Download Syllabus-PHAR 590 w05

PHAR 590 Principles of Drug Action
Course Syllabus
I. General Catalog Description
5 credits, Principles of Drug Action
PREREQ:
COREQ:
Principles of Drug Actions is an introductory course that explores the basic concepts inherent
to a full understanding of how drugs act upon the body and the body acts upon drugs. These
concepts encompass drug absorption and distribution, drug design and characterization of
drug interactions with specialized cellular components, drug activation of biologic response
via biochemical or molecular transduction mechanisms, drug-induced toxicities and drug
biotransformation or excretion.
II. General Goal
Provide graduate students with a foundational understanding of the principles that dictate
interactions of drugs with biological systems.
III. Outcomes
At the successful conclusion of this experience, a successful student will be able to:
A. Describe processes responsible for drug absorption from varying sites of
administration.
B. Explain the variety of compartments into which drugs can be distributed and their
significance.
C. Detail mechanisms of drug biotransformation and general concepts of drug
elimination
D. Understand how investigators design novel drug entities based upon their
application of medicinal chemistry to modification of lead compounds.
E. Differentiate between receptor and non-receptor mediated drug actions.
F. Characterize drug interactions with receptors or enzymes.
G. Characterize and quantify responses to drug action
H. Understand different mechanisms of transduction
I. Discuss untoward effects resulting from drug administration
J. Understand principles of drug toxicity
IV. Course Content
PHAR 590, Winter 2005 Tentative schedule
5 Total credits
Some words of caution; although specific subjects can be readily identified, students
should be aware that specific topics within biomedicine are interrelated. Instructors
expect students to utilize and build upon concepts gained in one subject to develop a
more complete understanding of, and problem solve in, other areas.
Week one
Orientation to course
Drug Absorption and Distribution
Drug Absorption and Distribution
Week two
Special Topics: Introduction
Drug Metabolism
Drug Metabolism
Week three
Martin Luther King Day (observed)
Drug Metabolism
Drug Metabolism/Excretion
Week four
Special Topics: Absorption/Distribution/Metabolism/Excretion
Drug Excretion
Principles of Drug Design
Week five
Exam #1 (Absorption, Distribution, Biotransformation, Excretion)
Principles of Drug Design
Week six
Special Topics: Drug Design
Signal Transduction
Signal Transduction
Week seven
Special Topics: Signaling Mechanisms
Signal Transduction
Pharmacologic Principles
Week eight
Exam # 2 (Principles of Drug Design and Signal Transduction)
Pharmacologic Principles
Week nine
Special Topics: Principles of Pharmacology
Pharmacology
Toxicology
Week ten (Dead Week)
Special Topics: Toxicology
Toxicology
Toxicology
Finals week
Final exam
V. Materials and Resources
Biomedicine is a dynamic area of study and lectures or class discussion may supplement
information in the texts. Suggested and required readings will be identified by the
individual instructors
Recommended Texts:
Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry,
Editors: Block, J.H. and Beale, J. M., Jr.
ISBN: 0-7817-3481-9
Publisher: LIPPINCOTT, WILLIAMS, AND WILKINS
Edition: 11th, Year: 2004
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy
Eds: David E. Golan, Armen H. Tashjian, Ehrin J. Armstrong, Joshua M. Galanter, April
Wang Armstrong, Ramy A Arnaout, Harris S Rose
ISBN# 0-7817-4678-7
Copyright 2005 LIPPINCOTT, WILLIAMS AND WILKINS
A website for the course is maintained through the OSU's Blackboard5® site through
your ONID account. Phar 590, should appear under the "Courses" section.
VI.
Faculty Members Responsible for the Course
Jane Ishmael, Ph.D., Course Coordinator
Gary DeLander, Ph.D.
Mark Leid, Ph.D.
Phil Proteau, Ph.D.
Theresa Filtz, Ph.D.
Tony Collins, Ph.D.
Rosita Rodriguez-Proteau, Ph.D.
VII.
Format
The class will meet from 9 am until 10.50 am Tuesday and Thursday. Students are also
expected to attend a weekly tutorial. This is an opportunity for more in-depth discussion of
concepts presented during the regular class period. Evening sessions will take the form of a
Journal Club, with individual instructors assigning articles/papers beforehand. Students are
expected to read all relevant papers and should come prepared to actively participate in the
group discussions.
VIII. Academic Honesty
Students are expected to have read and understood the current information regarding
academic honesty at Oregon State University. This information is available at
http://oregonstate.edu/admin/stucon/achon.htm Also, students are encouraged to ask the
course instructors if there are any questions regarding acceptable behavior.
IX.
Assessment and Evaluation
Final grades will be base on performance in examinations, the completion of a term paper
and participation in class discussions
A. Examinations
Three 100 point examinations will be given. Note, the last exam is given during final exam
week. Each examination will cover all material contained within a specific module,
however, students can expect that related material from topics completed earlier in the
academic year may also be included on the examination.
*** All students are expected to take all regularly scheduled examinations. Students unable
to take an examination at the scheduled time must notify the course coordinator prior to the
examination. Make up examinations will not be offered.
Examinations are generally graded on a 90 – 80 – 70 percentile rank and students must show
competency on each examination. Competence is considered to be performance at a grade of
‘C’ or better and is typically demonstrated by a score of 70% or greater on the examination.
Failure to demonstrate competency will be clearly indicated.
B. Signal Transduction Research Assignment
All students are expected to write a paper on an assigned topic in the area of Signal
Transduction. The paper will be worth 50 points (12.5 % of the final grade).
C. Participation in group discussions (evening class)
All students are expected to read and critically evaluate the scientific literature that is
assigned to them before class. Active participation in group discussions will be noted by the
instructor and scored on a scale of 10 for a total of 50 points (12.5 % of the final grade).
X.
Grading:
Assignment of grades following finals week will be as follows:
1. A 90 – 80 – 70 - 65 percent score will roughly correspond to grades of A, B, C and D,
respectively.
XI. Methods for Assessing the Quality of Course Instruction
Approved Oregon State University forms will be used following College of Pharmacy
procedures.
XII.
Completed by:
Jane Ishmael
November, 2004