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Developmentally Appropriate Explanations for Medications for Children • Nurses need a solid understanding of growth and development to ensure safe administration of medications to children and to give developmentally appropriate explanations for the medication to children and their caregivers. – Why the drug is needed – What the child will experience – What is expected of the child – How the parents can participate and support their child Eight Rights of Pediatric Medication Adapt administration principles and techniques to meet the child’s needs. Note that medication administration, regardless of the route, requires a solid knowledge base about the drug and its action and...how to calculate! – Right medication – Right patient – Right time – Right route of administration – Right dose – Right documentation – Right to be educated – Right to refuse Pharmacodynamics vs. Pharmacokinetics • Pharmacodynamics – Behavior of medication at the cellular level – Affected by the physiologic immaturity of some body systems in a child • Pharmacokinetics – Movement of drugs throughout the body via absorption, distribution, metabolism, and excretion – Affected by the child’s age, weight, body surface area, and body composition • Biotransformation – the alteration of chemical structures from their original form allowing for the eventual excretion of the substance – Is affected by the same variations affecting distribution in children Factors Affecting Distribution of Medication in Children • Medication distribution is altered in infants and young children – Increased metabolic rate – Higher percentage of body water than adults – More rapid extracellular fluid exchange – Decreased body fat – Liver immaturity, altering first-pass elimination – Differences in hepatic enzyme production – Decreased amounts of plasma proteins available for drug binding – Immature blood–brain barrier, especially neonates, allowing permeation by certain medications Factors Affecting Absorption of Medications in Children • Although a drug’s mechanism of action is the same in any individual, the physiologic immaturity of some body systems in a child can affect a drug’s pharmacodynamics. • Factors that affect absorption of medications into the child's bloodstream. – Oral medications: slower gastric emptying, increased intestinal motility, a proportionately larger small intestine surface area, higher gastric pH, and decreased lipase and amylase secretion compared with adults – Intramuscular absorption: amount of muscle mass, muscle tone and perfusion, and vasomotor instability – Subcutaneous absorption: decreased perfusion – Topical absorption of medications: increased due to greater body surface area and greater permeability of infant’s skin Factors Affecting Metabolism of Medications in Children • The immaturity of the kidneys until age 18 months to 2 years affects the Renal BF, GFR, and active tubular secretion resulting in a longer half-life and increases potential for toxicity of drugs excreted by the kidneys Determining Children’s Doses by Body Weight • Weigh the child. – If the child’s weight is in pounds, convert it to kilograms (divide the child’s weight in pounds by 2.2). • Check a drug reference for the safe dose range (e.g., 10 to 20 mg/kg of body weight). • Calculate the low safe dose. • Calculate the high safe dose. • Determine if the dose ordered is within this range. Impact on Medications • Infants and young children require very small doses of medication, thus making accurate calculation/ measurement very important • Calculate dosage based on Body Weight (kg) or Body Surface Area (m2) to ensure the child receives the correct drug dosage within a safe therapeutic range – Body weight = mg/kg/day or mg/kg/dose (commonly) – BSA (m2) = 8 Impact on Medications • Compare ordered dosage to recommended dosage • If dosage seems unsafe, consult with ordering practitioner before administering • Use special measuring devices to accurately provide the prescribed dosage • Measuring out a dose with common household utensils is unacceptable • Monitor child closely for signs/ symptoms of toxicity 9 11 Guidelines to Determine BSA 1. Measure the child’s height. 2. Determine the child’s weight. 3. Using the nomogram, draw a line to connect the height measurement in the left column and the weight measurement in the right column. 4. Determine the point where this line intersects the line in the surface area column. This is the BSA, expressed in meters squared (m2). Forms of Oral Medications • Review the forms of oral medications (liquids [elixirs, syrups, or suspensions], powders, tablets, and capsules) and how they are administered to children. • Demonstrate the proper technique for administering medication to children via the oral, rectal, ophthalmic, otic, intravenous, intramuscular, and subcutaneous routes. – – – – Liquids Elixirs Syrups Suspensions • Powders • Tablets • Capsules SIM LAB • when using a dropper or oral syringe (without a needle) for infants or young children, they should direct the liquid toward the posterior side of the mouth, give the drug slowly in small amounts (0.2 to 0.5 mL), and allow the child to swallow before more medication is placed in the mouth. Providing Atraumatic Care When Administering Medications • The nurse should encourage the child to participate in care and provide the child with developmentally appropriate options. – – – – Using comforting positions Using topical anesthetic prior to injections Educating the child and parents Preventing medication errors • Discuss interventions to decrease discomfort and pain for the child who is to receive an injection. • It is essential to ensure the child doesn't move to prevent injury. Ears • Younger than 3 – Pull pinna down and back • Older than 3 – Pull pinna up and back naso-gastric, and naso-jejunal feedings • ADVANTAGES • • • • • The major advantage of over gastrostomy or jejunostomy feeding are: they do not require surgery. the tubes can be inserted quickly they can be used either for short periods or intermittently with relatively low risk. • DISADVANTAGES • • • • The disadvantages of NG feeding may include: nose or throat irritation and discomfort (especially if used long-term); increased mucus secretion; partial blockage of the nasal airways (problematic if suffer allergies or colds) • Naso-gastric feeding can occasionally contribute to recurrent earache and sinusitis. • With infants, NG feeding can become relied upon and decrease the suck/swallow mechanism. Intramuscular Injection Sites • Intramuscular administration of medication is used infrequently in children because it is painful and children often lack adequate muscle mass. • Note that immunizations are frequently administered IM. Discuss the preferred IM injection sites for children, needle size, and solution amount. Subcutaneous vs. Intradermal • Subcutaneous (SQ) administration – Distributes medication into the fatty layers of the body – Insulin administration, heparin, and certain immunizations • Intradermal (ID) administration – Deposits medication just under the epidermis – Tuberculosis screening and allergy testing Intravenous • Most medications given by the IV route must be given at a specified rate and diluted properly to prevent overdose or toxicity due to the rapid onset of action that occurs with this route. • Use of the IV route requires that the child have an IV device inserted, peripherally or centrally. • Preferred sites for peripheral IV medication administration, including the hands, feet, and forearms, and in infants, the scalp if all other veins fail. • Central IV therapy usually is administered through a large vein, such as the subclavian, femoral, or jugular vein or the vena cava. The tip of the device lies in the superior vena cava just at the entrance to the right atrium. • Numerous devices for central venous access are available, and the type chosen depends on the duration of the therapy, the child’s diagnosis, the risks to the child from insertion, and the ability of the child and family to care for the device. • Although central venous access devices can be used short term, the majority are used for moderate- to long-term therapy. Factors Affecting the Choice of Equipment for IV Therapy • • • • • • • IV therapy is determined by: The solution or medication to be administered The duration of the therapy The age and developmental level of the child The child’s status The condition of the child’s veins Equipment used for peripheral venous access including peripheral intermittent infusion devices or saline or heparin locks EMLA Cream • a eutectic mixture of lidocaine 2.5% and prilocaine 2.5% • EMLA cream is a local anesthetic (numbing medication) • It works by blocking nerve signals in your body. • EMLA cream is used to numb normal intact Principles of Atraumatic Care Managing IV Therapy • • • • • • • • • • • Gather equipment before approaching child. Select hand rather than wrist or upper arm veins. Ensure adequate pain relief. Allow anesthetic to prepared site to dry. Use a barrier to avoid pinching the skin. If needed, use a device to trans-illuminate the vein. Make only two attempts to gain access. Encourage parental participation. Coordinate care with other departments. Secure line with minimal amount of tape. Protect the site from bumping Administering IV fluids to an infant or child • Requires close attention to the child’s fluid status. • Place the formula for determining the amount of fluid to be administered in a day (24 hours) • 100 mL per kg of body weight for the first 10 kg • 50 mL per kg of body weight for the next 10 kg • 20 mL per kg of body weight for the remainder of body weight in kilograms Administering IV fluids to an infant or child (PER HOUR) • The simple method we are going to look at is known as the 4:2:1 method. This method will give you a quick way of calculating the required mls per hour • 4 ml/kg/hr for the first 10 kg, • adding 2 ml/kg/hr for the second 10 kg • and 1 ml/kg/hr for each kg over 20 kg. • The most accurate way to do this is to compare their current weight with their pre-morbid weight, that is, their weight before they became ill. • This is usually not practical and so the less accurate method of clinically assessing their deficit must be used: Urine Output • In addition to monitoring the fluid infusion, the nurse should closely monitor the child’s output. • Note that the expected urine output for children and adolescents is 1.0 to 2.0 mL/kg/hour. • When measuring the output of an infant or child who is not toilet trained or who is incontinent, weigh the diaper to determine the output. REMEMBER: 1 gram = 1ml of fluid Measures to Reduce Complications With TPN • Nutritional support can be administered IV through a peripheral or central venous catheter. • Parenteral nutrition given via a central venous access is termed total parenteral nutrition (TPN). • The concentration and components of the solution determine the type of parenteral nutrition. • Review the guidelines for administering TPN and how nurses can prevent complications Measures to Reduce Complications With TPN • Monitor the child’s vital signs closely for changes. – FEVER • Adhere to strict aseptic technique . • Ensure that the system remains a closed system at all times. • Use occlusive dressings. • Adhere to agency policy for flushing of the catheter and maintaining catheter patency. • Assess intake and output frequently. • Monitor blood glucose levels and obtain laboratory tests as ordered to evaluate for changes in fluid and electrolytes. • VIEW: TPN Instructions for Parents under,” STUFF”