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Table S3: List of predicted results of Blast, STRING, HMMER, SMART and INTERPROSCAN for 444 HPs from T. pallidum ssp. pallidum S. Protein Uniprot Major BLAST hit Predicted HMMER SMART INTERPROSC No name ID functional AN partner (STRING) 1. HP TPASS _0004 B2S1V4 RNA binding protein recombination protein RecF Protein of unknown function (DUF721) No match found PH domainlike 2. HP TPASS _0008 B2S1V7 Lipoprotein 3. HP TPASS _0010 B2S1V8 No match found DNA topoisomerase (ATPhydrolyzing) subunit A No match found No match found beta and betaprime subunits of DNA dependent RNApolymerase Nucleotidylyl transferase No match found 4. HP TPASS _0012 B2S1W 0 TonB dependent receptor ATP-dependent protease LA No match found 5. HP TPASS _0013 B2S1W 1 Lipoprotein No match found Protein of unknown function DUF3798 UDPGlycosyltrans ferase/glycog en phosphorylase TRAF domain-like Protein of unknown function DUF3798 6. HP TPASS _0014 B2S1W 2 Transcriptional regulator No match found 7. HP TPASS _0017 B2S1W 5 Tetratricopeptide repeat (TPR) containing protein transcription elongation factor 8. HP TPASS _0021 B2S1W 9 Helicase C-terminal 9. HP TPASS _0022 B2S1X0 Helicase C-terminal 10. HP TPASS _0024 B2S1X2 Trk family potassium (K+) transporter, NAD+ binding protein sodium- and chloridedependent transporter sodium- and chloridedependent transporter K+ transport protein Protein of unknown function DUF3798 Tetratricopept ide repeat (TPR) containing protein No match found Helicase conserved Cterminal domain potassium (K+) transporter, NAD+ binding protein L-aspartase Tetratricopept ide repeat (TPR) containing protein Phase 1 flagellin Nitrile hydratase alpha chain TrkA_N, TrkA_C domain Protein of unknown function (DUF721) No match found No match found Protein of unknown function DUF3798 Tetratricopeptid e repeat (TPR) containing protein No match found Helicase conserved Cterminal domain Regulator of K+ conductance, Cterminal 11. HP TPASS _0025 B2S1X3 Peptidase_M16C aminopeptidase P Peptidase M16C associated Peptidase M16C associated Metalloenzyme, LuxS/M16 peptidase-like 12. HP TPASS _0031 B2S1X9 No significant match found chaperonin GroEL No match found Thiolase-like Transmembrane region 13. HP TPASS _0033 B2S1Y1 Membrane protein HP TPASS _0039 B2S1Y7 No significant match found Protein of unknown function (DUF1361) No match found Cysteine proteinases 14. 16S ribosomal RNA methyltransferas e RsmE regulatory protein Protein of unknown function DUF1361 No match found 15. HP TPASS _0041 B2S1Y9 No significant match found No match found No match found 16. HP TPASS _0042 B2S1Z0 lytic transglycosylase LysM domain 17. HP TPASS _0046 B2S1Z4 peptidoglycanbinding lysin domain-containing protein PSP1 domaincontaining protein ribulosephosphate 3epimerase 18. HP TPASS _0047 B2S1Z5 Protein of unknown function (DUF327) signal peptidase II-like activity PSP1 Cterminal conserved region Protein of unknown function (DUF327) 19. HP TPASS _0048 B2S1Z6 cell shape determination protein CcmA signal peptidase II-like activity Polymerforming cytoskeletal 20. HP TPASS _0049 B2S1Z7 M23/M37 peptidase domain-containing protein signal peptidase II-like activity Peptidoglycan hydrolase LytM Peptidase_M2 3 Peptidase M23 21. HP TPASS _0050 B2S1Z8 phosphoribosyl transferase protoporphyrino gen oxidase Phosphoribos yl transferase domain Pribosyltran Phosphoribosyl transferase 22. HP TPASS _0054 B2S202 rRNA (adenosine-2'O-)methyltransferase methylates position 2 of adenine 2503 in 23S rRNA RNA 2'-O ribose methyltransfe rase substrate binding SpoU_methyl ase RNA 2'-O ribose methyltransfera se substrate binding ATP synthase (F1-ATPase), gamma subunit Thymidylate synthasecomplementin g protein Thy1 LysM domain No match found LysM domain containing protein PSP1 domain PSP1 Cterminal domain Nicotinate mononucleoti de:5,6dimethylbenzi midazole phosphoribos yltransferase (CobT) DUF583 domain Protein of unknown function (DUF327) Polymerforming cytoskeletal 23. HP TPASS _0055 B2S203 oxaloacetate decarboxylase subunit gamma pyruvate carboxylase subunit B 24. HP TPASS _0059 B2S207 oxidation resistance protein replicative DNA helicase DnaB 25. HP TPASS _0064 B2S212 starch synthase 30S ribosomal protein S6 26. HP TPASS _0065 B2S213 SAM dependent methyltransferase 27. HP TPASS _0066 B2S214 No significant match found Specifically methylates position 2 of adenine 2503 in 23S rRNA flagellar motor switch protein FliM 28. HP TPASS _0067 B2S215 TPR domaincontaining protein 29. HP TPASS _0068 B2S216 Fe-S-cluster redox enzyme 30. HP TPASS _0069 B2S217 N-acetylmuramoylL-alanine amidase ATP-dependent Clp protease SH3 domain of SH3b2 type 31. HP TPASS _0070 B2S218 phosphoenolpyruvat e-protein phosphotransferase ATP-dependent Clp protease No match found 32. HP TPASS _0072 B2S220 glutaredoxin ATP-dependent Clp protease, subunit B 33. HP TPASS _0073 B2S221 HDOD domain protein No significant match found 34. HP TPASS B2S227 bifunctional aldehyde oxidase/xanthine dehydrogenase quinoline 2oxidoreductase Specifically methylates position 2 of adenine 2503 in 23S rRNA DNA-directed RNA polymerase subunit beta Oxaloacetate decarboxylase , gamma chain No match found OAD_gamma Sodium iontranslocating decarboxylase Concanavalin A-like lectins/glucan ases alphaketoacid dehydrogenas e kinase, Nterminal domain S-adenosyl-Lmethioninedependent methyltransfe rases Tetratricopept ide repeat (TPR) No match found Tetratricopept ide repeat containing protein Tetratricopeptid e repeat containing protein Ribosomal RNA large subunit methyltransfe rase N Terminal deoxynucleoti dyl transferase Aldolase Ribosomal RNA large subunit methyltransfera se No match found Glutaredoxin Glutaredoxin glutaredoxinrelated Histidine kinase-, DNA gyrase B-, and HSP90like ATPase Molybdopteri n-binding domain of aldehyde HATPase_c Histidine kinase-like ATPase, ATPbinding domain Aldehyde oxidase and xanthine dehydrogenas Aldehyde oxidase/xanthin e dehydrogenase, Mitochondrial branchedchain alphaketoacid dehydrogenas e kinase Methyltransfe rase Tetratricopept ide repeat (TPR) containing protein Tetratricopept ide repeat containing protein 4Fe-4S single cluster domain No match found RNA methyltransfera se No match found Transmembrane domain _0079 dehydrogenas e e, a/b hammerhead domain FAD binding protein molybdopterin binding 35. HP TPASS _0081 B2S229 FAD binding domain in molybdopterin dehydrogenase quinoline 2oxidoreductase FAD binding domain in molybdopteri n dehydrogenas e glycosyl hydrolase Molybdopterin dehydrogenase, FAD-binding 36. HP TPASS _0083 B2S231 glycoside hydrolase domain protein 37. HP TPASS _0084 B2S232 thioredoxin family protein 38. HP TPASS _0086 B2S234 PilZ domain protein 39. HP TPASS _0087 B2S235 No significant match found UDP-Nacetylmuramoyl alanine--Dglutamate ligase PTS system, nitrogen regulatory IIA component PTS system, nitrogen regulatory IIA component rRNA methylase (Trans)glycos idases glycosyl hydrolase No match found Thioredoxinlike No match found PilZ domain PilZ domain PilZ domain Protein of unknown function DUF192 Tryptophan synthase beta subunit-like PLPdependent enzymes Hemedependent peroxidase 40. HP TPASS _0088 B2S236 Histidine kinase cyclic nucleotide binding protein No match found 41. HP TPASS _0093 B2S241 Transcriptional regulator RNA polymerase sigma-24 factor zinc-finger domain containing No match found No match found 42. HP TPASS _0095 B2S243 Tetratricopeptide repeat (TPR) containing protein phosphate acetyltransferase HP TPASS _0110 B2S258 excinuclease ABC, A subunit-related protein RNA polymerase sigma-54 factor Tetratricopept ide repeat (TPR) containing protein alpha/betaHydrolases Tetratricopeptid e repeat (TPR) containing protein 43. Tetratricopept ide repeat (TPR) containing protein No match found 44. HP TPASS _0118 B2S266 No significant match found amino acid ABC transporter, ATP-binding protein PLC-like phosphodieste rases No match found 45. HP TPASS _0121 B2S269 lysine 2,3aminomutase lysyl-tRNA synthetase Type IV pili methylaccepting chemotaxis transducer Nterm Lysine-2,3aminomutase Elp_3 domain Lysine-2,3aminomutase Protein of unknown function DUF192 No match found No match found 46. HP TPASS _0123 B2S271 tetratricopeptide repeat protein GTP-dependent nucleic acidbinding protein EngD Tetratricopept ide repeat (TPR) containing protein Outer membrane protein betabarrel domain 47. HP TPASS _0126 B2S274 imidazole glycerol phosphate synthase subunit No match found 48. HP TPASS _0127 B2S275 No significant match found No match found 49. HP TPASS _0128 B2S276 No significant match found No match found 50. HP TPASS _0129 B2S277 glutamate 5-kinase No match found No match found 51. HP TPASS _0130 B2S278 Repeat protein K protein TprD No match found 52. HP TPASS _0132 B2S280 lantibiotic dehydratase domaincontaining protein No match found No match found Nucleoplasmi n-like/VP (viral coat and capsid proteins) Pyruvate kinase Cterminal domain-like Nitrous oxide reductase, Nterminal domain No match found 53. HP TPASS _0133 B2S281 Outer membrane protein No match found No match found DNA/RNA polymerases Outer membrane protein 54. HP TPASS _0134 B2S282 Outer membrane protein No match found No match found WD40 repeatlike Outer membrane protein 55. HP TPASS _0135 B2S283 No significant match found No match found No match found Sec7 domain No match found 56. HP TPASS _0136 B2S284 Outer membrane protein No match found No match found alpha/betaHydrolases Outer membrane protein 57. HP TPASS _0137 B2S285 No significant match found No match found No match found No match found No match found 58. HP B2S286 PAS/PAC sensor protein K+ transport protein 7tm Chemosensor PYP-like sensor domain Transmembrane domain Protein of unknown function (DUF2715) No match found TPR-like Tetratricopeptid e repeat (TPR) containing protein Outer membrane protein Outer membrane protein/outer membrane enzyme PagP , beta-barre Protein of unknown function (DUF2715) No match found Hepatitis B viral capsid No match found No match found No match found TPASS _0138 y receptor 59. HP TPASS _0139 B2S287 60. HP TPASS _0148 B2S295 Trk family potassium (K+) transporter, NAD+ binding protein Membrane protein 61. HP TPASS _0149 B2S296 62. HP TPASS _0150 B2S297 63. HP TPASS _0151 B2S298 TrkA_N domain (K+ transport protein) Trypsin-like serine proteases Regulator of K+ conductance, Nterminal possible alphaamylase 1 TrkA-N domain (K+ transport protein) No match found Membrane protein possible alphaamylase 1 Regulatory protein YrvL ITPase-like Membrane protein PTS fructose transporter subunit IIA nitrogen fixation protein No match found AhpD-like No match found nitrogen fixation protein NQR2, RnfD, RnfE family NQR2, RnfD, RnfE domain NADH-quinone reductase NQR2/RnfD 64. HP TPASS _0153 nitrogen fixation protein PAP2 family Acid phosphatase/va nadiumdependent haloperoxidase RNA pseudouridylate synthase fibronectin binding protein RNA pseudouridyla te synthase Acid phosphatase/ Vanadiumdependent haloperoxidas e PseudoU_synt h_2 domain 65. HP TPASS _0154 B2S2A1 66. HP TPASS _0156 B2S2A3 4-hydroxybenzoylCoA thioesterase prolyl-tRNA synthetase Thioesterase 4HBT domain HP TPASS _0157 B2S2A4 glycerol-3phosphate Oacyltransferase possible lysophosphatidic acid acyltransferase acyltransferas e 68. HP TPASS _0158 B2S2A5 HAD-superfamily hydrolase prolyl-tRNA synthetase Glycerol-3phosphate (1)acyltransferas e Haloacid dehalogenaselike hydrolase Acyl-CoA thioester hydrolase YbgC/YbaW family Phospholipid/gl ycerol acyltransferase 67. Hydrolase Haloacid dehalogenaselike hydrolase 69. HP TPASS _0159 B2S2A6 glutamate--cysteine ligase No match found No match found PLPdependent transferases No match found 70. HP TPASS B2S2A8 peptidoglycan glycosyltransferase No match found No match found No match found No match found NADH dehydrogenase (ubiquinone), subunit RnfD B2S2A0 acid phosphatase/vanadiu mdependenthaloperox idase related protein K+ transport protein Membrane protein Pseudouridine synthase _0161 71. HP TPASS _0169 B2S2B6 No significant match found No match found No match found No match found diguanylate cyclase protein Pfs (Responsible for cleavage of the glycosidic bond in both 5'methylthioadeno sine) No match found 72. HP TPASS _0172 B2S2B9 GGDEF domain No match found B2S2C0 diguanylate cyclase No match found HP TPASS _0174 B2S2C1 protein of unknown function DUF115 No match found (Trans)glycos idases No match found 75. HP TPASS _0175 B2S2C2 protein of unknown function DUF115 No match found 76. HP TPASS _0176 B2S2C3 ABC transporter ATP-binding protein No match found Uncharacteriz ed protein conserved in bacteria (DUF2140) protein of unknown function DUF115 protein of unknown function DUF115 No match found Photosyntheti c reaction centre, Hchain, cytoplasmic domain Actin-like ATPase domain 73. HP TPASS _0173 74. Bcr-Abl oncoprotein oligomerizati on domain SMAD/FHA domain Protein of unknown function DUF115 No match found 77. HP TPASS _0177 B2S2C4 protein of unknown function DUF115 No match found Clavaminate synthase-like 78. HP TPASS _0178 B2S2C5 Aconitate hydratase No match found protein of unknown function DUF115 No match found 79. HP TPASS _0179 B2S2C6 No significant match found No match found No match found 80. HP TPASS _0180 B2S2C7 dioxygenases related to 2-nitropropane dioxygenase No match found No match found 81. HP TPASS _0181 B2S2C8 septum formation initiator Bifunctional enzyme that catalyzes the formation of 4diphosphocytidy l-2 Septum formation initiator protein of unknown function DUF115 No match found P-loop containing nucleoside triphosphate hydrolases Fe-only hydrogenase Aspartate/orni thine carbamoyltran sferase Divlc domain No match found No match found No match found Septum formation initiator 82. HP TPASS _0182 B2S2C9 Sua5/YciO/YrdC/Y wlC family protein (Translation factor) 30S ribosomal protein S2 Telomere recombinatio n Sua5_yciO_yr dC domain 83. HP TPASS _0183 B2S2D0 testican-3 isoform 4 SsrA-binding protein 84. HP TPASS _0214 B2S2G2 No significant match found 50S ribosomal protein L17 Domain of unknown function (DUF3876) Desulfoferrod oxin, Nterminal domain 85. HP TPASS _0222 B2S2G9 methyltransferase domain protein D,Dcarboxypeptidas e Thioesterase/t hiol ester dehydraseisomerase Tryptophan synthase beta subunit-like PLPdependent enzymes Phospholipase D/nuclease 86. HP TPASS _0223 B2S2H0 pyridoxal phosphatedependent aspartate aminotransferase 87. HP TPASS _0224 B2S2H1 No significant match found 88. HP TPASS _0226 B2S2H3 cobalt transport protein cobalt ABC transporter 89. HP TPASS _0231 B2S2H8 pseudouridine synthase, RluA family 90. HP TPASS _0232 B2S2H9 91. HP TPASS _0245 92. Nacetylphosphinot hricin-tripetidedeacetylase leucine-rich repeat protein TpLRR Domain of unknown function (DUF4200) Aminotransfe rase class I and II Aminotransfe rase DHBP synthase RibB-like alpha/beta domain No match found No match found No match found Pyridoxal phosphatedependent transferase No match found Copperbinding of amyloid precursor, CuBD Cobalt transport protein No match found No match found No match found tRNA pseudouridine 55 synthase RNA pseudouridyla te synthase Pseudouridine synthase Pseudouridine synthase No significant match found possible antisigma F factor antagonist No match found No match found No match found B2S2J2 ATPase 30S ribosomal protein S7 HP TPASS _0246 B2S2J3 P-loop containing nucleoside triphosphate hydrolase von Willebrand factor, type A HP TPASS _0248 B2S2J5 ALDH-like No match found 94. HP B2S2J7 NacetylmuramoylL-alanine amidase NacetylmuramoylL-alanine amidase 30S ribosomal protein S20 P-loop containing nucleoside triphosphate hydrolases VWA domain 93. von Willebrand factor type A domain-containing protein sporulation and spore germination P-loop containing nucleoside triphosphate hydrolase von Willebrand factor type A domain Sporulation and spore germination No match found Multiheme cytochrome No match found No significant match found TPASS _0250a 95. HP TPASS _0253 B2S2K1 polymer-forming cytoskeletal family protein apolipoprotein Nacyltransferase Polymerforming cytoskeletal 96. HP TPASS _0258 B2S2K6 signal peptide protein thymidylate kinase No match found Head and neck region of the ectodomain of NDV fusion glycoprotein Snake toxinlike Polymerforming cytoskeletal 97. HP TPASS _0259 B2S2K7 LysM domaincontaining protein protein Smf LysM domain LysM domain LysM domain 98. HP TPASS _0260 B2S2K8 SH3 type 3 domaincontaining protein catabolite gene activator Bacterial SH3 domain SH3 type 3 domain No match found 99. HP TPASS _0263 B2S2L1 fibronectin type III domain-containing protein deoxyribosephosphate aldolase Fibronectin type III FN3 domain Fibronectin type 3 domain 100. HP TPASS _0266 B2S2L4 No significant match found amino acid ABC transporter No match found No match found 101. HP TPASS _0267 B2S2L5 Polymer-forming cytoskeletal polynucleotide adenylyltransfer ase Polymerforming cytoskeletal 102. HP TPASS _0268 B2S2L6 TPR domaincontaining protein polynucleotide adenylyltransfer ase Tetratricopept ide repeat Thiamin pyrophosphok inase, catalytic domain RNA polymerase subunit RPB10 Tetratricopept ide repeat 103. HP TPASS _0269 B2S2L7 MiaB-like tRNA modifying enzyme Methylthiotrans ferase, Nterminal HP TPASS _0273 B2S2M 1 membrane protein MiaB-like tRNA modifying enzyme No match found Elp3 domain 104. tRNA delta(2)isopentenylpyro phosphate transferase chromosome partitioning protein No match found membranebound protein 105. HP TPASS _0278 B2S2M 6 No significant match found bifunctional cytidylate kinase No match found Protein kinase-like No match found 106. HP TPASS B2S2M 8 amidohydrolase bifunctional cytidylate kinase No match found Pectin lyaselike No match found No match found Polymerforming cytoskeletal Tetratricopeptid e repeat _0280 107. HP TPASS _0281 B2S2M 9 No significant match found bifunctional cytidylate kinase No match found Class II aaRS and biotin synthetases No match found 108. HP TPASS _0282 B2S2N0 TPR domaincontaining protein ribosomal protein S1 Tetratricopept ide repeat No match found Tetratricopeptid e repeat 109. HP TPASS _0284 B2S2N2 radical SAM additional 4Fe4Sbinding SPASM domain-containing protein spore coat polysaccharide biosynthesis protein F Lysozymelike No match found 110. HP TPASS _0285 B2S2N3 spiro-SPASM protein Elp3 domain 4Fe4S-binding SPASM domain 111. HP TPASS _0286 B2S2N4 glycosyl transferase family HP TPASS _0287 B2S2N5 SAC3/GANP family protein 113. HP TPASS _0289 B2S2N7 cytidylyltransferase domain-containing protein spore coat polysaccharide biosynthesis protein F Nucleotidediphosphosugar transferases Glyceraldehy de-3phosphate dehydrogenas e-like, Cterminal domain Methyltransfe rase No match found 112. spore coat polysaccharide biosynthesis protein F spore coat polysaccharide biosynthesis protein F spore coat polysaccharide biosynthesis protein F Spore Coat Polysaccharid e Biosynthesis Protein SpsA; Chain A spiro-SPASM protein 114. HP TPASS _0290 B2S2N8 Cof-like hydrolase phosphoribosylp yrophosphate synthetase Hydorlase haloacid dehalogenaselike hydrolase 115. HP TPASS _0291 B2S2N9 FMN-dependent family dehydrogenase outer membrane protein TpN50 HP TPASS _0293 B2S2P1 coat F domaincontaining protein phosphoribosylp yrophosphate synthetase FMNdependent dehydrogenas e UBC-like FMNdependent dehydrogenase 116. FMNdependent dehydrogenas e No match found No match found 117. HP TPASS _0296 B2S2P4 dephospho-CoA kinase 4'phosphopantethe inyl transferase DephosphoCoA kinase DephosphoCoA kinase DephosphoCoA kinase 118. HP TPASS B2S2P5 sporulation and cell division repeat Catalyzes the phosphorylation Sporulation related Sporulation related Sporulationrelated domain No match found No match found S-adenosyl-Lmethioninedependent methyltransfe rases haloacid dehalogenaselike hydrolase No match found Methyltransfera se _0297 protein sugar ABC superfamily ATP binding cassette transporter branched-chain amino acid ABC transporter permease of the 3'hydroxyl group of dephosphocoenz ymA ribose/galactose ABC transporter, ATP-binding protein ribose/galactose ABC transporter domain domain No match found GHMP Kinase, Cterminal domain BPD_transp_ 2 domain No match found BPD_transp_ 2 domain ABC transporter, permease Peptidase MA superfamily 119. HP TPASS _0299 B2S2P7 120. HP TPASS _0301 B2S2P9 121. HP TPASS _0302 B2S2Q0 branched-chain amino acid ABC transporter permease ribose/galactose ABC transporter 122. HP TPASS _0304 B2S2Q2 DNA mismatch repair protein MutL DNA mismatch repair protein MutL 123. HP TPASS _0307 B2S2Q5 PASTA domain containing protein amino acid ABC transporter PASTA domain Quinoprotein alcohol dehydrogenas e-like PASTA domain 124. HP TPASS _0310 B2S2Q8 single-stranded DNA-binding protein amino acid ABC transporter 125. HP TPASS _0311 B2S2Q9 No significant match found No match found singlestranded DNA-binding protein No match found singlestranded DNA-binding protein Fe-only hydrogenase 126. HP TPASS _0312 B2S2R0 Membrane protein No match found 127. HP TPASS _0314 B2S2R2 No significant match found No match found Protein of unknown function DUF368 Subtilisin-like 128. HP TPASS _0315 B2S2R3 type I Lasparaginase No match found Protein of unknown function DUF368 Protein of unknown function DUF2715 Protein of unknown function DUF2715 129. HP TPASS B2S2R5 No significant match found membrane lipoprotein Branchedchain amino acid transport system / permease component Branchedchain amino acid transport system / permease component Peptidase MA superfamily No match found Fe,Mn superoxide dismutase (SOD), Cterminal domain alpha/betaHydrolases ABC transporter, permease PASTA domain single-stranded DNA-binding protein No match found Protein of unknown function DUF368 Protein of unknown function DUF2715 Protein of unknown function DUF2715 No match found _0318 130. HP TPASS _0320 B2S2R7 No significant match found membrane lipoprotein No match found No match found No match found 131. HP TPASS _0324 B2S2S1 outer membrane protein outer membrane protein No match found Porin No match found 132. HP TPASS _0325 B2S2S2 outer membrane protein outer membrane protein 133. HP TPASS _0332 B2S2S9 No significant match found 6phosphogluconat e dehydrogenase Family of unknown function (DUF490) No match found Purine and uridine phosphorylase s BRCT domain Family of unknown function (DUF490) No match found 134. HP TPASS _0333 B2S2T0 outer membrane lipoprotein carrier protein LolA No significant match found 135. HP TPASS _0334 B2S2T1 DNA-binding helixturn-helix protein, transcriptional regulator rod shapedetermining protein outer membrane lipoprotein carrier protein LolA lambda repressor-like DNA-binding domain Outer membrane lipoprotein carrier protein LolA HTH_XRE family DNA binding protein Outer membrane lipoprotein carrier protein LolA DNA-binding domain 136. HP TPASS _0335 B2S2T2 CAAX amino terminal protease No significant match found CAAX protease selfimmunity CAAX protease self-immunity 137. HP TPASS _0338 B2S2T5 No significant match found dimethyladenosi ne transferase Mid2 like cell wall stress sensor 138. HP TPASS _0339 B2S2T6 RluA family pseudouridine synthase tRNA pseudouridine synthase A RNA pseudouridyla te synthase Abi domain (CAAX protease selfimmunity) GHMP Kinase, Cterminal domain RNA pseudouridyla te synthase 139. HP TPASS _0346 B2S2U3 Lipoprtein 140. HP TPASS _0347 B2S2U4 Lipoprtein HP TPASS _0348 B2S2U5 heptaprenyl diphosphate synthase Protein of unknown function DUF2715 Protein of unknown function DUF2715 Heptaprenyl diphosphate synthase OMPA-like (Outer membrane protein) DNA-binding domain 141. phospho-Nacetylmuramoylpentapeptidetransferase phospho-Nacetylmuramoylpentapeptidetransferase peptidyl-prolyl cis-trans isomerase 142. HP B2S2U9 transcriptional gamma-glutamyl Transcription HydB/Nqo4- Heptaprenyl diphosphate synthase No match found Pseudouridine synthase, RluC/RluD Protein of unknown function DUF2715 Protein of unknown function DUF2715 Heptaprenyl diphosphate synthase component I Transcriptional TPASS _0352 Coactivator p15 kinase al Coactivator p15 (PC4) like coactivator p15 143. HP TPASS _0355 B2S2V2 CDP-alcohol phosphatidyltransfer ase RNA-binding protein No match found PX domain No match found 144. HP TPASS _0358 B2S2V5 glycosyl hydrolase No significant match found Glycosyl hydrolase Glycosyl Hydrolase Glycosyl hydrolase 145. HP TPASS _0359 B2S2V6 1-deoxy-D-xylulose 5-phosphate reductoisomerase No significant match found No match found DNA-binding domain No match found 146. HP TPASS _0360 B2S2V7 molecular chaperone DnaK No match found No match found No match found 147. HP TPASS _0368 B2S2W 5 ECF subfamily RNA polymerase sigma24 factor chromosome segregation protein Topoisomeras e DNA binding C4 zinc finger No match found Fibronectin type III No match found 148. HP TPASS _0369 B2S2W 6 tetratricopeptide repeat protein chromosome segregation protein tetratricopepti de repeat protein alpha/betaHydrolases Outer membrane lipoprotein 149. HP TPASS _0370 B2S2W 7 No significant match found Rhabdovirus spike glycoprotein Armadillo repeat No match found 150. HP TPASS _0371 B2S2W 8 4-(cytidine 5'diphospho)-2-Cmethyl-D-erythritol kinase 4diphosphocytidy l-2-C-methyl-Derythritol kinase 4-(cytidine 5'diphospho)-2C-methyl-Derythritol kinase 4diphosphocytid yl-2-C-methylD-erythritol kinase 151. HP TPASS _0373 B2S2X0 tRNA(Ile)-lysidine synthase lysidine synthase tRNA-Ilelysidine synthetase 4diphosphocyti dyl-2-Cmethyl-Derythritol kinase tRNA(Ile)lysidine synthase 152. HP TPASS _0374 B2S2X1 Tetratricopeptide repeat 50S ribosomal protein Tetratricopept ide repeat Protein prenylyltransf erase Tetratricopeptid e-like helical 153. HP TPASS _0375 B2S2X2 No significant match found No match found Homeodomai n-like No match found 154. HP TPASS B2S2X3 Lipoprotein Ligates lysine onto the cytidine present at position 34 of the AUA codon flagellar protein No match found hiamin diphosphatebinding fold (THDP- No match found LysidinetRNA(Ile) synthetase _0376 binding) 155. HP TPASS _0377 B2S2X4 flagellar basal bodyassociated protein FliL flagellar protein No match found PreATP-grasp domain No match found 156. HP TPASS _0381 B2S2X8 Membrane protein Integral membrane protein Integral membrane protein Membrane bound protein 157. HP TPASS _0382 B2S2X9 No significant match found UDP-Nacetylmuramoyl alanyl-Dglutamyl-2, 6diaminopimelate --D-alanyl-Dalanine cell division protein No match found No match found No match found 158. HP TPASS _0384 B2S2Y1 S-adenosylmethyltransferase 16S rRNA (cytosine(140 2)-N(4))methyltransfe rase Methyltransfe rase Ribosomal RNA small subunit methyltransfera se H 159. HP TPASS _0385 B2S2Y2 cell division protein FtsL Exhibits Sadenosyl-Lmethioninedependent methyltransferas e activity cell division protein HP TPASS _0392 B2S2Y9 tetratricopeptide repeat protein cell division protein ABC transporter involved in vitamin B12 uptake, BtuC tetratricopepti de repeat protein No match found 160. Cell division protein FtsL (Septum formation initiator) tetratricopepti de repeat protein 161. HP TPASS _0404 B2S301 metallo-betalactamase glutamate racemase Metallo-betalactamase Metallohydrolase/oxi doreductase 162. HP TPASS _0408 B2S305 chromosome segregation ATPase domain protein ankyrin Apolipoprotei n Homeodomai n-like No match found 163. HP TPASS _0409 B2S306 No significant match found phosphoglycolat e phosphatase No match found Cytochrome P450 No match found 164. HP TPASS _0412 B2S309 phosphoglucomu tase No match found HP TPASS _0415 B2S312 PurA ssDNA and RNAbinding protein No match found DNA/RNAbinding protein 165. PURalpha/beta/gamma DNA/RNA-binding protein pyrroline-5carboxylate synthetase-like protein No match found 166. HP B2S317 acid phosphatase survival protein Cobalamin (vitamin B12)dependent enzymes Terpenoid D-alanine glycine permease No match Tetratricopeptid e repeatcontaining domain Beta-lactamase No match found TPASS _0420 found synthases 167. HP TPASS _0421 B2S318 tetratricopeptide repeat protein transcription factor tetratricopepti de repeat protein TPR-like 168. HP TPASS _0422 B2S319 tyrosine phosphatase No match found No match found 169. HP TPASS _0423 B2S320 peptide ABC transporter ATPase No match found 170. HP TPASS _0425 B2S322 GTP cyclohydrolase V-type ATP synthase subunit E P-loop containing nucleotide triphosphate hydrolases No match found Formate dehydrogenas e/DMSO reductase, domains 1-3 P-loop containing nucleoside triphosphate hydrolases Hemedependent peroxidases 171. HP TPASS _0431 B2S328 pantothenate kinase, type III Type III pantothenate kinase Type III pantothenate kinase Type III pantothenate kinase 172. HP TPASS _0432 B2S329 serine/threonine protein kinase Sgk2 lipopolysacchari de core biosynthesis protein Catalyzes the phosphorylation of pantothenate No match found Golgi alphamannosidase II No match found 173. HP TPASS _0436 B2S332 Phosphoesterase DNA polymerase I Phosphoester ase Phosphoesteras e, DHHA1 174. HP TPASS _0437 B2S333 multidrug resistance outer membrane protein No match found No match found DHH superfamily protein, subfamily 1 HAD-like 175. HP TPASS _0438 B2S334 nucleosidediphosphate kinase Phosphatase Nucleosidetriphosphatase 176. HP TPASS _0441 B2S337 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase Inorganic polyphosphate/ATPNAD kinase NAD synthetase ATP-NAD kinase 177. HP TPASS _0443 B2S339 transcriptional regulator DNA repair protein No match found Inorganic polyphosphat e/ATP-NAD kinase Lipoxigenase 178. HP TPASS _0444 B2S340 LysM/M23/M37 peptidase DNA repair protein Peptidase LysM peptidase Tetratricopeptid e repeatcontaining domain No match found P-loop containing nucleoside triphosphate hydrolase No match found No match found Non-canonical purine NTP pyrophosphatas e Inorganic polyphosphate/ ATP-NAD kinase No match found Peptidase M23 179. HP TPASS _0447 B2S343 tetratricopeptide repeat protein 4-hydroxy-3methylbut-2-en1-yl diphosphate synthase uracil phosphoribosyltr ansferase tetratricopepti de repeat protein prenylyltransf erase tetratricopeptide repeat protein 180. HP TPASS _0449 B2S345 tetratricopeptide repeat protein tetratricopepti de repeat protein tetratricopepti de repeat protein tetratricopeptide repeat protein 181. HP TPASS _0451 B2S347 No significant match found uracil phosphoribosyltr ansferase No match found No match found No match found 182. HP TPASS _0453 B2S349 sugar ABC transporter substratebinding protein isoleucyl-tRNA synthetas No match found No match found No match found 183. HP TPASS _0454 B2S350 type IV pilus assembly PilZ No match found No match found CheY-like No match found 184. HP TPASS _0455 B2S351 No significant match found transcriptionrepair coupling factor No match found Fibronectin type III No match found 185. HP TPASS _0456 B2S352 No significant match found 50S ribosomal protein No match found Clavaminate synthase-like No match found 186. HP TPASS _0457 B2S353 DNA polymerase III subunit delta No match found No match found No match found No match found 187. HP TPASS _0458 B2S354 segregation and condensation protein chromosome segregation protein HP TPASS _0459 B2S355 RsuA family pseudouridine synthase GTP-binding protein EngA Segregation and condensation protein Zinc finger domain Segregation and condensation protein 188. segregation and condensation protein RNA pseudouridyla te synthase 189. HP TPASS _0460 B2S356 tetratricopeptide repeat protein No match found tetratricopepti de repeat protein tetratricopepti de repeat protein tetratricopeptide repeat protein 190. HP TPASS _0461 B2S357 transcriptional regulator No match found 191. HP TPASS _0462 B2S358 Outer membrane protein No match found lambda repressor-like DNA-binding domain No match found HTH_XRE domain (DNA binding) Subtilisin-like lambda repressor-like DNA-binding domain No match found 192. HP B2S359 Outer membrane No match found No match Heme- No match found Pseudouridine synthase, RsuA/RluB/E/F TPASS _0463 protein found dependent peroxidases Catalyzes the formation of N(7)methylguanine at position 46 (m7G46) in tRNA Catalyzes the formation of N(7)methylguanine at position 46 (m7G46) in tRNA No match found S-adenosyl-Lmethioninedependent methyltransfe rase tRNA (guanineN(7)-)methyltransfe rase tRNA (guanineN(7)-)methyltransfera se No match found Pleckstrinhomology domain (PH domain) No match found No match found "Helical backbone" metal receptor No match found 193. HP TPASS _0464 B2S360 tRNA (guanineN(7)-)methyltransferase 194. HP TPASS _0465 B2S361 peptidase M23 195. HP TPASS _0466 B2S362 No significant match found 196. HP TPASS _0467 B2S363 No significant match found No match found No match found Clavaminate synthase-like No match found 197. HP TPASS _0468 B2S364 tetratricopeptide repeat protein periplasmic serine protease tetratricopepti de repeat protein tetratricopepti de repeat protein tetratricopeptide repeat protein 198. HP TPASS _0470 B2S365 tetratricopeptide repeat protein No match found tetratricopepti de repeat protein tetratricopepti de repeat protein tetratricopeptide repeat protein 199. HP TPASS _0471 B2S366 tetratricopeptide repeat protein apolipoprotein Nacyltransferase tetratricopepti de repeat protein tetratricopepti de repeat protein tetratricopeptide repeat protein 200. HP TPASS _0473 B2S368 ribose/galactose ABC transporter permease excinuclease ABC subunit C Immunoglobu lin No match found 201. HP TPASS _0474 B2S369 YebC/PmpR family DNA-binding regulatory protein aspartyl-tRNA synthetase YebC-like transcriptional regulatory protein 202. HP TPASS _0479 B2S374 ABC transporter ATP-binding protein glucose-6phosphate 1dehydrogenase Nucleotidebinding domain 203. HP TPASS _0480 B2S375 Membrane protein No match found Positive regulator of sigma(E), RseC/MucC DNA-binding regulatory protein, YebC/PmpR family Protein of unknown function (DUF2715) No match found Protein of unknown function (DUF2715) No match found Pyruvoyl dependent aspartate decarboxylase 204. HP TPASS _0481 B2S376 chromosome segregation ATPase No match found Divergent CCT motif No match found CHASE3 domain beta and betaprime subunits of DNA dependent RNApolymerase 4-helical cytokine 205. HP TPASS _0482 B2S377 No significant match found No match found 206. HP TPASS _0484 B2S379 FecR protein fibronectinbinding protein FecR protein FecR protein FecR protein 207. HP TPASS _0487 B2S382 208. HP TPASS _0489 B2S384 phosphoribosylamin oimidazolesuccinocarboxamide synthase Metallo-betalactamase family protein antigen, p83/100 Quinoprotein alcohol dehydrogenas e Metallo-betalactamase Tricorn protease Nterminal domain Metallo-betalactamase Quinonprotein alcohol dehydrogenase 209. HP TPASS _0490 B2S385 antirepressor protein No match found Formate/glyce rate dehydrogenas e catalytic domain-like YceG family protein No match found 210. HP TPASS _0491 B2S386 aminodeoxychorism ate lyase RNA polymerase sigma factor YceG family protein 211. HP TPASS _0494 B2S389 zinc ribbon domain DNA primase zinc ribbon domain L domain-like Putative zinc ribbon domain 212. HP TPASS _0496 B2S390 TPR domaincontaining protein rod shapedetermining protein tetratricopepti de repeat protein tetratricopepti de repeat protein TPR domaincontaining protein 213. HP TPASS _0502 B2S396 ankyrin repeat protein ankyrin ankyrin repeat protein ankyrin repeat protein Ankyrin repeatcontaining domain 214. HP TPASS _0503 B2S397 Uridine kinases rod shapedetermining protein No match found DHH phosphoestera ses No match found 215. HP TPASS _0504 B2S398 No significant match found No match found No match found No match found No match found 216. HP B2S3A6 bifunctional 2-C- 2-C-methyl-D- 2-C-methyl- Bifunctional 2-C-methyl-D- RNA polymerase sigma factor RpoD No match found No match found Beta-lactamaselike YceG family protein TPASS _0512 methyl-D-erythritol 4-phosphate cytidylyltransferase/ 2-C-methyl-Derythritol 2,4cyclodiphosphate synthase Organic solvent tolerance protein erythritol from CTP and 2-Cmethyl- Derythritol 4phosphate D-erythritol 2,4cyclodiphosp hate synthase enzyme IspD/ispF erythritol 2,4cyclodiphosphat e synthase excinuclease ABC subunit A Organic solvent tolerance protein Thiamin pyrophosphok inase Organic solvent tolerance protein Thiamine pyrophosphok inase Organic solvent tolerance protein Thiamine pyrophosphokin ase Colicin V production protein Colicin V production protein Colicin V production protein V-type ATP synthase subunit C ATPase, V0 complex, c/d subunit 217. HP TPASS _0515 B2S3A9 218. HP TPASS _0518 B2S3B2 thiamine pyrophosphokinase phosphomethypy rimidine kinase 219. HP TPASS _0522 B2S3B5 colicin V production CvpA 220. HP TPASS _0534 B2S3C6 vacuolar-type ATPase subunit C undecaprenyldip hosphomuramoylpentap eptide beta-Nacetylglucosami nyltransferase V-type ATPase, subunit I 221. HP TPASS _0535 B2S3C7 E3 ubiquitin-protein ligase No match found No match found Thymidylate synthase/dCM P hydroxymeth ylase No match found 222. HP TPASS _0539 B2S3D1 RTA-like protein phosphoglycerat e kinase No match found No match found No match found 223. HP TPASS _0544 B2S3D6 endonuclease/exonu clease/phosphatase family protein Endonuclease /Exonuclease/ phosphatase Endonuclease /Exonuclease/ phosphatase Endonuclease/e xonuclease/pho sphatase 224. HP TPASS _0548 B2S3E0 Outer membrane protein transport protein methylgalactosid e ABC transporter, periplasmic galactosebinding protein penicillin tolerance protein TPR-like 225. HP TPASS _0552 B2S3E4 foldase PrsA phosphatase Outer membrane protein transport protein Matrix protein (MA), p15 Outer membrane protein transport protein No match found 226. HP TPASS _0553 B2S3E5 Membrane protein phosphoglycolat e phosphatase Domain of unknown function DUF20 Ribosomal protein L13 Domain of unknown function DUF20 No match found No match found 227. HP TPASS _0557 B2S3E9 ABC transporter substrate-binding protein membrane protein 228. HP TPASS _0558 B2S3F0 NiCoT family nickel (Ni2+)-cobalt (Co2+) transporter No match found 229. HP TPASS _0561 B2S3F3 beta-propeller domain of methanol dehydrogenase type protein flagellar biosynthetic protein 230. HP TPASS _0563 B2S3F5 DnaJ domaincontaining protein spore coat polysaccharide biosynthesis protein 231. HP TPASS _0564 B2S3F6 No significant match found 232. HP TPASS _0565 B2S3F7 233. HP TPASS _0567 B2S3F9 GDSL-like lipase/acylhydrolase domain-containing protein flagellar protein FlbB spore coat polysaccharide biosynthesis protein alginate Oacetylation protein 234. HP TPASS _0570 B2S3G2 Membrane protein No match found 235. HP TPASS _0572 B2S3G4 FMN-binding protein No match found 236. HP TPASS _0573 B2S3G5 retinal-specific ATPbinding cassette transporter-like 237. HP TPASS _0577 B2S3G8 Peptidase S8 and S53 subtilisin kexin sedolisin flagellar hook protein No match found peptide chain release factor Protein of unknown function DUF1007 High-affinity nickeltransport protein TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase DnaJ domain No match found Protein of unknown function (DUF459) No match found TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase FMN-binding domain (Ferric reductase like transmembran e component) No match found No match found EF-hand High-affinity nickeltransport protein No match found DnaJ molecular chaperon homology domain E2 regulatory, transactivatio n domain SGNH hydrolase Glyceraldehy de-3phosphate dehydrogenas e-like, Cterminal domain Cu,Zn superoxide dismutaselike Protein of unknown function DUF1007 Nickel/cobalt transporter, high-affinity No match found DnaJ molecular chaperon homology domain No match found Protein of unknown function (DUF459) No match found TPM domain FMN-binding domain (Ferric reductase like transmembran e component) No match found FMN-binding domain (Ferric reductase like transmembrane component) No match found Carboxypepti dase regulatory domain-like No match found 238. HP TPASS _0579 B2S3H0 No significant match found integral membrane protein No match found Argininosucci nate synthetase No match found 239. HP TPASS _0580 B2S3H1 MacB-like periplasmic core domain protein ABC transporter FtsX-like permease family Permease FtsXlike 240. HP TPASS _0582 B2S3H3 MacB-like periplasmic core domain protein integral membrane protein FtsX-like permease family Lipoprotein releasing system, permease protein FtsX-like permease family 241. HP TPASS _0583 B2S3H4 ubiquitin C-terminal hydrolase 3 No match found No match found No match found No match found 242. HP TPASS _0584 B2S3H5 glutamate-1semialdehyde aminotransferase oligopeptide ABC transporter No match found alpha/betaHydrolase No match found 243. HP TPASS _0587 B2S3H8 DNA-directed DNA polymerase III delta subunit phosphocarrier protein HPr No match found post-AAA+ oligomerizati on No match found 244. HP TPASS _0588 B2S3H9 DNA-directed DNA polymerase III delta subunit HP TPASS _0590 B2S3I1 ribosomal protein DNA polymerase III, delta subunit No match found DNA polymerase III, delta subunit Ribosomal protein L36 (RpmJ-2) DNA polymerase III, delta subunit 245. DNA polymerase III subunits gamma and tau No match found 246. HP TPASS _0592 B2S3I3 serine-type D-AlaD-Ala carboxypeptidase No match found (Trans)glycos idase 247. HP TPASS _0593 B2S3I4 3-oxoacyl-[acylcarrier protein] reductase No match found D-alanyl-Dalanine carboxypeptid ase No match found 248. HP TPASS _0594 B2S3I5 signal peptide protein adenylate kinase DNA/RNA polymerase 249. HP TPASS _0598 B2S3I8 WD domain, G-beta repeat protein phosphatidate cytidylyltransfer ase Domain of unknown function DUF2147 No match found 250. HP TPASS B2S3I9 cyclic nucleotidebinding protein zinc protease CpXC protein Actin-like ATPase YVTN repeatlike/Quinopro tein amine dehydrogenas e Zinc finger domain Permease FtsXlike No match found D-alanyl-Dalanine carboxypeptidas e No match found Domain of unknown function DUF2147 Cytochrome cd1-nitrite reductase-like, haem d1 domain Zinc finger domain _0599 251. HP TPASS _0607 B2S3J7 No significant match found 30S ribosomal protein S2 No match found Trypsin-like serine protease No match found 252. HP TPASS _0608 B2S3J8 HEAT repeat protein 30S ribosomal protein S2 HEAT repeats ARM repeat Armadillo-type fold 253. HP TPASS _0612 B2S3K2 Fe-S cluster assembly protein SufB ABC transporter, ATP-binding protein Protein binding protein SUF system FeS cluster assembly, SufB 254. HP TPASS _0613 B2S3K3 Fe-S cluster assembly protein SufB ABC transporter, ATP-binding protein Seven-hairpin glycosidases SUF system FeS cluster assembly, SufD 255. HP TPASS _0617 B2S3K7 pyrogenic exotoxin B No match found Bacterial adhesin 256. HP TPASS _0618 B2S3K8 proto-oncogene cRel No match found 257. HP TPASS _0619 B2S3K9 Lipoprotein No match found 258. HP TPASS _0622 B2S3L2 tetratricopeptide repeat protein No match found Uncharacteriz ed protein family (UPF0051) Uncharacteriz ed protein family (UPF0051) Protein of unknown function (DUF2715) Protein of unknown function (DUF2715) Protein of unknown function (DUF2715) tetratricopepti de repeat protein 259. HP TPASS _0624 B2S3L4 OmpA family protein 260. HP TPASS _0625 B2S3L5 tetratricopeptide repeat protein membranebound lytic murein transglycosylase D nicotinate phosphoribosyltr ansferase Protein of unknown function (DUF2715) Protein of unknown function (DUF2715) Protein of unknown function (DUF2715) Tetratricopeptid e repeatcontaining domain Outer membrane protein, OmpA/MotB, C-terminal No match found 261. HP TPASS _0629 B2S3L9 2-dehydro-3deoxygluconokinase 262. HP TPASS _0636 B2S3M 5 DNA repair protein RecO 263. HP TPASS B2S3M 7 Na+-driven multidrug efflux OmpA family DNA topoisomerase I, dispensable insert domain Fe,Mn superoxide dismutase Bacterial transcritptiona l activator domain OmpA family protein tetratricopepti de repeat protein Protein prenylyltransf erase flagellar basal body rod modification protein recombination protein RecR (DNA repair) No match found Cysteine proteinase No match found Recombinatio n protein O C terminal beta-carbonic anhydrase No match found tRNA delta(2)isopentenylpyro Membrane MotB of No match found No match found _0638 pump phosphate transferase 264. HP TPASS _0645 B2S3N4 No significant match found lysyl-tRNA synthetase 265. HP TPASS _0646 B2S3N5 NHL repeat containing protein seryl-tRNA synthetase 266. HP TPASS _0648 B2S3N7 Tetratricopeptide TPR_1 repeatcontaining protein metalloprotease 267. HP TPASS _0651 B2S3P0 7TM receptor with intracellular metal dependent phosphohydrolase metalloprotease 268. HP TPASS _0656 B2S3P5 269. HP TPASS _0661 B2S3Q0 Gammaaminobutyrate:alpha -ketoglutarate aminotransferase golgi trafficking protein GRIP 270. HP TPASS _0665 B2S3Q4 271. HP TPASS _0666 272. protonchannel complex MotA/MotB No match found Thiamin diphosphatebinding fold No match found NHL repeat (Trans)glycos idases Six-bladed beta-propeller, TolB-like Tetratricopept ide repeat containing protein 7TM receptor with intracellular HD hydrolase Tetratricopept ide repeat containing protein 7TM receptor with intracellular HD hydrolase No match found No match found Periplasmic binding protein-like II Tetratricopeptid e repeat containing protein Metaldependent phosphohydrola se, 7TM intracellular domain No match found flagellar hookassociated protein FlgN-like No match found No match found peptidase T uridine kinase No match found Acyl-CoA Nacyltransferas e No match found B2S3Q5 ABC multidrug transporter No match found No match found No match found HP TPASS _0668 B2S3Q7 YGGT family protein DNA polymerase III subunit alpha YGGT family Subdomain of clathrin and coatomer appendage domain YGGT family 273. HP TPASS _0674 B2S3R3 Smr domain protein glutamyl-tRNA synthetase Smr domain Smr domain Smr protein/MutS2 C-terminal 274. HP TPASS _0675 B2S3R4 GumN protein No match found TraB family GumN protein Pheromone shutdown, TraB 275. HP TPASS B2S3R5 carbon monoxide dehydrogenase No match found No match found P-loop containing nucleoside No match found No match found _0676 triphosphate hydrolase Protein kinase 276. HP TPASS _0677 B2S3R6 RIO1-domaincontaining protein No match found No match found 277. HP TPASS _0678 B2S3R7 glutamate-1semialdehyde aminotransferase No match found No match found PLPdependent transferase No match found 278. HP TPASS _0679 B2S3R8 C-C motif chemokine 20 isoform 1 precursor No match found 7TM diverse intracellular signalling Cyclin-like No match found 279. HP TPASS _0690 B2S3S9 No significant match found recombinase A No match found Subtilisin-like No match found 280. HP TPASS _0691 B2S3T0 ScpA/B protein chromosomal partition during cell division ScpA/B protein ScpA/B protein 281. HP TPASS _0693 B2S3T2 O-succinylbenzoateCoA ligase 5,10methenyltetrahy drofolate synthetase No match found 282. HP TPASS _0697 B2S3T6 2-polyprenylphenol hydroxylase nicotinamidase 283. HP TPASS _0698 B2S3T7 Lipoprotein No match found 284. HP TPASS _0699 B2S3T8 No significant match found No match found 285. HP TPASS _0700 B2S3T9 UBA/THIF-type NAD/FAD binding protein DNA-directed RNA polymerase Protein of unknown function (DUF2715) Protein of unknown function (DUF2715) MerR HTH family regulatory protein No match found Substratebinding domain of HMG-CoA reductase FAD-linked oxidase Prokaryotic chromosome segregation/con densation protein ScpA No match found 286. HP TPASS _0702 B2S3U1 M23B subfamily peptidase single-strandedDNA-specific exonuclease 287. HP TPASS _0703 B2S3U2 M23B subfamily peptidase 288. HP B2S3U5 M23/M37 peptidase Acyl-CoA dehydrogene DNA-binding domain No match found Protein of unknown function (DUF2715) Protein of unknown function (DUF2715) No match found Metallohydrolase/oxi doreductase No match found Peptidase family M23 Peptidase M23 Peptidase M23 single-strandedDNA-specific exonuclease No match found Clavaminate synthase No match found carboxyl- Peptidase Peptidase Peptidase M23 TPASS _0706 domain-containing protein terminal protease family M23 M23 RNA polymerase sigma factor WhiG RNA polymerase sigma factor WhiG RNA polymerase sigma factor WhiG No match found No match found "Helical backbone" metal receptor No match found Protein of unknown function (DUF3918) Jag Nterminus Enolase Cterminal domain No match found JagN domain Jag N-terminus Protein of unknown function (DUF1128) Flagellar biosynthesis protein, FliO Ribonuclease H No match found Flagellar biosynthesis protein, FliO Flagellar biosynthesis protein, FliO 289. HP TPASS _0707 B2S3U6 No significant match found 290. HP TPASS _0708 B2S3U7 rhomboid family protein 291. HP TPASS _0710 B2S3U9 polymerase 292. HP TPASS _0711 B2S3V0 ABC transporter-like protein 293. HP TPASS _0719 B2S3V8 Flagellar biosynthesis protein, FliO Flagellar biosynthesis protein 294. HP TPASS _0723 B2S3W 2 ribosomal RNA large subunit methyltransferase No match found No match found No match found No match found 295. HP TPASS _0730 B2S3W 9 CDP-diacylglycerol-glycerol-3phosphate 3phosphatidyltransfer ase CDP-alcohol phosphatidylt ransferase CDP-alcohol phosphatidyltr ansferase CDP-alcohol phosphatidyltra nsferase 296. HP TPASS _0731 B2S3X0 NUDIX hydrolase CDPdiacylglycerol-glycerol-3phosphate 3phosphatidyltran sferase treponemal aqueous protein NUDIX domain NUDIX domain NUDIX hydrolase domain 297. HP TPASS _0733 B2S3X2 glucan synthase-like protein methylenetetrah ydrofolate dehydrogenase Outer membrane protein betabarrel domain OMPA-like 298. HP TPASS _0738 B2S3X7 iojap-like ribosomeassociated protein 50S ribosomal protein Iojap/YbeBlike No match found 299. HP TPASS _0739 B2S3X8 LytR family transcriptional regulator No match found 300. HP TPASS B2S3X9 nicotinate-nucleotide adenylyltransferase LytR cell enveloperelated transcriptiona l attenuator HD domain cell enveloperelated transcriptional attenuator domain Metal dependent Outer membrane protein/outer membrane enzyme PagP , beta-barrel Protein Iojap/ribosomal silencing factor RsfS Cell enveloperelated transcriptional attenuator reversible adenylation of Metal dependent _0740 nicotinate mononucleotide reversible adenylation of nicotinate mononucleotide nicotinate (nicotinamide ) nucleotide adenylyltransf erase Protein of unknown function DUF464 No match found phosphohydro lases with conserved 'HD' moti nicotinatenucleotide adenylyltransf erase phosphohydrola ses with conserved 'HD' moti nicotinatenucleotide adenylyltransfer ase FMNdependent nitroreductase Protein of unknown function DUF464 No match found 301. HP TPASS _0741 B2S3Y0 nicotinate-nucleotide adenylyltransferase 302. HP TPASS _0744 B2S3Y3 Ribosomal protein 50S ribosomal protein 303. HP TPASS _0747 B2S3Y6 RNA modification GTPase TrmE pyruvate phosphate dikinase 304. HP TPASS _0749 B2S3Y8 RNA polymerase beta subunit cytoplasmic filament protein A No match found (Trans)glycos idases No match found 305. HP TPASS _0750 B2S3Y9 von Willebrand factor A laminin-binding protein HP TPASS _0752 B2S3Z1 sporulation and cell division repeat protein 307. HP TPASS _0753 B2S3Z2 major facilitator transporter Nucleoside transporter TRADD, Nterminal domain No match found 308. HP TPASS _0759 B2S3Z8 No significant match found methylthiolation of N6(dimethylallyl)a denosine PTS system, nitrogen regulatory IIA component penicillinbinding protein von Willebrand factor type A domain Prim-pol domain von Willebrand factor, type A 306. von Willebrand factor type A domain Sporulation related domain No match found No match found No match found 309. HP TPASS _0761 B2S400 No significant match found penicillinbinding protein No match found No match found 310. HP TPASS _0762 B2S401 No significant match found penicillinbinding protein Protein of unknown function DUF115 sialyltransfera se cstii PLPdependent transferase No match found 311. HP TPASS _0763 B2S402 TPR repeatcontaining response regulator No match found Tetratricopept ide repeat No match found No match found 312. HP TPASS _0764 B2S403 HD domaincontaining protein Sadenosylmethion ine synthetase HD domain Metal dependent phosphohydro lases with Metal dependent phosphohydrola ses with GroEL equatorial domain No match found conserved 'HD' motif (Trans)glycos idases conserved 'HD' motif No match found Sodiumdependent phosphate transport protein No match found 313. HP TPASS _0766 B2S405 No significant match found elongation factor G Mitochondrial fission regulator 314. HP TPASS _0771 B2S410 Na/Pi cotransporter family protein sodium/protondependent alanine transporter Na+/Picotransporter Na+/Picotransporter 315. HP TPASS _0772 B2S411 LysR family transcriptional regulator integral membrane protein FliG Nterminal domain No match found 316. HP TPASS _0776 B2S415 phosphoribosyltransf erase No match found Phosphoribos yl transferase domain Phosphoribos yltransferases No match found 317. HP TPASS _0777 B2S416 histidyl-tRNA synthetase No match found Zinc finger, ZZ type DNA/RNA polymerase No match found 318. HP TPASS _0781 B2S420 peptidase M23 NAD synthetase LAGLIDAD G-like domain No match found No match found 319. HP TPASS _0782 B2S421 peptidase M23 No match found Peptidase family M23 No match found No match found 320. HP TPASS _0783 B2S422 Pyrrolo-quinoline quinone No match found No match found No match found 321. HP TPASS _0784 B2S423 LPS ABC transporter, LPSbinding protein LptC ABC transporter FAD-linked reductase 322. HP TPASS _0785 B2S424 OstA-like protein ABC transporter Lipopolysacc harideassembly, LptC-related OstA-like protein Quinoprotein amine dehydrogenase, beta chain-like Lipopolysaccha ride assembly, LptC-related OstA-like protein Organic solvent tolerance-like, N-terminal 323. HP TPASS _0787 B2S426 cation diffusion facilitator family transporter No match found No match found Galactosebinding domain No match found 324. HP TPASS _0788 B2S427 SPFH domaincontaining protein No match found No match found No match found No match found 325. HP TPASS B2S428 sigma E regulatory protein MucB/RseB No match found No match found No match found No match found _0789 326. HP TPASS _0791 B2S430 tRNA (Guanine37N(1)-) methyltransferase flagellar filament 33 kDa core protein No match found (Trans)glycos idases No match found 327. HP TPASS _0793 B2S432 No significant match found flagellar filament 33 kDa core protein No match found ARM repeat No match found 328. HP TPASS _0795 B2S434 No significant match found Sadenosylmethion ine synthetase No match found No match found No match found 329. HP TPASS _0796 B2S435 thiamine biosynthesis protein ApbE ApbE family (Thiamine biosynthesis lipoprotein) Thiamine biosynthesis lipoprotein ApbE Thiamine biosynthesis lipoprotein ApbE 330. HP TPASS _0799 B2S438 lytic transglycosylase subunit conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5hydroxymethyl2- methyl pyrimidine (HMP) moiety of thiamine methionyl-tRNA synthetase No match found No match found No match found 331. HP TPASS _0802 B2S441 glycerol kinase protein ATP-dependent Clp protease, subunit A No match found No match found No match found 332. HP TPASS _0803 B2S442 DHH family phosphoesterase DHH phosphoestera ses DHH phosphoestera ses Phosphoesteras e, RecJ-like 333. HP TPASS _0811 B2S450 No significant match found sugar ABC transporter, ATP-binding protein No match found No match found No match found No match found 334. HP TPASS _0813 B2S451 small-conductance mechanosensitive channel thioredoxin reductase No match found Mitochondrial glycoprotein MAM33-like No match found 335. HP TPASS _0815 B2S453 acetyltransferase, GNAT family thioredoxin reductase Acetyltransfer ase (GNAT) family Acetyltransfer ase (GNAT) family Acyl-CoA Nacyltransferas 336. HP TPASS _0816 B2S454 plasma membrane sodium ion/proton antiporter Sod2 No match found No match found UBC-like No match found 337. HP TPASS _0818 B2S456 PTS fructose transporter subunit IIA, partial reversible conversion of 2phosphoglycerat e into phosphoenolpyr uvate ribonuclease Z No match found Caspase-like No match found 338. HP TPASS _0820 B2S458 Tetratricopeptide repeat containing protein Tetratricopept ide repeat containing protein Mechanosensi tive ion channel Tetratricopept ide repeat containing protein Mechanosensi tive ion channel tRNA pseudouridine synthase A No match found No match found Tetratricopeptid e repeat containing protein Mechanosensiti ve ion channel MscS, Cterminal No match found 339. HP TPASS _0822 B2S460 desulfoferrodoxi n 340. HP TPASS _0825 B2S463 MscS family small conductance mechanosenstive ion channel No significant match found 341. HP TPASS _0826 B2S464 Membrane protein 4'phosphopantethe inyl transferase DisA bacterial checkpoint controller nucleotidebinding DNA integrity scanning protein, DisA, N-terminal B2S465 YbbR-like protein 4'phosphopantethe inyl transferase DisA bacterial checkpoint controller nucleotidebinding YbbR-like protein 342. HP TPASS _0827 YbbR-like protein YbbR-like protein 343. HP TPASS _0829 B2S467 Membrane protein tRNA pseudouridine synthase A 344. HP TPASS _0832 B2S470 sporulation/spore germination protein arginyl-tRNA synthetase Protein of unknown function DUF2225 Sporulation and spore germination RNA 3'terminal phosphate cyclase Sporulation and spore germination Protein of unknown function DUF2225 Sporulation and spore germination 345. HP TPASS _0833 B2S471 LPXTG-motif cell wall anchor domaincontaining protein No match found No match found No match found No match found 346. HP TPASS _0836 B2S474 pilus modification protein PilQ threonyl-tRNA synthetase No match found Nucleoside hydrolase No match found 347. HP TPASS _0839 B2S477 transposase integral membrane protein Ferritin-like No match found 348. HP TPASS _0840 B2S478 MFS transporter integral membrane protein Domain of unknown function (DUF4098) MFS general substrate transport ARM repeat Major facilitator superfamily domain, general substrate transporter 349. HP TPASS _0845 B2S483 YaiI/YqxD family protein 50S ribosomal protein YaiI/YqxD famil Protein of unknown function UPF0178 Protein of unknown function UPF0178 350. HP TPASS _0846 B2S484 cell division protein ZapA 50S ribosomal protein Cell division protein ZapA Cell division protein ZapA Cell division protein ZapA 351. HP TPASS _0847 B2S485 Maf transcription factor 50S ribosomal protein No match found No match found 352. HP TPASS _0851 B2S489 No significant match found translation initiation factor IF-3 Trimeric LpxA-like enzymes Trimeric LpxAlike 353. HP TPASS _0854 B2S492 HAMP domaincontaining protein anti-sigma F factor antagonis Protein of unknown function (DUF904) Cocaine and amphetamine regulated transcript protein (CART) HAMP domain HAMP linker domain HAMP linker domain 354. HP TPASS _0855 B2S493 Outer membrane protein ATP binding protein No match found Protein prenylyltransf erase No match found 355. HP TPASS _0856 B2S494 Outer membrane protein No match found FYVE/PHD zinc finger No match found 356. HP TPASS _0857 B2S495 (E)-beta-farnesene synthase-like No match found Outer membrane protein transport protein No match found MHC antigenrecognition domain No match found 357. HP TPASS _0858 B2S496 Outer membrane protein No match found No match found No match found 358. HP TPASS _0859 B2S497 Outer membrane protein No match found No match found Carbamoyl phosphate synthetase, small subunit Serpin like 359. HP TPASS _0860 B2S498 Tetratricopeptide repeat containing protein No match found UBC-like No match found 360. HP TPASS _0864 B2S4A2 LysM/M23/M37 peptidase HP B2S4A3 Outer membrane protein Peptidase family M23 (LysM domain) TPR-like Peptidase family M23 (LysM domain) 361. hydrolysis of both 2',3'-cyclic AMP and 2',3'cyclic GMP No match found Tetratricopept ide repeat containing protein Peptidase family M23 (LysM domain) No match found No match found No match found TPASS _0865 362. HP TPASS _0867 B2S4A4 PHD-finger domaincontaining protein flagellar filament 34.5 kDa core protein No match found DNA polymerase beta No match found 363. HP TPASS _0869 B2S4A6 cAMP-binding protein flagellar filament 31 kDa core protein No match found Metalloprotea ses ("zincins"), No match found 364. HP TPASS _0871 B2S4A8 No significant match found No match found No match found Porin No match found 365. HP TPASS _0873 B2S4B0 Ubiquitin carboxylterminal hydrolase flagellar hookassociated protein tRNA nucleotidyltra nsferase No match found No match found 366. HP TPASS _0874 B2S4B1 ABC transporter flagellar hookassociated protein No match found Nucleic acidbinding protein No match found 367. HP TPASS _0875 B2S4B2 ATP-binding protein alanine racemase ATP-binding protein 368. HP TPASS _0876 B2S4B3 glycoprotease family protein Glycoprotease RNA threonylcarbam oyl adenosine modification protein TsaE Glycoprotease 369. HP TPASS _0877 B2S4B4 phosphohydrolase DNAbinding/iron metalloprotein/A P endonuclease sensory transduction histidine kinase P-loop containing nucleotide triphosphate hydrolases Glycoproteas e 370. HP TPASS _0878 B2S4B5 lysosomal alphamannosidase-like ABC transporter No match found Metal dependent phosphohydro lases with conserved 'HD' motif Nudix Metal dependent phosphohydrola ses with conserved 'HD' motif No match found 371. HP TPASS _0879 B2S4B6 ABC transporter ABC transporter ABC transport system ABC transport system 372. HP TPASS _0882 B2S4B9 PBS lyase HEATlike repeat protein translation elongation factor P HEAT repeats ARM repeat ABC-type uncharacterised transport system Armadillo-type fold 373. HP TPASS B2S4C0 permease, YjgP/YjgQ family integral membrane protein Permease YjgP/YjgQ Permease YjgP/YjgQ HD domain (Phosphohydr olase) Permease YjgP/YjgQ _0883 374. HP TPASS _0884 B2S4C1 permease, YjgP/YjgQ family integral membrane protein permease YjgP/YjgQ family Permease YjgP/YjgQ Permease YjgP/YjgQ 375. HP TPASS _0893 B2S4D0 Ribosome maturation factor maturation of 30S ribosomal subunits YhbC-like, N-terminal domain Ribosome maturation factor rimP Ribosome maturation factor RimP 376. HP TPASS _0894 B2S4D1 NYN domain, limkain-b1-type ATP-dependent nuclease, subunit A NYN domain, limkain-b1type Class II aaRS and biotin synthetases NYN domain, limkain-b1-type 377. HP TPASS _0895 B2S4D2 CrcB family protein ATP-dependent nuclease, subunit A Domain of unknown function DUF302 Domain of unknown function DUF302 378. HP TPASS _0896 B2S4D3 ATP synthase CF1 alpha subunit No match found No match found P-loop containing nucleoside triphosphate hydrolase alpha/betaHydrolase 379. HP TPASS _0899 B2S4D6 PD-(D/E)XK nuclease family protein ATP-dependent nuclease, subunit A PD-(D/E)XK nuclease superfamily ARM repeat PD-(D/E)XK nuclease 380. HP TPASS _0900 B2S4D7 PD-(D/E)XK nuclease family protein ATP-dependent nuclease, subunit A PD-(D/E)XK nuclease superfamily PD-(D/E)XK nuclease superfamily 381. HP TPASS _0901 B2S4D8 MATE family multi antimicrobial extrusion protein ATP-dependent nuclease, subunit A MatE P-loop containing nucleoside triphosphate hydrolase Mate efflux family protein 382. HP TPASS _0904 B2S4E1 sialic acid synthase ribosomal protein S16 No match found ARM repeat 383. HP TPASS _0906 B2S4E3 KH domain containing protein ribosomal protein S16 KH domain FAH 384. HP TPASS _0907 B2S4E4 16S rRNA processing protein RimM Essential for efficient processing of 16S rRNA Ribosome maturation factor rimM 385. HP TPASS _0910 B2S4E7 glycosyltransferaselike protein tRNA (guanineN(1)-)methyltransferas e RimM Nterminal domain (Ribosome maturation factor) No match found No match found No match found Multi antimicrobial extrusion protein No match found K homology domain, prokaryotic type Ribosome maturation factor RimM No match found 386. HP TPASS _0911 B2S4E8 FlhB domain containing protein No match found FlhB HrpN YscU SpaS Family FlhB HrpN YscU SpaS Family 387. HP TPASS _0912 B2S4E9 HD-GYP domaincontaining protein No match found HD domain 388. HP TPASS _0913 B2S4F0 endonuclease No match found Restriction endonuclease like Metal dependent phosphohydro lases with conserved 'HD' motif Restriction endonucleaselike 389. HP TPASS _0914 B2S4F1 Fe-S oxidoreductase Mg2+ transport protein No match found 390. HP TPASS _0915 B2S4F2 Tetratricopeptide repeat containing protein Mg2+ transport protein 391. HP TPASS _0916 B2S4F3 iron-only hydrogenase maturation protein Mg2+ transport protein 392. HP TPASS _0918 B2S4F5 phosphatidate cytidylyltransferase integral membrane protein Tetratricopept ide repeat containing protein NADHubiquinone oxidoreductas e-F ironsulfur binding region No match found 393. HP TPASS _0920 B2S4F7 TPR domain containing protein NADH oxidase 394. HP TPASS _0922 B2S4F9 No significant match found No match found 395. HP TPASS _0923 B2S4G0 PEGA domaincontaining protein 396. HP TPASS _0927 B2S4G4 AraC family transcriptional regulator Anticodonbinding domain of a subclass of class I aminoacyltRNA synthetase TPR domaincontaining protein P-loop containing nucleoside triphosphate hydrolase Type III secretion system substrate exporter FlhBlike Metal dependent phosphohydrola ses with conserved 'HD' motif Restriction endonuclease type II-like No match found Tetratricopeptid e repeatcontaining domain No match found GTPase activation domain No match found Tetratricopept ide repeat containing protein No match found TPR repeatcontaining protein Tetratricopeptid e repeatcontaining domain No match found No match found PEGA domain PEGA domain PEGA domain signal peptidase I No match found No match found No match found TGS-like 397. HP TPASS _0928 B2S4G5 PpiC-type peptidylprolyl cis-trans isomerase No match found No match found DNA primase core No match found 398. HP TPASS _0929 B2S4G6 PpiC-type peptidylprolyl cis-trans isomerase No match found PPIC-type PPIASE domain FKBP-like No match found 399. HP TPASS _0930 B2S4G7 No significant match found No match found sialyltransfera se cstii GroES-like 400. HP TPASS _0931 B2S4G8 Alpha-alpha trehalase Trehalase Trehalase 401. HP TPASS _0932 B2S4G9 Crp/Fnr family transcription regulator UDP-Nacetylmuramoyl alanyl-Dglutamate--2,6diaminopimelate ligase No match found Protein of unknown function DUF115 Trehalase No match found No match found 402. HP TPASS _0937 B2S4H4 phosphodiesterase pyruvate oxidoreductase 403. HP TPASS _0938 B2S4H5 NAD dependent epimerase/dehydrata se family protein pyruvate oxidoreductase Calcineurinlike phosphoestera se No match found 404. HP TPASS _0940 B2S4H7 No significant match found pyruvate oxidoreductase 405. HP TPASS _0941 B2S4H8 NADPHprotochlorophyllide oxidoreductase 406. HP TPASS _0942 B2S4H9 407. HP TPASS _0944 408. 409. No match found Phosphodieste Calcineurin-like rase phosphoesterase Nucleoplasmi n-like No match found No match found No match found No match found No match found No match found Pyrrolidone carboxyl peptidase No match found FlgN protein flagellar protein FlgN protein FlgN protein FlgN-like domain B2S4I1 Tetratricopeptide repeat containing protein flagellar protein TPR-like Tetratricopeptid e-like helical HP TPASS _0950 B2S4I7 glutamate dehydrogenase 50S ribosomal protein Tetratricopept ide repeat containing protein No match found Guanido kinase No match found HP TPASS B2S4J1 Tetratricopeptide repeat containing protein pheromone shutdown protein Tetratricopept ide repeat containing Tetratricopept ide repeat containing Tetratricopeptid e repeatcontaining _0954 protein protein domain 410. HP TPASS _0955 B2S4J2 No significant match found pheromone shutdown protein No match found Cysteine proteinase No match found 411. HP TPASS _0956 B2S4J3 Lipoprotein dicarboxylate transporter No match found "Helical backbone" metal receptor No match found 412. HP TPASS _0959 B2S4J6 flagellar protein flagellar basal body rod protein Rod binding protein Rod binding protein 413. HP TPASS _0962 B2S4J9 efflux ABC transporter, permease protein ABC transporter FtsX-like permease family FtsX-like permease family Permease FtsXlike 414. HP TPASS _0963 B2S4K0 ABC transporter FtsX-like permease family HP TPASS _0966 B2S4K3 possible membrane fusion protein No match found 416. HP TPASS _0967 B2S4K4 Outer membrane protein possible membrane fusion protein 417. HP TPASS _0968 B2S4K5 chemotaxis protein possible membrane fusion protein 418. HP TPASS _0969 B2S4K6 Outer membrane protein ABC transporter Protein of unknown function (DUF3238) Cleavage and polyadenylati on factor 2 Cterminal No match found Macrolide export ATPbinding/perm ease protein Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor Immunoglobu lin-like betasandwich Permease FtsXlike 415. macrolide export ATPbinding/permease protein Outer membrane protein 419. HP TPASS _0970 B2S4K7 No significant match found No match found 420. HP TPASS _0972 B2S4K9 iron permease FTR1 domain protein 421. HP TPASS _0974 B2S4L1 Anti-sigma-28 factor, FlgM membrane antigen, pathogenspecific RNA polymerase sigma factor 422. HP TPASS B2S4L2 16S rRNA methyltransferase diphosphate-fructose-6- No match found No match found Immunoglobu lin-like betasandwich No match found Outer membrane efflux protein No match found No match found Ribonuclease H-like No match found Iron permease FTR1 family Iron permease FTR1 family Valyl tRNA synthetase tRNA binding arm Methyltransfe rase Molybdenum cofactorbinding domain Ribosomal RNA small Macrolide export ATPbinding/permea se protein No match found rRNA small subunit _0975 phosphate 1phosphotransfera se signal peptidase II No match found subunit methyltransfe rase I alpha/betaHydrolase NIF3 (NGG1p interacting factor 3) TatD related DNase NIF3 (NGG1p interacting factor 3) TatD related DNase dinuclear metal center protein sensory transduction histidine kinase No match found FMN-linked oxidoreductas e No match found DMT superfamily drug/metabolite transporter integral membrane protein EamA-like transporter family Drug/metabolite transporter B2S4M 4 No significant match found integral membrane protein Multidrug resistance efflux transporter EmrE No match found No match found No match found HP TPASS _0988 B2S4M 5 integral membrane protein integral membrane protein integral membrane protein 430. HP TPASS _0990 B2S4M 7 MarC family multiple antibiotic resistance transporter Tetratricopeptide repeat containing protein rubredoxin 431. HP TPASS _0992 B2S4M 9 L-Ala-D/L-Glu epimerase rubredoxin Tetratricopept ide repeat containing protein No match found Tetratricopept ide repeat containing protein Galactosebinding domain Multiple antibiotic resistance (MarC)-related Tetratricopeptid e repeat containing protein No match found 432. HP TPASS _0994 B2S4N1 magnesium (Mg2+)dependent deoxyribonuclease flagellar hookbasal body protein TatD related DNase TatD family hydrolase Deoxyribonucle ase, TatDrelated 433. HP TPASS _0996 B2S4N3 cyclic nucleotidebinding domain protein protease IV P22_AR Nterminal domain ARM repeat No match found 434. HP TPASS _1000 B2S4N7 No significant match found cell division protein Lumazine synthase No match found 435. HP B2S4N8 trypsin-like serine No match found L,Dtranspeptidase catalytic domain Protein of FAD/NAD(P) No match found 423. HP TPASS _0976 B2S4L3 Prolyl oligopeptidase family 424. HP TPASS _0977 B2S4L4 YbgI/family dinuclear metal center protein signal peptidase II 425. HP TPASS _0979 B2S4L6 TatD family hydrolase histidine phosphokinase/p hophatase 426. HP TPASS _0983 B2S4M 0 iron ABC transporter ATPbinding protein 427. HP TPASS _0986 B2S4M 3 428. HP TPASS _0987 429. methyltransfera se I No match found TatD related DNase TPASS _1001 protease unknown function (DUF4035) secreted protein -binding domain 436. HP TPASS _1002 B2S4N9 Protein of unknown function DUF2259, secreted No match found Galactose mutarotaselike Protein of unknown function DUF2259, secreted No match found 437. HP TPASS _1003 B2S4P0 Polyketide Synthase III No match found No match found Six-hairpin glycosidase 438. HP TPASS _1014 B2S4Q1 tetratricopeptide repeat protein transcription antitermination protein TPR-like No match found 439. HP TPASS _1018 B2S4Q5 2',3'-cyclicnucleotide 2'phosphodiesterase 2',3'-cyclicnucleotide 2'phosphodieste rase K homology RNA-binding domain 440. HP TPASS _1029 B2S4R6 RNA binding protein RNA binding domain RNA binding domain RNA binding domain 441. HP TPASS _1030 B2S4R7 No match found No match found No match found 442. HP TPASS _1032 B2S4R9 eukaryotic translation initiation factor 4 gamma 1like Membrane protein Catalyzes the hydrolysis of both 2',3'-cyclic AMP and 2',3'cyclic GMP into 3'-AMP and 3'GMP, respectively, at the 3'- terminal of RNA RNA-binding domaincontaining protein No match found Tetratricopept ide repeat containing protein K homology RNA-binding domain 443. HP TPASS _1033 B2S4S0 patatin family phospholipase DUF1312 domain containing protein integral membrane protein Protein of unknown function (DUF1312) Patatin-like phospholipase Thioesterase/t hiol ester dehydraseisomerase Patatin-like phospholipase Protein of unknown function (DUF1312 Patatin-like phospholipase 444. HP TPASS _1034 B2S4S1 CaCA family calcium (Ca2+):cation antiporter sodium/protondependent alanine transporter Sodium/calci um exchanger protein Sodium/calciu m exchanger protein Sodium/potassi um/calcium exchanger