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Lab: Cell Cycle Modeling Lab Instructions Using snap beads make: 2 chains of 7 red beads 2 chains of 5 red beads 2 chains of 7 yellow beads 2 chains of 5 yellow beads 1. Title a piece of paper Cell Cycle Modeling Lab. Write your name in the top right corner. When drawing each stage of the cell cycle include color. 2. Form chromosomes by connecting 2 chains of 7 red beads with a centromere (pipe cleaner). Repeat with the other 2 red chains. 3. Repeat step 2 with the yellow beads. You should now have 4 chromosomes total, 2 red chromosomes and 2 yellow chromosomes 4. Use 2 long pieces of string to make the parent cell membrane and 2 shorter pieces of string to make the nuclear membrane. 5. Model the Cell Cycle. Use the following instructions and your notes to help you. 6. Arrange the chromosomes in the center and use the string to make the nuclear membrane and cell membrane of the parent cell. This is Interphase. Draw Interphase. Label: interphase, chromosome, chromatid, centromere, cell membrane, nuclear membrane. Write at least 1 sentence explaining what happens in this stage of the cell cycle. 7. Remove the nucleus. This is Prophase. Spindle fibers appear in this stage. For this lab the spindle fibers are imaginary. Draw prophase. Label: Prophase, chromosome, spindle fibers, centrioles. Write at least 1 sentence explaining what happens in this stage of the cell cycle. 8. Line up the chromosomes in the center (equator) of the cell. This is metaphase. Draw metaphase. Include spindle fibers attaching to the chromatids. Label: metaphase, equator, spindle fibers. Write at least 1 sentence explaining what happens in this stage of the cell cycle. 9. Separate chromatids toward the centrioles at either end (pole) of the cell. This is anaphase. Draw anaphase. Label: anaphase, centrioles, chromatids. Write at least 1 sentence explaining what happens in this stage of the cell cycle. 10. Slightly pinch the middle of the cell to represent the start of cytokinesis during telophase. Place strings to represent the nuclei forming in each new cell. Draw telophase. Label: telophase, chromosomes, nuclear membrane, centrioles. Write at least 1 sentence explaining what happens in this stage of the cell cycle. 11. Create two new cells to represent cytokinesis. Draw cytokinesis. Label: cytokinesis, both nuclei, chromatin. Write at least 1 sentence explaining what happens in this stage of the cell cycle. 12. Practice the stages of the cell cycle (interphase, mitosis, cytokinesis) until you can do it and name it without looking at notes or the book. 13. Demonstrate that you can do this to the teacher and get 10 points. Turn in your drawings. Include these words in your sketches and demonstration quiz: Chromosomes Chromatids Centromeres Cell membrane Nuclear membrane Spindle fibers Centrioles Equator Poles Prophase Metaphase Anaphase Telophase Mitosis Cytokinesis