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From: Structural and Elemental Evidence for Edema in the Retina, Retinal Pigment Epithelium, and Choroid during
Recovery from Experimentally Induced Myopia
Invest. Ophthalmol. Vis. Sci.. 2004;45(8):2463-2474. doi:10.1167/iovs.03-1009
Figure Legend:
Electron micrographs comparing the morphology of a nondeprived fellow eye and recovering eyes (T = 0, 24, 48, 72,
96, and 120 hr) in the vicinity of the basal membrane of the RPE and Bruch’s membrane. Note, the dramatic changes in
the thickness of Bruch’s membrane and the structure of the basal membrane of the RPE cells in the deprived eyes over
the 120 hours. During the early stages of refractive recovery the inner and outer collagenous layers of Bruch’s
membrane, normally appearing as crisp dots (transverse section of collagen fibrils), were not readily apparent until the
membrane had begun to increase in thickness at around 72 hours after occlusion. Likewise, the structure and regularity
of the
infoldings 6/11/2017
of the basal membrane
the RPE for
were
dramatically
compromised
by formCopyright
deprivation
(compare
Fig.reserved.
7
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, Control with T = 0 hr) but improved substantially over the recovery period, though there was still evidence of edema in