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ARTERIAL HAEMODYNAMICS AND WAVE INTENSITY – Concepts, controversies, and clinical applications Sir Alexander Fleming Building, Imperial College, London 1st-3rd April 2004 Reduced compliance of central arteries and increased reflections from peripheral arteries are major causes of left ventricular disease, through their deleterious effects on ventriculo-vascular coupling. Much treatment in heart failure and hypertension is intended to ameliorate these effects, but the precise mechanisms of drugs acting on the vasculature and their consequences for the heart are difficult to study in clinical practice. Recent developments suggest that comprehensive non-invasive assessment of interactions between vascular and ventricular function may now be possible. This international symposium on arterial function and wave intensity will be a forum for an ‘in depth’ review of recent research, involving fluid dynamicists, engineers, experimental physiologists, clinical investigators, and cardiologists and vascular physicians. Topics to be discussed will include physical principles and measurement techniques, new methods of assessing large arterial function and ventriculo-arterial coupling, clinical applications, and the results of early clinical studies of wave intensity. The atmosphere will be informal, to promote as much discussion as possible and to allow time for consideration of directions for future research. Scientific Committee Dr Alan Fraser, Cardiff Professor Kim Parker, London Dr Frank Schön, Düsseldorf Professor Motoaki Sugawara, Tokyo Professor John Tyberg, Calgary Dr Chris Jones, Cardiff Local host Professor Kim Parker, Physiological Flow Studies Group, Department of Bioengineering, Imperial College for Science, Technology and Medicine, London, UK. Sponsors Aloka, Tokyo, Japan 1 PROGRAMME Thursday 1st April 2004 14.00: Session 1: Basic concepts and applications of wave intensity Chairmen: Chris Jones, Cardiff John Tyberg, Calgary Fundamental concepts of wave intensity Kim Parker, London Non-invasive implementation for clinical measurement Motoaki Sugawara, Tokyo Comparison of wave intensity with catheter-derived indices Nobuyuki Ohte, Nagoya 16.15: Session 2: Arterial disease and ventriculo-vascular coupling Chairmen: Kim Parker, London Alan Fraser, Cardiff Translating the biology of vascular disease into clinical research Tudor Griffith, Cardiff Pathophysiological insights from wave intensity in animal models John Tyberg, Calgary Friday 2nd April 2004 09.00: Session 3: Are measurements of wave intensity and arterial stiffness ready for clinical use? Chairmen: Motoaki Sugawara, Tokyo Henryk Siniawski, Berlin Relationships between flow, diameter and pressure Victoria Franke, London Regional variations in wave intensity and sources of error Andrew Zambanini, London Reproducibility – Tokyo studies Kiyomi Niki, Tokyo Reproducibility – Cardiff studies Dragos Vinereanu, Bucharest 2 10.45: Session 4: Non-invasive diagnosis of circulatory health – Alternative techniques and clinical utility Chairmen: John Goodfellow, Cardiff Tony Dart, Melbourne Using flow-mediated dilatation to assess endothelial function John Deanfield, London t.b.c. Using applanation tonometry for pulse wave analysis in hypertension and diabetes Ian Wilkinson, Cambridge t.b.c. Using wave speed and separation of waves Ashraf Khir, London Using wave speed as a clinical tool Jim Cameron, Melbourne Using pulse wave velocity Katarina Naka, Ioannina t.b.c. 14.00: Session 5: Clinical studies of arterial wave intensity Chairmen: Frank Schön, Dusseldorf Alun Hughes, London Hypertension and heart failure Simon Thom, London Heart valve disease and cardiomyopathy Kiyomi Niki, Tokyo Stratification of treatment for left heart failure Henryk Siniawski, Berlin 16.00: Clinical demonstration – Dr K Niki and Dr H Siniawski 16.30: Session 6: Wave intensity at other sites – recent insights & new questions Chairmen: Simon Gibbs, London Michael Frenneaux, Cardiff In the coronary circulation Jos Spaan, Amsterdam t.b.c. In the left ventricle Juin-Jr Wang, Calgary In the pulmonary circulation Aoife O’Brien, Cork 3 Saturday 3rd April 2004 09.00: Session 7: Targeting risk factors for cardiovascular disease Chairmen: Tudor Griffith, Cardiff John Deanfield, London t.b.c. Risk factors and conduit arterial function Tony Dart, Melbourne The genetics of conduit arterial function Stephane Laurent, Paris Vascular disease, subclinical left ventricular dysfunction, and heart failure Alan Fraser, Cardiff 11.30: Session 8: Priorities for research Chairmen: Kim Parker, London Alan Fraser, Cardiff Developments in engineering Akimitsu Harada, Tokyo An integrated approach to vascular and cardiac disease Chris Jones, Cardiff General discussion 4