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Lip Teh December 2005 Eyelid Anatomy and Evaluation Embryology eyelids develop from mesenchymal folds above and below the optic cup beginning during the 4 - 5 week week 10 – eyelids make contact along their margin and temporarily fuse by desmosomes, thus isolating the eyes from amniotic fluid begin to separate at 20 weeks Failure of complete separation results clinically in varying degrees of ankyloblepharon Levator develops late in the 3rd month Initially, the levator and superior rectus are blended as one common muscle. When the fetus reaches 60 mm in length, the levator muscle separates. This unique two-stage embryogenesis may explain why the levator muscle is the eye muscle most prone to defects. Anatomy Lip Teh December 2005 Eyelid skin thinnest in human body (0.7mm), upper thicker than lower. dense sweat glands least sebaceous glands Blood supply marginal arcade - superior and inferior marginal palpebral arcades peripheral arcade – at proximal end of tarsal plate contibutors: 1. superomedial - dorsal nasal artery, supraorbital artery, supratrochlea artery 2. superolateral - frontal branch of superficial temporal artery (Zygomaticoorbital – branch of middle temporal artery), lacrimal artery 3. inferomedial - angular artery, infraorbital artery 4. inferolateral - zygomaticofacial artery, transverse facial artery Lip Teh December 2005 Nerve supply superomedial - supraorbital nerve, supratrochlea nerve, infratrochlea nerve (V1) superolateral – lacrimal (v1) inferomedial - infraorbital nerve(v2), infratrochlea nerve inferolateral - zygomaticofacial nerve (v2) Lymphatics preauricular nodes – upper lid, lateral canthus, lateral ½ of lower lid submandibular nodes (via lymphatics of facial vein) – medial canthus, medial ½ lower lid layers anterior lamellae - skin and orbicularis middle lamellae - septum posterior lamellae – tarsus, retractors and conjunctiva Lip Teh December 2005 Orbicularis oculi palpebral (preseptal, pretarsal) and orbital parts gentle blink - pretarsal and preseptal hard blink –orbital part Riolan's muscle - at lid margin, forms gray line orbicularis oculi has a direct muscle attachment to the inferior orbital rim from the anterior lacrimal crest out to approximately the level of the medial corneoscleral limbus above the origin of the levator labii superioris. Lateral to this point, the attachment of the orbicularis to the rim is indirect through the orbicularis retaining ligament Nerve suppy (on deep surface): o Superior - temporal and zygomatic branches o Inferior – segmental supply from buccal and zygomatic branches o Relevance is that subciliary skin/muscle flaps will not denervate the muscle Lip Teh December 2005 Orbicularis retaining ligament (orbito-malar ligament)PRS Sept 2002 bilaminar septum-like structure attaching the orbicularis oculi to the inferior orbital rim. The attachment of the retaining ligament is broader and stronger inferolaterally than centrally. Aging changes of the retaining ligament are associated with distension, elongation, and thinning. Lip Teh December 2005 ORL is negligible medially, increases to a maximum centrally, and then diminishes laterally. Its laxity creates a V-shaped deformity Levator palpebrae Lie deep to the preaponeurotic fat 55mm (40mm muscle), 10-15mm excursion origin – lesser wing of sphenoid changes direction from horizontal to vertical at Whitnall’s ligament (superior to muscle) insertion anterior fibres – orbital septum/skin forming supratarsal fold posterior fibres – anterior surface of tarsus 3-4mm below superior border medial horn – posterior limb of medial canthal ligament lateral horn – superior edge of lateral canthal ligament, dividing lacrimal gland into orbital and palpebral parts Alternative theory (R Siegel) Dynamic fusion between levator aponeurosis and septum with intervening fat (zipper or conjoint fascia). Eyelid folds at the superior end of the fusion Take too much fat and the fusion point will move superiorly giving the impression of ptosis. Lip Teh December 2005 Mullers muscle nonstriated smooth muscle (10mm long, 15mm wide) 2-3mm of excursion inserts superior border of tarsal plate nerve supply: sympathetic (T1) via internal carotid artery Inferior Oblique muscle originates on the orbital floor, 5.14 ± 1.21 mm posterior to the inferior orbital rim, on a line extending from the infraorbital foramen to 10 ± 0.9 mm medial to the supraorbital notch along the supramedial orbital rim. Lip Teh December 2005 Capsulopalpebral ligament Condenses from Lockwood’s ligament (inferior oblique) 5mm length Equivalent to levator for lower lid Some fibres insert into dermis to contribute to lower eyelid crease Deep to the fascia lies the inferior tarsal muscle, which is analogous to Mueller's muscle. Tarsus firm, dense fibrous tissue, contains Meibomian glands extends from lateral canthus to punctum superior 30mm long, 1mm thick, 10mm wide attachments – pretarsal obicularis, levator (anterior), Mullers(superior), conjunctiva (posterior), canthal tendons inferior 25mm long, 1mm thick, 5mm wide attachments – pretarsal obicularis, capsulopalpebral ligament, conjunctiva, canthal tendons Medial canthal tendon anterior limb – anterior lacrimal crest (anterior to lacrimal sac) posterior limb – posterior lacrimal crest vertical limb – directed superoposteriorly. Unlike lateral tendon, this inserts strongly into bone (Sharpys fibers) medial retinaculum – formed by 1. deep head of pretarsal orbicularis 2. medial horn of levator 3. medial part of Lockwoods ligament Lip Teh December 2005 4. medial rectus check ligaments 5. orbital septum 6. Whitnall’s ligament Lateral canthal tendon inserts into periosteum (not to bone) around Whitnalls tubercle (2mm deep to lateral orbital rim, 10mm below ZF suture) has superficial and deep (or anterior and posterior), and superior and inferior, attachments to the orbital rim lateral retinaculum – formed by 1. lateral canthal tendon 2. preseptal and pretarsal orbicularis 3. lateral horn of levator 4. Lockwood’s ligament 5. lateral check ligaments lateral palpebral raphe lies superficial - joining the upper and lower preseptal orbicularis muscle Septum orbitale arcus marginalis is where periosteum meets the septum Lip Teh December 2005 Upper lid – inserts into levator aponeurosis 10-15mm above tarsus Lower lid – insers into capsulopalpebral fascia 5mm below tarsus Laterally, the septum is attached to the orbital margin, 1.5 mm in front of the Whitnall’s tubercle attachment of the lateral canthal tendon. The Eisler fat pocket separates the lateral canthal tendon from the orbital septum. From there, the septum continues along the superior orbital rim at the arcus marginalis. Superomedially, the septum bridges the supraorbital groove, passes inferomedially anterior to the trochlea, and then follows the posterior lacrimal crest. As it runs down the posterior lacrimal crest, it lies anterior to the medial check ligament and posterior to the Horner muscle (and hence behind the lacrimal sac). The line of attachment crosses the lacrimal sac fascia to reach the anterior lacrimal crest at the level of the lacrimal tubercle. From there, it passes inferiorly down the anterior lacrimal crest and laterally along the inferior orbital rim. A few millimeters lateral to the zygomaticomaxillary suture, the attachment leaves the rim and lies several millimeters from it on the facial aspect of the zygomatic bone, thus forming the fat-filled premarginal recess of Eisler. The line of attachment then continues to again reach the lateral orbital rim just below the level of the Whitnall ligament. Lip Teh December 2005 The orbicularis muscle fibers, together with skin (anterior lamella) insert anteriorly on the outer edge of the lateral orbital rim. The tarsoligamentous sling (posterior lamella) inserts as the lateral canthal tendon inside the lateral rim on the lateral orbital tubercle. Postseptal/preaponerotic fat pads acts as a cushion to the eyelid and divides the septum from the levator aponeurosis, this fat remains relatively constant regardless of obesity or weight loss. There is a greater amount of connective tissue and blood vessels in white fat (medial compartments); the yellow fat (lateral) has a greater amount of carotenoids. Lip Teh December 2005 Upper eyelid: 2 fat pads 1. long thin central fat pocket, preaponeurotic fat, yellow 2. globular medial fat pad – derived from intraconal orbital fat, white 3. Separated by superior oblique 4. medial fat pad is associated with the infratrochlear nerve and the terminal branch of the ophthalmic artery Lower eye lid 3 fat pads (nasal, middle, and temporal) 5. The medial and central fat pads are separated by the inferior oblique proper 6. Lateral fat pad sits in Eisler’s recess, separated by arcuate expansion of inferior oblique Lacrimal glands Basic secretors 1. goblet cells(conjuctival, tarsal and limbal) – inner layer mucin 2. accessory glands of Krause and Wolfring (fornices) - aqueous 3. meibomian glands (tarsal plate) - oil Reflex secretors – main lacrimal gland o Lateral horn of the levator palpebrae superioris divides the lacrimal gland into an orbital(66%) and a palpebral lobe (33%) o lateral palpebral lobe is prone to prolapse and may be visible externally. o Ducts from orbital lobe pass through palpebral lobe. which in turn empties into the superolateral conjunctival fornix via six to twelve tear ductules. Extirpation of palpebral lobe equals total excision of glands o Pilosebaceous(sweat) glands of Zeiss and the apocrine glands of Moll are located anterior to the meibomian glands within the distal eyelid margin (at the cilia) 1. infected meibomian gland leads to internal hordeolum 2. infected Zeiss or Moll gland leads to external hordeolum Tear = 3 layers 1. Innermost – mucous layer from goblet cells. Thinnest layer (0.05 m thick) 2. Middle – aqueous layer from Krause and Wolfring (7.0 m thick) 3. Outermost – lipid layer from Meibomian-stabilise and reduce evaporation (0.11 m thick) – also reduces surface tension so tears don’t form doplets on cornea Needs presence of intact neural system o Afferent fibres from the cornea (ophthalmic division of the trigeminal nerve, V1) synapse in the nucleus of the spinal tract of V. Within the brainstem, secondary axons from this nucleus synapse in the reticular formation. This initiates bilateral contact with the facial nerve (VII) motor nuclei which, in turn, innervate both orbicular muscles resulting in eyelid closure. o stimulation of the cornea gives rise to stimulation of the parasympathetic facial nerve fibres via the salivary nucleus through to the greater petrosal nerve. o From the pterygopalatine ganglion, the post-synaptic fibres follow the zygomatic nerve via the lacrimal nerve to the gland itself Lip Teh December 2005 o normal or basal tear flow is predominantly under sympathetic control by regulating the gland’s blood supply, whereas reflex tear secretion is under parasympathetic control as a result of trigeminal nerve stimulation. Drainage system 1. Evaporative 15% 2. Canaliculi 85% (lower 80%, upper 20%) 3. Punctum Lacrimale - Each is a small round or oval orifice (~0.3mm in diameter) at the summit of papillae lacrimalis, situated at the junction of the ciliary & lacrimal portion of lid margin medially. It is in line with the openings of tarsal glands. 4. Each canaliculi has 2 mm vertical component and a 7-8 mm horizontal component 5. Upper horizontal limb is directed medially & inferiorly while the lower limb is directed medially & superiorly, both piercing lacrimal fascia & unite (>90%) forming a small diverticulum ( sinus of Maier ) prior of entering lateral wall of lacrimal sac ~ 2.5 mm below its apex, at the level of the lower border of medial canthal tendon. Valve of Rosenmuller within diverticulum prevents reflux. 6. Lacrimal sac - 12-15mm in vertical length. Portion above entrance of common canaliculus is the fundus ~3-4mm in height & is normally compressed by the medial canthal tendon. Anterior ethmoidal sinus lies medially. Lip Teh December 2005 Lip Teh December 2005 Tear composition 1. proteins/enzymes a. protein composition of the closed-eye tear(immediately upon waking) is significantly different from that of the open and reflex-eye tear. b. protein constituents of human tears maintain the surface integrity of the cornea and conjunctiva, protect the eye from microbial invasion, maintain the stability of the tear film and also act as a lubricant between the eye and eyelids c. Secretory IgA, lactoferrin, lipocalin(tear-specific prealbumin) and lysozyme d. predominant proteins in reflex and open-eye tears are lactoferrin, lipocalin and lysozyme e. closed-eye tear is characterised by an increase in sIgA, albumin and decrease in lactoferrin, lipocalin and lysozyme. 2. electrolytes a. 297 mEq/l b. Na 132 mmol/L, K 24 mmol/L, HCO2 32.8mmol/L, Ca 0.8 mmol/L, Mg 0.61 mmol/L 3. Superior Transverse Ligament (Whitnall’s ligament) extends from the lacrimal gland fossa to the trochlea acts as a fulcrum to allow for the change in direction of the levator and as a Lip Teh December 2005 check ligament for the levator muscle Inferior Suspensory Ligament (Lockwood’s ligament) originates as a fibroelastic tissue from the inferior oblique muscle as two sheets. Anteriorly these sheets fuse to form Lockwood’s ligament. Anterior to Lockwood’s ligament is the capsulopalpebral fascia. Preseptal Fat Submuscular areolar tissue deep to the orbicularis oculi muscle. The lid may be split into anterior and posterior portions through this potential plane, which is reached by division at the gray line of the lid margin. In the upper lid, this plane is traversed by fibers of the levator aponeurosis, some of which pass through the orbicularis to attach to the skin to form the lid crease. In the lower eyelid, this plane is traversed by fibers of the orbitomalar ligament. Lip Teh December 2005 Superior continuance in this submuscular plane arrives at the retro-orbicularis oculi fat (ROOF), which is best developed in the eyebrow region. Suborbicularis oculi fat (SOOF) is found in the lower lid in a continuance of this plane. Ramirez believes that ptosis of SOOF forms the malar fat pad which is anterior to zygomaticus major and levator labii superioris Evaluation History 1) aesthetic concerns – wrinkles/forehead/eyelids/bulges 2) functional concerns – blocking vision 3) ocular history - dry eyes, contact lenses 4) systemic diseases – bleeding disorders, thyroid disease, myasthenia gravis 5) medications –aspirin Surface assessment 1. Brow position Hairline 5-6cm Midpupil to bottom of brow >23mm With brow elevated, check eyes can still close—if not brow lift is limited Get patient to close eyes in relaxed posture, then have patient open eyes—measure automatic brow elevation=compensated brow ptosis = this compensation will be lost if brow-only ptosis done Close eyes and totally relax forehead—press thumbs against brow to obstruct elevation by frontalis—now open eyes—this is resting brow posture and position of brow if bleph-only procedure is performed Lip Teh December 2005 2. Globe Visual acuity Visual fields especially with ptosis Proptosis vs exopthalmos o Exopthalmos defined as protusion secondary to endocrine dysfunction and proptosis as due to nonendocrine causes Shallow anterior chamber - glaucoma Bells Phenomenon Reflex between facial and oculomotor nuclei Corneal reflex Reflex between V1 and Facial nerve 3. Lid aesthetics Palpebral fissure is 1/5 of facial width intercanthal distance 28-32mm in female 32-34mm male (1/2 interpupillary distance) hyperteloric vs telecanthus Supratarsal crease (margin-crease distance) results from a fusion of the levator aponeurosis, orbital septum, and fascia of the orbicularis oculi into the dermis. 8-10mm above lid margin in Caucasians males, 10-11 in females Siegel believes that the height shoud be determined by the balance of levator vs orbicularis (zipper fascia). Slightly lower fold if levator is weak. 2-3mm in most Asians Palpebral fissure distance 10-11mm upper lid margin overlaps limbus 1-2mm (limbus usually 11mm) lower lid crease 4-6mm below lid margin margin touches limbus lateral commissure more mobile and more acute angle lateral canthus higher than medial (0-2mm male, 2-4mm female) mongoloid if this exaggerated reverse slant - Treacher Collins Visible pretarsal skin 3-6mm Factors determining amount of visualised pre-tarsal skin 1. Posture of brow at rest—the lower the brow the more lid overhang 2. Amount of skin redundancy 3. Level at which levator aponeurosis joins septum—ie level of fold 4. Lid fat—more fat=less pretarsal skin Lip Teh December 2005 The mean height of the eye fissure measured from the upper lid (P s) to lower lid (P i) margin at the midpupil was 10.8 ± 1.2 mm. The mean length of the eye fissure measured from medial to lateral canthus was 30.7. The mean inclination of the eye fissure was 4.1 degrees ± 2.2 degrees 4. Eyelid Bags Consider 1. excess skin a. loss of skin elasticity - leading to rhytides, color and texture changes, and festoon formation. The thin skin unveils underlying irregularities including orbicularis, orbital fat, and the tear trough. 2. excess fat – orbital fat prolapse a. upper lid – reduced pretarsal skin show or lower crease b. lower lid – eyelid bags defined below by the junction of the septum at the orbital rim. fat compartments may be visualised c. may also be due to SOOF or malar fat pads d. Unlike oedema, orbital fat is ballotable. 3. excess fluid a. eyelid accumulates fluid preferentially in systemic edema or local edema such as facial allergy b. worse after a salty meal or in the morning. c. Purplish color d. Limited inferiorly by the orbital rim because of the cutaneous ligaments, but it does not show the orbital compartmentalization of orbital fat. 4. excess muscle a. combines with loss of skin elasticity to contribute to dynamic and static rhytides b. Festoons of hypotonic muscle are diagnosed by the squinch test, in which the patient tightly contracts the orbicularis and the fold disappears. 5. tear trough depression a. feature of eyelid and midface aging b. more likely in those with maxillary hypoplasia c. due to loss of subcutaneous fat with thinning of the skin over the orbital rim ligaments combined with cheek descent Lip Teh December 2005 5. Lid ptosis Elevated position of tarsal crease suggests levator dehiscence Differentiate from pseudoptosis (excess skin) ptosis measurements (in primary gaze) Upper lid to limbus overlap 1. 1-2mm mild 2. 3 moderate 3. >4mm severe Marginal reflex distance -1 (light reflex to upper lid margin) 1. >2.5mm normal Marginal reflex distance -2 (light reflex to lower lid margin) 1. >5mm normal eyelid excursion (levator function) 1. 0-4mm poor (severe >4mm ptosis) 2. 5-7 fair (3mm ptosis) 3. 8-10 good (1-2mm ptosis) 4. >11 mm excellent 6. Lid support (lower lid) Distraction test pull lid away from globe >7mm abnormal Snap back test pulls lid away and inferiorly and allow to retract Grade 0 - normal lid that returns to position immediately on release Grade I - approximately 2-3 sec Grade II - 4-5 sec Grade III - >5 sec but does return to position with blinking Grade IV - never returns to position and continues to hang down in frank ectropion after the snap-back test Cheek lift o Assess for cicatricial ectropion o If lid margin reaches level of upper limbus, no problem Intraoperative (Codner) Pull the incised lower lid laterally Distance the lower lid stretches to the orbital rim represents the amount of redundancy. <3mm overlap – canthopexy, otherwise canthoplasty 7. Canthal laxity tests Lateral canthal tendon Pull lower lid medially away from lateral canthus and measure displacement of lateral canthal corner; the greater the distance the more the laxity Grade 0 - <2mm (normal) Grade I - 2-4 mm Grade II - 4-6 mm Grade III - > 6 mm Grade IV - >6mm and does not return to baseline even after blinking Lip Teh December 2005 Medial canthal tendon distract the lower lid laterally. Grade 0 – <2mm (normal) Grade I - 2 mm displacement Grade II - 3 mm Grade III - >3 mm Grade IV - does not return to baseline 8. Lacrimal apparatus Look for Prolapsed gland Everted puncta Canalicular test involves injection of saline into the lower canaliculus through a lacrimal cannula. o If the saline comes out the upper canaliculus, the test is considered positive; ie, the ducts are patent at least as far as their union with each other or with the lacrimal sac. Lip Teh December 2005 Primary dye test Checks for intranasal staining after 1 drop fluorescein application in the eye If dye is seen, the test is said to be positive, meaning there is no obstruction in the lacrimal passages and the epiphora is due to hypersecretion. Secondary dye test Follows the primary test – saline is flushed via a lacrimal canula. Staining in the nose implies a partial obstruction. Slit lamp examination Stains: Rose bengal stains not only dead and devitalized cells but also healthy cells that are protected inadequately by a mucin coating. Fluorescein pools in epithelial erosions and stains exposed basement membrane. Decreased tear meniscus Increased debris in the tear film Superficial punctate keratopathy Tear film breakup time (BUT) Looks at stability of the tear film Measure the average time for the first small hole to appear in the tear film when the fluorescent stained cornea is viewed using a cobalt blue filter on a slit lamp Abnormal if <10s Schirmer test 1 Measures basal and reflex production 5x35mm Whatman no 41 5mm is placed on lateral third of lower lid Left for 5mins Normal is 15mm, abnormal <10mm, very abnormal <5 mm Schirmer test 2 (perform if above is abnormal) Measures basic secretion Instill LA drops then dry with cotton tip applicator Normal is 10mm, abnormal <5mm, <3mm is very abnormal. Note: in ophthalmology literature, Schirmers 2 refers to a reflex secretion test o Perform by irritating the nasal mucosa with a cotton-tipped applicator prior to measuring tear production filter paper. Wetting <15 mm after 5 min is considered abnormal. 9. Cheek aesthetics malar hypoplasia – globe vector relationship on lateral view between the anteriormost projection of the globe and the malar eminence. Negative = angles posteriorly, indicates an absence of support for the lower lid. Lip Teh December 2005 the cheek mass should lie an average of 1.5 mm anterior to the cornea(positive vector) superior sulcus deformity central/medial fullness – fatpad herniation lateral fullness – prolapse of lacrimal gland deepening – fat atrophy, orbital fracture, enucleation hypertrophy of orbicularis – patients who squint a lot lower lid aging o orbital malar weakens – descend of malar fat pad o malar crescent – hollowing of infraorbital region and sagging cheek o increased distance between lower lid and check junction o nasolabial folds deepen Tests for myasthenia gravis edrophonium (Tensilon) test has remained the first-line test for diagnosis of MG. The Tensilon test consists of injecting a small amount of the medication edrophonium intravenously. If the patient has MG the ocular muscle weakness, the ptosis, the general muscle weakness and/or nystagmus will improve dramatically for a short period of time. acetylcholine receptor antibody titer (AChR Ab) peek test – attempt to forcibly open closed eyes, fatigue results in one or both eyes opening, and the patient appears to “peek” at the examiner. fatigue test - This consists of having the patient look at an object held up by the examiner in front of the patient. After a short period of time the eyelid(s) will droop in the person with ocular MG. sleep test, which is based on the tendency for MG symptoms to improve following rest, may be especially useful in cases where a Tensilon test is technically difficult. This may be used in small children, patients with poor veins, or allergy or sensitivity to anticholinesterase drugs such as Tensilon. morning/evening comparison test is similar in concept to the sleep test. The Lip Teh December 2005 patient is photographed, and the ptosis and ocular motility are compared at different times during the day. Old photographs are very helpful to determine how long the patient has drooping the of the upper eyelids. ice test is a simple test for ocular MG in patients who have ptosis. A surgical glove filled with ice is held against the droopy eyelid for several minutes. In ocular myasthenia the patient can open his/her eyelid normally for a short period of time after the ice is removed.