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Chapter 25
Respiratory
System
Fig. 25.1
• Upper respiratory tract
• Sinuses
• Nasal cavity
• Pharynx
• Lower respiratory tract
•
•
•
•
Larynx
Trachea
Bronchi
Lungs
Sphenoidal sinus
Frontal sinus
Nasal cavity
Upper
respiratory
Pharynx
tract
Larynx
Trachea
Lower
respiratory
Bronchi
tract
Lungs
Pleura
Diaphragm
Fig. 25.1
• Conducting portion transports
air
• Nose, nasal cavity, pharynx, larynx,
trachea, airways
• Respiratory portion does gas
exchange
• respiratory bronchioles, alveolar
ducts, alveoli (air sacs)
Sphenoidal sinus
Frontal sinus
Nasal cavity
Upper
respiratory
Pharynx
tract
Larynx
Trachea
Lower
respiratory
Bronchi
tract
Lungs
Pleura
Diaphragm
External Respiration
• Exchange of gases between
atmosphere and blood
• inhalation of air
• diffusion into blood
Internal Respiration
• Exchange of gases between
blood and cells of the body
• transport from lungs to body and
back
Other Functions
• Gas conditioning
• warming
• humidifying
• cleansing of particulates
• Sound production
• Olfaction
• Defense
Fig.
25.10
• Lungs surrounded by
pleura
Parietal pleura
Visceral pleura
Pleural cavity
• simple squamous
epithelium called
mesothelium
Parietal pleura
Pleural cavity
Visceral pleura
Diaphragm
• Outer surface is parietal
pleura
• Inner surface (contact with
lung) is visceral pleura
• Pleural cavity divides
pleural layers, has thin
layer of fluid
Fig.
25.11
Apex
Superior lobe
Horizontal fissure
Oblique fissure
Middle lobe
Cardiac notch
Inferior lobe
Lingula
Base
Right lung
Left lung
(a) Lateral views
Fig.
25.11
Apex
Superior lobe
Oblique fissure
Pulmonary artery
Main bronchus
Pulmonary veins
Hilum
Root of the lung
Horizontal
fissure
Cardiac impression
Cardiac notch
Middle lobe
Inferior lobe
Oblique
fissure
Oblique fissure
Base
Right lung
Lingula
Left lung
(b) Medial views
Fig. 25.2
Superior nasal concha
Middle nasal concha
Nasal Inferior nasal concha
cavity
Vestibule
Nostril
Hard palate
• Vestibule is area
behind nostrils
Superior meatus
Middle meatus
Inferior meatus
Nasal
cavity
• Nasal cavity includes nasal
conchae (bony ridges)
• Divide nasal cavity into 3 air
passages called nasal meatus
• Create turbulence, slow air
passage, ensure air is warmed
and humidified
Fig. 25.2
Superior nasal concha
Middle nasal concha
Nasal Inferior nasal concha
cavity
Vestibule
Nostril
Hard palate
• Hard palate is
bottom of nasal
cavity
• Nasal septum divides
right and left sides
Superior meatus
Middle meatus
Inferior meatus
Nasal
cavity
• Nasal cavity is lined with
pseudostratified ciliated
columnar epithelium with
goblet cells
• produce mucus
• highly vascularized
Fig. 25.2
Paranasal
sinuses
Frontal sinus
Sphenoidal sinus
• Paranasal sinuses named for
bone
• frontal sinus housed in frontal
bone
• sphenoidal sinus housed in
sphenoid bone
• maxillary sinuses housed in
maxillary bone
Fig. 25.3
Copyright © McGraw-Hill Education. Permission required for reproduction or display.
Frontal
Ethmoidal
Sphenoidal
Maxillary
Fig. 25.2
• Pharynx = throat
• divided into 3 parts
• pathway for food and air until epiglottis
• Nasopharynx usually for air only
Pharynx:
Nasopharynx
Oropharynx
Laryngopharynx
(b) Regions of pharynx
• soft palate blocks food from mouth
• lined with pseudostratified ciliated columnar
epithelium
• Oropharynx pathway for air and food
• lined with non-keratinized stratified squamous
epithelium
• Laryngopharynx extends from hyoid bone to
larynx and esophagus
• lined with non-keratinized stratified squamous
epithelium
• Auditory tube opens into
nasopharynx
• Soft palate lifts to block
passage of food to nasal
cavity during swallowing
Fig. 25.2
Opening of auditory tube
Soft palate
Uvula
Nasopharynx
Oropharynx
Laryngopharynx
Palatine tonsil
Lingual tonsil
Pharynx
Fig. 25.2
• Tonsils provide first line of
defense in immune system
Pharyngeal tonsil
Nasopharynx
Oropharynx
Laryngopharynx
Palatine tonsil
Lingual tonsil
Pharynx
• Epiglottis flips down during
swallowing to cover opening
to trachea
• Food passes down
esophagus
Fig. 25.2
Nasopharynx
Oropharynx
Laryngopharynx
Larynx
Epiglottis
Thyroid cartilage
Cricoid cartilage
Esophagus
Trachea
Pharynx
Fig. 25.2
• Larynx is voice box
• Air passage
• Produces sound
Epiglottis
Larynx
Thyroid cartilage
Cricoid cartilage
Fig. 25.4
Epiglottis
Hyoid bone
Thyrohyoid membrane
(extrinsic)
Thyroid cartilage
Thyrohyoid muscle (extrinsic)
Laryngeal prominence
Cricothyroid muscle
(extrinsic)
Cricoid cartilage
Cricotracheal ligament (extrinsic)
Trachea
(a) Anterior view
• Opening to larynx is laryngeal
inlet
• 9 pieces of cartilage
• held in place by ligaments and
muscles
• Thyroid cartilage is largest
• front has v-shaped projection
called laryngeal prominence
• creates Adam’s apple
Fig. 25.6
• Trachea = windpipe
• Kept open by tracheal cartilage rings
Esophagus
Thyroid cartilage
Larynx
Cricoid cartilage
Trachea
Tracheal cartilage
Anular ligament
Right main Left main
bronchus bronchus
• C-shaped
• connected by ligaments
• open ends connected by trachealis
muscle and elastic, ligamentous
membrane
• pushes against trachea during swallowing
• contracts during coughing; decreases
diameter of trachea, increases speed of
airflow
Tracheotomy
Trachea
Thyroid
cartilage
Thyroid
gland
Suprasternal
notch
Tracheotomy
tube
Cricoid
cartilage
Incision
1 Incision is made superior to
suprasternal notch. Thyroid may
have to be cut as well.
Scalpel
Sutures
2 Retractors separate the tissue, and
an incision is made through the
third and fourth tracheal rings.
3 A tracheotomy tube is inserted,
and the remaining incision is
sutured closed.
Fig. 25.6
Posterior
Esophagus
• Trachea cross-section
• Lined with pseudostratified ciliated
columnar epithelium
• goblet cells secrete mucin
• cilia propels mucus and dust toward
larynx and pharynx for swallowing
Trachealis muscle
Lumen of trachea
Mucosa
Submucosa
Tracheal cartilage
LM 8x
Anterior
Fig. 25.6
Mucosa
Trachea cross-section
Pseudostratified Lamina
ciliated columnar propria
epithelium
Basement Submucosa
membrane
Posterior
Esophagus
Trachealis muscle
Lumen of trachea
Mucosa
Submucosa
Mucus
Lumen
Tracheal cartilage
LM 8x
Anterior
(d)
• Lined with pseudostratified ciliated columnar epithelium
• goblet cells secrete mucin
• cilia propels mucus and dust toward larynx and pharynx for swallowing
Fig. 25.6
• Trachea splits at sternal
angle into left and right
main bronchi
Trachea
Carina (internal
projection)
Right main
bronchus
Left main
bronchus
Fig. 25.7
Main bronchi
Lobar bronchi
Larynx
Segmental bronchi
Smaller bronchi
Trachea
(b)
Right main bronchus
Left main bronchus
Right lobar bronchus
Right segmental bronchus
Left lobar bronchus
Left segmental bronchus
Smaller bronchi
Smaller bronchi
Fig. 25.8
• Bronchi branch into
bronchioles
• lined with simple columnar or
cuboidal epithelium
• no cartilage in walls
• smooth muscle around walls
causes bronchoconstriction/
bronchodilation
• Terminal bronchioles are end
of conducting pathway
Bronchiole
Branch of
pulmonary artery
Terminal bronchiole
Respiratory bronchiole
Page 769
• Asthma causes bronchial
constriction
• Treatment is inhaled steroids
Mucus
Mucosa
Submucosa
Normal airway
Swollen submucosa
Mucosa
Narrowed airway
Extra mucous
secretion
Airway during an asthma attack
• Terminal bronchioles branch
into respiratory bronchioles
Bronchiole
• branch into smaller bronchioles
• divide into alveolar ducts
• lined with simple squamous
epithelium
• each ends in alveolar sac
Branch of
pulmonary vein
Fig. 25.8
Branch of
pulmonary artery
Terminal bronchiole
Pulmonary
arteriole
Pulmonary
capillary
beds
Pulmonary
venule
Respiratory bronchiole
Alveolar duct
Alveoli
Alveolar pores
Interalveolar
septum
Alveolar sac
Elastic fibers
Connective tissue
• Each alveolus is ¼ to ½ mm
diameter
• Thin wall promotes gas diffusion
• Alveolar pores are holes
between adjacent alveoli
Bronchiole
Branch of
pulmonary artery
Terminal bronchiole
• promote gas diffusion
Branch of
pulmonary vein
Fig. 25.8
Pulmonary
arteriole
Pulmonary
capillary
beds
Pulmonary
venule
Respiratory bronchiole
Alveolar duct
Alveoli
Alveolar pores
Interalveolar
septum
Alveolar sac
Elastic fibers
Connective tissue
Respiratory Alveolar
bronchiole
sac
Alveolar
ducts
Terminal
Respiratory
bronchiole Alveoli bronchiole
Alveoli
Alveolar
duct
Fig. 25.8
LM 60x
(b)
SEM 180x
(c)
Fig. 25.9
• Pulmonary capillaries run
between alveoli
• Type I cells promote gas
diffusion
• Type II cells secrete surfactant
Erythrocyte
Pulmonary
capillaries
• reduces surface tension in fluid
lining alveolua
Alveolar type I cell
Alveolar type II cell
Alveolar
macrophages
Alveolar pores
Interalveolar
septum
(a)
• Macrophages consume foreign
objects
Fig. 25.9
Nucleus Nucleus of capillary
endothelial cell
Interalveolar of alveolar
type I cell
Erythrocyte
septum
Diffusion of CO2
Alveolus
Respiratory
membrane
Diffusion of O2
Alveolar epithelium
Fused basement membranes
of the alveolar epithelium and
the capillary endothelium
Capillary endothelium
Capillary
Page 764
Copyright © McGraw-Hill Education. Permission required for reproduction or display.
Left lung
Chest x-ray of a patient with pneumonia in the left lung. A normal lung
appears as a black space on an x-ray because its spongy structure is not
dense. In contrast, a pneumonia lung appears white or opaque on an
x-ray due to accumulation of fluid and cells.
© Collection CNRI/Phototake
Page 764
Respiratory
bronchiole
Alveolar duct Alveoli
Thickened
alveolar walls
Fluid and leukocytes
in alveoli
LM 30x
Normal lung tissues.
LM 75x
Tissues within a lung affected by
pneumonia.
Page 770
Alveoli
Enlarged alveolus
Deposits
Alveoli are small,
numerous, and
well formed.
Nonsmoker’s lungs: Lungs are pink.
Alveoli are enlarged,
less numerous, and
contain black deposits.
Smoker’s lungs: Lungs are blackened.