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Cellular Respiration
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9-1 Chemical Pathways
9-1 Chemical Pathways
Food serves as a source of raw materials for the
cells in the body and as a source of energy.
Animal Cells
Animal
Mitochondrion
Plant
Plant Cells
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9-1 Chemical Pathways
Both plant and animal cells carry out the final
stages of cellular respiration in the mitochondria.
Animal Cells
Outer membrane
Intermembrane
Mitochondrion
space
Inner
membrane
Matrix
Plant Cells
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Chemical Energy and Food
Chemical Energy and Food
One gram of the sugar glucose
(C6H12O6), when burned in the presence
of oxygen, releases 3811 calories of heat
energy.
A calorie is the amount of energy
needed to raise the temperature of 1 gram
of water 1 degree Celsius.
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Overview of Cellular Respiration
What is cellular respiration?
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9-1 Chemical Pathways
Overview of Cellular Respiration
Electrons carried in NADH
Electrons carried
in NADH and
FADH2
Pyruvic
acid
Glucose
Glycolysis
Cytoplasm
Mitochondrion
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Overview of Cellular Respiration
Cellular respiration is the process that
releases energy by breaking down
glucose and other food molecules in the
presence of oxygen.
3 parts:
Glycolysis
Krebs Cycle
Electron Transport Chain
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Overview of Cellular Respiration
The equation for cellular respiration is:
6O2 + C6H12O6 → 6CO2 + 6H2O +
Energy
oxygen + glucose → carbon dioxide + water +
Energy
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Overview of Cellular Respiration
Glycolysis takes place in the
cytoplasm. The Krebs cycle and electron
transport take place in the mitochondria.
Glycolysis
Cytoplasm
Mitochondrion
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Glycolysis
What happens during the
process of glycolysis?
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9-1 Chemical Pathways
Glycolysis
ATP Production
At the beginning of glycolysis, the cell uses up 2
molecules of ATP to start the reaction.
2 ATP
2 ADP
4 ADP
4 ATP
Glucose
2 Pyruvic
acid
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9-1 Chemical Pathways
Glycolysis
When glycolysis is complete, 4 ATP molecules
have been produced.
2 ATP
2 ADP
4 ADP
4 ATP
Glucose
2 Pyruvic
acid
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9-1 Chemical Pathways
Glycolysis
This gives the cell a net gain of 2 ATP molecules.
2 ATP
2 ADP
4 ADP
4 ATP
Glucose
2 Pyruvic
acid
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9-1 Chemical Pathways
Glycolysis
NADH Production
One reaction of glycolysis removes 4 high-energy
electrons, passing them to an electron carrier
called NAD+.
2 ATP
2 ADP
4 ADP
4 ATP
Glucose
2NAD+
2 Pyruvic
acid
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9-1 Chemical Pathways
Glycolysis
Each NAD+ accepts a pair of high-energy electrons
and becomes an NADH molecule.
2 ATP
2 ADP
4 ADP
4 ATP
Glucose
2NAD+
2
2 Pyruvic
acid
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Glycolysis
The NADH molecule holds the
electrons until they can be transferred to
other molecules.
2 ATP
2 ADP
4 ADP
2NAD+
4 ATP
2
2 Pyruvic
acid
To the electron
transport chain
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Glycolysis
The Advantages of
Glycolysis
The process of glycolysis is so fast that
cells can produce thousands of ATP
molecules in a few milliseconds.
Glycolysis does not require oxygen.
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9-2 The Krebs Cycle and
Electron Transport
Oxygen is required for the final steps of
cellular respiration.
Because the pathways of cellular
respiration require oxygen, they are
aerobic.
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The Krebs Cycle
What happens during the
Krebs cycle?
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The Krebs Cycle
During the Krebs cycle, pyruvic
acid is broken down into carbon
dioxide in a series of energyextracting reactions.
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The Krebs Cycle
The Krebs cycle
begins when pyruvic
acid produced by
glycolysis enters the
mitochondrion.
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The Krebs Cycle
One carbon
molecule is
removed, forming
CO2, and electrons
are removed,
changing NAD+ to
NADH.
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The Krebs Cycle
Coenzyme A joins
the 2-carbon
molecule, forming
acetyl-CoA.
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The Krebs Cycle
Acetyl-CoA then
adds the 2-carbon
acetyl group to a 4carbon compound,
forming citric acid.
Citric acid
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Citric acid is broken down into a 5-carbon
compound, then into a 4-carbon
compound.
The Krebs Cycle
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The Krebs Cycle
Two more molecules of CO2 are released and
electrons join NAD+ and FAD, forming NADH and
FADH2
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The Krebs Cycle
In addition, one molecule of ATP is generated.
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The Krebs Cycle
The energy tally from 1 molecule of pyruvic acid
is
•
•
•
4 NADH
1 FADH2
1 ATP
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Electron Transport
How are high-energy
electrons used by the
electron transport chain?
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Electron Transport
Electron Transport
The electron transport
chain uses the high-energy
electrons from the Krebs
cycle to convert ADP into
ATP.
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Electron Transport
High-energy electrons from NADH and FADH2 are
passed along the electron transport chain from one
carrier protein to the next.
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Electron Transport
At the end of the chain, an enzyme combines
these electrons with hydrogen ions and oxygen to
form water.
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Electron Transport
As the final electron acceptor of the electron
transport chain, oxygen gets rid of the low-energy
electrons and hydrogen ions.
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Electron Transport
When 2 high-energy electrons move down the
electron transport chain, their energy is used to
move hydrogen ions (H+) across the membrane.
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Electron Transport
During electron transport, H+ ions build up in the
intermembrane space, so it is positively charged.
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Electron Transport
The other side of the membrane, from which those
H+ ions are taken, is now negatively charged.
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Electron Transport
The inner membranes of the mitochondria contain
protein spheres called ATP synthases.
ATP
synthase
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Electron Transport
As H+ ions escape through channels into these
proteins, the ATP synthase spins.
Channel
ATP
synthase
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Electron Transport
As it rotates, the enzyme grabs a low-energy ADP,
attaching a phosphate, forming high-energy ATP.
Channel
ATP
synthase
ATP
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The Totals
The Totals
Glycolysis produces just 2 ATP
molecules per molecule of glucose.
The complete breakdown of glucose
through cellular respiration, including
glycolysis, results in the production of 36
molecules of ATP.
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The Totals
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Comparing Photosynthesis
and Cellular Respiration
Comparing Photosynthesis and Cellular Respiration
The energy flows in photosynthesis
and cellular respiration take place in
opposite directions.
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Comparing Photosynthesis and Cellular Respiration
On a global level, photosynthesis and
cellular respiration are also opposites.
•
Photosynthesis removes carbon
dioxide from the atmosphere and cellular
respiration puts it back.
•
Photosynthesis releases oxygen into
the atmosphere and cellular respiration
uses that oxygen to release energy from
food.
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• What happens when there
is no oxygen present???
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Fermentation
Fermentation
When oxygen is not present, glycolysis
is followed by a different pathway.
The combined process of this pathway
and glycolysis is called fermentation.
Fermentation releases energy from
food molecules by producing ATP in the
absence of oxygen.
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Common Foods that use
fermentation
• Coffee
• Salami
• Chocolate
• Beer
• Tea
• Wine
• Sourdough bread
• Sauerkraut
• Cheese
• Pickles
• Yogurt
• vinegar
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Fermentation
What are the two main
types of fermentation?
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Alcoholic Fermentation
Yeasts and a few other
microorganisms use alcoholic
fermentation, forming ethyl alcohol and
carbon dioxide as wastes.
The equation for alcoholic fermentation
after glycolysis is:
pyruvic acid + NADH → alcohol + CO2
+ NAD+
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Fermentation
Lactic Acid Fermentation
In many cells, pyruvic acid that accumulates as
a result of glycolysis can be converted to lactic
acid.
This type of fermentation is called lactic acid
fermentation. It regenerates NAD+ so that
glycolysis can continue.
The equation for lactic acid fermentation after
glycolysis is:
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pyruvic acid + NADH → lactic acid + NAD+End Show
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• Lactic acid build up in the muscles
causes a burning sensation –
caused by the lack of Oxygen
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