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P020A Handout 5 I. Identify the causative agent and the effects on the fetus in the following maternal infections: Rubella, Toxoplasmosis, Syphilis, Cytomegalovirus A. General development concepts 1. ______________ - _______________ development 2. ______________ - _______________ development B. Rubella: AKA _______________________________________ C. Congenital Rubella Syndrome (CRS) AKA: ________________________ syndrome 1. Etiology: __________________________ a. Critical time: ___________________ trimester 2. S&S: _____________________ a. ID: _________________________________________ b. _______________________ defects 1) ____________________ & ___________________ c. ______________________ defects d. ______________ cephaly e. ______________ abnormalities f. __________________________ 3. Treatment 4. Prevention: ________________________________ D. Toxoplasmosis: 1. ________________________ parasite 2. ______________ placental spread E. Congenital Toxoplasmosis 1. Etiology a. ______________ undercooked meat b. ______________ feces c. _______ pasteurized mild 2. S&S: _____________________ a. Triad: 1) ____________ cephalus 2) Intracranial _____________________ 3) Chorio_________________________ b. ID: _________________________ c. Sensory: ________________________ d. _______________________________ e. ____________ birth weight f. Hepatosplemomegaly _____________________________ 3. Treatment: ____________________________ 4. Diagnosis a. __________________________________ b. __________________________________ F. Syphilis 1. Transplacental spread G. Congenital Syphilis 1. Etiology: a. Spirochete bacterium: ____________________________ b. Vulnerable Time period: _____________________________ 2. S&S a. Early Stage 1) ______________ to ______________ 2) ______________ discharge 3) Blistery ___________________ 4) No _________________ bridge b. Stage 1) Hutchinson’s triad i. Hutchinson’s ________________ ii. ___________________________ iii. ________________ 2) ID 3) _______________ pain 4) ______________________________ loss 3. Treatment a. Mom: Prenatal _____________& ________________________ b. Delivery: __________________________________ H. Cytomegalovirus 1. _____________ - like infection: ________________________ 2. Etiology: ____________________________ spread I. Congenital Cytomegalovirus 1. S&S: a. Inflammation of the ________________________ b. Hepatosplenomegaly _____________________ c. ____________ birth weight d. ________________________ e. ________________________ f. __________ cephaly 2. Diagnostic tests a. Antibody ________________ against ___________ b. ________________________ level c. ________________________ screen 3. Treatment a. Focus on __________________________ 4. Prognosis II. III. 5. Prevention a. PG: _________________________________________ J. Small Group Questions 1. #31 Describe the cause, sequence of events, pathology and preventative factors of erythroblastosis fetalis. #32 Describe the relationship of the Rh factor disorders and kernicterus A. Erythroblastosis Fetalis 1. _______________________ disease a. _____________ incompatibility b. _____________ incompatibility 2. Neonate ______________ destruction 3. S&S a. __________________ b. _________________________ Jaundice c. __________________ 4. Treatment a. ________________ therapy 1) ___________________ breaks down when exposed to _______ b. Blood ___________________ B. ABO Incompatibility 1. Etiology: a. Mom blood type: ____________________ b. Fetus blood type: ____________________ 2. S&S a. _________________ b. _________________ c. Severe _______________________ 1) Brain damage due to ___________________________________ 3. Treatment a. _________________ therapy C. Rh incompatibility 1. Etiology / Pathophysiology a. Mom blood type: __________________ b. Fetus blood type: __________________ c. Mom develops _________________________ to __________ d. Immune response ___________________________________ 1) ________________________ 2) ________________________ __________ cannot metabolize ______________________________ 2. S&S a. Utero IV. 1) _______________________ 2) ________________________ b. ________________________ c. ________________________ d. ________________________ e. ________________________ 3. Treatment (neonate) a. ________________________ b. ________________________ 4. Prevention! a. ________________________ 1) Prevents development of ______________________________ D. Kernicterus 1. Definition: ___________________ brain damage due to destruction of _________in ______ _______ bilirubin crosses “_____________________________barrier” Brain ___________________ 2. Etiology a. _____________ incompatibility b. _____________ c. _____________ anomalies d. _____________ incompatibilities 3. S&S a. Characteristic: ________________________________ b. ___________________ athetosis c. Spastic ____________________ d. Hypotonia e. Anemia f. Hypoxia Describe the fetal effects from maternal use of the following teratogens: Narcotics, Marijuana, Alcohol, Thalidomide, Anti-convulsants, Tobacco A. Teratogen 1. Potential to _________________________________________ B. Narcotics 1. Examples: ___________________________________________ 2. Effects: a. Retarded _________________________ 1) _____________ birth _______________________ b. ________________________ 1) Withdrawal Begins: _____________________________________ i. Tremors ___________________________ ii. ___________ swallow reflex iii. __________________ iv. _____________________ v. _______ temp ________________________ 2) Up to 6 mo S&S i. Hyper ______________________________ ii. Hyper ______________________________ iii. Tremulousness iv. ___________ social responsiveness 3) Congenital abnormality _________________________ C. Cocaine 1. Drug type: ____________________ 2. Action: _________________ blood vessels ___________________ to brain 3. Trassmission: __________________________& _________________________ 4. Effects Mom: _______ risk of ________________________________ 5. Effects Baby: a. _________________________ b. _________________________ c. _________________________ 6. Withdrawal: Begins ________________________________________ a. ______________ cardia b. ______________ c. Hyper_______________________ d. _________________ problems e. _________________ problems f. ___ risk of ____________________ D. Marijuana 1. Type of drug: __________________________ 2. Effects: Baby a. _______ muscle mass b. __________________ c. ____ __________________ reflex E. Alcohol 1. Type of drug: _____________________________________ 2. Effects: _____________________ a. Fetal Alcohol _____________________ 1) ____________ severe b. Fetal Alcohol _____________________ F. Thalidomide G. Anti-convulsants H. Tobaccoa