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THE CELL CYCLE: A CLOSER LOOK! BIOLOGY 12 FUNNY? REVIEW (FROM LAST CLASS): WHICH STAGE IS LONGEST? INTERPHASE • Aka the resting phase (but not really…) • Essentially, the cell is in between divisions and is carrying out maintenance activities of the cell • Made up of 3 sub-phases: 1. G1 phase 2. S phase 3. G2 phase INTERPHASE: G1 PHASE • 1st growth phase • Cell mature by making more cytoplasm & organelles • Cell carries on its normal metabolic activities, such as synthesising proteins INTERPHASE: S PHASE • Synthesis stage • DNA is copied or replicated Two identical copies of DNA Original DNA INTERPHASE: G2 PHASE • 2nd Growth Stage • Occurs after DNA has been copied • All cell structures needed for division are completed (e.g. centrioles) • Both organelles & proteins continue to be synthesized MITOSIS • Aka karyokinesis • Division of the nucleus • Only occurs in eukaryotes • Made up of 4 phases: 1. 2. 3. 4. Prophase Metaphase Anaphase Telophase MITOSIS: PROPHASE • Early prophase: • Centrioles: make spindle fibres and move towards opposite plates • Chromosomes shorten and thicken (now visible under a microscope) • Late prophase: • Centrioles reach poles • Nuclear membrane (envelope) & nucleolus start to disappear MITOSIS: METAPHASE • Spindle fibres attach to centromeres • Sister chromatids (doubled chromosomes) line up at equator (middle of cell) • Guided by spindle fibers MITOSIS: ANAPHASE • Centromeres divide in two • Spindle fibers contract and pull sister chromatids towards opposite ends of cell (pole) • Each pole (future daughter cells) will have an identical set of chromosomes MITOSIS: TELOPHASE • Sister chromatids at opposite poles • Spindle disassembles • Nuclear membrane forms around each set of sister chromatids • Nucleolus reappears • Chromosomes loss their distinct outlines reappear as chromatin IN PICTURES: • Prophase • Metaphase • Anaphase • Telophase 15 CYTOKINESIS: • Means division of the cytoplasm • Division of cell into two, identical halves called daughter cells • Would this happen the same way in plants and animal cells? Why or why not? • In plant cells, cell plate forms at the equator to divide cell • In animal cells, cleavage furrow forms to split cell CYTOKINESIS Cleavage furrow in animal cell Cell plate in animal cell 17 HELPFUL HINT? • • • • • • Interphase Prophase Metaphase Anaphase Telophase Cytokinesis IPMATC Amimation: • http://www.youtube.com/watch?v=AhgRhXl7w_g& feature=fvsr TO DO: • Mitosis colouring sheet • Labelling sheet • Nelson Bio 11 Book • #1 to 9