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A Review of Scientific Papers About Head and Neck Cancers
Provedor de dados: 52
Autores: Paoli,Severo de; Fonseca,Adenilson de Souza da; Paoli,Flávia de; Geller,Mauro; Presta,Giuseppe Antonio;
Santos-Filho,Sebastião David; Bernardo-Filho,Mário.
Head and neck cancer is one of the 10 most frequent cancers worldwide, with an estimated 500000 new cases diagnosed annually.
Treatment of head and neck cancers require a multidisciplinary approach due their complexity and the functional and esthetic
alterations that cancer can cause. The interest of the scientific community in a specific subject can be evaluated by analyzing of
the
number
and
the
quality
of
published
papers
on
the
topic.
The
information
obtained
from
PubMed
(www.ncbi.nlm.nih.gov/sites/entrez) has been used as a tool in various publications to aid the evaluation of the scientific interest
in specific research areas The aim of this work is to evaluate, using PubMed, the scientific interest in studies of head and neck
cancer treatments such...
Tipo: Journal article
Palavras-chave: Scientific interest; PubMed; Cancer; Surgery; Radiotherapy; Chemotherapy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700011
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy
Provedor de dados: 52
Autores: Pereira,Kércia Regina Santos Gomes; Açucena,Maria Kadja Meneses Torres; Villarim Neto,Arthur; Rêgo,Amália
Cínthia Meneses; Bernardo-Filho,Mário; Azevedo,Ítalo Medeiros; Araújo Filho,Irami; Medeiros,Aldo Cunha.
Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the
metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m
biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were
not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30
minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a
Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls
(0.4±0.02),...
Tipo: Journal article
Palavras-chave: Splenectomy; Sodium phytate; Biodistribution; Liver.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033
Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with
technetium99m (99mTc-MDP) in Wistar rats
Provedor de dados: 52
Autores: Holanda,Cecília Maria de Carvalho Xavier; Leite,Rodrigo de Carvalho Holanda; Nunes,Reginauro Alves da Silva;
Oliveira,Harina Alves de; Catanho,Maria Teresa Jansen de Almeida; Souza,Grace Mary Lima de; Bernardo-Filho,Mário.
The aim of this work was to study the effect of antimalarial drugs on the bioavailability of 99mTc-MDP in rats. Mefloquine (MQ)
and artemisinin (AM) were administered in two treated groups (T) and sorbitol in control group (C) for 7 days. Then,
99mTc-MDP was injected in all groups and %ATI was calculated. A significant increase of %ATI in MQ group, from C to T,
occurred in spleen (0.35±0.10to0.58±0.13), liver (1.69±0.28to3.31±0.07)
and blood (0.79±0.17to2.09±0.53). The %ATI increased significantly in AM group:femur
(2.76±0.59to5.98±0.70),
liver
(1.69±0.28to4.59±0.68),
lungs
(0.29±0.05to6.22±0.86), spleen (0.35±0.10...
Tipo: Journal article
Palavras-chave: Drug interaction; Radiopharmaceuticals; 99mTc-MDP; Antimalarial drugs; Mefloquine; Artemisinin.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000300004
Effects of clove (Caryophyllus aromaticus L.) on the labeling of blood constituents with
technetium-99m and on the morphology of red blood cells
Provedor de dados: 52
Autores: Paoli,Severo de; Giani,Tania Santos; Presta,Giuseppe Antonio; Pereira,Marcia Oliveira; Fonseca,Adenilson de Souza
da; Brandão-Neto,José; Medeiros,Aldo da Cunha; Santos-Filho,Sebastião David; Bernardo-Filho,Mário.
Clove (Caryophyllus aromaticus L.) has been used for clinical procedures. Blood constituents labeled with technetium-99m
(99mTc) are used in nuclear medicine. The aim of this work was to evaluate the effects of clove extract on the labeling blood
constituents with 99mTc and on the morphology of red blood cells. Blood samples were incubated with clove, stannous chloride
and 99mTc. Plasma, blood cells, insoluble fractions of plasma and blood cells were separated. The radioactivity was counted and
percentage of radioactivity (%ATI) to each blood fraction was calculated. The shape and morphometric parameter (perimeter/area
ratio) were evaluated. Clove extract altered significantly (p<0.05) the %ATI of blood constituents and the shape of red blood
cells...
Tipo: Journal article
Palavras-chave: Technetium-99m; Blood constituents; Red blood cells; Morphology; Caryophyllus aromaticus L.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600022
Evaluation of possible failure of the mononuclear phagocyte system after total splenectomy in rats
Provedor de dados: 52
Autores: Marques,Ruy Garcia; Petroianu,Andy; Oliveira,Márcia Betânia Nunes de; Bernardo-Filho,Mário; Portela,Margareth
Crisóstomo.
Young and adult Wistar rats were submitted to total splenectomy and compared to animals not submitted to any surgical
manipulation in order to evaluate the phagocytic function of spleen. The animals were infected with Escherichia coli labeled with
technetium-99m and killed 20 minutes later. Liver, lung, spleen and a blood clot sample were taken. No significant differences
were found in the percentage of bacterial radioactivity uptake in mononuclear phagocyte system (MPS) organs in young and adult
splenectomized rats. However, phagocytosis index by macrophages of MPS organs was smaller in splenectomized animals than in
control group. Splenectomized rats were associated with a higher blood bacterial radioactivity uptake than animals of the control
group...
Tipo: Journal article
Palavras-chave: Spleen; Splenectomy; Technetium-99m; Escherichia coli; Phagocytosis; Mononuclear phagocyte system.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000200006
In Vitro study of Vellozia pusilla pohl (Velloziaceae), a Brazilian plant species: antitumoral activity
and labeling of blood elements
Provedor de dados: 52
Autores: Dantas,Ana Letícia Almeida; Valente,Lígia Maria Marino; Morais,Lilia Aparecida Salgado de; Feliciano,Glaucio;
Bernardo-Filho,Mário.
Vellozia pusilla Pohl is a species of the botanic family Velloziaceae that occurs in the subtropical regions of South America and,
although it lives under conditions of high solar irradiation and low water availability, shows great longevity. The methanol extract
of roots, stem and leaf sheaths of this species showed an antitumoral activity through the inhibition of the enzyme Topoisomerase
I when analyzed by an in vitro bioassay employing DNA repair or recombination deficient mutants of the yeast Saccharomyces
cerevisiae. In the evaluation of the effect of Vellozia pusilla methanol extract on the labeling of RBC, blood of mice was treated
with 99mTc tracer solutions. The percentage of radioactivity (%ATI) bound to plasma (P) and blood cells (BC) was...
Tipo: Journal article
Palavras-chave: Drug interaction; Antitumoral activity; Technetium-99m; Blood elements; Velloziaceae.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700008
Uncaria tomentosa extract: evaluation of effects on the in vitro and in vivo labeling of blood
constituents with technetium-99m
Provedor de dados: 52
Autores: Moreno,Silvana Ramos Farias; Carvalho,Jorge José de; Nascimento,Ana Lúcia; Olej,Beni; Rocha,Emely Kazan;
Arnobio,Adriano; Bernardo-Filho,Mário; Caldas,Luiz Querino de Araújo; Honeycut,Hayden.
The influence (in vivo and in vitro) of an Uncaria tomentosa extract (Cats claw) on the labeling of red blood cells (RBCs) and
plasma and cellular proteins with technetium-99m (Tc-99m) was evaluated. For the in vivo treatment, animals were treated with
Cats claw. For the in vitro treatment, heparinized blood was incubated with Cats claw before the addition of stannous chloride
(SnCl2) and Tc-99m. Samples of plasma (P) and RBCs were separated and also precipitated with trichloroacetic acid. The soluble
and insoluble fractions of P and RBCs were isolated. The analysis of the results of the in vivo study, indicates that there is no
significant alteration on the uptake of Tc-99m by the blood constituents, but it significantly decrease (p<0.05) the labeling...
Tipo: Journal article
Palavras-chave: Uncaria tomentosa; Technetium-99m; Radiolabeling; Blood constituents.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700024