Download European Society of Cardiology

ARTERIAL HAEMODYNAMICS AND WAVE INTENSITY –
Concepts, controversies, and clinical applications
Sir Alexander Fleming Building,
Imperial College, London
1st-3rd April 2004
Reduced compliance of central arteries and increased reflections from
peripheral arteries are major causes of left ventricular disease, through their
deleterious effects on ventriculo-vascular coupling. Much treatment in heart failure
and hypertension is intended to ameliorate these effects, but the precise
mechanisms of drugs acting on the vasculature and their consequences for the
heart are difficult to study in clinical practice. Recent developments suggest that
comprehensive non-invasive assessment of interactions between vascular and
ventricular function may now be possible.
This international symposium on arterial function and wave intensity will be
a forum for an ‘in depth’ review of recent research, involving fluid dynamicists,
engineers, experimental physiologists, clinical investigators, and cardiologists and
vascular physicians. Topics to be discussed will include physical principles and
measurement techniques, new methods of assessing large arterial function and
ventriculo-arterial coupling, clinical applications, and the results of early clinical
studies of wave intensity. The atmosphere will be informal, to promote as much
discussion as possible and to allow time for consideration of directions for future
research.
Scientific Committee
Dr Alan Fraser, Cardiff
Professor Kim Parker, London
Dr Frank Schön, Düsseldorf
Professor Motoaki Sugawara, Tokyo
Professor John Tyberg, Calgary
Dr Chris Jones, Cardiff
Local host
Professor Kim Parker,
Physiological Flow Studies Group,
Department of Bioengineering,
Imperial College for Science, Technology and Medicine,
London, UK.
Sponsors
Aloka, Tokyo, Japan
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PROGRAMME
Thursday 1st April 2004
14.00: Session 1: Basic concepts and applications of wave intensity
Chairmen:
Chris Jones, Cardiff
John Tyberg, Calgary
Fundamental concepts of wave intensity
Kim Parker, London
Non-invasive implementation for clinical measurement
Motoaki Sugawara, Tokyo
Comparison of wave intensity with catheter-derived indices
Nobuyuki Ohte, Nagoya
16.15: Session 2: Arterial disease and ventriculo-vascular coupling
Chairmen:
Kim Parker, London
Alan Fraser, Cardiff
Translating the biology of vascular disease into clinical research
Tudor Griffith, Cardiff
Pathophysiological insights from wave intensity in animal models
John Tyberg, Calgary
Friday 2nd April 2004
09.00: Session 3: Are measurements of wave intensity and arterial stiffness
ready for clinical use?
Chairmen:
Motoaki Sugawara, Tokyo
Henryk Siniawski, Berlin
Relationships between flow, diameter and pressure
Victoria Franke, London
Regional variations in wave intensity and sources of error
Andrew Zambanini, London
Reproducibility – Tokyo studies
Kiyomi Niki, Tokyo
Reproducibility – Cardiff studies
Dragos Vinereanu, Bucharest
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10.45: Session 4: Non-invasive diagnosis of circulatory health –
Alternative techniques and clinical utility
Chairmen:
John Goodfellow, Cardiff
Tony Dart, Melbourne
Using flow-mediated dilatation to assess endothelial function
John Deanfield, London t.b.c.
Using applanation tonometry for pulse wave analysis in hypertension and diabetes
Ian Wilkinson, Cambridge t.b.c.
Using wave speed and separation of waves
Ashraf Khir, London
Using wave speed as a clinical tool
Jim Cameron, Melbourne
Using pulse wave velocity
Katarina Naka, Ioannina t.b.c.
14.00: Session 5: Clinical studies of arterial wave intensity
Chairmen:
Frank Schön, Dusseldorf
Alun Hughes, London
Hypertension and heart failure
Simon Thom, London
Heart valve disease and cardiomyopathy
Kiyomi Niki, Tokyo
Stratification of treatment for left heart failure
Henryk Siniawski, Berlin
16.00: Clinical demonstration – Dr K Niki and Dr H Siniawski
16.30: Session 6: Wave intensity at other sites – recent insights & new questions
Chairmen:
Simon Gibbs, London
Michael Frenneaux, Cardiff
In the coronary circulation
Jos Spaan, Amsterdam
t.b.c.
In the left ventricle
Juin-Jr Wang, Calgary
In the pulmonary circulation
Aoife O’Brien, Cork
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Saturday 3rd April 2004
09.00: Session 7: Targeting risk factors for cardiovascular disease
Chairmen:
Tudor Griffith, Cardiff
John Deanfield, London
t.b.c.
Risk factors and conduit arterial function
Tony Dart, Melbourne
The genetics of conduit arterial function
Stephane Laurent, Paris
Vascular disease, subclinical left ventricular dysfunction, and heart failure
Alan Fraser, Cardiff
11.30: Session 8: Priorities for research
Chairmen:
Kim Parker, London
Alan Fraser, Cardiff
Developments in engineering
Akimitsu Harada, Tokyo
An integrated approach to vascular and cardiac disease
Chris Jones, Cardiff
General discussion
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