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Autism and Dentistry Diana Zschaschel DDS , Diana Zschaschel, DDS UCLA BA Psychology 1992 Behavioral Therapist for Autism UCLA DDS 1997 UCLA GPR 1999 Dental Consultant California Regional Centers Hospital Priveleges, UCLA St. Vincents Started Angels’Smiles NPO 2007 ADA Diversity in Leadership Class 2008 History of Autism First “diagnosed” 1943 by Leo Kanner “Autism” from Latin “auto” meaning “self absorbed” Prevalence debatable as frequent as 1/150 births Neuropsychiatric disorder Spectrum disorder Other related disorders Diagnosis by 3 years of old No known cause or cure Characteristics of Autism What we see Physical Cognitive Behavioral Emotional Dental Autistic Children Cognition Cognitive Skills IQ Can be within normal limits Unable to test appropriately Savant Skills: 10%Savant Syndrome, a disorder in which individuals with neurological developmental delays in socialization and communication (3) possess "astonishing islands of brilliance that stand in stark, markedly incongruous contrast to the overall handicap" ( Stimulus Overselectivity Savant Skill S.Wiltshire Behavioral Perseverative Behaviors: Repetitive acts, routines Self Stimulatory Behaviors Self Injurious Behaviors-Self-injurious behavior is one of the most devastating behaviors exhibited by people with developmental disabilities. The most common forms of these behaviors include: head-banging, hand-biting, and excessive self- rubbing and scratching. There are many possible reasons why a person may engage in selfinjurious behavior, ranging from biochemical to the social environment. Possible reasons for SI Behaviors Biochemical Seizures Genetic Arousal Pain Sensory Frustration Research of S-I Behavior Some researchers have suggested that the levels of certain neurotransmitters are associated with self-injurious behavior. Beta-endorphins are endogenous opiate-like substances in the brain, and self-injury may increase the production and/or the release of endorphins. As a result, the individual experiences an anesthesia-like effect and, ostensibly, he/she does not feel any pain while engaging in the behavior (Sandman et al., 1983). Furthermore, the release of endorphins may provide the individual with a euphoric-like feeling. Support for this explanation comes from studies in which drugs that block the binding at opiate receptor sites (e.g., naltrexone and naloxone) can successfully reduce self-injury (Herman et al., 1989). Research on laboratory animals as well as research on administering drugs to human subjects have indicated that low levels of serotonin or high levels of dopamine are associated with selfinjury (DiChiara et al., 1971; Mueller & Nyhan, 1982). In a study on a heterogeneous population of mentally retarded individuals, Greenberg and Coleman (1976) administered drugs, such as reserpine and chlorpromazine, to reduce serotonin levels. These researchers observed a dramatic increase in both aggressive and self-aggressive behavior. Drugs that elevate dopamine levels, such as amphetamines and apomorphine, have been shown to initiate self-injurious behavior (Mueller & Nyhan, 1982; Mueller et al., 1982). Interestingly, Coleman (1994) studied a group of autistic children who had low levels of calcium (i.e., hypocalcinuria). These individuals often exhibited eye-poking behavior. When given calcium supplements, the eye-poking decreased substantially. In addition, language functioning improved. Emotional Considerations Emotional Lability Emotionally Distant??? Dental Considerations Delayed eruption of primary and permanent dentition Higher Pain tolerance Sensitivities to visual, sensory or auditory stimulation Caries rate Caries Rate Dependent on: High carbohydrate diet Candy as a reward Medication Elixirs Behavioral Management What can DDS do Pediatric standards Tell Show do Not excessive words Sounds may be distracting Touch sensitization Possible Non Compliance Behavioral Management Desensitization-a systematic series of appointments that help “desensitize” autistic individuals to the dental appointment/procedures Multiple appointment s At home parents practice with child with instruments like a dental office May take several visits Medical History Allergies Gluten allergies Milk allergies Seizures Immune system dysfunction GI disturbances Mood disorders Behavioral Assessment Ask questions First appointment may not be able to open mouth of patient; observe behavior Watch patient while asking parent/guardian questions Are they fidgety, do they follow your command. Are the parents intervening to help control child Behavioral Issues Mood disorders/Emotional Lability Limited Attention Span Other psychological issues (OCD, bipolar disorder) Asperger’s Disorder Self abusive behavior Aggressive behavior Dentistry and Autism Use of Nitrous Use of Mercury Use of Fluoride Treatment considerations Amalgam controversy Composite/ Fuji Vaccination controversy Fluoride consideration Topical/Varnish MI Paste Dependent if there are milk allergies Mercury and dental Amalgam No causal relationship Unable to clear body of heavy metals Thimerosal- methyl mercury preservative (removed from vaccines) Alternatives- Fuji glass ionomer, composite Fluoride Fluoride inhibits critical antioxidant enzymes that have been linked to excitotoxic reactions in the brain Ask if autistic individual swallows toothpaste GERD, GI disturbances Seizure meds (are they more prone to caries) Recommend MI Paste (check for milk allergies) Recommend quarterly cleanings Nitrous Oxide Inhibits enzyme methionine synthase Children with genetic enzyme deficiency (methylenetetrahydrofolate-MTHFR)- involved in chemical pathways of the DNA during use of nitrous. B12 deficiency also at risk Abnormalities in folic acid metabolism Treatment Options Office Bite blocks-watch for gag reflex Molt Papoose/ parent/ guardian present Oral Sedation IV sedation General Anesthesia/ referral Office Treatment Wheelchairs that can lean back Mouth Molt Bite Block Papoose if needed with parent in room Hospital Setting Proper referral Complex medical history Behavior unmanageable Contact University Local Dental Society for referrals AAHD-American Association of Hospital Dentists Resources www.autismnow.com www.autismspeaks.org www.autism-pdd.net www.autismsociety.org www.autism.com Thank you for your attention Diana Zschaschel (310) 854-6102 www.angelssmiles.net Email: [email protected]