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THE CALGARY CENTRE FOR ENGINEERED CARE The healthcare services of the future will focus on significantly improving care, while reducing cost both in the hospital and at home. Remote, wireless systems and sensors capable of vital sign monitoring, movement monitoring, on demand drug delivery systems, and continuous near real-time blood analysis are key components in providing this type of care. We are, however, not yet at the stage where this can be done in a reliable, safe and cost effective way. At the University of Calgary (UofC), we have developed not only the interdisciplinary skills but also the collaborative framework to undertake this ambitious work. The Calgary Centre for Engineered Care (CCEC) at the University of Calgary, will take a major leadership role in the development of the “engineered care” initiatives. The university’s support has allowed us to create the first Centre for Health Engineering in Canada. This unique centre brings together a multi-disciplinary team of researchers from science, engineering and medicine, with the skills and background to create a host of new devices that will be tested and will find applications in the healthcare environment. The centre will also add to the growing, globally recognized leadership of Alberta in nano- and micro-fabrication capabilities. The potential benefits to the university, city, province and country are huge, in terms of research leadership, commercial spin-offs and quality of life benefits associated with our success. A key component of the CCEC is the Advanced Microsystems Integration Facility (AMIF), a facility that will enable the development and integration of novel microsystems devices. As an example, the new Medical Ward of the 21st Century, constructed at the Foothills Hospital in Calgary, will incorporate sophisticated biomedical sensors, attached to stationary and mobile devices, all connected to wireless, self-organizing networks that will report vital signs to central sites, or on demand. The intent of the Medical Ward of the 21st Century is to provide faster response to emergency situations, reduce costs, eliminate errors and increase patient safety. AMIF is absolutely essential to realizing the ambitious goals of this ward. Our long-term vision for The Calgary Center for Engineered Care is to “be world leaders in the design, fabrication and implementation of novel next generation medical sensors and actuators, and in the training of highly qualified personnel able to develop, implement and use these advanced technologies." The CCEC and the Medical Ward of the 21st Century team offer a unique mix of engineering and patient-centred healthcare. The Medical Ward of the 21st Century is a fully functional clinical ward designed to deploy the most up-to-date medical technology. The Ward, housed at Foothills Hospital in Calgary, includes: A four-bed observation ward with bedside retractable toilets and dedicated support space to house the most acutely ill patients on the unit. Moveable walls that can be used to isolate patients. Duplication of gasses such as oxygen, air and suction at each bedside. Dedicated education rooms. Complete wireless access to patient data using laptops and handheld devices The CCEC brings together the engineering, medical and nursing expertise needed to expand the ward’s functionality to include: Monitoring of a patient’s vital signs using remote sensing technology. Page 1 of 4 On demand monitoring of patient location and movement. training of students in the resulting new equipment and protocols. The ability of medical personnel to continuously monitor patient vital signs, combined with automatic alarm systems triggering when vital signs fall outside of preset boundaries will dramatically improve their ability to provide superior care to patients. Ultimately, this will be enhanced with in-building location systems – a currently unresolved problem, where our team is confident we can be leaders. Further, monitoring can be integrated with drug delivery, initially controlled from a central location but eventually operating in a semi autonomous manner. The combination of these capabilities along with the other attributes of the Ward will make this a truly unique facility in North America and, possibly, the world. We believe that within the next five years, the CCEC will achieve the following: Design of unique low-cost, self-calibrating sensors using our microsystems integration techniques to achieve devices not possible with a standard, single fabrication technology. Development of the necessary wireless hardware and software tools. Testing in a real hospital ward environment. Training of postgraduate students in emerging technologies. Patenting and possible commercialization of the new devices. Improved and safer healthcare for all patients. The CCEC will lead the way to profound changes in the way that hospitals are operated. These changes will have substantial social impact on the way healthcare is provided – allowing for greater flexibility as well as improved care. In the coming years, there will be significant opportunities for large revenues to be derived from the commercialization of the results of the research. The intellectual property (IP) generated will include new low-cost and low-power sensors and actuators that are accurate, along with low-power radio frequency transmission circuits that will substantially lengthen the battery life of the proposed devices as compared to existing systems, possibly eliminating the need for batteries altogether. The potential for IP contributions and commercialization in areas of importance to Alberta and Albertans is significant, as are the social and health benefits associated with their actualization. Page 2 of 4 Anticipated Impact of the Centre Research In the short term, the impacts of the centre may be measured in terms of new knowledge, multidisciplinary trainees and intellectual property in the areas of the life sciences and information and communication technologies. Examples of the markets1 that the research has the potential to support include: The microelectronic medical implants market. This market, worth in the order of $11.9 billion in 2004, is expected to grow annually at 22.1% to $32.3 billion by 2009. (From a BCC report dated September 2004) The US market alone for patient monitoring devices is expected to grow at an annual rate of 8.1% to $4.3 billion USD by 2008. (From a BCC report dated October 2003) There is a real opportunity to make an early jump into the area of nano-scale devices and molecular modeling. This market, worth an estimated $400 million worldwide in 2002, is expected to grow to $1.37 billion by 2007. (From a BCC report dated September 2003). The market for drug delivery systems is huge ($38.8 billion in 2002), and will continue with double-digit growth to reach an estimated $74.5 billion by 2008. (From a BCC report dated September 2003). Forecasts for growth in the non-invasive and minimally invasive medical device market worldwide suggest a value of $4.88 and $8.33 billion USD by 2007, respectively. (From a BCC report dated May 2003). This initiative has the potential to become In the longer term (5-10 years), the proposed a cornerstone of the provincial life research will directly impact patient quality of life sciences and information and example: 1) creating flexibility in terms of the communications technology strategies, environment in which care is provided (home, driving technology development and life hospital, other settings); 2) permitting better science opportunities. monitoring of disease states and patient condition; improving the capacity to respond to patient needs novel drug delivery systems. These benefits have potential to translate into savings in the healthcare such as fewer beds and less care required due to better patient outcomes. by, for and, 3) through the system, This initiative is not only worthy in its own right but is also key to the development, testing and validation of fundamental sensing, monitoring and tracking technologies that will find use in many other sectors, including energy, finance, retail and manufacturing. For example: 1 The technology developed in this project will be directly applicable to sensor networks in the oil patch, in military and emergency services, as well as in forestry and agriculture – fundamental sectors of Alberta’s economy. The development of sophisticated micro-sensors, and the development technologies that allows them to be fabricated, will lead to spin-off initiatives in the life sciences, nano- and microelectronics, communications, oil and gas, agriculture and forestry. Low-power wireless communication systems for personal area networks, smart clothes, automatic billing systems, object tracking and identification. These types of products will become All Market figures are based on reports found at: http://www.bccresearch.com/biotech/ Page 3 of 4 ubiquitous in our society within the next few years, and the proposed research will have a direct impact on the supporting technologies. Novel MEMS devices can be used in communications systems, health diagnostics, display systems, and in the automotive and aircraft industries. The development of techniques to facilitate the integration of devices fabricated in diverse technologies (such as MEMS, microfluidics and CMOS IC's) will find application beyond instrumentation, healthcare, and environmental monitoring. The successful development of indoor location of personnel will have a huge impact on society, from location and monitoring of firefighters in burning buildings to deployment of paramedics to heart attack victims, along with new location-based services. This global business is growing at a rate of 50% per year. Clearly, the research and development opportunities enabled by this initiative will spin-off diverse benefits in many key economic sectors worth billions of dollars. We propose to proactively pursue opportunities for commercialization, develop a strong network of industry partners, and assess our designs for potential use in multiple economic contexts. This will be accelerated and facilitated by the fact that many of the members of our team have experience in IP protection. It is, therefore, our expectation that the UofC can leverage this opportunity into a strong development and commercialization thrust. Page 4 of 4