Download Powerpoint

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

page
1
page
2
page
3
page
4
page
5
page
6
page
7
page
8
Document related concepts
no text concepts found
Transcript 
Protective Role for B-1b B Cells and IgM in ObesityAssociated Inflammation, Glucose Intolerance, and Insulin
ResistanceSignificance
by Daniel B. Harmon, Prasad Srikakulapu, Jennifer L. Kaplan, Stephanie N. Oldham,
Chantel McSkimming, James C. Garmey, Heather M. Perry, Jennifer L. Kirby,
Thomas A. Prohaska, Ayelet Gonen, Peter Hallowell, Bruce Schirmer, Sotirios
Tsimikas, Angela M. Taylor, Joseph L. Witztum, and Coleen A. McNamara
Arterioscler Thromb Vasc Biol
Volume 36(4):682-691
March 23, 2016
Copyright © American Heart Association, Inc. All rights reserved.
Loss of Id3 in B cells attenuates glucose intolerance and adipose tissue insulin resistance in
diet-induced obese (DIO) mice.
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
Adipose tissue–specific increases in B-1 cells, total IgM, and T15 natural IgM antibodies in
Id3Bcell KO mice with diet-induced obese (DIO).
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
Loss of Id3 in B cells leads to increased adipose tissue B-1b B cells and IgM secretion in chowfed mice.
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
Id3 regulates B-1b B-cell survival.
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
Reduced adipose tissue inflammation in Id3B cell KO diet-induced obese (DIO) mice and
decreased adipose tissue M1 macrophage inflammation after treatment with B-1b–conditioned
media.
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
B-1b B cells lacking Id3 attenuate diet-induced glucose intolerance, whereas B-1b B cells unable
to secrete IgM have no effect.
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
B-1 B cells in human omental adipose tissue correlate with serum phosphorylcholine (PC)-IgM
levels.
Daniel B. Harmon et al. Arterioscler Thromb Vasc Biol.
2016;36:682-691
Copyright © American Heart Association, Inc. All rights reserved.
Related documents