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Nutrition Therapy for Metabolic Stress and Critical Illness Lauren Hoover & Clare Howard KNH 411 November 8, 2016 Patient Chris McKinley, Male, 37 y.o. -Summary: Patient has weighed over 250 pounds. since age 15 with steady weight gain, recently reaching a high of 424 pounds, then lost 24 pounds prior to his bariatric surgery. Four months ago, he received the Roux-en-Y gastric bypass. Total weight loss to date is approx. 100 pounds. However, now he is admitted to the MICU from the ER with probable sepsis. -Vital Signs (Admitting)-Temp.: 102.5 BP: 135/90 Pulse: 98 Resp. Rate: 23 Height: 5’10” Weight: 325 lbs. Patient History -Onset of disease: Experienced flu-like symptoms over previous 48 hours, became acutely SOB - brought to ER -Medical Hx: Type 2 DM, Htn, hyperlipidemia, osteoarthritis -Medications: Lovastatin 60 mg/day (Also has been off diabetes medications for 2 mo.) -Tobacco Use: none -Alcohol Use: Socially, none since surgery -Family Hx: Father - Type 2 DM, CAD, Htn, COPD; Mother - Type 2 DM, CAD, osteoporosis Roux-en-Y Gastric Bypass Surgery Sepsis/SIRS • Etiology - Combination of pro-inflammatory cytokine release, coagulation factor imbalance, altered cell metabolism, hypoperfusion, and hypotension • Diagnosis - increased WBC count, HR, and respirations, and fever or hypothermia. Others include inflammatory variables • Pathophysiology - originating source of infection/trauma, initial inflammatory response resulting in vascular permeability, continues to an anti-inflammatory response with resulting organ dysfunction. – Increased gluconeogenesis = catabolism of muscle mass Patient’s Laboratory Results Reference Range 2/23 Value Potassium (mEq/L) 3.5-5.1 5.8 Carbon dioxide (mEq/L) 23-29 31 Glucose (mg/dL) 70-99 385 Phosphate (mg/dL) 2.2-4.6 2.1 Bilirubin, total (mg/dL) <1.2 1.3 Bilirubin, direct (mg/dL) <0.3 0.7 Patient’s Laboratory Results cont. Reference Range 2/23 Value CPK (U/L) 55-170 220 Fibrinogen (mg/dL) 160-450 525 Lactate (mEq.L) 0.3-2.3 4.2 Cholesterol (mg/dL) <200 320 HDL-C (mg/dL) >50 32 VLDL (mg/dL) 7-32 45 LDL (mg/dL) <130 232 Patient’s Laboratory Results cont. Reference Range 2/23 Value HbA1c (%) <5.7 6.8 PT (sec) 11-13 14.5 INR 0.9-1.1 1.4 PTT (sec) 24-34 37 WBC (x10^3/mm^3) 3.9-10.7 23.5 Hemoglobin ( g/dL) 14-17 12.5 Hematocrit (%) 41-51 38 Patient’s Laboratory Results cont. Urinalysis results: -Protein, glucose ketones, and Bact present, Treatment for Sepsis • Treat the infection first • Support patient with ventilation, antibiotics, hemodynamic, renal, and metabolic support • Insulin therapy, antimicrobial agents, coagulation-modulating drugs Physician’s Assessment/Plan -Diagnosis of severe sepsis, pneumonia -Maintain current mechanical ventilation, continue vancomycin, Zosyn -Sedated with Versed and fentanyl -Initiate enteral feeding per nutrition consult Nutrition Therapy - Assessment Height = 5’10” = 1.78m Current Wt. = 325 lbs. = 147.73 kg Usual BW = 425 lbs. %Usual BW = 76.5 % Ideal BW (using Hamwi method) = 166 lbs. = 75.5 kg BMI = 46.6 kg/m^2 Nutrition Therapy - Diagnosis • Inadequate protein-energy intake related to NPO current diet, as evidenced by lab results, specifically total protein, albumin, and prealbumin • Increased nutrient needs related to inability to consume regular diet as evidenced by intubation and sedated state. Nutrition Therapy - Intervention Calculation of Energy, Protein and Fluid needs: Energy - 25-30 kcal/kg IBW Protein - 1.2-1.5 g/kg IBW Energy - 1890-2270 kcals Protein - 91-113 g Fluids - 1 mL/kcal Fluids - 1890-2270 mL Nutrition Therapy - Intervention Enteral Nutrition Plan: -Formula chosen - Isocal HN Plus (1.20 kcal/mL, 54 g protein/L) -For continuous feeding - 1800 mL/24 hours = 75 mL/hr. via pump -For bolus feeding - 1800 mL/4 feedings = 450 mL/feeding Initial start rate of 20 mL/hour, increase by 15 mL every 4 hours to achieve 75 mL/hr, change to bolus feeding 6 times/day (300 mL), then to 4 times/day (450 mL). Nutrition Therapy - Intervention Enteral Nutrition: 1800 mL of Isocal HN Plus provides -1800 mL fluid -2160 kcals -97 g protein *An additional 100-200 mL of fluid can be given. Nutrition Therapy Monitoring/Evaluation -Initially (if unstable): I/O, electrolytes, BUN, creatinine, weight, hydration status, vital signs, bowel function, blood glucose daily, and TG, liver function tests weekly. -When Stable: I/O, electrolytes, BUN, creatinine, weight, hydration status, vital signs, bowel function, blood glucose 1-3 times/week, and TG, liver function tests as needed. -Monitor any intolerance via symptoms, such as vomiting, nausea, diarrhea, abdominal pain, etc. Change feeding progression if needed . References International Dietetic & Nutrition Terminology (IDNT): Reference Manual. Standardized Language for Nutrition Care Process. Academy of Nutrition and Dietetics, 2014. Retrieved from ncpt.webauthor.com Mahan, L.K., Escott-Stump, S., Raymond, J.L. Krause’s Food Nutrition & Diet Therapy, 13th ed. Philadelphia, PA: W.B. Saunders Company, 2012 Nelms M. Medical Nutrition Therapy A Case Study Approach 5th ed., Cengage Learning, 2017. Nelms M. Sucher K, Lacey, K. Nutrition Therapy and Pathophysiology. 3rd ed. Cengage Learning, 2016. Questions?