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Meiosis: Georgia Performance Standards: SB2c:Using Mendel’s laws, explain the role of meiosis in reproductive variability. SB2e: Compare the advantages of sexual reproduction and asexual reproduction in different situations. Essential Questions: • How are haploid gamete cells produced from diploid cells? • How does meiosis generate variation in offspring? Warm-up: • Normal human body cells each contain 46 chromosomes. • The cell division process that body cells undergo is called mitosis and produces daughter cells that are virtually identical to the parent cell. • Working with a partner, discuss and answer the questions that follow. Warm-up: 1. How many chromosomes would a sperm or an egg contain if either one resulted from the process of mitosis? 2. If a sperm containing 46 chromosomes fused with an egg containing 46 chromosomes, how many chromosomes would the resulting fertilized egg contain? Do you think this would create any problems in the developing embryo? 3. In order to produce a fertilized egg with the appropriate number of chromosomes (46), how many chromosomes should each sperm and egg have? Chapter 10 Sexual Reproduction and Genetics Chromosomes and Chromosome Number Human body cells have 46 chromosomes Each parent contributes 23 chromosomes 22 autosomes (undergoes mitosis) 1 sex chromosome (X or Y) (undergoes meiosis) Homologous chromosomes—one of two paired chromosomes, one from each parent Chapter 10 Sexual Reproduction and Genetics 10.1 Meiosis Chromosomes and Chromosome Number Same length Same centromere position Carry genes that control the same inherited traits Sexual Reproduction and Genetics Sexual Reproduction v. Asexual Reproduction • Sexual reproduction • Beneficial genes multiply faster over time. Asexual reproduction • The organism inherits all of its chromosomes from a single parent. • Genetically different (variation in genes) • The new individual is genetically identical to its parent. • EX: Meiosis, and conjugation (Prokaryotes) • Ex: mitosis and binary fission (Prokaryotes) Haploid & Diploid: • A human has 46 chromosomes in their somatic cells (body cells) – Diploid (2N) - 2 sets of chromosomes – One set from mom and one set from dad • Homologous chromosomes (same) • When males and female produce gametes (sex cells) like sperm and egg cells, then the chromosome separate (Law of segregation) • Each gamete will then receive one set of chromosomes (haploid 1N) How are haploid (N) gamete cells produced from diploid (2N) cells? • Meiosis - a process of reduction division in which the number of chromosomes per cell is cut in half through the separation of homologous chromosomes in a diploid cell. – meiosis I, and meiosis II • By the end of meiosis II, the diploid cell that entered meiosis has become 4 haploid cells. Meiosis I • Prior to meiosis I, each chromosome is replicated. • In prophase of meiosis I, however, each chromosome pairs with its corresponding homologous chromosome to form a structure called a tetrad. • There are 4 chromatids in a tetrad. This pairing of homologous chromosomes is the key to understanding meiosis. Meiosis I Con’t: • As homologous chromosomes pair up and form tetrads in meiosis I, they may exchange portions of their chromatids in a process called crossing-over. • Crossing-over results in the exchange of alleles between homologous chromosomes and produces new combinations of alleles. • Video • The homologous chromosomes separate, and two new cells are formed. • The two cells produced by meiosis I have sets of chromosomes and alleles that are different from each other and from the diploid cell that entered meiosis I. • Video Crossing-Over Section 11-4 Go to Section: Meiosis I Interphase I Prophase I Metaphase I Cells undergo a round of DNA replication, forming duplicate Chromosomes. Each chromosome pairs with its corresponding homologous chromosome to form a tetrad. Spindle fibers attach to the chromosomes that line up in the middle of the cell. Go to Section: Anaphase I The fibers pull the homologous chromosomes toward the opposite ends of the cell. Meiosis II • The two cells produced by meiosis I now enter a second meiotic division. • The chromosomes don’t replicate again, before entering meiosis II. – Thus, each of the cell’s chromosomes has 2 chromatids. • During metaphase II of meiosis, 2 chromosomes line up in the center of each cell. • In anaphase II, the paired chromatids separate. Each of the four daughter cells produced in meiosis II receives 2 chromatids. • Those four daughter cells now contain the haploid number (N)—just 2 chromosomes each. • Video Clip • Video Clip Meiosis II Prophase II Meiosis I results in two haploid (N) daughter cells, each with half the number of chromosomes as the original. Go to Section: Metaphase II The chromosomes line up in a similar way to the metaphase stage of mitosis. Anaphase II The sister chromatids separate and move toward opposite ends of the cell. Telophase II Meiosis II results in four haploid (N) daughter cells. Gamete Formation: • In male animals, the haploid gametes produced by meiosis are called sperm. • In female animals, generally only one of the cells produced by meiosis is involved in reproduction. – The other three cells, called polar bodies, usually are not involved in reproduction. Meiosis produces four genetically different haploid cells. Spermatogenesis (production of sperm cells) Oogenesis (production of egg (ova) cells) Chapter 10 Sexual Reproduction and Genetics Comparing Mitosis and Meiosis • Mitosis results in the production of two genetically identical diploid cells • A diploid cell that divides by mitosis gives rise to two diploid (2N) daughter cells. • The daughter cells have sets of chromosomes and alleles that are identical to each other and to the original parent cell. • Meiosis produces four genetically different haploid cells. • Meiosis, on the other hand, begins with a diploid cell but produces four haploid (N) cells. • These daughter cells have sets of chromosomes and alleles that are genetically different from the diploid cell and from one another. Ticket Out the Door: 1. Describe the main results of meiosis. 2. What are the principal differences between mitosis and meiosis? 3. What do the terms diploid and haploid mean? 4. What is crossing-over? 5. In human cells, 2N = 46. How many chromosomes would you expect to find in a sperm cell? In an egg cell? In a white blood cell? Explain.