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UNIT 7 The Respiratory System 11 - 1 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Respiratory System Obtains O2, removes Co2 = Primary functions Filters incoming air Control temperature & H2O content Produce vocal sounds Participate in sense of smell Regulation of blood pH The Pathway of Oxygen to the Internal Cell Mouth and nose Pharynx (throat) Larynx (voice box) Trachea (windpipe) Bronchi Bronchioles Alveoli (air sacs) 11 - 3 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. External and Internal Respiration External The process of getting oxygen from the nose to the alveolus and into capillaries and the return of carbon dioxide to the nose Internal The exchange of oxygen and carbon dioxide at the cellular level 11 - 4 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. The Respiratory System 11 - 5 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. https://www.youtube.com/watch?v=bHZs vBdUC2I 11 - 6 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Nose - cavity that is divided by a wall of cartilage called the septum. The structures inside the nose warm and filter the air. Cilia (hairs that warm the air) Conchae (3 bones that add moisture) Mucous membranes (trap dust and bacteria) 11 - 7 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Nasal conchae – bones that curl out from lateral walls of nasal cavity on each side, dividing cavity into passageways Supports mucous membrane 11 - 8 Rich in goblet cells Organs of the Respiratory System 11 - 9 Paranasal Sinuses – air-filled spaces within maxillary, frontal, ethmoid, and sphenoid bones Reduce weight of skull Resonant chambers – affect quality of voice Organs of the Respiratory System Pharynx Also called the throat Passageway for food and air Connects the mouth to the larynx 11 - 10 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Larynx Also called the voice box Home to the thyroid cartilage (Adam's apple), cricoid cartilage, and epiglottis A tube made up of nine separate cartilages to maintain openness Lined with mucous membranes that form two folds called the vocal cords 11 - 11 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. 11 - 12 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Vocal Cords https://www.youtube.com/watch?v=B3hlo oOjAxE 11 - 13 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. How Voice Sounds Are Produced The vocal cords move across the larynx when struck by air. The vocal cords are held tense by contracting muscles. The degree of tension and length of the vocal cords determine the pitch of the voice. The tighter and longer the cords, the higher the pitch. 11 - 14 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Epiglottis Lid on the top of the larynx When food is swallowed, the lid closes so that food is directed down the esophagus and not into the lungs. Air passes over the open epiglottis and enters the larynx. 11 - 15 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. 11 - 16 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Trachea, Bronchi, and Bronchioles 11 - 17 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of The Respiratory System Trachea Also called the windpipe Held open by C-shaped rings of cartilage The wall between the rings is elastic to adjust for body positions. Above the middle of the sternum, the trachea divides into two sections called bronchi. 11 - 18 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. 11 - 19 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Bronchial Tree – branched airways leading from trachea to microscopic air sacs in lungs Branches into right and left primary bronchi – 5th thoracic vertebrae Then divides into secondary bronchi Then into tertiary bronchi, then into smaller and smaller tubes = bronchioles 11 - 20 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. 11 - 21 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Bronchioles continue to divide and lead to alveolar ducts alveolar sacs alveoli – lie within capillary networks 11 - 22 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. The Structure and Function of the Alveolus Also called the air sacs Clusters of capillaries located at the ends of each bronchiole The body contains approximately 500 million alveoli. 11 - 23 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Organs of the Respiratory System Lungs – soft, spongy, cone shaped Mediastinum separates right and left lungs medially Diaphragm and thoracic cage enclose them Right lung is larger than left Right – 3 lobes Left – 2 lobes 11 - 24 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. 11 - 25 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. The Pleural Covering Each lung, with its blood vessels and nerves, is enclosed in a membrane called the visceral pleura. A membrane called the parietal pleura lines the chest cavity. The space between the pleura contains fluid to prevent friction during respiration. 11 - 26 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Inspiration Atmospheric pressure – weight of air that forces air into lung Pressures inside and outside lung are about the same, but change with inspiration and exhalation Pressure in alveoli decreases (inspiration) atmospheric pressure pushes air into airways 11 - 27 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Inspiration Impulses on phrenic nerves (cervical plexuses) stimulate diaphragm to contract Diaphragm moves downward, thoracic cavity enlarges, pressure in alveoli falls atmospheric pressure forces air into airways Intercostal muscles may also be stimulated, opening thoracic cavity even more 11 - 28 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Inspiration Moist pleural membranes help lung expansion, but moist inner surfaces of alveoli have opposite effect Attraction of H2O molecules create surface tension make it harder for alveoli to inflate Some cells produce surfactant to reduce tendency to collapse 11 - 29 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Surfactant A fatty molecule located on the respiratory membrane Maintains the inflated alveolus so that it does not collapse between respirations Important in premature babies lack of surfactant resp. distress 11 - 30 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Expiration These forces come from elastic recoil of tissues and surface tension Diaphragm relaxes At the same time, surface tension develops in alveoli, diameters of alveoli decrease Increases alveoli pressure, air forced out 11 - 31 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. The Diaphragm and the Brain and How They Relate to Breathing 11 - 32 The main muscle of respiration is called the diaphragm. When the diaphragm contracts, it produces a vacuum that causes air to be drawn in. When the diaphragm relaxes, air is forced out of the lungs. (continued) Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. The Diaphragm and the Brain and How They Relate to Breathing Breathing is controlled by the respiratory center in the brain. An increase in carbon dioxide or a drop in oxygen triggers the respiratory center to force respirations. 11 - 33 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Respiratory Center Neurons that control inspiration and expiration are scattered throughout the pons and medulla oblongata 11 - 34 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Medullary Rhythmicity Area 2 neuron groups that extend the length of medulla oblongata Dorsal Respiratory Group Ventral Respiratory Group 11 - 35 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Dorsal Respiratory Group Controls basic rhythm of inspiration Neurons emit bursts of impulses that signal diaphragm to contract Impulses begin weakly, strengthen for about 2 seconds and then diminish Neurons inactive during expiration Re-fire impulses after expiration 11 - 36 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Ventral Respiratory Group Quiet during normal breathing When more forceful breathing is required, neurons generate impulses that increase respiratory movements 11 - 37 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Pneumotaxic Area Neurons located in Pons Continuously transmits impulses that inhibit inspiratory bursts from dorsal respiratory group Controls breathing rate Pneumotaxic inhibition increased = breathing rate increases Inhibition weak = breathing rate decreases 11 - 38 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Factors Affecting Breathing Interference with O2 supply to brain may cause fainting Someone who is emotionally upset may hyperventilate dizzy, lose conciousness Lowered Co2 followed by rise in pH (respiratory alkalosis) Localized vasoconstriction of cerebral arterioles Decreased blood flow to brain 11 - 39 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Occurrences That Alter Breathing Coughing Hiccoughs 11 - 40 Deep breaths followed by forceful exhalation that can clear mucus from the lower respiratory tract Caused by spasm of the diaphragm, possibly the result of an irritation to the diaphragm (continued) Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Occurrences That Alter Breathing Sneezing Yawning Air is forced through the nose to clear the upper respiratory structures Deep, prolonged breath that can be caused by a drop in oxygen levels Crying A change in the breathing pattern that is in response to emotions 11 - 41 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Gas Exchange https://study.com/academy/lesson/gasexchange-in-the-human-respiratorysystem.html 11 - 42 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Oxygen Transport Over 98% of O2 that blood transports binds the hemoglobin in RBC The remaining O2 dissolves in plasma In lungs, PO2 (partial pressure) is relatively high O2 dissolves in blood and combines rapidly with iron atoms creating oxyhemoglobin 11 - 43 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Oxygen Transport Chemical bonds between O2 and hemoglobin are unstable As Po2 decreases, oxyhemoglobin molecules release O2 Diffuses into nearby cells that have depleted their O2 supply during cellular respiration 11 - 44 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Oxygen Transport More O2 is released as 11 - 45 Co2 concentration increases Blood becomes more acidic Blood temp. increases O2 deficiency in tissues = hypoxia Carbon Dioxide Transport Blood transports Co2 to lungs As Co2 dissolved in plasma Part of a compound formed by bonding to hemoglobin Form of a bicarbonate ion 11 - 46 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Carbon Dioxide Transport Transporting Co2 in bicarbonate form is most common Co2 + H2O H2CO3 (carbonic acid) Once in alveoli, carbonic acid breaks down into Co2 and H2O under influence of carbonic anhydrase 11 - 47 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Diagnostic Exams 11 - 48 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Perfusion Scans Examination of the lungs after intravenous administration of a radioactive dye to provide an image of pulmonary blood flow Can be used to diagnose blood vessel obstruction 11 - 49 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Ventilation Scans Examination of the lungs following the inhalation of a mixture of air and gases from a mask or bag that shows what areas of the lungs are ventilated during respiration 11 - 50 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Arterial Blood Gas Studies Measures the partial pressures of both oxygen and carbon dioxide and determines the pH 11 - 51 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Bronchoscopy and Chest X-Ray Bronchoscopy Chest x-rays 11 - 52 A tube is inserted into the trachea to view the airways or to remove a foreign body Studies that tell the general health of the lungs and surrounding tissue Bronchoscopy https://www.youtube.com/watch?v=v9sJ VicR9PY 11 - 53 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Diseases and Disorders 11 - 54 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Resp. Failure, Conditions, Diseases https://study.com/academy/lesson/conditi ons-associated-with-respiratoryfailure.html https://study.com/academy/lesson/typesof-respiratory-conditions-diseases.html 11 - 55 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Allergic Rhinitis and Asthma Allergic rhinitis A reaction of the eyes, nose, and sinuses to airborne allergens Asthma A chronic disorder that causes swelling, inflammation, and constriction of the bronchi and bronchioles Can be caused by exposure to allergens 11 - 56 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Lung Cancer 11 - 57 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Atelectasis and Bronchitis Atelectasis Lack of air in the lungs resulting from collapse of the alveolus Bronchitis Acute or chronic disease that results in inflammation of the bronchial walls and narrowing of the airways 11 - 58 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Chronic Obstructive Pulmonary Disease (COPD) A chronic condition that is usually the result of a combination of respiratory disorders A progressive disease that causes dyspnea, respiratory failure, and death 11 - 59 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Emphysema and Epistaxis Emphysema Irreversible enlargement of the air spaces in the lungs caused by destruction of the alveolar walls Results in the inability to exchange oxygen and carbon dioxide Epistaxis Nosebleeds 11 - 60 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Laryngitis and Pleurisy Laryngitis Acute or chronic inflammation of the vocal cords Pleurisy Inflammation of the pleura that results as a complication of infections, pneumonia, tuberculosis, or injury 11 - 61 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Paroxysmal Nocturnal Dyspnea Associated with chronic lung disease or left ventricular heart failure Individuals awaken at night with a sensation of suffocation that is probably caused by an accumulation of fluid in the lungs 11 - 62 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Pneumonia and Pneumothorax Pneumonia Acute infection of the lung tissues The leading cause of death among patients already in a weakened state Pneumothorax Air or gas that has accumulated between the two pleural layers, causing collapse of the lung tissue 11 - 63 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Respiratory Distress Syndrome Can kill infants between the ages of birth and 8 months of age Normal breathing becomes rapid and shallow. The nostrils flare and the sternum retracts. The infant “grunts.” https://www.youtube.com/watch?v=J2R8 MOoQtd8 11 - 64 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. Tuberculosis Acute or chronic bacterial lung infection that is highly contagious The body reacts to the bacteria by converting destroyed tissue into a cheeselike material that can develop into fiber optic obstruction of the lung cavities. 11 - 65 Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved.