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Electrotherapy’s Role in Pain Management Philadelphia 2004 Joseph A. Gallo, ATC, PT Associate Professor Hesser College Applied Medical Sciences Clinician Performance Rehab Workshop Agenda z z z z Electrotherapy for pain: why use it? General electrophysiology a practical review Waveform principles Clinical Selection of waveforms and parameter settings Introduction z Why the interest in electrotherapy??? z Why the confusion??? z Importance of terminology z “The Parameters” z Why treat the pain impairment??? Fundamentals “we can only build as high as our foundation is deep” - unknown The pain Impairment z z ¾ ¾ ¾ What is pain? What Physiologic and psychological effect does it have on our patients? Inhibition of muscle Lack of confidence, tentativeness, depression Poorly managed acute pain can lead to chronic pain, chronic inhibition of mm, disuse atrophy and contracture Concepts Related to Pain z z z z z Subjective response Central Biasing Psychosocial component of pain appears to be accentuated when other life stressors are predominate Role of positive belief systems and attitude Ethnicity1 1. Zborowski M: People in Pain. Sanfrancisco, Jossey-Bass, 1969 Treating Pain: The Controversy Argument #1 ¾ “Using passive modalities to treat pain is of no use; the cause of the pain must be identified and resolved” Argument #2 “ Pain interferes with treatment of the underlying pathology and if left untreated can lead to further dysfunction” Assessing Pain Pain assessment is critical to assessing the effectiveness of electroanalgesia treatments Numeric pain scale (NPS) 0-10 High test retest reliability (ICC = .96)1 Strong correlation to VAS (r=.85)2 Visual analogue Scale (VAS) 1. Ferraz et al. J Rheumatol. 1991;18:1269. 2. Paice et al. Cancer Nurs. 1997;20:88-93 z z ¾ ¾ Assessing Pain Continued z Body Pain Diagram z Mcgill pain questionnaire z Interview/history/symptom behavior Pain/Inflammatory Cycle Neurobiology of Pain Electrotherapy and Pain Control z Theories of pain control using electrotherapy – Gate Control Theory – Opiate-mediated Control Gate Theory of Pain Control z Melzak and Wall 1965 z Substantia Gelatinosa and T-cell (dorsal horn of SC) controls nerve impulses to the brain. Only allows one impulse through at a time; like a gate. – A-delta afferents “fast pain” 4-30 m/s – C- fibers “slow pain” 0.5 -2 m/s – A-beta afferents “pleasant/fast” 36-72 m/s T-cell Pain Sensory Motor Brain Opiate-Mediated pain Control Descending endogenous opiate system Supraspinal pain modulation that produces a descending inhibition of pain chemically at the dorsal horn of the spinal cord The spinal gate is closed from influence from above The periaductal gray matter secretes endogenous opiates in the blood plasma and cerebral spinal fluid Endogenous opiate peptides - enkephalins, beta-endorphin – Endorphin means “Morphine Within” – longer lasting pain suppression – Enkephalin means “Within the Head” – shorter acting pain suppression Opiate-Mediated pain Control – – – Chronic pain patients have been found to have below normal levels of endorphins in their cerebral spinal fluid Endorphins have been shown to increase in the cerebral spinal fluid with twitch level electrical stimulation. Goal of electrotherapy is to boost the levels of Endorphins in a patient What is Electrotherapy? z It is the application of electrical stimulation transmitted through the body via electrodes for therapeutic purposes. z The current flows through the body from one electrode to the other and causes different physiological reactions depending on the type of current selected, the parameters of the selected current. Review of Electrotherapy Currents: Yes! It Is This Simple Electrotherapy Currents Pulsed Current Alternating Current Direct Current Pulsed Current Alternating Current Direct Current Selecting Electrotherapy Parameters: Terminology z “Electrotherapy is about building pulses (PC) or cycles (AC)” z “The ht (amplitude), Width (phase or cycle duration), and frequency are maniplulated to create a desired physiologic response” Pulse (PC) and Cycle (AC) Characteristics z Amplitude: (intensity) mA = “how tall” z Width: microseconds ¾ Phase duration (Pulsed current) ¾ Cycle duration (alternating current) Carrier frequency of 2500 Hz = 400 microseconds Carrier frequency of 5000 Hz = 200 microseconds Strength Duration Curve: the basis for selection amplitude and “width” Frequency z Refers to how many times per second the pulse or cycle is delivered z Termed beat frequency when AC is used z Difference between carrier frequency and beat frequency ¾ Carrier frequency indirectly describes cycle duration General Electrophysiology z Clinical Stimulators – Patients tissue Generic Stimulator completes an electrical circuit – The lead wires carry the current from the stimulator through the electrodes to and Anode positive pole Cathode negative pole through the patient + – Skin is a resistor impeding current flow Generic Patient – Subcutaneous tissue is a conductor General Electrophysiology z Target Tissue Generic Stimulator – Sensory, motor, or pain nerve fibers z The current flows through the target tissue to the other electrode and up the other lead wire to the stimulator + - Generic Patient The patient completes the circuit Electrode Issues z z z z Electrodes should be placed so the flow of current can reach the target tissue The farther apart the deeper the penetration Placed too close the potential exists for greater concentration Superficially this can result in discomfort Choosing appropriate electrode size z ¾ ¾ ¾ Small electrode (ex: 2 x 2 inches) Increases current density Recruits fewer motor units More uncomfortable Large electrode (ex: 4 x 5 inches) ¾ Decreases current density ¾ Recruits more motor units ¾ More comfortable z Electrode Skin Interface z The skin is a resistor to the flow of current – Good skin preparation is important – To lower impedance clean the skin (alcohol or soap) – Proper electrodes and conductive medium are essential – Pearls and pitfalls Electrode Placement Strategies For Pain z • • Bracket structure a. Proximal / Distal b. Medial / Lateral c. Anterior / Posterior Directly over the site of pain Interferential is a quad polar (4) electrode application. The area should be bracketed “X”. Bi-polar placement Electrode Placement Strategies Cont.. Structure and Innervation a. Major nerve root b. Dermatome c. Superficial peripheral nerve d. Acupuncture and trigger points z a b Quad-polar placement Literature review of applications: USA Application Pain Management Acute Chronic Spasms Post-Operative Muscle Weakness Min to moderate Moderate to Sever Disuse Atrophy Re-education Increase ROM Prevent Venous Thrombosis IFC Premod VMS HVP √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ √ yes Inflammation / Edema Increase local circulation Tissue healing Spasticity management Contracture management √ √ √ MicroCurrent √ √ √ √ √ √ Russian √ √ √ √ √ √ Three Categories of Electrotheraputic Currents z z Direct Current: Historically refereed to as “Galvanic Current” involves the + continuous or 0 uninterrupted flow of charged particles. Clinical apllications – Iontophoresis – Stimulating denervated muscle Direct Current Alternating Current z Historically referred to as “Faradic Current” involves the continuous or uninterrupted bidirectional flow of charged particles. – Interferential Stimulation – Premodualted – Russian Beat Frequency: 100 Hz Pulsed Current z Pulsed or interrupted current is an isolated unit of uni- or bidirectional movement of charged particles that periodically ceases for a finite period of time. – Twin Peak High Volt Pulsed Current – Monophasic, biphasic VMS™, Microcurrent, Common TENS, Low Volt Waveforms: various configurations of the 3 electrotherapy currents z z z z z z z High Volt Pulsed current Biphasic VMS™ Premodulated Interferential Russian Microcurrent High Voltage Pulsed Current z High Volt current is a rapid succession of two brief high voltage impulses. The current flows in only one direction, which is determined by the selection of either a “positive” or “negative” polarity setting. VMS™ z z VMS™ a trademarked name of the Chattanooga Group Variable Muscle Stimulation – Symmetrical Biphasic Square Waveforms with a 100 mSec interphase interval Premodulated z The two medium frequency sine waves are mixed in the system and delivered to the patient with two electrodes. Premodulated Current Beat Frequency: 100 Hz Premodulated Current – is simply taking two alternating medium frequency currents mixed within the electronics of the unit and delivered through two electrodes. Clinical Benefits z z z z Comfortable Simple two pad setup Easily applied to small joints of the upper extremity Acute or chronic pain Interferential Quad-Polar z Alternating Current z Continuous medium-frequency sine wave z Uses two channels of differing carrier frequencies to create a “beat” frequency within the tissues. – Scan - amplitude modulation – Sweep - frequency modulation – Intensity - output amplitude Interferential Channel 1 5,000 Hz Channel 2 5,100 Hz Interferential Characteristics z z Amplitude modulated, medium frequency, sine wave Interferential Current – is simply taking two channels of alternating medium frequency current and arranging the electrodes in a crossing pattern. Ch. 2 Ch. 1 Ch. 1 Ch. 2 Clinical Benefits z Comfort z Targeting hard to reach tissues (e.g.subscapularis) z Pain modulation – Acute – Chronic Acute or chronic pain Russian z Characteristics – Sinusoidal alternating current with a 2,500 Hz carrier frequency. – Current modulated at 50 Hz 2500 Hz Burst Microcurrent z z ¾ ¾ ¾ Subsensory level Microcurrent wave forms vary btwn manufacturers Pulsed current Alternating current Low intensity direct current Clinical Decision Process: choosing a waveform to meet your objective z z Concept: “the waveform is not the treatment” We use waveforms to deliver a specific electrotherapy intervention (e.g. sensory level electroanalgesia) Always choose treatment first than choose suitable waveform International overlay Options There are 5 waveforms approved for pain management by the FDA. z Interferential Quad-Polar z Premodulated Bi-polar z Microcurrent z TENS – Symmetrical and Asymmetrical Biphasic Electrotherapy Treatments for Pain Modulation z z z z Sensory level electroanalgesia (AKA: high frequency TENS, Conventional Tens) Waveforms - IFC, Premod, HVPC, Biphasic Motor level electroanalgesia (AKA: low frequency TENS, acupuncture like TENS) Waveforms - IFC, Premod, Biphasic Brief Intense TENS (need a unit with on/off time) Waveforms - Biphasic, “Russian” (AC) * High Intensity Noxious Electrical Stimulation for pain modulation Sensory Level Electroanalgesia AKA: High frequency TENS or Conventional TENS Acute pain management Phase Duration: 2-50 microseconds Frequency: >80 pps On/off time: none Amplitude: Perceptible tingling, no motor response should be elicited Duration of Rx: 15-30 min • -Amplitude, frequency or duration modulations can be used to minimize accommodation- Mech of action: segmental non-opiate, gate control theory Sensory Level Electroanalgesia Using the IFC or Premod waveform z z z Acute Pain Management Gate Control 4 pad application (IFC), 2 pads (premod) – Carrier frequency: 5000 HZ (usually preprogramed) – Beat Frequency: 80-150 Hz, fast sweep – Intensity Level: Sufficient to produce a moderate strong, sensory tingling effect, with no motor response – Duration: 20-30 minutes Interferential Stimulation: De Domenico Ph.D Sensory Level Electroanalgesia Clinical Application Notes z z z z z Believed to relieve pain through the gate control theory of pain modulation via hyperstimulation of A-beta nerves Treatment of choice for acute conditions Amplitude: increase to twitch and back off slightly Literature reports little pain relief post Rx; pain relief beyond Rx time may occur if pain-spasm cycle is interrupted Waveforms: Pulsed Current, *HVPC, IFC(AC), Premod (AC) Robinson AJ, Snyder-Mackler L. Clinical Electrophysiology. 2nd ed. Williams & Wilkins. Introduction to Motor Level Electroanalgesia: “Twitch Level Stimulation” z z z Endorphins are released at a pulses rate range of 1 to 15 pps (approx.) Twitch level stimulation Enkephalins are released at the higher pulse rates of 80 pps and up. Twitch level stimulation Endorphin induced pain suppression lasts longer than pain suppression induced by enkephalins Motor Level Electroanalgesia AKA: Low frequency TENS, Acupuncture like Tens, opiate induced electroanalgesia, twitch level stimulation Phase Duration: ≥ 150 microseconds Frequency: 2-4 pps (≤ 10 pps is acceptable) On/off time: None Amplitude: Strong visible muscle contraction Duration of treatment: Literature suggests 3045 minutes Robinson AJ, Snyder Mackler L. Clinical Electrophysiology Motor Level Electroanalgesia Using Premod or IFC waveform ¾ ¾ Mode: 2 pad application(premod) 4 pad application (IFC) Carrier frequency: 2500 – 5000 Hz (usually pre-programed in machine (e.g. Chatt vectra = 5000Hz) ¾ ¾ ¾ ¾ Beat Frequency:1 to 10 Hz or 2 Hz constant On/off time: none Intensity Level: Strong visible muscle contraction Duration: 30-45 minutes Interferential Stimulation: De Domenico Ph.D Motor Level Electroanalgesia Clinical Application Notes z z z z z Believed to reduce pain through the activation of endogenous opiates The literature reports greater carry over of pain relief; up to several hours Research suggests that stronger contractions produce greater analgesia Not a good choice for acute injuries Waveforms: pulsed currents, IFC (AC), and Premod (AC) High Intensity Noxious Electrical Stimulation for Pain Modulation Type of Stimulator: Alternating Current unit Carrier Frequency: 2500 Hz Frequency: 50 bursts / second On / Off Time: 12 sec on / 8 seconds rest Electrode Placement: Small electrodes (1x2cm) directly over the site of pain Amplitude: maximum tolerable Treatment time: 10 minutes High Intensity Noxious Cont.. z z z Excellent preliminary results in pilot studies and in one published case report Theoretical Construct of Case report - Decreased force output (strength) can be caused by mm inhibition secondary to pain. –not always a strength issue- speedy return of strength after just 2 ES treatments to painful patella tendon No high quality research studies to date Muller et al J Orthop Sports Phys Ther. 2000;30:138-142. Brief Intense TENS AKA: Hyperstimulation analgesia Phase Duration: > 300 microseconds Frequency: 100-150 pps Amplitude: Noxious with visible and palpable muscle contraction On time: 10 -15 seconds Off time: 4-7 seconds Duration of Rx: 15-30 minutes Brief Intense TENS: Clinical Application Notes z z z z z The high frequency (pps) and limited rest between contractions is believed to induce electrical fatigue of muscles in spasm Since this is an aggressive treatment method, not all patients are candidates Not indicated for acute injuries Good clinical results for reduction of muscle spasm associated with LBP (opinion) Duration of pain relief: < 30 min Microcurrent z z z Monophasic rectangular wave with selectable or alternating polarity Stimulation at a subsensory level (< 1mA) Do you believe in something you can not feel? z What are your experiences? z More studies are necessary Clinical Applications z Common treatment guidelines: – Healing phase z Ultra-low frequencies under 1 Hz (.3 Hz) z Ultra-low amplitude 10-80 uA – Pain Settings z High frequency 3 - 30 Hz z Amplitude 150 - 600 uA – Patients not responding at 3-30 Hz range should proceed to 300-990 Hz range * Linda Manley M.Ed, ATC, PT - Microcurrent Universal Treatment Techniques and Applications Common Treatment guidelines cont.. Treatment time: z Probes – 5-30 seconds per site – GSR mode helps locate areas of low impedance z Electrodes – General soft tissue injuries 20-30 minutes – Nerve root and low back injuries 30-60 minutes Polarity guidelines: positive for acute conditions negative for chronic conditions HVPC to Retard the formation of Edema z Fish, Mendel and associates published extensively from 1990 through 1997 on electrical stimulation and edema – HVPC waveform to a sensory level cathode at the site of injury retards the formation of edema. – Stimulation when applied to acute inflammation does not reduce it but retards the formation of edema. – Excellent addition to standard acute care of athletic injuries; must begin prior to the formation of edema HVPC: Prevention of Edema z Mechanism – Reduce the leakage of large protein molecules and fluid from the blood, through the walls of the small blood vessels into the interstitium. Parameter Settings z z z z z z z Waveform: Twin Peak High Volt Pulsed Current Frequency: 120 pps Polarity: Negative Ramp: None Amplitude: 10% below motor threshold Time: 30 minutes 4 times per day Electrode placement – Cathode (negative electrode) placed over the site of injury. Should be smaller in size than the anode (positive electrode) – Anode (positive) placed in a convenient site. Does not need to be proximal as the effects are local effects. Water Bath Technique z Electrode placement – Carbon rubber cathode (-) immersed in room temperature water with accompanying edematous limb – Anode (+) electrode placed proximally on same limb or trunk Summary of Key Points z z z Treating the pain impairment can interrupt the pain spasm cycle and allow rehab to progress faster Chose electrotherapy treatments based on stage of tissue healing and desired physiologic response Remember that the waveform is not the treatment – choose the treatment first than select a waveform that has the necessary characteristics to deliver the treatment. Often several correct options! Summary of Key Points z ¾ ¾ ¾ Utilize the continuum of electrotherapy treatments based on stage of healing Progress from sensory level to motor level analgesia (opiates) when tissue is ready Assess pain pre and post treatment to determine effectiveness of electrotherapy the intervention HVPC role in standard acute care of athletic injuries Questions Thank You z Email [email protected] z Office Number (603) 668-6660 x2119