-orthogonality of the lead system. The list of lead vector magnitudes in table 1 shows that the Frank system best meets the desired condition of equal lead weights. The BRODY, ARZBAECHER 536 Table 1 Summary of First-Degree Lead-Field Parameters Lead System Lead Magnitudes (mv./cm.) X "Unit" Y "Unit" z "Unit" or type Idceal x X McFee axial Y z Frank Y SVEC-III z X Y Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 Tetrahedron Symmetric McFee grid Proj. grid 1.606 1.476 2.240 1.448 1.395 1.371 Angles between cooIrd. planes, degrees YZIZX XY YZ vectors Direction cosines -V a 1.0000 .0000 .0000 .9990 .0256 .0637 .9897 .0753 .0450 .9595 z 1.286 1.048 1.545 aVF 1.527 .1479 (Y) y z 1.680 .0244 1.321 .0584 z 1.279 .0447 .0256 .0061 .0000 1.0000 .0000 .0000 .9996 .0528 .1217 .9804 .1766 .1894 .9996 .1376 .9890 .9997 .0394 .0550 .0000 .0000 1.0000 90.0 90.0 90.0 (TSP = 1.0000 ) .0440 .0092 .9966 .0752 .1823 .9833 .2087 .0092 .9905 88.9 (TSP 78.3 93.5 .9920) 91.3 110.3 .9165) (TSP 79.1 (TSP 83.9 102.4 84.2 = .9434) .0066 -.0014 .9975 .9975 Magnitudes and anatomic orientation of the lead vectors of the various connections studied. In the case of the three complete lead systems the angles between the vectorcardiographic coordinate planes are also given. The index of mutual orthogonality of the three axes, TSP, is the triple scalar product of each system's unit base vectors. direction cosines, angles between coordinate plane, and triple scalar products show that the axial lead system meets the conditions of mutual orthogonality of axes and parallelism with corresponding anatomic axes more satisfactorily than either of the other two systems. On the other hand, the axial system is the least satisfactory so far as scaling factors are concerned. This is a readily correctible situation, however. The relative weights of the SVEC-1IJ leads are also rather unsatisfactory. They were somewhat better in their raw form, before a specified correction multiplier of 0.75 was applied to the X lead, and a multiplier of 0.71 to the Y lead. The properties of the four single leads listed in table 1 do not indicate that they possess any unique merit so far as their first-degree parameters are concerned. It is anticipated that the higher degree leadfield components, p,,,,, and qMD, which are computed according to the principles expressed in equation 3, will eventually serve as a basis for determining the mtiltipolar components of the equivalent cardiac generator. Pending such application, however, find that the physical significance of these coefficients is greatly clarified when each is multiplied by a "normalizing factor," K. In zeroth-order cases the normalizing factor is we (4a) 2n + 1 For coefficients above the zeroth order the normalizing factor is (r, K= (- (n r2 inm)! )"42n+ 1 (n+m)M! (4b) The r0 in equations 4 is the radius of the spherical sampling pattern, which in the present study is 8.52 cm. The r1 is the radius of a sphere that is large enough to contain the cardiac mass. Somewhat arbitrarily we chose a value of 7.5 cm. The normalized p,,, and q,nm coefficients derived from this study are presented through (inraiiiifion, Voluime XXIX, April 1964 CORRECTED VECTORCARDIOGRAPHIC LEADS 537 Table 2 Dipolar and Non-Dipolar Lead-Field Parameters Lead n pnO Rect. tank z Tetr. 1 2 2 3 1 2 .002 .048 .004 1.987 .201 .076 .049 .120 6.650 .019 .001 .261 .022 .057 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 .144 6.298 .363 .158 1.046 .008 .840 .678 .963 .026 5.668 .306 .071 .098 .275 .145 1.140 .819 .003 .155 .496 .239 6.462 .602 .069 7.181 .175 .079 .693 .062 .061 .586 .041 .093 .049 1.084 .358 .004 9.623 .292 .988 .588 .005 .152 2.037 .064 .101 5.931 .267 1.016 1.755 .018 .406 6.688 .422 .645 1.006 .168 .006 1.157 .097 .028 5.670 .007 .146 5.500 .056 .147 X (I) Axial X Axial y Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 Axial z Frank X Frank y Frank z SVECIII X SVECIII z Tetr. y (aVF) Symmetr. y MeFee grid z Proj. grid z 3 1 Pnl .302 .011 Individual coefficients pn2 qnl .013 .022 .023 5.025 1.466 .159 6.948 .086 .045 .164 .313 .066 .618 .031 .209 6.207 .355 .585 .455 .046 .131 .267 .141 .010 7.124 .796 .568 .041 .039 .018 .978 .334 .025 .178 .112 .083 .334 .149 .027 .248 .066 .008 qn2 pn3 qn3 Lumped coefficients 1.000 .005 .001 .001 .001 .084 .133 .103 .012 .033 .106 .688 .254 .168 .092 .037 .700 .166 .038 .044 .032 .044 .004 .214 .429 .627 .136 .869 .283 .503 .019 .082 .014 .158 .156 .491 .076 .241 .057 .087 .195 .134 .086 .710 .024 .016 .221 .286 .023 1.783 .051 .262 .234 .169 .117 .412 .162 .073 .021 .009 .006 .143 .039 .070 .021 .010 .036 .018 .156 .053 .437 .116 .068 .006 1.000 .086 .038 1.000 .054 .026 .343 .063 .026 .042 .065 .035 .002 .003 .008 .004 1.000 .275 .047 1.000 .104 .110 1.000 .097 .029 1.000 .075 .171 1.000 .183 .103 1.000 .105 .049 1.000 .140 .177 1.000 .677 .116 .288 .132 1.000 .567 .461 .108 .155 1.000 .124 .027 1.000 .038 Summary of lead-field components through the third degree and order. The individual components of nth degree and mth order, P,,m and q,5m. have been so normalized that the values given in the table show the root-meansquare contribution of each to the lead-field potential over an imaginary spherical surface, 7.5 cm. in radius, which contains the heart. The relative lumped values for each degree are given in the right-hand column. These numbers indicate the sensitivity of each lead connection to the dipolar, quadripolar, and octapolar fractions of the equivalent cardiac generator. Circulation, Volume XXIX, April 1964 538 Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 the third order and degree in table 2. In this form each coefficient indicates the root-meansquare contribution from each component of corresponding degree and order to the leadfield potential over an imaginary 7.5-cm. radius spherical surface that contains the heart. The peak magnitude of an individual component contribution is roughly twice its root-mean-square contribution. The total, or lumped, contribution of components of a given degree is the square root of the sum of squares of all components of that degree. The lumped contributions appear to be of considerable significance, since, when listed in ascending degree, they respectively indicate the sensitivity of the lead connection to dipolar, quadripolar, octapolar, etc., components of the equivalent cardiac generator. The relative sensitivities of the various leads investigated in this study are presented in lumped form in the right-hand column of table 2, with the dipole sensing characteristics of each lead arbitrarily taken as unity. The validity of the experimental method is illustrated by measurements of a uniform field generated in a rectangular tank. The lumped second- and third-degree components of the field were determined as 0.8 and 0.4 per cent, respectively, as compared to theoretically ideal values of zero. Table 2 illustrates that several of the corrected vectorcardiographic leads possess sizable non-dipolar sensing characteristics. The relative quadripolar sensitivity of the group is greatest (28.8 per cent) in lead X of the SVEC-III system. The greatest octapolar sensitivity occurs in the Z leads as a group, being greatest in the axial and Frank systems and somewhat less in the SVEC-III system. The X connection of the SVEC-III system consists of equally weighting the lead-I electrodes with a supplementary pair of anteriorly located thoracic electrodes. This synthesis from two bipolar leads improves the anatomic orientation of the resultant lead axis, but it is interesting to note that it does not materially reduce the quadripolar sensitivity of lead I, and it increases the magnitude of octapolar sensitivity. BRODY, ARZBAECHER Attainment of a satisfactory vertical lead does not seem to offer any serious problems. The best of the entire group that we studied is the symmetrical Y configuration,'4 with a lumped second-degree component of 3.8 per cent and a third-degree component of 1.8 per cent. As remarked upon above, it is the anteroposterior connections of the three lead systems that tend to deviate most widely from theoretically ideal conditions. It appears that this undesirable situation can be improved by the substitution of anteroposterior grid electrodes as the Z lead. The quadripole sensing properties of both the McFee-Johnston and projected 13 grids are not significantly different from the Frank Z, but somewhat better than the SVEC-III and axial Z's. It is in the matter of octapolar sensing content that the major gain is achieved, since it is evident in table 2 that the lumped third-degree components of either grid connection are quite small in comparison to the other three lead Z connections. Graphic Analysis Although accurate quantification of lead parameters was the primary goal of this study, we have found it quite illuminating to supplement such information with tle qualitative information that can be derived from the graphic method of lead-field mapping. The computer was programmed to accept the coefficients that were derived from the sampling sphere measurements, and from these data to compute lead-field potentials at numerous, systematically located points in three mutually orthogonal planes passing through the cardiac center of the torso model. The points were arrayed in the form of a 12 by 12-cm. square Cartesian grid, with a 1-cm. spacing between the individual points. The planes in which this process was performed were chosen respectively parallel to the frontal, sagittal, and horizontal planes of the torso model. Interpolation to determine the location of the desired whole-numbered values of potential and automatic plotting of the lead-field isopotentials were done according to the principles of a previously described program." (Circultion, Volumne XXIX, April 1964 539 CORRECTED VECTORCARDIOGRAPHIC LEADS The metric scale of the plots was approximately 2.5 to 1, with a 0.1-inch resolution of point location on the ordinates. Immediately behind each automatically plotted point a number was printed which indicated the next order of resolution, giving a net equivalent resolution of 0.1 mm. Those isopotential maps of special interest were reproduced manually, with the computer plots serving as a matrix for the reproduction. Back HORIZ. Figures 1 through 5 present a series of particularly pertinent isopotential maps. Visual analysis of the maps is a fairly simple matter. By definition the lead field of a perfect vectorcardiographic connection is uniform: that is, its flux lines are straight and parallel, and its isopotential surfaces (which are normal to the flux lines) are plane and mutually parallel. Therefore the traces of the isopotential surfaces in a plane parallel to the flux Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 HORIZ. Back SAG IT. Head Front FRONTAL Head -111 11T1' 111r 1 _1 i£ _, _ _ 111 11 CR 11 4-1 4- 14 c ac it- 0 0 Foot11 _ Foot X fo ot AXIAL Z Figure 1 Axial lead system. Maps of the X and Z lead-field isopotential surfaces as they intersect coordinate planes passing through the cardiac center. In this and the other illustrations the equipotential interval is 2.0 mv., and the grid interval of the Cartesian coordinates is 1.0 cm. The constant term of the lead field, po0 is so chosen that the zero isopotential surface passes through the center of the grid, which also coincides with the cardiac center. Lead X shows rather good symmetry of its reciprocal field about the lead axis. This design goal is less well approximated in lead Z, which shows proximity electrode distortion toward the frontal aspect in both the horizontal and sagittal plane views. Circulation, Volume XXIX, April 1964 BRODY, ARZBAECHER 540 Back HORIZ. Back HORIZ. W_ __ _i c4a) _J Fr ont Front Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 Head SAGIT. y 1 \ 1 1 0 J) _i 1 1 j 1 1 / Y U- ir A 1 1 1 1 1 1 o 1 ' 0 1 11 / 1 "---1 1 Foot Foot X 1 1 L A \ -1 j FRANK Z Figure 2 Frank lead system. Same leads and views as figure 1. Both lead fields appear relatively uniform in the central portions of their horizontal plane views, with proximity electrode distortion evident toward the margins. In both cases the tendency toward central region uniformity is limited to the horizontal plane views. This is a consequence of limiting electrode placement on the body surface to a single transverse plane. lines would form of straight, parallel and equally spaced lines. Departures from this a set pattern are generally easy to recognize. Although the illustrations speak rather well for themselves, some aspects warrant specific comment. The X and Z lead characteristics of the three complete vector systems, axial, Frank, and SVEC-III, are respectively displayed in figures 1, 2, and 3. As is to be expected from the quantitative determination of coefficients (cf. table 2), none of these lead fields closely approximates the ideal configura- tion. The primary design consideration of the axial system connections is that their lead fields be symmetrically disposed about corresponding geometric axes passing through the cardiac center. Figure 1 shows that this condition is met rather well in the case of the X lead and somewhat less well in the case of the Z lead. The horizontal plane maps of the Frank X and Z leads indicate that a considerable degree of correction has been accomplished in the central region. Peripherally, however, the X lead is distorted toward the Circulation, Volume XXIX, April 1964 CORRECTED VECTORCARDIOGRAPHIC LEADS left and the Z lead toward the front by electrode proximity effects. Both leads are less well corrected out of the horizontal plane. This is more or less to be expected, since the leads are made up of body-surface electrodes which lie only in the transverse plane which passes through the cardiac center. Except for some misalignment of orientation in the sagittal plane the Z lead of the SVEC-III system shows a fair amount of straightening in the central portion, with the expected electrode proximity distortion toward the margins of the maps. Misalignment and especially distorHORIZ. 541 tion are most conspicuous in lead X of the SVEC-III connections. This appears to be the least desirable of the various corrected leads. The best vertical (symmetrical Y) and second best anteroposterior (McFee-Johnston grid) connections are shown in figure 4. It is likely that the symmetrical Y lead does not deviate in any clinically significant respect from the theoretically ideal form. The grid connection approximates the ideal configuration less satisfactorily but seems superior in this respect to the other Z leads. Figure 5 illustrates the characteristics of HORIZ Bock Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 .T /T / _-A 11 _1l~~~~~~~~~~fY M... Front Hea _E _ Front J - - Front 1 Mi-TT £1 1 1\l 10 FRONTAL Back Head 'SAGIT. Head c CE)a 0 i Foot X Foot SVECIm z Figure 3 SVEC-III lead system. Same leads and views as figures 1 and 2. The Z lead displays about the same amount of distortion as the corresponding axial and Frank leads (cf. text and table 2). Lead X shows striking proximity electrode effects. It is the least well corrected connection of the three systems, and except for anatomic axis orientation is inferior to the tetrahedral X. Circulation, Volume XXIX, April 1964 BRODY, ARZBAECHER 542 FRONTAL Ecc __~~~~~~~~~~~~~~~~~ ._ _ - He ad SAGIT. Head __ 4- (0 _j 1 I 1 -I1 0 t __ -7~~Fo __= _ _ _ 0 C) _ m _F_o_t SYMMETRICAL Y Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 H OR IZ . Head 1I _ __ _ e SAGIT. Back -- 1-11-___ a-0)-J U a 0 U- -I I Front Foot McFEE-JOHNSTON GRID Figure 4 Lead-field maps of two relatively wvell corrected derivations. The symmnetrical Y lead probably does not deviate in a clinically significant nmanner from the theoretic ideal. The grid type of anteroposterior connection is superior to the other types of Z leads analyzed. It is likely that further improvemnent in the grid type of leadis feasible. two other vertical leads, the Frank Y and lead aV1. Distortion due to the use of a back electrode is evident in the first case, and the proximity effects of the left arm connection are apparent in the second case. In both cases deviation from the anatomic vertical axis is greater than is necessary, since this kind of distortion is virtually eliminated in the neck to left leg and symmetrical Y type of electrode application. Discussion The resolution of lead fields into their spherical harmonics components was first proposed by McFee and Johnston. The importance of their original proposal has increased greatly with the development of newer knowledge regarding the tensor characteristics of these components and their relationship to the various multipolar components of the equivalent cardiac generator. Now that instrumentation adequate for experimental implementation has been developed, the McFeeJohnston proposal appears to offer the most systematic and thorough method of quantitaCirculation, Volumse XXIX, April 1964 543 CORRECTED VECTORCARDIOGRAPHIC LEADS tively evaluating lead characteristics in the biophysics laboratory. Of the three corrected vectorcardiographic lead systems analyzed by this advanced method, the axes of McFee's axial connections were most nearly mutually orthogonal. The design specifications of this system do not call for uniform (i.e., distortion free) lead fields, but simply for symmetry of the fields about the lead axes. As described above, this design condition is achieved reasonably well. As judged from its lumped relative quadripole Heod FRONTAL Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 1 =- and octapole sensing characteristics, we find the axial X lead somewhat better corrected than the corresponding Frank lead, and considerably better than the SVEC-III lead. Judged in the same way, the axial Y lead (same as the SVEC-JJL Y lead except for scaling factor) is rather superior to Frank's Y connection. Second-degree distortion of the axial Z lead is less than that of the other two systems. Third-degree distortion is not significantly less than that of Frank's Z lead, and is somewhat greater than in the SVEC-III sysHood SAGIT. I APIWIm = £_ X C_== 4- ____ 1- 1 t c 0 LL -J TF Foot Foot FRANK Y FRONTAL Head SAGIT. Head L .I I I1F 1ot - - - -1 __ ___ C~~~~~~~~~~ mL I~ - e 04- L I- 1 T1 1 1 .~~. 1 = =-r--= =_- ----__ _ _L_1 Foot 11 1 = 1 c 0 4- --- 1 1 cU .X l1l Foot TETRAHEDRAL Y Figure (AVF) 5 Lead-field maps illustrating two relatively unsatisfactory types of vertical derivation. The Frank Y lead appears fairly uniform in the frontal plane (upper left), but distortion due to inclusion of a back electrode is evident in the sagittal plane view (upper right). The frontal-plane view of lead aVF (lower left) shows the distortion that is due to the proximity of the left-arm attachment. Circulation, Volume XXIX1 April 1964 544 We find, therefore, that the Frank Z is less well corrected than either of the other two, but we can make little distinction between the SVEC-III and axial Z connections except for the somewhat more satisfactory lead axis orientation of the latter. It thus appears that the axial system possesses several relatively favorable characteristics. Equalization of scale factors is poor, however. On the basis of our present information it is our proposal that in using the axial system the X channel be recorded at approximately 92 per cent and the Z channel at approximately 66 per cent of the Y channel sensitivity. These recommendations may have to be modified somewhat after torso models representing other types of bodily habitus have been similarly studied. The simplicity of constructing and accurately placing the axial leads was a major consideration in the development of the system.12 Although such matters of clinical practicality are not directly pertinent to the primary purpose of the present study they may be of some account in the choice of lead system. In principle, the grid type of anteroposterior lead has much to commend it. XVe fail to find any reports in the literature which indicate that it has had extensive clinical trial. It might be difficult or impossible to apply accurately to female subjects because of the left breast mass. As far as we are aware the lead vector magnitude and orientation of the grid connections in the three-dimensional situation, which are given in table 1, have not previously been available. The shape of the human torso is roughly that of an ellipsoid with three unequal axes. This goemetric configuration has a direct bearinig on the number of electrodes required to produce various corrected leads. Because leads representing the long-axis component of vector forces (Y leads) may be formed from remotely located electrodes little difficulty has been encountered in developing a satisfactory connection. Contrariwise, short-axis registration (Z leads) requires the use of proximately located electrodes. The pitfalls involved in relying on a highly limited num- tem. BRODY, ARZBAECHER Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 ber of proximity electrodes for accurate vector registration have been pointed out previously.15 The grid type of anteroposterior connection, although its characteristics can be improved, exemplifies the manner in which numerous proximity electrodes may be uised to reduce distortion in the registration of shortaxis components. According to the same principles the difficulties involved in reducing the distortion of X lead registration should be intermediate to those posed by the other two connections. In choosing a vectorcardiographic lead system the clinician faces a problem that is less perplexing now than previously. Partly by definition and partly by implication the vectorcardiogram is intended as an accurate display of the dipolar fraction of the equivalent cardiac generator. It is now rather certain that the equivalent generator exhibits significant non-dipolar components during ventricular depolarization.5 '; It is equally certain that the older, uncorrected lead systems are deficient in the desired properties of orthonormality and insensitivity to non-dipolar components. There is no need for the clinician to abandon an uncorrected lead system if he believes that it may possess singular merit. At the same time, however, he would best serve the clinical science of vectorcardiography by employing in addition one of the better corrected lead systems. In this way the desired conditions of standardization and distortion-free technic can be approximated without necessarily eliminating the search for special virtue in other types of lead connections. Summary The sensitivity of several corrected vectorcardiographic leads to dipolar, quadripolar, and octapolar components of the equivalent cardiac generator was determined in an electrically homogeneous torso model of the human body. A new experimental method, which insured that the desired parameters were determined for the entire cardiac region, was employed. Three complete vector systems were thus studied: McFee's axial, Frank's, and the SVECCirculation, Volumne XXIX, April 1964 CORRECTED VECTORCARDIOGRAPHIC LEADS Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 III. Individual leads also studied included the tetrahedron X (lead I), the tetrahedron Y (lead aVF), the "symmetrical Y," and two grid types of anteroposterior connections. Except for poor adjustment of scale factors the axial leads were found to be the best corrected of the three complete systems. With relative X, Y, and Z channel sensitivities of 0.92, 1.00, and 0.66, respectively, the axial lead system can be recommended as the best of the three. Of all the connections studied, we found the X lead of the SVEC-III system to be the most inadequately corrected. We failed to confirm that the inclusion of weighted back electrode potentials, as employed in Frank's Y lead, improves the characteristics of the neck to left leg connection as a vertical lead. We find the symmetrical Y lead superior to both lead aVF and the neck to left leg connection. The grid type of anteroposterior connection is superior to the other types of corrected Z leads that we investigated, but could probably be corrected further by improvements in design. The use of corrected leads is to be encouraged as a means of achieving standardization and approximating the biophysical conditions implicit in the basic concept and purpose of 3. 4. 5. 6. 7. 8. 9. 10. 11. vectorcardiography. Acknowledgment We are greatly indebted to Dr. Elliot V. Newman of Vanderbilt University for making available to us the torso model used in this study. Mr. Charles Eddlemon assisted in the preparation of illustrations. References 1. ARZBAECHER, R. C., AND BRODY, D. A.: Electrocardiographic lead tensor measuring system. IEEE Tr. Biomed. Electronics. In press. 2. BRODY, D. A., BRADSHAW, J. C., AND EVANS, J. W.: The elements of an electrocardiographic Circulation, Volume XXIX, April 1964 12. 13. 14. 15. 545 lead tensor theory. Bull. Math. Biophys. 23: 31, 1961. BRODY, D. A.: The use of computers in electrophysiology. Circulation Research 11: 549, 1962. BRODY, D. A., AND BRADSHAW, J. C.: The equivalent generator components of uniform double layers. Bull. Math. Biophys. 24: 183, 1962. TACCARDI, B.: Distribution of heart potentials on the thoracic surface of normal human subjects. Circulation Research 12: 341, 1963. HORAN, L. G., FLOWERS, N. C., AND BRODY, D. A.: Body surface potential distribution: Comparison of naturally and artificially produced signals as analyzed by the digital computer. Circulation Research 13: 373, 1963. MCFEE, R., AND JOHNSTON, F. D.: Electrocardiographic leads. I. Introduction; II. Analysis; III. Synthesis. Circulation 8: 554, 1953; 9: 255, 1954; 9: 868, 1954. BRODY, D. A., AND ROMANS, W. E.: A model which demonstrates the quantitative relationship between the electromotive forces of the heart and the extremity leads. Am. Heart J. 45: 263, 1953. BRODY, D. A., BRADSHAW, J. C., AND EVANS, J. W.: A theoretical basis for determining heart-lead relationships of the equivalent cardiac multipole. IRE Tr. Biomed. Electronics 8: 139, 1963. FRANK, E.: An accurate clinically practical system for spatial vectorcardiography. Circulation 13: 737, 1956. SCHMITT, 0. H., AND SIMONSON, E.: The present status of vectorcardiography. Arch. Int. Med. 96: 574, 1955. MCFEE, R., AND PARRUNGAO, A.: An orthogonal lead system for clinical electrocardiography. Am. Heart J. 62: 93, 1961. BARBER, M. R., AND FISCHMANN, E. J.: A lead system recording total outward cardiac dipole strength. Brit. Heart J. 23: 649, 1961. EVANS, J. W., ERB, B. D., AND BRODY, D. A.: Comparative proximity and remoteness characteristics of conventional electrocardiographic leads. Am. Heart J. 61: 615, 1961. BRODY, D. A.: Limited reliability of precordial electrodes as vectorcardiographic leads. Science 125: 352, 1957. A Comparative Analysis of Several Corrected Vectorcardiographic Leads DANIEL A. BRODY, ROBERT C. ARZBAECHER and Harry A. Phillips Downloaded from http://circ.ahajournals.org/ by guest on June 14, 2017 Circulation. 1964;29:533-545 doi: 10.1161/01.CIR.29.4.533 Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 1964 American Heart Association, Inc. All rights reserved. Print ISSN: 0009-7322. 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