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July 2011 The Team Amnon Engelberg, LLB, MBA -CEO • Established and managed several companies including Eltan Communication , and in the life sciences; Salivizer, PhyMag, Calcident Jacob Dagan, Dr. Sc.&Eng.- COB and VP BD • Founder and manager of medical device companies and a publicly traded corporation. Dr. Erella Pines, DDS. - CTO • A dentist with 17 years experience and valued serial entrepreneur, the initiator of the idea. Advisory Board Joshua Wolfson Yair Karni Leading weight and health specialist Prof. Adrian Becker Silicon Rubber Specialist Prof. of Orthodontics Hebrew University Jerusalem Prof. Ilan Charuzi • Leading Bariatric Surgeon Nadav Meirson • Leading physical training specialist Overweight and Obesity A Global Health Problem * • • • • 1.5 Billion People are Overweight In the US 2/3 of the population is overweight * Diets, Food Supplements, Drugs, Physical Activity, Surgery – only partially effective. Inadequate lifestyle and bad eating habits are Major Factors Contributing to Weight Gain * http://www.who.int/dietphysicalactivity/publications/facts/obesity/en * http://www.cdc.gov/NCHS/data/hestat/obesity_adult_07_08/obesity_adult_07_08.pdf Overweight and Obesity (Cont.) Overweight is a major contributor to other health problems* Chewing rate can be voluntarily controlled (Chewing rate = chewing per minute) Research show that slow eating results in smaller calorie intake* * http://www.webmd.com/diet/features/dieting-is-out-healthy-eating-is-in?page=2 * http://www.wrongdiagnosis.com/artic/niddk_statistics_related_to_overweight_and_obesity_niddk.htm#cost * http://www.ajcn.org/cgi/content/abstract/90/2/269 * http://www.endotext.org/obesity/obesity17/obesityframe17.htm The Nobesity Method Behavioral change leading to slower eating and smaller bites utilizing Nobesity’s Slow Bite device The “Slow Bite” is used as a feedback device reminding the user to take smaller bites and slow down chewing The “Slow Bite” Device An intra oral device inserted between the teeth in the upper and lower jaws prior to the meal Moderately Limiting the extent of the mouth opening Signals the person to take smaller bites of food and slow down chewing Total Size - 4 cm. Assembled Holder & Band Technology The disposable elastic, a unique composition of two types of rubber silicone providing strength for “dental floss” insertion and flexibility to create tension. A disposable applicator for insertion and automatic release in place between teeth in upper and lower jaws. Slow Bite in user’s Mouth Competition SMART™ (Scientific intake) a safe, removable, custom made oral device that is placed comfortably in the upper palate (the roof of the mouth) only while eating. SMART™ combines five modes of action to achieve weight loss: It makes you take smaller bites, slowing food intake. It requires thorough chewing of food before swallowing. It ends “gulping” or “wolfing” of food. By slowing food intake, it permits triggering of the body’s builtin satiety response when one has eaten less food, so users feel satisfied, but on less calories. Sold 5,000 units during first year of operations (2005) * * Information obtain by correspondence with the company * http://www.scientificintake.com Competitors (Cont.) The Mandometer® Treatment The Mandometer® Method treats eating disorders by teaching patients how to eat and recognize hunger and satiety with the help of a small computer that receives information from a small scale beneath your plate of food. At the same time, the patient’s own eating speed and perception of satiety is shown on the screen. The patient then gradually learns to model its disordered pattern of eating to the normal pattern of eating. * http://www.mando.se/en/start-page/start-page-/1.aspx Competitors (Cont.) Powerseed The little mindfulness assistant travels comfortably in your pocket or purse, always available throughout the day. Stylish and simple-touse, the Powerseed produces silent visible signals or soft audible tones to discreetly coach you through your weight control strategies. The Powerseed mindful eating system coaches you to: Slow your eating and savor your meals Reduce food intake without dieting Focus on your weight control intentions * http://www.powerseed.com Competitors (Cont.) Small Bite Inc. • A complex system installed by an orthodontist limiting the mouth opening. * www.smallbite.com Market position Simple disposable low cost device and applicator Safe to use Requires no visit to the dentist or other third party assistance Does not interfere with taste of food and enjoyment of meal Does not disturb speech and is not painful Go to market Initial contacts were established with Henry Schein Inc . Henry Schein Ranks #339 in FORTUNE 500 Ranking of America's Largest Companies Serves approximately 85% of the estimated 136,000 U.S. and Canadian office-based dental practices, dental laboratories, as well as governments and other institutions Serves approximately 45% of the estimated 250,000 U.S. office-based physician practices, surgical centers and other alternate-care sites Serves approximately 240,000 office-based dental, medical and animal health practices through operations or affiliates in 21 countries outside of North America* * http://www.henryschein.com * Letter of willingness to support on file Go to market (Cont.) Briut Clalit agreed to conduct the clinical tests and sell the product in exchange for equity in the company.* Maccabi Health Care Services agreed to conduct clinical tests, terms to be determined * Letter of intent on file US market sales years 3 - 8 U.S Population 310,000,000 60% overweight 186,000,000 Unit Ex-Factory price $9 (Set of 30) (Retail Est. at $45) Market penetration rate Years 3-8 Potential customers 0.01% 18,600 Total annual revenue 1,670,000 0.05% 93,000 8,370,000 0.1% 186,000 16,070,400 0.25% 465,000 41,850,000 1% 1,860,000 167,400,000 Regulatory According to regulatory experts, only registration with the F.D.A will be required. IP U.S.A pending patent Application number: International PCT Confirmation No. Future IP protection Manufacturing Method Brand name protection 12808364 PCT/IL08/01653 3176 Budget (Highlights) No. Type of expense Budgeted at $ Percent of budget 1 Wages 300,000 18.86 2 Materials, Molds and Products 200,000 12.57 3 subcontractors 350,000 22.01 4 Patents 100,000 6.29 Testing 310,000 19.50 Equipment & Furniture 5,000 0.32 7 Misc. 75,000 4.72 8 Marketing 250,000 15.72 1,590,000 100 5 6 Total Two year work plan 2011 Activity 1. Fine tune elastic 1. Limited compliance tests 1. Finalize details of clinical tests 1. Prepare production files 1. Production of initial test run 1. Prepare test protocol and obtain Helsinki approval 1. Packaging design 1. Clinical test 1. Marketing strategies 1. Analyze test results 1. Finalize marketing contracts start serial manufacturing 1. Finalize packaging and start sales 1-3 2012 4-6 7-9 10-12 1-3 4-6 7-9 10-12 Nobesity at a glance Obtained a grant from Tnufa for first product prototype development (The grant was provided during the years 2007 – 2008) Developed a disposable device and applicator Conducted basic patent search and applied for Patents. Signed M.O.U with Briut Clalit for clinical trials In negotiations for an initial distribution agreement with a major U.S. corporation Thank you Nobesity Ltd Contact Information Amnon Engelberg – 054-8190800 Dr. Jacob Dagan – 054-3097560 [email protected] [email protected]